Personal information

Emails & domains

Verified email domains

Websites & social links

Researchgate
Linkedin

Countries

United States, Germany

Activities

Collapse all

Employment (3)

NIH Clinical Center: Md., Md., US

2020-09 to present | MD- Postdoc (NIAAA)
Employment
Source: Self-asserted source
Josephin Wagner

Clienia Schlössli AG Privatklinik für Psychiatrie: Oetwil am See, Zürich, CH

2020 to 2020-09 | MD- resident physician (Psychiatry)
Employment
Source: Self-asserted source
Josephin Wagner

University of Zurich: Zurich, CH

2015 to 2018 | MD- Resident physician (Neurosurgery)
Employment
Source: Self-asserted source
Josephin Wagner

Education and qualifications (3)

Charité - Universitätsmedizin Berlin: Berlin, DE

2013 to 2020 | Doctoral student (MD) (Neurosurgery)
Education
Source: Self-asserted source
Josephin Wagner

University of Zurich: Zurich, CH

2015 to 2019 | MSc (Neurosurgery)
Education
Source: Self-asserted source
Josephin Wagner

Charité – Universitätsmedizin Berlin: Berlin, DE

2008 to 2014 | MD
Education
Source: Self-asserted source
Josephin Wagner

Funding (1)

Center on Compulsive Behaviors (CCB)

Grant
NIH Clinical Center (Md., Md., US)
Source: Self-asserted source
Josephin Wagner

Works (26)

A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking

Nature Human Behaviour
2024-11-11 | Journal article
DOI: 10.1038/s41562-024-02040-1
Contributors: Daniel B. Rosoff; Josephin Wagner; Andrew S. Bell; Lucas A. Mavromatis; Jeesun Jung; Falk W. Lohoff
Source: check_circle
Crossref

PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury

Brain, Behavior, and Immunity
2024-07 | Journal article
DOI: 10.1016/j.bbi.2024.04.022
Contributors: Josephin Wagner; Lauren M. Park; Partha Mukhopadhyay; Csaba Matyas; Eszter Trojnar; Ruslan Damadzic; Jeesun Jung; Andrew S. Bell; Lucas A. Mavromatis; Ali M. Hamandi et al.
Source: check_circle
Crossref

Major Psychiatric Disorders, Substance Use Behaviors, and Longevity

JAMA Psychiatry
2024-06-18 | Journal article
DOI: 10.1001/jamapsychiatry.2024.1429
Part of ISSN: 2168-622X
Contributors: Daniel B. Rosoff; Ali M. Hamandi; Andrew S. Bell; Lucas A. Mavromatis; Lauren M. Park; Jeesun Jung; Josephin Wagner; Falk W. Lohoff
Source: Self-asserted source
Josephin Wagner

Evaluating the Cardiovascular Impact of Genetically Proxied PCSK9 and HMGCR Inhibition in East Asian and European Populations: A Drug-Target Mendelian Randomization Study

Circulation: Genomic and Precision Medicine
2024-02 | Journal article
DOI: 10.1161/CIRCGEN.122.004224
Contributors: Daniel B. Rosoff; Andrew S. Bell; Lucas A. Mavromatis; Ali Hamandi; Lauren Park; Jeesun Jung; Josephin Wagner; Pal Pacher; David Ray; George Davey Smith et al.
Source: check_circle
Crossref

The Genetics of Alcohol Use Disorder

Alcohol and Alcohol-related Diseases
2023 | Book chapter
DOI: 10.1007/978-3-031-32483-3_32
Part of ISBN: 9783031324826
Part of ISBN: 9783031324833
Contributors: Josephin Wagner; Andrew S. Bell; Jeesun Jung; Falk W. Lohoff
Source: Self-asserted source
Josephin Wagner

Multi‐omics analysis of alcohol effects on the liver in young and aged mice

Addiction Biology
2023-12 | Journal article
DOI: 10.1111/adb.13342
Part of ISSN: 1355-6215
Part of ISSN: 1369-1600
Contributors: Lea Zillich; Josephin Wagner; Rachel H. McMahan; Lauren M. Park; Colin Hodgkinson; Elizabeth J. Kovacs; Falk W. Lohoff
Source: Self-asserted source
Josephin Wagner

62. A MENDELIAN RANDOMIZATION STUDY OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 INHIBITION AND STROKE: EVIDENCE FOR BENEFITS BEYOND LOW-DENSITY LIPOPROTEIN CHOLESTEROL LOWERING

European Neuropsychopharmacology
2023-10 | Journal article
DOI: 10.1016/j.euroneuro.2023.08.167
Part of ISSN: 0924-977X
Contributors: Lauren Park; Daniel Rosoff; Lucas Mavromatis; Andrew Bell; Ali Hamandi; Jeesun Jung; Josephin Wagner; Partha Mukhopadhyay; Pal Pacher; Leandro Vendruscolo et al.
Source: Self-asserted source
Josephin Wagner

82. NOVEL THERAPEUTIC DRUG TARGET DISCOVERIES FOR ALCOHOL USE DISORDER AND PROBLEM DRINKING: A MULTI-LEVEL PROTEOME-WIDE MENDELIAN RANDOMIZATION STUDY

European Neuropsychopharmacology
2023-10 | Journal article
DOI: 10.1016/j.euroneuro.2023.08.187
Part of ISSN: 0924-977X
Contributors: Daniel Rosoff; Josephin Wagner; Andrew Bell; Lucas Mavromatis; Ali Hamandi; Lauren Park; Jeesun Jung; Falk Lohoff
Source: Self-asserted source
Josephin Wagner

Assessing the impact of PCSK9 and HMGCR inhibition on liver function: drug-target Mendelian Randomization analyses in 4 ancestries

Cellular and Molecular Gastroenterology and Hepatology
2023-09 | Journal article
DOI: 10.1016/j.jcmgh.2023.09.001
Part of ISSN: 2352-345X
Contributors: Daniel B. Rosoff; Andrew S. Bell; Josephin Wagner; Lucas A. Mavromatis; Ali Hamandi; Lauren Park; Jeesun Jung; Falk W. Lohoff
Source: Self-asserted source
Josephin Wagner

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging

Nature aging
2023-08-07 | Journal article
DOI: 10.1038/s43587-023-00455-5
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner

Evaluating the hepatic efficacy and cardiometabolic profile of PNPLA3, TM6SF2, and other therapeutic targets for NALFD: a drug-target Mendelian randomization analysis

Journal of Hepatology
2023-06 | Journal article
DOI: 10.1016/s0168-8278(23)02234-1
Part of ISSN: 0168-8278
Contributors: Daniel Rosoff; Lucas Mavromatis; Andrew Bell; Ali Hamandi; Lauren Park; Jeesun Jung; Josephin Wagner; David Ray; Falk Lohoff
Source: Self-asserted source
Josephin Wagner

Proprotein convertase subtilisin/kexin type 9 (PCSK9) in the central nervous system

Neuroscience & Biobehavioral Reviews
2023-06 | Journal article
DOI: 10.1016/j.neubiorev.2023.105155
Part of ISSN: 0149-7634
Contributors: Andrew S. Bell; Josephin Wagner; Daniel B. Rosoff; Falk W. Lohoff
Source: Self-asserted source
Josephin Wagner

564. PCSK9 Inhibition via Alirocumab Attenuates Neuroinflammation in a Rat Model of Chronic Alcohol Consumption

Biological Psychiatry
2023-05 | Journal article
DOI: 10.1016/j.biopsych.2023.02.804
Part of ISSN: 0006-3223
Contributors: Josephin Wagner; Lauren Park; Ruslan Damadzic; Jisoo Lee; Falk Lohoff
Source: Self-asserted source
Josephin Wagner

Novel Therapeutic Drug Target Discoveries for Alcohol Use Disorder and Problem Drinking: A Multi-Level Proteome-Wide Mendelian Randomization Study

Biological Psychiatry
2023-05 | Journal article
DOI: 10.1016/j.biopsych.2023.02.092
Part of ISSN: 0006-3223
Contributors: Daniel Rosoff; Josephin Wagner; Andrew Bell; Lucas Mavromatis; Jeesun Jung; Falk Lohoff
Source: Self-asserted source
Josephin Wagner
grade
Preferred source (of 3)‎

Multi-omic underpinnings of epigenetic aging and human longevity.

Nature communications
2023-04-19 | Journal article
DOI: 10.1038/s41467-023-37729-w
PMID: 37076473
PMC: PMC10115892
Contributors: Lucas A. Mavromatis; Rosoff DB; Bell AS; Jeesun Jung; Wagner J; Falk W. Lohoff
Source: Self-asserted source
Josephin Wagner
grade
Preferred source (of 3)‎

<i>PCSK9</i> Base Editing Therapeutics and Ischemic Stroke

ACS Chemical Neuroscience
2022-12-07 | Journal article
DOI: 10.1021/acschemneuro.2c00663
Part of ISSN: 1948-7193
Part of ISSN: 1948-7193
Contributors: Josephin Wagner; Andrew S. Bell; Falk W. Lohoff
Source: Self-asserted source
Josephin Wagner
grade
Preferred source (of 2)‎

Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug‐Target Mendelian Randomization Study

Journal of the American Heart Association
2022-11 | Journal article
DOI: 10.1161/JAHA.122.026122
Contributors: Andrew S. Bell; Daniel B. Rosoff; Lucas A. Mavromatis; Jeesun Jung; Josephin Wagner; Falk W. Lohoff
Source: check_circle
Crossref

Mendelian Randomization Study of PCSK9 and HMG-CoA Reductase Inhibition and Cognitive Function

Journal of the American College of Cardiology
2022-08 | Journal article
DOI: 10.1016/j.jacc.2022.05.041
Part of ISSN: 0735-1097
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner
grade
Preferred source (of 2)‎

Additive Effects of Stress and Alcohol Exposure on Accelerated Epigenetic Aging in Alcohol Use Disorder.

Biological psychiatry
2022-07-16 | Journal article | Author
DOI: 10.1016/j.biopsych.2022.06.036
PMID: 36182531
Contributors: Jeesun Jung; Daniel McCartney; Josephin Wagner; Yoo J; Andrew Bell; Lucas A. Mavromatis; Rosoff DB; Colin Hodgkinson; Sun H; Schwandt M et al.
Source: Self-asserted source
Josephin Wagner
grade
Preferred source (of 2)‎

Alcohol use disorder is associated with DNA methylation-based shortening of telomere length and regulated by TESPA1: implications for aging

Molecular Psychiatry
2022-06-15 | Journal article
DOI: 10.1038/s41380-022-01624-5
Part of ISSN: 1359-4184
Part of ISSN: 1476-5578
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner
grade
Preferred source (of 2)‎

W89. ALCOHOL USE DISORDER IS ASSOCIATED WITH DNA METHYLATION-BASED SHORTENING OF TELOMERE LENGTH AND REGULATED BY TESPA1: IMPLICATIONS FOR AGING

European Neuropsychopharmacology
2021-10 | Journal article
DOI: 10.1016/j.euroneuro.2021.08.172
Part of ISSN: 0924-977X
Contributors: Jeesun Jung; Josephin Wagner; Falk Lohoff
Source: Self-asserted source
Josephin Wagner

Interleukin 6-Mediated Endothelial Barrier Disturbances Can Be Attenuated by Blockade of the IL6 Receptor Expressed in Brain Microvascular Endothelial Cells

Translational Stroke Research
2018-12 | Journal article
DOI: 10.1007/s12975-018-0614-2
Part of ISSN: 1868-4483
Part of ISSN: 1868-601X
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier

PLOS Pathogens
2018-11-29 | Journal article
DOI: 10.1371/journal.ppat.1007424
Part of ISSN: 1553-7374
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

Fluids and Barriers of the CNS
2017-10 | Journal article
DOI: 10.1186/s12987-017-0071-4
Part of ISSN: 2045-8118
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner
grade
Preferred source (of 2)‎

Autocrine release of angiopoietin-2 mediates cerebrovascular disintegration in Moyamoya disease

Journal of Cerebral Blood Flow &amp; Metabolism
2017-04 | Journal article
DOI: 10.1177/0271678x16658301
Part of ISSN: 0271-678X
Part of ISSN: 1559-7016
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner

Intravascular Inflammation Triggers Intracerebral Activated Microglia and Contributes to Secondary Brain Injury After Experimental Subarachnoid Hemorrhage (eSAH)

Translational Stroke Research
2017-04 | Journal article
DOI: 10.1007/s12975-016-0485-3
Part of ISSN: 1868-4483
Part of ISSN: 1868-601X
Contributors: Josephin Wagner
Source: Self-asserted source
Josephin Wagner

Peer review (4 reviews for 2 publications/grants)

Review activity for International journal of cardiology. (1)
Review activity for PloS one. (3)
How many people are using ORCID?