Personal information

Websites & social links

INEB website; i3S website

Other IDs

ResearcherID: K-1271-2013
Scopus Author ID: 9634048000
Scopus Author ID: 56721206800
Ciência ID: 7713-0BE4-AC65

Keywords

Dendrimers, Organic Chemistry, NMR, Nanoparticles, Nanomedicine, Gene Therapy, Biodegradability, Cli

Biography

Victoria Leiro got her PhD in Organic Chemistry from the University of Santiago de Compostela (Spain), in December 2007. Before finishing her PhD, she was hired in the context of the project “Synthesis of dendrimers for delivery of anticarcinogenic drugs”, in collaboration with the Spanish company of biotechnology Pharmamar S.A.
Since 2011, she is a Research Scientist in the nBTT-nanoBiomaterials for Targeted Therapies Group at INEB-Instituto de Engenharia Biomédica and i3S-Instituto de Investigação e Inovação em Saúde (Porto, Portugal). Her research is focused on the development of new biodegradable nanobiomaterials (biodegradable dendrimers), as well as their application as vectors of different therapeutic nucleic acids targeted to the peripheral and central nervous systems, with the aim of promoting neuroregeneration and neuroprotection. She is also exploring her dendrimers as vectors of therapeutics for cancer treatment. Moreover, the development, functionalization, characterization (NMR) and biological evaluation of natural and synthetic polymers of great interest for different biomedical applications (including regenerative medicine) are also among her research interests.

Activities

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Employment (3)

Universidade do Porto Instituto de Investigação e Inovação em Saúde: Porto, Porto, PT

2017-06-01 to present | Research Scientist
Employment
Source: Self-asserted source
Victoria Leiro

INEB - Instituto de Engenharia Biomédica & i3S - Instituto de Investigação e Inovação em Saúde: Porto, PT

2011-04-01 to 2017-05-31 | Post-Doctoral Researcher
Employment
Source: Self-asserted source
Victoria Leiro

University of Santiago de Compostela: Santiago de Compostela, ES

2007-03-01 to 2009-12-31
Employment
Source: Self-asserted source
Victoria Leiro

Education and qualifications (3)

Universidade de Santiago de Compostela Facultade de Química: Santiago de Compostela, Galicia, ES

2003 to 2007 | Ph.D. (Organic Chemistry Departament)
Education
Source: Self-asserted source
Victoria Leiro

Universidade de Santiago de Compostela Facultade de Química: Santiago de Compostela, Galicia, ES

2002 to 2004 | MSc (Organic Chemistry)
Education
Source: Self-asserted source
Victoria Leiro

Universidade de Santiago de Compostela Facultade de Química: Santiago de Compostela, Galicia, ES

1997 to 2002 | Graduate
Education
Source: Self-asserted source
Victoria Leiro

Funding (9)

Contracted Researcher

2017-06 to present | Contract
INEB - Instituto de Engenharia Biomédica. NORTE-01-0145-FEDER-000012, Structured Programme on Bioengineering Therapies for Infectious Diseases and Tissue Regeneration (Porto, PT)
GRANT_NUMBER:

i3S.HOST_RL4_ID_01_2017
Source: Self-asserted source
Victoria Leiro

Post-doctoral Fellow

2014-04 to 2017-05 | Grant
INEB - Instituto de Engenharia Biomédica. Project NORTE-01-0145-FEDER-000012, financed by Norte Portugal Regional Operational Programme (NORTE 2020) (Porto, PT)
GRANT_NUMBER:

3S.HOST_RL4_BPD_02_2016 (NORTE-01-0145-FEDER-000012)
Source: Self-asserted source
Victoria Leiro

Post-doctoral Fellow

2011-04 to 2014-03 | Grant
Foundation for Science e Technology, Ministry of Science, Technology and Higher Education (Lisboa, PT)
GRANT_NUMBER:

SFRH/BPD/69110/2010
Source: Self-asserted source
Victoria Leiro

Formación de Profesorado Universitario (FPU)

2003-03 to 2007-02 | Grant
Ministry of Education, Culture and Sport (Madrid, ES)
GRANT_NUMBER:

AP2002-0611
Source: Self-asserted source
Victoria Leiro

Premio de Licenciatura

2003 to 2023 | Award
Local Government of Monterroso (27560) – Lugo. (Monterroso - Lugo, ES)
Source: Self-asserted source
Victoria Leiro

Premio Extraordinario de Licenciatura en Química 2002/2003

2003 to 2003 | Award
University of Santiago de Compostela (Santiago de Compostela, ES)
Source: Self-asserted source
Victoria Leiro

Master-Scholarship

2002-10 to 2003-02 | Grant
Government of Galicia (Xunta de Galicia). (Santiago de Compostela, ES)
Source: Self-asserted source
Victoria Leiro

Premio extraordinario fin de carrera 2002 de la Comunidad Autónoma de Galicia

2002 to present | Award
Government of Galicia (Xunta de Galicia) (Santiago de Compostela, ES)
Source: Self-asserted source
Victoria Leiro

Collaboration-Scholarship

2001-10 to 2002-09 | Grant
Ministry of Education, Culture and Sport (Madrid, ES)
Source: Self-asserted source
Victoria Leiro

Works (25)

Engineered chitosan-derived nanocarrier for efficient siRNA delivery to peripheral and central neurons

2024-09-10 | Preprint
DOI: 10.1101/2024.09.05.611434
Contributors: Ana P. Spencer; Adriana Vilaça; Miguel Xavier; Rafael Santos; Ariel Ionescu; María Lázaro; Victoria Leiro; Eran Perlson; Sofia C. Guimarães; Ben M. Maoz et al.
Source: check_circle
Crossref

Unveiling the potential of neuron-targeted dendriplexes for siRNA delivery using a PNS-CNS-on-Chip

2024-09-10 | Preprint
DOI: 10.1101/2024.09.05.611457
Contributors: Ana P. Spencer; Miguel Xavier; Sofia C. Guimarães; Adriana Vilaça; Ariel Ionescu; Rafael Santos; María Lázaro; Eran Perlson; Victoria Leiro; Ben M. Maoz et al.
Source: check_circle
Crossref

Biological Response Following the Systemic Injection of PEG–PAMAM–Rhodamine Conjugates in Zebrafish

Pharmaceutics
2024-04-30 | Journal article
DOI: 10.3390/pharmaceutics16050608
Contributors: Beatriz Custódio; Patrícia Carneiro; Joana Marques; Victoria Leiro; Ana M. Valentim; Mafalda Sousa; Sofia D. Santos; José Bessa; Ana P. Pêgo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Enhancement of hMSC In Vitro Proliferation by Surface Immobilization of a Heparin-Binding Peptide

Molecules
2023-04-13 | Journal article
DOI: 10.3390/molecules28083422
Contributors: Maura Cimino; Paula Parreira; Victoria Leiro; Aureliana Sousa; Raquel M. Gonçalves; Cristina C. Barrias; M. Cristina L. Martins
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Dendrimers and Derivatives as Multifunctional Nanotherapeutics for Alzheimer’s Disease

Pharmaceutics
2023-03-24 | Journal article
DOI: 10.3390/pharmaceutics15041054
Contributors: Débora A. Moreira; Sofia D. Santos; Victoria Leiro; Ana P. Pêgo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Versatile fully biodegradable dendritic nanotherapeutics

Biomaterials
2022-02 | Journal article
DOI: 10.1016/j.biomaterials.2021.121356
Contributors: Victoria Leiro; Ana Patrícia Spencer; Natália Magalhães; Ana Paula Pêgo
Source: check_circle
Crossref

Grafting MSI-78A onto chitosan microspheres enhances its antimicrobial activity

Acta Biomaterialia
2022-01 | Journal article
DOI: 10.1016/j.actbio.2021.09.063
Contributors: Diana R. Fonseca; Ana Moura; Victoria Leiro; Ricardo Silva-Carvalho; Berta N. Estevinho; Catarina L. Seabra; Patrícia C. Henriques; Mónica Lucena; Cátia Teixeira; Paula Gomes et al.
Source: check_circle
Crossref

Breaking Barriers: Bioinspired Strategies for Targeted Neuronal Delivery to the Central Nervous System

Pharmaceutics
2020-02-23 | Journal article
DOI: 10.3390/pharmaceutics12020192
Contributors: Ana P. Spencer; Marília Torrado; Beatriz Custódio; Sara C. Silva-Reis; Sofia D. Santos; Victoria Leiro; Ana P. Pêgo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Conjugation Chemistry Principles and Surface Functionalization of Nanomaterials

Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation
2018 | Book
Part of DOI: 10.1016/B978-0-323-50878-0.00002-1
EID:

2-s2.0-85054688402
Contributors: Leiro, V.; Parreira, P.; Freitas, S.C.; Martins, M.C.L.; Pêgo, A.P.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Dendrimers as Powerful Building Blocks in Central Nervous System Disease: Headed for Successful Nanomedicine

Advanced Functional Materials
2018 | Journal article
DOI: 10.1002/adfm.201700313
EID:

2-s2.0-85019665316
Contributors: Leiro, V.; Duque Santos, S.; Lopes, C.D.F.; Paula Pêgo, A.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Fine tuning neuronal targeting of nanoparticles by adjusting the ligand grafting density and combining PEG spacers of different length

Acta Biomaterialia
2018 | Journal article
DOI: 10.1016/j.actbio.2018.08.005
EID:

2-s2.0-85051662392
Contributors: Pereira Gomes, C.; Leiro, V.; Ferreira Lopes, C.D.; Spencer, A.P.; Pêgo, A.P.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia

Journal of Controlled Release
2018 | Journal article
DOI: 10.1016/j.jconrel.2018.10.006
EID:

2-s2.0-85055160262
Contributors: Santos, S.D.; Xavier, M.; Leite, D.M.; Moreira, D.A.; Custódio, B.; Torrado, M.; Castro, R.; Leiro, V.; Rodrigues, J.; Tomás, H. et al.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Biodegradable PEG–dendritic block copolymers: synthesis and biofunctionality assessment as vectors of siRNA

Journal of Materials Chemistry B
2017 | Journal article
DOI: 10.1039/C7TB00279C
Contributors: Victoria Leiro; João Pedro Garcia; Pedro M. D. Moreno; Ana Patrícia Spencer; Marcos Fernandez-Villamarin; Ricardo Riguera; Eduardo Fernandez-Megia; Ana Paula Pêgo
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Delivering siRNA with dendrimers: In vivo applications

Current Gene Therapy
2017 | Journal article
DOI: 10.2174/1566523217666170510160527
EID:

2-s2.0-85027834551
Contributors: Leiro, V.; Santos, S.D.; Pêgo, A.P.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Biodegradable Dendritic Structure, Methods and Uses Thereof

2017-11-30 | Patent
PAT:

WO/2017/203437 A1
Source: Self-asserted source
Victoria Leiro

A high-throughput bioimaging study to assess the impact of chitosan-based nanoparticle degradation on DNA delivery performance

Acta Biomaterialia
2016 | Journal article
DOI: 10.1016/j.actbio.2016.09.037
EID:

2-s2.0-84992170399
Contributors: Gomes, C.P.; Varela-Moreira, A.; Leiro, V.; Lopes, C.D.F.; Moreno, P.M.D.; Gomez-Lazaro, M.; Pêgo, A.P.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Delivery of Splice Switching Oligonucleotides by Amphiphilic Chitosan-Based Nanoparticles

Molecular Pharmaceutics
2016 | Journal article
DOI: 10.1021/acs.molpharmaceut.5b00538
EID:

2-s2.0-84957309922
Contributors: Moreno, P.M.D.; Santos, J.C.; Gomes, C.P.; Varela-Moreira, A.; Costa, A.; Leiro, V.; Mansur, H.; Peîgo, A.P.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Design and preparation of biomimetic and bioinspired materials

Bioinspired Materials for Medical Applications
2016 | Book
DOI: 10.1016/B978-0-08-100741-9.00001-2
EID:

2-s2.0-85009902000
Contributors: Leiro, V.; Moreno, P.M.; Sarmento, B.; Durão, J.; Gales, L.; Pêgo, A.P.; Barrias, C.C.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Functionalized chitosan derivatives as nonviral vectors: Physicochemical properties of acylated N,N,N-trimethyl chitosan/oligonucleotide nanopolyplexes

Soft Matter
2015 | Journal article
DOI: 10.1039/c5sm01403d
EID:

2-s2.0-84944345746
Contributors: Santos, J.C.C.; Moreno, P.M.D.; Mansur, A.A.P.; Leiro, V.; Mansur, H.S.; Pêgo, A.P.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

The Present and the Future of Degradable Dendrimers and Derivatives in Theranostics

Bioconjugate Chemistry
2015 | Journal article
DOI: 10.1021/bc5006224
EID:

2-s2.0-84937040940
Contributors: Leiro, V.; Garcia, J.P.; Tomás, H.; Pêgo, A.P.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Using a combination of magnetic anisotropic effects for the configurational assignment of amino alcohols

Chemistry - An Asian Journal
2010 | Journal article
DOI: 10.1002/asia.201000229
EID:

2-s2.0-77956462046
Contributors: Leiro, V.; Seco, J.M.; Quiñoa, E.; Riguera, R.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Assigning the configuration of amino alcohols by NMR: A single derivatization method

Organic Letters
2008 | Journal article
DOI: 10.1021/ol800853u
EID:

2-s2.0-51649089354
Contributors: Leiro, V.; Seco, J.M.; Quiñoá, E.; Riguera, R.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Cross interaction between auxiliaries: The chirality of amino alcohols by NMR

Organic Letters
2008 | Journal article
DOI: 10.1021/ol8008528
EID:

2-s2.0-51649125972
Contributors: Leiro, V.; Seco, J.M.; Quiñoá, E.; Riguera, R.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Absolute configuration of amino alcohols by <sup>1</sup>H-NMR

Chemical Communications
2005 | Journal article
DOI: 10.1039/b510806c
EID:

2-s2.0-28244434825
Contributors: Leiro, V.; Freire, F.; Quiñoá, E.; Riguera, R.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Boc-phenylglycine: A chiral solvating agent for the assignment of the absolute configuration of amino alcohols and their ethers by NMR

Tetrahedron Asymmetry
2004 | Journal article
DOI: 10.1016/j.tetasy.2004.04.032
EID:

2-s2.0-2942639912
Contributors: Pazos, Y.; Leiro, V.; Seco, J.M.; Quiñoá, E.; Riguera, R.
Source: Self-asserted source
Victoria Leiro via Scopus - Elsevier

Peer review (3 reviews for 3 publications/grants)

Review activity for Journal of controlled release. (1)
Review activity for Pharmaceuticals. (1)
Review activity for Pharmaceutics. (1)
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