Personal information

No personal information available

Activities

Employment (1)

Institute of Cancer Research: London, London, GB

Biostatistician (Genetics and Epidemiology)
Employment
Source: Self-asserted source
Mark Brook

Education and qualifications (2)

London School of Hygiene and Tropical Medicine: London, London, GB

2012 | MSc - Medical Statistics
Education
Source: Self-asserted source
Mark Brook

University of Nottingham: Nottingham, Nottinghamshire, GB

2009 | Ph.D. Astrophysics
Education
Source: Self-asserted source
Mark Brook

Works (50 of 62)

Items per page:
Page 1 of 2

A PSA SNP associates with cellular function and clinical outcome in men with prostate cancer.

Nature Communications
2024-11-06 | Journal article
SOURCE-WORK-ID:

282585

Part of ISSN: 2041-1723
Contributors: Srilakshmi Srinivasan; Thomas Kryza; Nathalie Bock; Brian W C Tse; Kamil A Sokolowski; Panchadsaram Janaththani; Achala Fernando; Leire Moya; Carson Stephens; Ying Dong et al.
Source: check_circle
Institute of Cancer Research

The psychosocial impact of prostate cancer screening for BRCA1 and BRCA2 carriers.

BJU International
2024-09 | Journal article
SOURCE-WORK-ID:

280760

Part of ISSN: 1464-4096
WOSUID:

WOS:001239662400001

Contributors: Elizabeth K Bancroft; Elizabeth C Page; Mark Brook; Jennifer Pope; Sarah Thomas; Kathryn Myhill; Brian T Helfand; Pooja Talaty; Kai-Ren Ong; Emma Douglas et al.
Source: check_circle
Institute of Cancer Research

Effect of polygenic risk score for clinically significant prostate cancer in a screening program: The BARCODE 1 study results.

Journal of Clinical Oncology
2024-06-01 | Other
SOURCE-WORK-ID:

281424

Part of ISSN: 0732-183X
WOSUID:

WOS:001275557402359

Contributors: Professor Rosalind Eeles; Elizabeth Kathryn Bancroft; Jana Kathlyn McHugh; Edward Saunders; Mark Brook; Eva McGrowder; Sarah Wakerell; Denzil James; Elizabeth Page; Andrea Osborne et al.
Source: check_circle
Institute of Cancer Research

Identification of Genes with Rare Loss of Function Variants Associated with Aggressive Prostate Cancer and Survival.

European Urology Oncology
2024-04 | Journal article
SOURCE-WORK-ID:

279808

Part of ISSN: 2588-9311
WOSUID:

WOS:001224018400001

Contributors: Ed Saunders; Tokhir Dadaev; Mark Brook; Sarah Wakerell; Koveela Govindasami; Reshma Rageevakumar; Nafisa Hussain; Andrea Osborne; Diana Keating; Artitaya Lophatananon et al.
Source: check_circle
Institute of Cancer Research

Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.

Nature Genetics
2023-12 | Other
SOURCE-WORK-ID:

274309

Part of ISSN: 1061-4036
WOSUID:

WOS:001142400800001

Contributors: Anqi Wang; Jiayi Shen; Alex A Rodriguez; Ed Saunders; Fei Chen; Rohini Janivara; Burcu F Darst; Xin Sheng; Yili Xu; Alisha J Chou et al.
Source: check_circle
Institute of Cancer Research

Reply to Kari Hemminki, Jianguang Ji, and Jan Sundquist's Letter to the Editor re: Mark N. Brook, Holly Ní Raghallaigh, Koveela Govindasami, et al. Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study. Eur Urol 2023;83:257-66.

European Urology
2023-07 | Other
SOURCE-WORK-ID:

271565

Part of ISSN: 0302-2838
WOSUID:

WOS:001035717500001

Contributors: Mark Brook; Holly Ní Raghallaigh; Zsofia Kote-Jarai; Professor Rosalind Eeles
Source: check_circle
Institute of Cancer Research

Evaluating approaches for constructing polygenic risk scores for prostate cancer in men of African and European ancestry.

American Journal of Human Genetics
2023-07-06 | Journal article
SOURCE-WORK-ID:

272276

Part of ISSN: 0002-9297
WOSUID:

WOS:001041604000001

Contributors: Burcu F Darst; Jiayi Shen; Ravi K Madduri; Alexis A Rodriguez; Yukai Xiao; Xin Sheng; Ed Saunders; Tokhir Dadaev; Mark Brook; Thomas J Hoffmann et al.
Source: check_circle
Institute of Cancer Research

Serum testosterone and prostate cancer in men with germline BRCA1/2 pathogenic variants.

BJUI Compass
2023-05 | Journal article
SOURCE-WORK-ID:

271125

Part of ISSN: 2688-4526
WOSUID:

WOS:001138737200007

Contributors: Alexander Dias; Mark Brook; Elizabeth K Bancroft; Elizabeth C Page; Anthony Chamberlain; Sibel Saya; Jan Amin; Christos Mikropoulos; Natalie Taylor; Kathryn Myhill et al.
Source: check_circle
Institute of Cancer Research

Evaluating Approaches for Constructing Polygenic Risk Scores for Prostate Cancer in Men of African and European Ancestry.

medRxiv
2023-05-15 | Other
SOURCE-WORK-ID:

272225

Contributors: Burcu F Darst; Jiayi Shen; Ravi K Madduri; Alexis A Rodriguez; Yukai Xiao; Xin Sheng; Ed Saunders; Tokhir Dadaev; Mark Brook; Thomas J Hoffmann et al.
Source: check_circle
Institute of Cancer Research

Family History of Prostate Cancer and Survival Outcomes in the UK Genetic Prostate Cancer Study.

European Urology
2023-03 | Journal article
SOURCE-WORK-ID:

269728

Part of ISSN: 0302-2838
WOSUID:

WOS:000992909900001

Contributors: Mark Brook; Holly Ní Raghallaigh; Koveela Govindasami; Tokhir Dadaev; Reshma Rageevakumar; Diana Keating; Nafisa Hussain; Andrea Osborne; Artitaya Lophatananon; UKGPCS Collaborators et al.
Source: check_circle
Institute of Cancer Research

Biochemical activity induced by a germline variation in KLK3 (PSA) associates with cellular function and clinical outcome in prostate cancer.

Res Sq
2023-03-28 | Other
SOURCE-WORK-ID:

273977

Contributors: Srilakshmi Srinivasan; Thomas Kryza; Nathalie Bock; Brian Wc Tse; Kamil A Sokolowski; Janaththani Panchadsaram; Leire Moya; Carson Stephens; Ying Dong; Joan Röhl et al.
Source: check_circle
Institute of Cancer Research

CanRisk-Prostate: A Comprehensive, Externally Validated Risk Model for the Prediction of Future Prostate Cancer.

Journal of Clinical Oncology
2023-02-10 | Journal article
SOURCE-WORK-ID:

268745

Part of ISSN: 0732-183X
WOSUID:

WOS:000946950600020

Contributors: Tommy Nyberg; Mark Brook; Lorenzo Ficorella; Andrew Lee; Joe Dennis; Xin Yang; Naomi Wilcox; Tokhir Dadaev; Koveela Govindasami; Michael Lush et al.
Source: check_circle
Institute of Cancer Research

The BARCODE1 Pilot: a feasibility study of using germline single nucleotide polymorphisms to target prostate cancer screening.

BJU International
2022-03 | Journal article
SOURCE-WORK-ID:

252180

Part of ISSN: 1464-4096
WOSUID:

WOS:000685453800001

Contributors: Sarah Benafif; Holly Ni Raghallaigh; Eva McGrowder; Ed Saunders; Mark Brook; Sibel Saya; Reshma Rageevakumar; Sarah Wakerell; Denzil James; Anthony Chamberlain et al.
Source: check_circle
Institute of Cancer Research

A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study.

The Lancet Oncology
2021-11 | Journal article
SOURCE-WORK-ID:

253034

Part of ISSN: 1470-2045
WOSUID:

WOS:000716464100035

Contributors: Elizabeth K Bancroft; Elizabeth C Page; Mark Brook; Sarah Thomas; Natalie Taylor; Jennifer Pope; Jana McHugh; Ann-Britt Jones; Questa Karlsson; Susan Merson et al.
Source: check_circle
Institute of Cancer Research

THE PROFILE STUDY-TARGETED SCREENING USING GERMLINE GENETICS IN MEN WITH A FAMILY HISTORY OF PROSTATE CANCER: THE ROLE OF MULTIPARAMETRIC MRI

Journal of Urology
2021-09-01 | Other
SOURCE-WORK-ID:

252764

Part of ISSN: 0022-5347
WOSUID:

WOS:000693688000160

Contributors: Holly Ni Raghallaigh; Pardeep Kumar; Aslam Sohaib; Mark Brook; Ed Saunders; Eva Mcgrowder; Sarah Wakerell; Alexander Dias; Kathryn Myhill; Matthew Hogben et al.
Source: check_circle
Institute of Cancer Research

THE PROFILE STUDY. TARGETED SCREENING USING GERMLINE GENETICS IN MEN WITH A FAMILY HISTORY OF PROSTATE CANCER

Journal of Urology
2021-09-01 | Other
SOURCE-WORK-ID:

252763

Part of ISSN: 0022-5347
WOSUID:

WOS:000693689000799

Contributors: Holly Ni Raghallaigh; Pardeep Kumar; Aslam Sohaib; Mark Brook; Ed Saunders; Eva Mcgrowder; Sarah Wakerell; Alexander Dias; Kathryn Myhill; Matthew Hogben et al.
Source: check_circle
Institute of Cancer Research

Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study.

European Urology Oncology
2021-08 | Journal article
SOURCE-WORK-ID:

250247

Part of ISSN: 2588-9311
WOSUID:

WOS:000683578800008

Contributors: Questa Karlsson; Mark Brook; Tokhir Dadaev; Sarah Wakerell; Ed Saunders; Kenneth Muir; David E Neal; Graham G Giles; Robert J MacInnis; Stephen N Thibodeau et al.
Source: check_circle
Institute of Cancer Research

The PROFILE study. Targeted screening using germline genetics in men with a family history of prostate cancer

European Urology
2021-06-01 | Other
SOURCE-WORK-ID:

252450

Part of ISSN: 0302-2838
WOSUID:

WOS:000674144301265

Contributors: Raghallaigh H Ni; Mark Brook; Ed Saunders; P Kumar; S Hazell; A Sohaib; A Dias; E Mcgrowder; S Wakerell; K Myhill et al.
Source: check_circle
Institute of Cancer Research

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Nature Genetics
2021-03 | Other
SOURCE-WORK-ID:

250342

Part of ISSN: 1061-4036
WOSUID:

WOS:000609060000001

Contributors: David V Conti; Burcu F Darst; Lilit C Moss; Ed Saunders; Xin Sheng; Alisha Chou; Fredrick R Schumacher; Ali Amin Al Olama; Sara Benlloch; Tokhir Dadaev et al.
Source: check_circle
Institute of Cancer Research

Comparative validation of the BOADICEA and Tyrer-Cuzick breast cancer risk models incorporating classical risk factors and polygenic risk in a population-based prospective cohort of women of European ancestry.

Breast Cancer Research
2021-02-15 | Journal article
SOURCE-WORK-ID:

250481

Part of ISSN: 1465-5411
WOSUID:

WOS:000620225000001

Contributors: Parichoy Pal Choudhury; Mark Brook; Amber N Hurson; Andrew Lee; Charlotta V Mulder; Penny Coulson; Minouk Schoemaker; Michael Jones; Anthony J Swerdlow; Nilanjan Chatterjee et al.
Source: check_circle
Institute of Cancer Research

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction.

Nature Genetics
2021-01 | Journal article
SOURCE-WORK-ID:

250218

Part of ISSN: 1061-4036
WOSUID:

WOS:000604822500004

Contributors: David V Conti; Burcu F Darst; Lilit C Moss; Ed Saunders; Xin Sheng; Alisha Chou; Fredrick R Schumacher; Ali Amin Al Olama; Sara Benlloch; Tokhir Dadaev et al.
Source: check_circle
Institute of Cancer Research

iCARE: An R package to build, validate and apply absolute risk models.

PLoS ONE
2020 | Journal article
SOURCE-WORK-ID:

234572

Part of ISSN: 1932-6203
WOSUID:

WOS:000534621500042

Contributors: Parichoy Pal Choudhury; Paige Maas; Amber Wilcox; William Wheeler; Mark Brook; David Check; Montserrat Garcia-Closas; Nilanjan Chatterjee
Source: check_circle
Institute of Cancer Research

Relationship of self-reported body size and shape with risk for prostate cancer: A UK case-control study.

PLoS ONE
2020 | Journal article
SOURCE-WORK-ID:

248760

Part of ISSN: 1932-6203
WOSUID:

WOS:000573848800023

Contributors: Mohammad Aladwani; Artitaya Lophatananon; Fredie Robinson; Aneela Rahman; William Ollier; Zsofia Kote-Jarai; David Dearnaley; Govindasami Koveela; Nafisa Hussain; Reshma Rageevakumar et al.
Source: check_circle
Institute of Cancer Research

Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.

International Journal of Cancer
2020-09-01 | Journal article
SOURCE-WORK-ID:

234488

Part of ISSN: 0020-7136
WOSUID:

WOS:000513360500001

Contributors: Minouk Schoemaker; Hazel B Nichols; Lauren B Wright; Mark Brook; Michael Jones; Katie M O'Brien; Hans-Olov Adami; Laura Baglietto; Leslie Bernstein; Kimberly A Bertrand et al.
Source: check_circle
Institute of Cancer Research

Comparative Validation of Breast Cancer Risk Prediction Models and Projections for Future Risk Stratification.

Journal of the National Cancer Institute
2020-03-01 | Journal article
SOURCE-WORK-ID:

228955

Part of ISSN: 0027-8874
WOSUID:

WOS:000582307200009

Contributors: Parichoy Pal Choudhury; Amber N Wilcox; Mark Brook; Yan Zhang; Thomas Ahearn; Nick Orr; Penny Coulson; Minouk Schoemaker; Michael Jones; Mitchell H Gail et al.
Source: check_circle
Institute of Cancer Research

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Nat Genet
2019 | Other
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun
2019 | Other
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Correction: Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease.

Br J Cancer
2019 | Other
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Germline DNA Repair Gene Mutations in Young-onset Prostate Cancer Cases in the UK: Evidence for a More Extensive Genetic Panel.

Eur Urol
2019 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Prostate Cancer Risk-Associated Single-Nucleotide Polymorphism Affects Prostate-Specific Antigen Glycosylation and Its Function.

Clin Chem
2019 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Shared heritability and functional enrichment across six solid cancers.

Nat Commun
2019 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Interim Results from the IMPACT Study: Evidence for Prostate-specific Antigen Screening in BRCA2 Mutation Carriers.

European Urology
2019-12 | Journal article
SOURCE-WORK-ID:

231802

Part of ISSN: 0302-2838
WOSUID:

WOS:000496915900018

Contributors: Elizabeth C Page; Elizabeth K Bancroft; Mark Brook; Melissa Assel; Mona Hassan Al Battat; Sarah Thomas; Natalie Taylor; Anthony Chamberlain; Jennifer Pope; Holly Ni Raghallaigh et al.
Source: check_circle
Institute of Cancer Research

Interim results from the IMPACT study: evidence for PSA screening in BRCA2 mutation carriers

British Journal of Cancer
2019-10-04 | Other
SOURCE-WORK-ID:

234361

Part of ISSN: 0007-0920
WOSUID:

WOS:000505173600035

Contributors: Elizabeth Page; Elizabeth Bancroft; Mark Brook; Melissa Assel; Judith Offman; Zsofia Kote-Jarai; Andrew Vickers; Hans Lilja; Professor Rosalind Eeles
Source: check_circle
Institute of Cancer Research

Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

Nature Communications
2019-09-23 | Other
SOURCE-WORK-ID:

232146

Part of ISSN: 2041-1723
WOSUID:

WOS:000487208000001

Contributors: Xia Jiang; Hilary K Finucane; Fredrick R Schumacher; Stephanie L Schmit; Jonathan P Tyrer; Younghun Han; Kyriaki Michailidou; Corina Lesseur; Karoline B Kuchenbaecker; Joe Dennis et al.
Source: check_circle
Institute of Cancer Research

Validation of breast cancer risk model incorporating classical risk factors and polygenic risk scores in 14 prospective cohort studies in 6 countries

Cancer Research
2019-07-01 | Other
SOURCE-WORK-ID:

232905

Part of ISSN: 0008-5472
WOSUID:

WOS:000488129903062

Contributors: Parichoy Pal Choudhury; Amber Wilcox; Chi Gao; Brian Carter; Anika Husing; Mark Brook; Mikael Eriksson; Kara Martin; Chris Scott; Min Shi et al.
Source: check_circle
Institute of Cancer Research

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.

Nat Genet
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women.

JAMA Oncol
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Breast Cancer Risk After Childbirth.

Ann Intern Med
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Breast Cancer Risk After Recent Childbirth: A Pooled Analysis of 15 Prospective Studies.

Ann Intern Med
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Nat Commun
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Germline variation at 8q24 and prostate cancer risk in men of European ancestry.

Nat Commun
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Homeobox B13 G84E Mutation and Prostate Cancer Risk.

Eur Urol
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium.

Int J Epidemiol
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Rare DNA repair gene mutations predispose to young onset and lethal prostate cancer in the UK

European Journal of Surgical Oncology
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease.

Br J Cancer
2018 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎

A meta-analysis of more than 237,380 men of diverse ancestries identifies 40 new risk loci for prostate cancer

Genetic Epidemiology
2018-10-01 | Other
SOURCE-WORK-ID:

240778

Part of ISSN: 0741-0395
WOSUID:

WOS:000447523100089

Contributors: Lilit C Moss; Xin Sheng; Ed Saunders; Mark Brook; Tokhir Dadaev; Professor Rosalind Eeles; Zsofia Kote-Jarai; David V Conti; Christopher A Haiman
Source: check_circle
Institute of Cancer Research

A functional variation in PSA (KLK3) gene that confers lower risk is also associated with more aggressive disease and lower survival in men with prostate cancer

BJU International
2018-08-01 | Other
SOURCE-WORK-ID:

218047

Part of ISSN: 1464-4096
WOSUID:

WOS:000441959100050

Contributors: Jyotsna Batra; Srilakshmi Srinivasan; Thomas Kryza; Nathalie Bock; Carson Stephens; Ying Dong; Janaththani Panchadsaram; Leire Moya; Joan Rohl; Joanna L Perry-Keene et al.
Source: check_circle
Institute of Cancer Research

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Cancer Research
2018-07-01 | Other
SOURCE-WORK-ID:

240769

Part of ISSN: 0008-5472
WOSUID:

WOS:000468818901297

Contributors: Marco Matejcic; Ed Saunders; Tokhir Dadaev; Mark Brook; Ali Amin Al Olama; Fredrick R Schumacher; Sonja I Berndt; Sara Benlloch; Kenneth Muir; Koveela Govindasami et al.
Source: check_circle
Institute of Cancer Research

DNA repair gene panel mutations in young onset prostate cancer cases in the.

Journal of Clinical Oncology
2018-02-20 | Other
SOURCE-WORK-ID:

226309

Part of ISSN: 0732-183X
WOSUID:

WOS:000436179500018

Contributors: Professor Rosalind Eeles; Daniel Leongamornlert; Ed Saunders; Sarah Wakerell; Ian Whitmore; Tokhir Dadaev; Clara Cieza Borrella; Koveela Govindasami; Mark Brook; Artitaya Lophatananon et al.
Source: check_circle
Institute of Cancer Research

The Premenopausal Breast Cancer Collaboration: A Pooling Project of Studies Participating in the National Cancer Institute Cohort Consortium.

Cancer Epidemiol Biomarkers Prev
2017 | Journal article
Source: Self-asserted source
Mark Brook
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2

Peer review (2 reviews for 2 publications/grants)

Review activity for European urology oncology. (1)
Review activity for European urology. (1)