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ResearcherID: C-2061-2015
Scopus Author ID: 6602348689
SciProfiles: 818377
ResearcherID: C-2061-2015

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Works (41)

Targeting the p90RSK/MDM2/p53 Pathway Is Effective in Blocking Tumors with Oncogenic Up-Regulation of the MAPK Pathway Such as Melanoma and Lung Cancer

Cells
2024-09-14 | Journal article
DOI: 10.3390/cells13181546
Contributors: Immacolata Maietta; Eleonora Viscusi; Stefano Laudati; Giuseppe Iannaci; Antonio D’Antonio; Rosa Marina Melillo; Maria Letizia Motti; Valentina De Falco
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Crossref
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Targeted Cancer Therapy and Mechanisms of Resistance

2022 | Journal article
DOI: 10.3390/BOOKS978-3-0365-2856-4
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Web of Science Researcher Profile Sync

p90RSK Regulates p53 Pathway by MDM2 Phosphorylation in Thyroid Tumors

Cancers
2022-12 | Journal article | Author
DOI: 10.3390/cancers15010121
Contributors: Immacolata Maietta; Francesca Del Peschio; Preziosa Buonocore; Eleonora Viscusi; Stefano Laudati; Giuseppe Iannaci; Michele Minopoli; Maria Letizia Motti; VALENTINA DE FALCO
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Multidisciplinary Digital Publishing Institute
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Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

Genes & Diseases
2022-03 | Journal article
DOI: 10.1016/j.gendis.2022.02.007
Part of ISSN: 2352-3042
Source: Self-asserted source
VALENTINA DE FALCO
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The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19)

Nutrients
2022-02 | Journal article | Author
DOI: 10.3390/nu14051000
Contributors: Maria Letizia Motti; Domenico Tafuri; Lorenzo Donini; Maria Teresa Masucci; VALENTINA DE FALCO; Mazzeo F
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Multidisciplinary Digital Publishing Institute
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Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: Identification of gain-of-function mutations in the RET proto-oncogene (Journal of Experimental and Clinical Cancer Research (2018) 37 (84) DOI: 10.1186/s13046-018-0746-y)

Journal of Experimental and Clinical Cancer Research
2018 | Journal article
DOI: 10.1186/s13046-018-0776-5
EID:

2-s2.0-85047947796

Part of ISBN:

17569966
Contributors: Oliveira, D.M.; Grillone, K.; Mignogna, C.; De Falco, V.; Laudanna, C.; Biamonte, F.; Locane, R.; Corcione, F.; Fabozzi, M.; Sacco, R. et al.
Source: Self-asserted source
VALENTINA DE FALCO via Scopus - Elsevier

Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: Identification of gain-of-function mutations in the RET proto-oncogene

Journal of Experimental and Clinical Cancer Research
2018 | Journal article
DOI: 10.1186/s13046-018-0746-y
EID:

2-s2.0-85045550597

Part of ISBN:

17569966
Contributors: Mendes Oliveira, D.; Grillone, K.; Mignogna, C.; De Falco, V.; Laudanna, C.; Biamonte, F.; Locane, R.; Corcione, F.; Fabozzi, M.; Sacco, R. et al.
Source: Self-asserted source
VALENTINA DE FALCO via Scopus - Elsevier

The molecular basis for RET tyrosine-kinase inhibitors in thyroid cancer

Best Practice and Research: Clinical Endocrinology and Metabolism
2017 | Journal article
DOI: 10.1016/j.beem.2017.04.013
EID:

2-s2.0-85019681383

Part of ISBN:

15321908 1521690X
Contributors: De Falco, V.; Carlomagno, F.; Li, H.-Y.; Santoro, M.
Source: Self-asserted source
VALENTINA DE FALCO via Scopus - Elsevier

Erratum: The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells (American Society for Clinical Investigation (2005) 115:4 (1068-1081) DOI: 10.1172/JCI22758)

Journal of Clinical Investigation
2016 | Journal article
DOI: 10.1172/JCI87342
EID:

2-s2.0-84964687599

Part of ISBN:

15588238 00219738
Contributors: Melillo, R.M.; Castellone, M.D.; Guarino, V.; De Falco, V.; Cirafici, A.M.; Salvatore, G.; Caiazzo, F.; Basolo, F.; Giannini, R.; Kruhoffer, M. et al.
Source: Self-asserted source
VALENTINA DE FALCO via Scopus - Elsevier

Fragment-Based Discovery of a Dual pan-RET/VEGFR2 Kinase Inhibitor Optimized for Single-Agent Polypharmacology

Angewandte Chemie (International ed. in English)
2015 | Journal article
DOI: 10.1002/anie.201501104
EID:

2-s2.0-84936768624

Part of ISBN:

15213773
Contributors: Frett, B.; Carlomagno, F.; Moccia, M.L.; Brescia, A.; Federico, G.; De Falco, V.; Admire, B.; Chen, Z.; Qi, W.; Santoro, M. et al.
Source: Self-asserted source
VALENTINA DE FALCO via Scopus - Elsevier

Calcium/Calmodulin-Dependent Protein Kinase II and Its Endogenous Inhibitor alpha in Medullary Thyroid Cancer

Clinical Cancer Research
2014 | Journal article
DOI:

10.1158/1078-0432.CCR-13-1683
Contributors: Russo, Eleonora; Salzano, Marcella; De Falco, Valentina; Mian, Caterina; Barollo, Susi; Secondo, Agnese; Bifulco, Maurizio; Vitale, Mario
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VALENTINA DE FALCO via ResearcherID
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Effects of combined administration of rapamycin, tolvaptan, and AEZ-131 on the progression of polycystic disease in PCK rats

American Journal of Physiology-Renal Physiology
2014 | Journal article
DOI:

10.1152/ajprenal.00694.2013
Contributors: Sabbatini, Massimo; Russo, Luigi; Cappellaio, Francesco; Troncone, Giancarlo; Bellevicine, Claudio; De Falco, Valentina; Buonocore, Preziosa; Riccio, Eleonora; Bisesti, Vincenzo; Federico, Stefano et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Ponatinib (AP24534) Is a Novel Potent Inhibitor of Oncogenic RET Mutants Associated With Thyroid Cancer

Journal of Clinical Endocrinology & Metabolism
2013 | Journal article
DOI:

10.1210/jc.2012-2672
Contributors: De Falco, Valentina; Buonocore, Preziosa; Muthu, Magesh; Torregrossa, Liborio; Basolo, Fulvio; Billaud, Marc; Gozgit, Joseph M.; Carlomagno, Francesca; Santoro, Massimo
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells

Cancer Research
2012 | Journal article
DOI:

10.1158/0008-5472.CAN-11-3320
Contributors: De Falco, Valentina; Tamburrino, Anna; Ventre, Simona; Castellone, Maria Domenica; Malek, Mouhannad; Manie, Serge N.; Santoro, Massimo
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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XB130 Mediates Cancer Cell Proliferation and Survival through Multiple Signaling Events Downstream of Akt

Plos One
2012 | Journal article
DOI:

10.1371/journal.pone.0043646
Contributors: Shiozaki, Atsushi; Shen-Tu, Grace; Bai, Xiaohui; Iitaka, Daisuke; De Falco, Valentina; Santoro, Massimo; Keshavjee, Shaf; Liu, Mingyao
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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XB130 Mediates Cancer Cell Proliferation and Survival through Multiple Signaling Events Downstream of Akt.

Figshare
2012 | Other
Contributors: Shiozaki, Atsushi; Shen-Tu, Grace; Bai, Xiaohui; Iitaka, Daisuke; De Falco, Valentina; Santoro, Massimo; Keshavjee, Shaf; Liu, Mingyao
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID

Mitochondrial Localization and Regulation of BRAF(V600E) in Thyroid Cancer: A Clinically Used RAF Inhibitor Is Unable to Block the Mitochondrial Activities of BRAF(V600E)

Journal of Clinical Endocrinology & Metabolism
2011 | Journal article
DOI:

10.1210/jc.2010-1071
Contributors: Lee, Min Hee; Lee, Seong Eun; Kim, Dong Wook; Ryu, Min Jeong; Kim, Sung Jin; Kim, Sung Joong; Kim, Yong Kyoung; Park, Ji Hoon; Kweon, Gi Ryang; Kim, Jin Man et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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The tyrosine kinase inhibitor ZD6474 blocks proliferation of RET mutant medullary thyroid carcinoma cells

Endocrine-Related Cancer
2011 | Journal article
DOI:

10.1677/ERC-09-0292
Contributors: Vitagliano, Donata; De Falco, Valentina; Tamburrino, Anna; Coluzzi, Sabrina; Troncone, Giancarlo; Chiappetta, Gennaro; Ciardiello, Fortunato; Tortora, Giampaolo; Fagin, James A.; Ryan, Anderson J. et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells

Journal of Clinical Endocrinology & Metabolism
2010 | Journal article
DOI:

10.1210/jc.2009-0373
Contributors: Salerno, Paolo; De Falco, Valentina; Tamburrino, Anna; Nappi, Tito Claudio; Vecchio, Giancarlo; Schweppe, Rebecca E.; Bollag, Gideon; Santoro, Massimo; Salvatore, Giuliana
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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The Ca2+-calmodulin-dependent kinase II is activated in papillary thyroid carcinoma (PTC) and mediates cell proliferation stimulated by RET/PTC

Endocrine-Related Cancer
2010 | Journal article
DOI:

10.1677/ERC-09-0214
Contributors: Rusciano, Maria Rosaria; Salzano, Marcella; Monaco, Sara; Sapio, Maria Rosaria; Illario, Maddalena; De Falco, Valentina; Santoro, Massimo; Campiglia, Pietro; Pastore, Lucio; Fenzi, Gianfranco et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Cytostatic Activity of Adenosine Triphosphate-Competitive Kinase Inhibitors in BRAF Mutant Thyroid Carcinoma Cells

Endocrine Reviews
2009 | Journal article
DOI: 10.1210/EDRV.30.7.9986
WOSUID: MEDLINE:28199516
Contributors: Salerno, Paolo; De Falco, Valentina; Tamburrino, Anna; Nappi, Tito Claudio; Vecchio, Giancarlo; Schweppe, Rebecca E; Bollag, Gideon; Santoro, Massimo; Salvatore, Giuliana
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Web of Science Researcher Profile Sync

Insights into the molecular function of the inactivating mutations of B-Raf involving the DFG motif

Biochimica Et Biophysica Acta-Molecular Cell Research
2009 | Journal article
DOI:

10.1016/j.bbamcr.2009.09.001
Contributors: Moretti, Sonia; De Falco, Valentina; Tamburrino, Anna; Barbi, Flavia; Tavano, Maria; Avenia, Nicola; Santeusanio, Fausto; Santoro, Massimo; Macchiarulo, Antonio; Puxeddu, Efisio
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets

Journal of Molecular Endocrinology
2009 | Journal article
DOI:

10.1677/JME-09-0024
Contributors: Cerrato, Aniello; De Falco, Valentina; Santoro, Massimo
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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The beta-Catenin Axis Integrates Multiple Signals Downstream from RET/Papillary Thyroid Carcinoma Leading to Cell Proliferation

Cancer Research
2009 | Journal article
DOI:

10.1158/0008-5472.CAN-08-1982
Contributors: Castellone, Maria Domenica; De Falco, Valentina; Rao, Deva Magendra; Bellelli, Roberto; Muthu, Magesh; Basolo, Fulvio; Fusco, Alfredo; Gutkind, Silvio; Santoro, Massimo
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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XB130, a tissue-specific adaptor protein that couples the RET/PTC oncogenic kinase to PI 3-kinase pathway

Oncogene
2009 | Journal article
DOI:

10.1038/onc.2008.447
Contributors: Lodyga, M.; De Falco, V.; Bai, X-H; Kapus, A.; Melillo, R. M.; Santoro, M.; Liu, M.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Functional Characterization of the Novel T599I-VKSRdel BRAF Mutation in a Follicular Variant Papillary Thyroid Carcinoma

Journal of Clinical Endocrinology & Metabolism
2008 | Journal article
DOI:

10.1210/jc.2008-0887
Contributors: De Falco, Valentina; Giannini, Riccardo; Tamburrino, Anna; Ugolini, Clara; Lupi, Cristiana; Puxeddu, Efisio; Santoro, Massimo; Basolo, Fulvio
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Targeting RET Kinase in Thyroid Cancer

Proceedings of the 13th International Congress of Endocrinology
2008 | Journal article
Contributors: Santoro, M.; Castellone, M. D.; Vitagliano, D.; De Falco, V.; Tamburrino, A.; Carlomagno, F.; GodoyMatos, A; Wass, J
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID

Biological role and potential therapeutic targeting of the chemokine receptor CXCR4 in undifferentiated thyroid cancer

Cancer Research
2007 | Journal article
DOI:

10.1158/0008-5472.CAN-07-0899
Contributors: De Falco, Valentina; Guarino, Valentina; Avilla, Elvira; Castellone, Maria Domenica; Salerno, Paolo; Salvatore, Giuliana; Faviana, Pinuccia; Basolo, Fulvio; Santoro, Massimo; Melillo, Rosa Marina
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Cytosolic phospholipase A(2)alpha regulates cell growth in RET/PTC-transformed thyroid cells

Cancer Research
2007 | Journal article
DOI:

10.1158/0008-5472.CAN-07-1997
Contributors: Mariggio, Stefania; Filippi, Beatrice Maria; Iurisci, Cristiano; Dragani, Luana Katia; De Falco, Valentina; Santoro, Massimo; Corda, Daniela
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase

Cancer Research
2007 | Journal article
DOI:

10.1158/0008-5472.CAN-06-0981
Contributors: De Falco, Valentina; Castellone, Maria Domenica; De Vita, Gabriella; Cirafici, Anna Maria; Hershman, Jerome M.; Guerrero, Carmen; Fusco, Alfredo; Melillo, Rosa Marina; Santoro, Massimo
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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A novel pathway of cell growth regulation mediated by a PLA(2)alpha-derived phosphoinositide metabolite

Faseb Journal
2006 | Journal article
DOI:

10.1096/fj.05-5397fje
Contributors: Mariggio, Stefania; Sebastia, Jordi; Filippi, Beatrice Maria; Iurisci, Cristiano; Volonte, Cinzia; Amadio, Susanna; De Falco, Valentina; Santoro, Massimo; Corda, Daniela
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Biochemical and molecular characterization of the novel BRAF(V599Ins) mutation detected in a classic papillary thyroid carcinoma

Oncogene
2006 | Journal article
DOI:

10.1038/sj.onc.1209448
Contributors: Moretti, S.; Macchiarulo, A.; De Falco, V.; Avenia, N.; Barbi, F.; Carta, C.; Cavaliere, A.; Melillo, R. M.; Passeri, L.; Santeusanio, F. et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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BRAF is a therapeutic target in aggressive thyroid carcinoma

Clinical Cancer Research
2006 | Journal article
DOI:

10.1158/1078-0432.CCR-05-2378
Contributors: Salvatore, G; De Falco, V; Salerno, P; Nappi, TC; Pepe, S; Troncone, G; Carlomagno, F; Melillo, RM; Wilhelm, SM; Santoro, M
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Osteopontin is overexpressed in human papillary thyroid carcinomas and enhances thyroid carcinoma cell invasiveness

Journal of Clinical Endocrinology & Metabolism
2005 | Journal article
DOI:

10.1210/jc.2005-0271
Contributors: Guarino, V; Faviana, P; Salvatore, G; Castellone, MD; Cirafici, AM; De Falco, V; Celetti, A; Giannini, R; Basolo, F; Melillo, RM et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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RAI(ShcC/N-Shc)-dependent recruitment of GAB1 to RET oncoproteins potentiates PI3-K signalling in thyroid tumors

Oncogene
2005 | Journal article
DOI:

10.1038/sj.onc.1208776
Contributors: De Falco, V; Guarino, V; Malorni, L; Cirafici, AM; Troglio, F; Erreni, M; Pelicci, G; Santoro, M; Melillo, RM
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

Journal of Clinical Investigation
2005 | Journal article
DOI:

10.1172/JCI22758
Contributors: Melillo, RM; Castellone, MD; Guarino, V; De Falco, V; Cirafici, AM; Salvatore, G; Caiazzo, F; Basolo, F; Giannini, R; Kruhoffer, M et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

Journal of Clinical Investigation
2005 | Journal article
DOI: 10.1172/JCI200522758
EID:

2-s2.0-20144387455

Part of ISBN:

00219738
Contributors: Melillo, R.M.; Castellone, M.D.; Guarino, V.; De Falco, V.; Cirafici, A.M.; Salvatore, G.; Caiazzo, F.; Basolo, F.; Giannini, R.; Kruhoffer, M. et al.
Source: Self-asserted source
VALENTINA DE FALCO via Scopus - Elsevier

A new germline RET mutation apparently devoid of transforming activity serendipitously discovered in a patient with atrophic autoimmune thyroiditis and primary ovarian failure

Journal of Clinical Endocrinology & Metabolism
2004 | Journal article
DOI:

10.1210/jc.2004-0365
Contributors: Orgiana, G; Pinna, G; Camedda, A; De Falco, V; Santoro, M; Melillo, RM; Elisei, R; Romei, C; Lai, S; Carcassi, C et al.
Source: Self-asserted source
VALENTINA DE FALCO via ResearcherID
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Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas

Oncogene
2004 | Journal article
DOI:

10.1038/sj.onc.1207790
Contributors: Castellone, MD; Guarino, V; De Falco, V; Carlomagno, F; Basolo, F; Faviana, P; Kruhoffer, M; Orntoft, T; Russel, JP; Rothstein, JL et al.
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VALENTINA DE FALCO via ResearcherID
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The oncogenic activity of RET point mutants for follicular thyroid cells may account for the occurrence of papillary thyroid carcinoma in patients affected by familial medullary thyroid carcinoma

American Journal of Pathology
2004 | Journal article
DOI:

10.1016/S0002-9440(10)63316-0
Contributors: Melillo, RM; Cirafici, AM; De Falco, V; Bellantoni, M; Chiappetta, G; Fusco, A; Carlomagno, F; Picascia, A; Tramontano, D; Tallini, G et al.
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VALENTINA DE FALCO via ResearcherID
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Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes

Oncogene
2003 | Journal article
DOI:

10.1038/sj.onc.1206112
Contributors: Castellone, MD; Cirafici, AM; De Vita, G; De Falco, V; Malorni, L; Tallini, G; Fagin, JA; Fusco, A; Melillo, RM; Santoro, M
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VALENTINA DE FALCO via ResearcherID
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Peer review (10 reviews for 6 publications/grants)

Review activity for Cancers. (4)
Review activity for Cells. (1)
Review activity for Diagnostics. (1)
Review activity for Journal of clinical medicine. (1)
Review activity for Molecules. (2)
Review activity for The International Journal of Biological Markers. (1)
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