Personal information

Websites & social links

https://biochemie.uni-goettingen.de/index.php/mitochondrial-communication-ag-dennerlein-2/

Keywords

Mitochondria, Cytochrome c oxidase, OXPHOS, Mitochondrial translation

Countries

Germany

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Employment (1)

Universitätsmedizin Göttingen: Göttingen, Lower Saxony, DE

2020-07-01 to present | Group leader (Institut of Cellular Biochemistry)
Employment
Source: Self-asserted source
Sven Dennerlein

Works (40)

Definition of the human mitochondrial TOM interactome reveals TRABD as new interacting protein

Journal of Cell Science
2025-03-19 | Journal article
DOI: 10.1242/jcs.263576
Contributors: Metin Özdemir; Silke Oeljeklaus; Schendzielorz Alexander; Marcel Morgenstern; Anusha Valpadashi; Roya Yousefi; Bettina Warscheid; Sven Dennerlein
Source: check_circle
Crossref

Super-resolution microscopy of mitochondrial mRNAs

2025-01-24 | Preprint
DOI: 10.1101/2025.01.23.634455
Contributors: Stefan Stoldt; Frederike Maass; Michael Weber; Sven Dennerlein; Peter Ilgen; Jutta Gärtner; Aysenur Canfes; Sarah V. Schweighofer; Daniel C. Jans; Peter Rehling et al.
Source: check_circle
Crossref

Cytochrome c oxidase biogenesis – from translation to early assembly of the core subunit COX1

FEBS Letters
2023-06 | Journal article
DOI: 10.1002/1873-3468.14671
Part of ISSN: 0014-5793
Part of ISSN: 1873-3468
Contributors: Sven Dennerlein; Peter Rehling; Ricarda Richter‐Dennerlein
Source: Self-asserted source
Sven Dennerlein

Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control

Nature Communications
2022-10-27 | Journal article
DOI: 10.1038/s41467-022-34088-w
Part of ISSN: 2041-1723
Contributors: Franziska Nadler; Elena Lavdovskaia; Angelique Krempler; Luis Daniel Cruz-Zaragoza; Sven Dennerlein; Ricarda Richter-Dennerlein
Source: Self-asserted source
Sven Dennerlein

HAX1-dependent control of mitochondrial proteostasis governs neutrophil granulocyte differentiation

Journal of Clinical Investigation
2022-05-02 | Journal article | Author
DOI: 10.1172/jci153153
Part of ISSN: 1558-8238
Contributors: Yanxin Fan; MARTA MURGIA; Monika I. Linder; Yoko Mizoguchi; Cong Wang; Marcin Łyszkiewicz; Natalia Ziȩtara; Yanshan Liu; Stephanie Frenz; Gabriela Sciuccati et al.
Source: Self-asserted source
Sven Dennerlein

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Cell Metabolism
2021-12 | Journal article
DOI: 10.1016/j.cmet.2021.11.001
Part of ISSN: 1550-4131
Contributors: Marcel Morgenstern; Christian D. Peikert; Philipp Lübbert; Ida Suppanz; Cinzia Klemm; Oliver Alka; Conny Steiert; Nataliia Naumenko; Alexander Schendzielorz; Laura Melchionda et al.
Source: Self-asserted source
Sven Dennerlein

Tmem160 contributes to the establishment of discrete nerve injury-induced pain behaviors in male mice

Cell Reports
2021-12 | Journal article
DOI: 10.1016/j.celrep.2021.110152
Part of ISSN: 2211-1247
Contributors: Daniel Segelcke; Hanna K. Fischer; Meike Hütte; Sven Dennerlein; Fritz Benseler; Nils Brose; Esther M. Pogatzki-Zahn; Manuela Schmidt
Source: Self-asserted source
Sven Dennerlein

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors

eLife
2021-12-31 | Journal article | Author
DOI: 10.7554/elife.68213
Part of ISSN: 2050-084X
Contributors: Sven Dennerlein; Sabine Poerschke; Silke Oeljeklaus; Cong Wang; Ricarda Richter-Dennerlein; Johannes Sattmann; Diana Bauermeister; Elisa Hanitsch; Stefan Stoldt; Thomas Langer et al.
Source: Self-asserted source
Sven Dennerlein
grade
Preferred source (of 2)‎

An in vitro system to silence mitochondrial gene expression

Cell
2021-11 | Journal article | Author
DOI: 10.1016/j.cell.2021.09.033
Part of ISSN: 0092-8674
Contributors: Luis Daniel Cruz-Zaragoza; Sven Dennerlein; Andreas Linden; Roya Yousefi; Elena Lavdovskaia; Abhishek Aich; Rebecca Rossen Falk; Ridhima Gomkale; Thomas Schöndorf; Markus T. Bohnsack et al.
Source: Self-asserted source
Sven Dennerlein
grade
Preferred source (of 2)‎

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Nature Communications
2021-07-13 | Journal article
DOI: 10.1038/s41467-021-24426-9
Part of ISSN: 2041-1723
Contributors: Corvin Walter; Adinarayana Marada; Tamara Suhm; Ralf Ernsberger; Vera Muders; Cansu Kücükköse; Pablo Sánchez-Martín; Zehan Hu; Abhishek Aich; Stefan Loroch et al.
Source: Self-asserted source
Sven Dennerlein

Functional coupling of presequence processing and degradation in human mitochondria

The FEBS Journal
2021-01 | Journal article
DOI: 10.1111/febs.15358
Part of ISSN: 1742-464X
Part of ISSN: 1742-4658
Contributors: Cansu Kücükköse; Asli Aras Taskin; Adinarayana Marada; Tilman Brummer; Sven Dennerlein; F.-Nora Vögtle
Source: Self-asserted source
Sven Dennerlein

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

Immunity
2021-01 | Journal article
DOI: 10.1016/j.immuni.2020.11.001
Part of ISSN: 1074-7613
Contributors: Luís Almeida; Ayesha Dhillon-LaBrooy; Carla N. Castro; Nigatu Adossa; Guilhermina M. Carriche; Melanie Guderian; Saskia Lippens; Sven Dennerlein; Christina Hesse; Bart N. Lambrecht et al.
Source: Self-asserted source
Sven Dennerlein

COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiol-reductase for Copper Metallochaperones in Mitochondria

Journal of Molecular Biology
2020-03 | Journal article
DOI: 10.1016/j.jmb.2020.01.036
Part of ISSN: 0022-2836
Contributors: David Pacheu-Grau; Michał Wasilewski; Silke Oeljeklaus; Christine Silvia Gibhardt; Abhishek Aich; Margarita Chudenkova; Sven Dennerlein; Markus Deckers; Ivan Bogeski; Bettina Warscheid et al.
Source: Self-asserted source
Sven Dennerlein

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome–nascent chain complex

EMBO reports
2020-01-07 | Journal article
DOI: 10.15252/embr.201948833
Part of ISSN: 1469-221X
Part of ISSN: 1469-3178
Contributors: Cong Wang; Ricarda Richter-Dennerlein; David Pacheu‐Grau; Fan Liu; Ying Zhu; Sven Dennerlein; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7

EMBO Molecular Medicine
2019-05 | Journal article
DOI: 10.15252/emmm.201809561
Part of ISSN: 1757-4676
Part of ISSN: 1757-4684
Contributors: Karthik Mohanraj; Michal Wasilewski; Cristiane Benincá; Dominik Cysewski; Jaroslaw Poznanski; Paulina Sakowska; Zaneta Bugajska; Markus Deckers; Sven Dennerlein; Erika Fernandez-Vizarra et al.
Source: Self-asserted source
Sven Dennerlein

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import

Journal of Cell Biology
2019-02-04 | Journal article
DOI: 10.1083/jcb.201806093
Part of ISSN: 0021-9525
Part of ISSN: 1540-8140
Contributors: Frank Richter; Sven Dennerlein; Miroslav Nikolov; Daniel C. Jans; Nataliia Naumenko; Abhishek Aich; Thomas MacVicar; Andreas Linden; Stefan Jakobs; Henning Urlaub et al.
Source: Self-asserted source
Sven Dennerlein

The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain

Scientific Reports
2018-11-15 | Journal article
DOI: 10.1038/s41598-018-35277-8
Part of ISSN: 2045-2322
Contributors: Sunit Mandad; Raza-Ur Rahman; Tonatiuh Pena Centeno; Ramon O. Vidal; Hanna Wildhagen; Burkhard Rammner; Sarva Keihani; Felipe Opazo; Inga Urban; Till Ischebeck et al.
Source: Self-asserted source
Sven Dennerlein

Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

Nature Communications
2018-10-12 | Journal article
DOI: 10.1038/s41467-018-06519-0
Part of ISSN: 2041-1723
Contributors: Eugenio F. Fornasiero; Sunit Mandad; Hanna Wildhagen; Mihai Alevra; Burkhard Rammner; Sarva Keihani; Felipe Opazo; Inga Urban; Till Ischebeck; M. Sadman Sakib et al.
Source: Self-asserted source
Sven Dennerlein

Sensing the Stress: A Role for the UPRmt and UPRam in the Quality Control of Mitochondria

Frontiers in Cell and Developmental Biology
2018-03-28 | Journal article
DOI: 10.3389/fcell.2018.00031
Part of ISSN: 2296-634X
Contributors: Sylvie Callegari; Sven Dennerlein
Source: Self-asserted source
Sven Dennerlein

The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2018-02 | Journal article
DOI: 10.1016/j.bbamcr.2017.11.010
Part of ISSN: 0167-4889
Contributors: Isotta Lorenzi; Silke Oeljeklaus; Abhishek Aich; Christin Ronsör; Sylvie Callegari; Jan Dudek; Bettina Warscheid; Sven Dennerlein; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis

eLife
2018-01-30 | Journal article
DOI: 10.7554/elife.32572
Part of ISSN: 2050-084X
Contributors: Abhishek Aich; Cong Wang; Arpita Chowdhury; Christin Ronsör; David Pacheu-Grau; Ricarda Richter-Dennerlein; Sven Dennerlein; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

Plasticity of Mitochondrial Translation

Trends in Cell Biology
2017-10 | Journal article
DOI: 10.1016/j.tcb.2017.05.004
Part of ISSN: 0962-8924
Contributors: Sven Dennerlein; Cong Wang; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

TORC1‐mediated sensing of chaperone activity alters glucose metabolism and extends lifespan

Aging Cell
2017-10 | Journal article
DOI: 10.1111/acel.12623
Part of ISSN: 1474-9718
Part of ISSN: 1474-9726
Contributors: Matea Perić; Anita Lovrić; Ana Šarić; Marina Musa; Peter Bou Dib; Marina Rudan; Andrea Nikolić; Sandra Sobočanec; Ana‐Matea Mikecin; Sven Dennerlein et al.
Source: Self-asserted source
Sven Dennerlein

Phospho-ubiquitin-PARK2 complex as a marker for mitophagy defects

Autophagy
2017-01-02 | Journal article
DOI: 10.1080/15548627.2016.1254852
Part of ISSN: 1554-8627
Part of ISSN: 1554-8635
Contributors: Sylvie Callegari; Silke Oeljeklaus; Bettina Warscheid; Sven Dennerlein; Michael Thumm; Peter Rehling; Jan Dudek
Source: Self-asserted source
Sven Dennerlein

Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates

Molecular and Cellular Biology
2016-11-01 | Journal article
DOI: 10.1128/mcb.00361-16
Part of ISSN: 1098-5549
Contributors: Isotta Lorenzi; Silke Oeljeklaus; Christin Ronsör; Bettina Bareth; Bettina Warscheid; Peter Rehling; Sven Dennerlein
Source: Self-asserted source
Sven Dennerlein

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

Cell
2016-10 | Journal article
DOI: 10.1016/j.cell.2016.09.003
Part of ISSN: 0092-8674
Contributors: Ricarda Richter-Dennerlein; Silke Oeljeklaus; Isotta Lorenzi; Christin Ronsör; Bettina Bareth; Alexander Benjamin Schendzielorz; Cong Wang; Bettina Warscheid; Peter Rehling; Sven Dennerlein
Source: Self-asserted source
Sven Dennerlein

Redox Imaging Using Cardiac Myocyte-Specific Transgenic Biosensor Mice

Circulation Research
2016-10-14 | Journal article
DOI: 10.1161/circresaha.116.309551
Part of ISSN: 0009-7330
Part of ISSN: 1524-4571
Contributors: Lija Swain; Andrea Kesemeyer; Stefanie Meyer-Roxlau; Christiane Vettel; Anke Zieseniss; Annemarie Güntsch; Aline Jatho; Andreas Becker; Maithily S. Nanadikar; Bruce Morgan et al.
Source: Self-asserted source
Sven Dennerlein

NSUN3 and ABH1 modify the wobble position of mt‐tRNA Met to expand codon recognition in mitochondrial translation

The EMBO Journal
2016-10-04 | Journal article
DOI: 10.15252/embj.201694885
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Contributors: Sara Haag; Katherine E Sloan; Namit Ranjan; Ahmed S Warda; Jens Kretschmer; Charlotte Blessing; Benedikt Hübner; Jan Seikowski; Sven Dennerlein; Peter Rehling et al.
Source: Self-asserted source
Sven Dennerlein

Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan

Scientific Reports
2016-06-27 | Journal article
DOI: 10.1038/srep28751
Part of ISSN: 2045-2322
Contributors: Matea Perić; Peter Bou Dib; Sven Dennerlein; Marina Musa; Marina Rudan; Anita Lovrić; Andrea Nikolić; Ana Šarić; Sandra Sobočanec; Željka Mačak et al.
Source: Self-asserted source
Sven Dennerlein

Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1

Molecular Biology of the Cell
2016-05-15 | Journal article
DOI: 10.1091/mbc.e15-12-0811
Part of ISSN: 1059-1524
Part of ISSN: 1939-4586
Contributors: Bettina Bareth; Miroslav Nikolov; Isotta Lorenzi; Markus Hildenbeutel; David U. Mick; Christin Helbig; Henning Urlaub; Martin Ott; Peter Rehling; Sven Dennerlein
Source: Self-asserted source
Sven Dennerlein

Integrating mitochondrial translation into the cellular context

Nature Reviews Molecular Cell Biology
2015-10 | Journal article
DOI: 10.1038/nrm4051
Part of ISSN: 1471-0072
Part of ISSN: 1471-0080
Contributors: Ricarda Richter-Dennerlein; Sven Dennerlein; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint during Cytochrome c Oxidase Assembly

Cell Reports
2015-09 | Journal article
DOI: 10.1016/j.celrep.2015.08.009
Part of ISSN: 2211-1247
Contributors: Sven Dennerlein; Silke Oeljeklaus; Daniel Jans; Christin Hellwig; Bettina Bareth; Stefan Jakobs; Markus Deckers; Bettina Warscheid; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

Cooperation between COA6 and SCO2 in COX2 Maturation during Cytochrome c Oxidase Assembly Links Two Mitochondrial Cardiomyopathies

Cell Metabolism
2015-06 | Journal article
DOI: 10.1016/j.cmet.2015.04.012
Part of ISSN: 1550-4131
Contributors: David Pacheu-Grau; Bettina Bareth; Jan Dudek; Lisa Juris; F.-Nora Vögtle; Mirjam Wissel; Scot C. Leary; Sven Dennerlein; Peter Rehling; Markus Deckers
Source: Self-asserted source
Sven Dennerlein

Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance

Journal of Cell Science
2015-01-01 | Journal article
DOI: 10.1242/jcs.161729
Part of ISSN: 1477-9137
Part of ISSN: 0021-9533
Contributors: Sven Dennerlein; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

The Heme a Synthase Cox15 Associates with Cytochrome <i>c</i> Oxidase Assembly Intermediates during Cox1 Maturation

Molecular and Cellular Biology
2013-10-01 | Journal article
DOI: 10.1128/mcb.00747-13
Part of ISSN: 1098-5549
Contributors: Bettina Bareth; Sven Dennerlein; David U. Mick; Miroslav Nikolov; Henning Urlaub; Peter Rehling
Source: Self-asserted source
Sven Dennerlein

MITRAC Links Mitochondrial Protein Translocation to Respiratory-Chain Assembly and Translational Regulation

Cell
2012-12 | Journal article
DOI: 10.1016/j.cell.2012.11.053
Part of ISSN: 0092-8674
Contributors: David U. Mick; Sven Dennerlein; Heike Wiese; Robert Reinhold; David Pacheu-Grau; Isotta Lorenzi; Florin Sasarman; Woranontee Weraarpachai; Eric A. Shoubridge; Bettina Warscheid et al.
Source: Self-asserted source
Sven Dennerlein

Translation termination in human mitochondrial ribosomes

Biochemical Society Transactions
2010-12-01 | Journal article
DOI: 10.1042/bst0381523
Part of ISSN: 0300-5127
Part of ISSN: 1470-8752
Contributors: Ricarda Richter; Aleksandra Pajak; Sven Dennerlein; Agata Rozanska; Robert N. Lightowlers; Zofia M.A. Chrzanowska-Lightowlers
Source: Self-asserted source
Sven Dennerlein

Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit

Biochemical Journal
2010-09-15 | Journal article
DOI: 10.1042/bj20100757
Part of ISSN: 0264-6021
Part of ISSN: 1470-8728
Contributors: Sven Dennerlein; Agata Rozanska; Mateusz Wydro; Zofia M. A. Chrzanowska-Lightowlers; Robert N. Lightowlers
Source: Self-asserted source
Sven Dennerlein

Hungry Codons Promote Frameshifting in Human Mitochondrial Ribosomes

Science
2010-01-15 | Journal article
DOI: 10.1126/science.1180674
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Contributors: Richard Temperley; Ricarda Richter; Sven Dennerlein; Robert N. Lightowlers; Zofia M. Chrzanowska-Lightowlers
Source: Self-asserted source
Sven Dennerlein

Repetitive DNA, molecular cytogenetics and genome organization in the King scallop (Pecten maximus)

Gene
2007-12 | Journal article
DOI: 10.1016/j.gene.2007.06.027
Part of ISSN: 0378-1119
Contributors: Maria A. Biscotti; Adriana Canapa; Ettore Olmo; Marco Barucca; Chee H. Teo; Trude Schwarzacher; Sven Dennerlein; Rica Richter; J.S. (Pat) Heslop-Harrison
Source: Self-asserted source
Sven Dennerlein

Peer review (2 reviews for 2 publications/grants)

Review activity for BMC biology. (1)
Review activity for Molecular systems biology. (1)
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