Personal information

Other IDs

Loop profile: 276612
Scopus Author ID: 7006701719

Activities

Collapse all

Employment (4)

Rutgers, The State University of New Jersey: New Brunswick, US

2024-02-05 to present | Adjunct Professor (Ernest Mario School of Pharmacy)
Employment
Source: Self-asserted source
Nicholas Meanwell

University of Michigan: Ann Arbor, US

2023-04-01 to present | Adjunct Professor (College of Pharmacy)
Employment
Source: Self-asserted source
Nicholas Meanwell

Baruch S. Blumberg Institute: Doylestown, US

2022-10 to present | Distinguished Professor
Employment
Source: Self-asserted source
Nicholas Meanwell

Bristol-Myers Squibb: Princeton, NJ, US

1982-08-12 to 2022-10-11 | Scientific Vice President (Small Molecule Drug Discovery)
Employment
Source: Self-asserted source
Nicholas Meanwell

Education and qualifications (1)

University of Sheffield: Sheffield, Sheffield, GB

1976-10-01 to 1979-09-30 | PhD (Chemistry)
Education
Source: Self-asserted source
Nicholas Meanwell

Professional activities (2)

Royal Society of Chemistry: London, London, GB

2000-01-01 to present | Fellow
Membership
Source: Self-asserted source
Nicholas Meanwell

American Chemical Society: Washington, DC, US

1981-07-01 to present | Fellow
Membership
Source: Self-asserted source
Nicholas Meanwell

Works (50 of 298)

Items per page:
Page 1 of 6

Preclinical Profile of the HIV-1 Maturation Inhibitor VH3739937

Viruses
2024-09 | Journal article | Author
DOI: 10.3390/v16101508
Contributors: Brian McAuliffe; Paul Falk; Jie Chen; Yan Chen; Sing-Yuen Sit; Jacob Swidorski; Richard Hartz; Li Xu; Brian Venables; Ny Sin et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors

Journal of Medicinal Chemistry
2019 | Journal article
DOI: 10.1021/acs.jmedchem.8b01473
EID:

2-s2.0-85061633339
Contributors: Peese, K.M.; Allard, C.W.; Connolly, T.; Johnson, B.L.; Li, C.; Patel, M.; Sorensen, M.E.; Walker, M.A.; Meanwell, N.A.; McAuliffe, B. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Allosteric Modulators of Drug Targets

Journal of Medicinal Chemistry
2019 | Journal article
DOI: 10.1021/acs.jmedchem.8b01902
EID:

2-s2.0-85059822681
Contributors: Haskell-Luevano, C.; Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective Na<inf>V</inf>1.7 Inhibitors for the Treatment of Pain

Journal of Medicinal Chemistry
2019 | Journal article
DOI: 10.1021/acs.jmedchem.8b01550
EID:

2-s2.0-85060034710
Contributors: Luo, G.; Chen, L.; Easton, A.; Newton, A.; Bourin, C.; Shields, E.; Mosure, K.; Soars, M.G.; Knox, R.J.; Matchett, M. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of new indole-based acylsulfonamide Na<inf>v</inf>1.7 inhibitors

Bioorganic and Medicinal Chemistry Letters
2019 | Journal article
DOI: 10.1016/j.bmcl.2018.12.013
EID:

2-s2.0-85059624264
Contributors: Wu, Y.-J.; Venables, B.; Guernon, J.; Chen, J.; Sit, S.-Y.; Rajamani, R.; Knox, R.J.; Matchett, M.; Pieschl, R.L.; Herrington, J. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Allosteric Modulators of Drug Targets Special Issue

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.8b00171
EID:

2-s2.0-85042609701
Contributors: Haskell-Luevano, C.; Georg, G.I.; Wang, S.; Meanwell, N.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Bioactivation of cyclopropyl rings by P450: An observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Xenobiotica
2018 | Journal article
DOI: 10.1080/00498254.2017.1409915
EID:

2-s2.0-85037728333
Contributors: Zhuo, X.; Wang, Y.-Z.; Yeung, K.-S.; Zhu, J.; Huang, X.S.; Parcella, K.E.; Eastman, K.J.; Kadow, J.F.; Meanwell, N.A.; Shu, Y.-Z. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation to Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.8b00277
EID:

2-s2.0-85046707132
Contributors: Subbaiah, M.A.M.; Meanwell, N.A.; Kadow, J.F.; Subramani, L.; Annadurai, M.; Ramar, T.; Desai, S.D.; Sinha, S.; Subramanian, M.; Mandlekar, S. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176)

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.8b00854
EID:

2-s2.0-85052407230
Contributors: Regueiro-Ren, A.; Swidorski, J.J.; Liu, Z.; Chen, Y.; Sin, N.; Sit, S.-Y.; Chen, J.; Venables, B.L.; Zhu, J.; Nowicka-Sans, B. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of morpholine-based aryl sulfonamides as Na<inf>v</inf>1.7 inhibitors

Bioorganic and Medicinal Chemistry Letters
2018 | Journal article
DOI: 10.1016/j.bmcl.2018.01.035
EID:

2-s2.0-85042640815
Contributors: Wu, Y.-J.; Guernon, J.; McClure, A.; Venables, B.; Rajamani, R.; Robbins, K.J.; Knox, R.J.; Matchett, M.; Pieschl, R.L.; Herrington, J. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.8b00759
EID:

2-s2.0-85048879772
Contributors: Wang, T.; Ueda, Y.; Zhang, Z.; Yin, Z.; Matiskella, J.; Pearce, B.C.; Yang, Z.; Zheng, M.; Parker, D.D.; Yamanaka, G.A. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.7b01788
EID:

2-s2.0-85050479164
Contributors: Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.7b01337
EID:

2-s2.0-85041617203
Contributors: Meanwell, N.A.; Krystal, M.R.; Nowicka-Sans, B.; Langley, D.R.; Conlon, D.A.; Eastgate, M.D.; Grasela, D.M.; Timmins, P.; Wang, T.; Kadow, J.F.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor

Bioorganic and Medicinal Chemistry Letters
2018 | Journal article
DOI: 10.1016/j.bmcl.2018.04.009
EID:

2-s2.0-85045033228
Contributors: Venables, B.L.; Sin, N.; Wang, A.X.; Sun, L.-Q.; Tu, Y.; Hernandez, D.; Sheaffer, A.; Lee, M.; Dunaj, C.; Zhai, G. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor

ACS Medicinal Chemistry Letters
2018 | Journal article
DOI: 10.1021/acsmedchemlett.7b00503
EID:

2-s2.0-85042057901
Contributors: Zheng, B.; D'Andrea, S.V.; Sun, L.-Q.; Wang, A.X.; Chen, Y.; Hrnciar, P.; Friborg, J.; Falk, P.; Hernandez, D.; Yu, F. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors

ACS Medicinal Chemistry Letters
2018 | Journal article
DOI: 10.1021/acsmedchemlett.8b00379
EID:

2-s2.0-85056447436
Contributors: Yeung, K.-S.; Beno, B.R.; Mosure, K.; Zhu, J.; Grant-Young, K.A.; Parcella, K.; Anjanappa, P.; Bora, R.O.; Selvakumar, K.; Wang, Y.-K. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation

Bioorganic and Medicinal Chemistry Letters
2018 | Journal article
DOI: 10.1016/j.bmcl.2018.03.067
EID:

2-s2.0-85044938196
Contributors: Chen, Y.; Sit, S.-Y.; Chen, J.; Swidorski, J.J.; Liu, Z.; Sin, N.; Venables, B.L.; Parker, D.D.; Nowicka-Sans, B.; Lin, Z. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease

Bioorganic and Medicinal Chemistry Letters
2018 | Journal article
DOI: 10.1016/j.bmcl.2017.11.005
EID:

2-s2.0-85034820312
Contributors: Bowsher, M.; Hiebert, S.; Li, R.; Wang, A.X.; Friborg, J.; Yu, F.; Hernandez, D.; Wang, Y.-K.; Klei, H.; Rajamani, R. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor

Bioorganic and Medicinal Chemistry Letters
2018 | Journal article
DOI: 10.1016/j.bmcl.2018.05.027
EID:

2-s2.0-85047086358
Contributors: Naidu, B.N.; Walker, M.A.; Sorenson, M.E.; Ueda, Y.; Matiskella, J.D.; Connolly, T.P.; Dicker, I.B.; Lin, Z.; Bollini, S.; Terry, B.J. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

The expanding role of prodrugs in contemporary drug design and development

Nature Reviews Drug Discovery
2018 | Journal article
DOI: 10.1038/nrd.2018.46
EID:

2-s2.0-85052217997
Contributors: Rautio, J.; Meanwell, N.A.; Di, L.; Hageman, M.J.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

A Synopsis of the Properties and Applications of Heteroaromatic Rings in Medicinal Chemistry

Advances in Heterocyclic Chemistry
2017 | Book
DOI: 10.1016/bs.aihch.2016.11.002
EID:

2-s2.0-85019054825
Contributors: Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Design strategies in the prodrugs of HIV-1 protease inhibitors to improve the pharmaceutical properties

European Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1016/j.ejmech.2017.07.044
EID:

2-s2.0-85028748209
Contributors: Subbaiah, M.A.M.; Meanwell, N.A.; Kadow, J.F.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Development of New Benzenesulfonamides As Potent and Selective Na<inf>v</inf>1.7 Inhibitors for the Treatment of Pain

Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1021/acs.jmedchem.6b01918
EID:

2-s2.0-85016302637
Contributors: Wu, Y.-J.; Guernon, J.; Shi, J.; Ditta, J.; Robbins, K.J.; Rajamani, R.; Easton, A.; Newton, A.; Bourin, C.; Mosure, K. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Development of the large-scale synthesis of tetrahydropyran glycine, a precursor to the HCV NS5A inhibitor BMS-986097

Journal of Organic Chemistry
2017 | Journal article
DOI: 10.1021/acs.joc.7b01852
EID:

2-s2.0-85047543906
Contributors: Mathur, A.; Wang, B.; Smith, D.; Li, J.; Pawluczyk, J.; Sun, J.-H.; Wong, M.K.; Krishnananthan, S.; Wu, D.-R.; Sun, D. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase

Bioorganic and Medicinal Chemistry Letters
2017 | Journal article
DOI: 10.1016/j.bmcl.2016.11.054
EID:

2-s2.0-85006846880
Contributors: Parcella, K.; Nickel, A.; Beno, B.R.; Sheriff, S.; Wan, C.; Wang, Y.-K.; Roberts, S.B.; Meanwell, N.A.; Kadow, J.F.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1021/acs.jmedchem.7b00328
EID:

2-s2.0-85019669634
Contributors: Yeung, K.-S.; Beno, B.R.; Parcella, K.; Bender, J.A.; Grant-Young, K.A.; Nickel, A.; Gunaga, P.; Anjanappa, P.; Bora, R.O.; Selvakumar, K. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase

Bioorganic and Medicinal Chemistry Letters
2017 | Journal article
DOI: 10.1016/j.bmcl.2017.06.024
EID:

2-s2.0-85020502917
Contributors: Zheng, B.Z.; D'Andrea, S.V.; Hanumegowda, U.; Knipe, J.O.; Mosure, K.; Zhuo, X.; Lemm, J.A.; Liu, M.; Rigat, K.L.; Wang, Y.-K. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of non-zwitterionic aryl sulfonamides as Na<inf>v</inf>1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

Bioorganic and Medicinal Chemistry
2017 | Journal article
DOI: 10.1016/j.bmc.2017.08.012
EID:

2-s2.0-85030316472
Contributors: Wu, Y.-J.; Guernon, J.; McClure, A.; Luo, G.; Rajamani, R.; Ng, A.; Easton, A.; Newton, A.; Bourin, C.; Parker, D. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Drug-target interactions that involve the replacement or displacement of magnesium ions

Bioorganic and Medicinal Chemistry Letters
2017 | Journal article
DOI: 10.1016/j.bmcl.2017.11.002
EID:

2-s2.0-85033576084
Contributors: Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Functionalized triazines as potent HCV entry inhibitors

Bioorganic and Medicinal Chemistry Letters
2017 | Journal article
DOI: 10.1016/j.bmcl.2016.12.038
EID:

2-s2.0-85009509110
Contributors: Mull, E.S.; Sun, L.-Q.; Zhao, Q.; Eggers, B.; Pokornowski, K.; Zhai, G.; Rajamani, R.; Jenkins, S.; Kramer, M.; Wang, Y.-K. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor

ACS Medicinal Chemistry Letters
2017 | Journal article
DOI: 10.1021/acsmedchemlett.7b00211
EID:

2-s2.0-85024133440
Contributors: Parcella, K.; Eastman, K.; Yeung, K.-S.; Grant-Young, K.A.; Zhu, J.; Wang, T.; Zhang, Z.; Yin, Z.; Parker, D.; Mosure, K. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Journal of Medicinal Chemistry, Technological Advances: Highlights 2015-2016

Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1021/acs.jmedchem.6b01600
EID:

2-s2.0-85018478467
Contributors: Djuric, S.W.; Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Structure-activity relationships of 4-hydroxy-4-biaryl-proline acylsulfonamide tripeptides: A series of potent NS3 protease inhibitors for the treatment of hepatitis C virus

Bioorganic and Medicinal Chemistry Letters
2017 | Journal article
DOI: 10.1016/j.bmcl.2016.12.013
EID:

2-s2.0-85008158191
Contributors: Wang, A.X.; Chen, J.; Zhao, Q.; Sun, L.-Q.; Friborg, J.; Yu, F.; Hernandez, D.; Good, A.C.; Klei, H.E.; Rajamani, R. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

MedChemComm
2017 | Journal article
DOI: 10.1039/c6md00636a
EID:

2-s2.0-85018521857
Contributors: Eastman, K.J.; Parcella, K.; Yeung, K.-S.; Grant-Young, K.A.; Zhu, J.; Wang, T.; Zhang, Z.; Yin, Z.; Beno, B.R.; Sheriff, S. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

2015 Philip S. Portoghese medicinal chemistry lectureship. Curing hepatitis C Virus infection with direct-acting antiviral agents: The arc of a medicinal chemistry triumph

Journal of Medicinal Chemistry
2016 | Journal article
DOI: 10.1021/acs.jmedchem.6b00915
EID:

2-s2.0-84983670454
Contributors: Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors

Bioorganic and Medicinal Chemistry
2016 | Journal article
DOI: 10.1016/j.bmc.2016.03.001
EID:

2-s2.0-84960970049
Contributors: Liu, Z.; Swidorski, J.J.; Nowicka-Sans, B.; Terry, B.; Protack, T.; Lin, Z.; Samanta, H.; Zhang, S.; Li, Z.; Parker, D.D. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase

Bioorganic &amp; medicinal chemistry letters
2016 | Journal article
DOI: 10.1016/j.bmcl.2015.12.058
EID:

2-s2.0-84985024527
Contributors: Hewawasam, P.; Tu, Y.; Gao, M.; Hanumegowda, U.; Knipe, J.; Lemm, J.A.; Parker, D.D.; Rigat, K.L.; Roberts, S.B.; Meanwell, N.A. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing

Journal of Medicinal Chemistry
2016 | Journal article
DOI: 10.1021/acs.jmedchem.6b00821
EID:

2-s2.0-84986540217
Contributors: Sun, L.-Q.; Mull, E.; Zheng, B.; D'Andrea, S.; Zhao, Q.; Wang, A.X.; Sin, N.; Venables, B.L.; Sit, S.-Y.; Chen, Y. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

ACS Medicinal Chemistry Letters
2016 | Journal article
DOI: 10.1021/acsmedchemlett.6b00010
EID:

2-s2.0-84974530201
Contributors: Regueiro-Ren, A.; Liu, Z.; Chen, Y.; Sin, N.; Sit, S.-Y.; Swidorski, J.J.; Chen, J.; Venables, B.L.; Zhu, J.; Nowicka-Sans, B. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Identification and characterization of BMS-955176, a second-generation HIV-1 maturation inhibitor with improved potency, antiviral spectrum, and Gag polymorphic coverage

Antimicrobial Agents and Chemotherapy
2016 | Journal article
DOI: 10.1128/AAC.02560-15
EID:

2-s2.0-84974533259
Contributors: Nowicka-Sans, B.; Protack, T.; Lin, Z.; Li, Z.; Zhang, S.; Sun, Y.; Samanta, H.; Terry, B.; Liu, Z.; Chen, Y. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space

Chemical Research in Toxicology
2016 | Journal article
DOI: 10.1021/acs.chemrestox.6b00043
EID:

2-s2.0-84964692636
Contributors: Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Inhibitors of HIV-1 attachment: The discovery and structure-activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
DOI: 10.1016/j.bmcl.2015.11.009
EID:

2-s2.0-84949591466
Contributors: Swidorski, J.J.; Liu, Z.; Yin, Z.; Wang, T.; Carini, D.J.; Rahematpura, S.; Zheng, M.; Johnson, K.; Zhang, S.; Lin, P.-F. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
DOI: 10.1016/j.bmcl.2016.03.019
EID:

2-s2.0-84960539102
Contributors: Swidorski, J.J.; Liu, Z.; Sit, S.-Y.; Chen, J.; Chen, Y.; Sin, N.; Venables, B.L.; Parker, D.D.; Nowicka-Sans, B.; Terry, B.J. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

PLoS Pathogens
2016 | Journal article
DOI: 10.1371/journal.ppat.1005990
EID:

2-s2.0-85002428412
Contributors: Lin, Z.; Cantone, J.; Lu, H.; Nowicka-Sans, B.; Protack, T.; Yuan, T.; Yang, H.; Liu, Z.; Drexler, D.; Regueiro-Ren, A. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Synergistic Activity of Combined NS5A Inhibitors

Antimicrobial Agents and Chemotherapy
2016 | Journal article
DOI: 10.1128/AAC.02639-15
EID:

2-s2.0-84960449874
Contributors: O'Boyle, D.R.; Nower, P.T.; Gao, M.; Fridell, R.; Wang, C.; Hewawasam, P.; Lopez, O.; Tu, Y.; Meanwell, N.A.; Belema, M. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design

Journal of Medicinal Chemistry
2015 | Journal article
DOI: 10.1021/jm501853m
EID:

2-s2.0-84929384579
Contributors: Beno, B.R.; Yeung, K.-S.; Bartberger, M.D.; Pennington, L.D.; Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Applications of Fluorine in Medicinal Chemistry

Journal of Medicinal Chemistry
2015 | Journal article
DOI: 10.1021/acs.jmedchem.5b00258
EID:

2-s2.0-84942638403
Contributors: Gillis, E.P.; Eastman, K.J.; Hill, M.D.; Donnelly, D.J.; Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Daclatasvir (Daklinza): The First-in-Class HCV NS5A Replication Complex Inhibitor

Innovative Drug Synthesis
2015 | Book
Part of DOI: 10.1002/9781118819951.ch3
EID:

2-s2.0-84982221037
Contributors: Belema, M.; Pack, S.K.; Meanwell, N.A.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action

Proteins: Structure, Function and Bioinformatics
2015 | Journal article
DOI: 10.1002/prot.24726
EID:

2-s2.0-84929354492
Contributors: Langley, D.R.; Roy Kimura, S.; Sivaprakasam, P.; Zhou, N.; Dicker, I.; McAuliffe, B.; Wang, T.; Kadow, J.F.; Meanwell, N.A.; Krystal, M.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

Nature
2015 | Journal article
DOI: 10.1038/nature15711
EID:

2-s2.0-84946909697
Contributors: Sun, J.-H.; O'Boyle, D.R.; Fridell, R.A.; Langley, D.R.; Wang, C.; Roberts, S.B.; Nower, P.; Johnson, B.M.; Moulin, F.; Nophsker, M.J. et al.
Source: Self-asserted source
Nicholas Meanwell via Scopus - Elsevier
Items per page:
Page 1 of 6

Peer review (53 reviews for 12 publications/grants)

Review activity for ACS central science. (1)
Review activity for ACS chemical biology. (1)
Review activity for ACS chemical neuroscience. (1)
Review activity for ACS medicinal chemistry letters. (8)
Review activity for ACS omega. (1)
Review activity for Chemical research in toxicology. (2)
Review activity for Chemical reviews. (3)
Review activity for Journal of medicinal chemistry. (14)
Review activity for Journal of organic chemistry. (11)
Review activity for Journal of the American Chemical Society. (4)
Review activity for Medicinal chemistry research. (1)
Review activity for Organic letters. (6)
How many people are using ORCID?