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Biography

Dr. Huimin Zhao is the Steven L. Miller Chair of chemical and biomolecular engineering at the University of Illinois at Urbana-Champaign (UIUC), director of NSF AI Institute for Molecule Synthesis (moleculemaker.org), and Editor in Chief of ACS Synthetic Biology. He received his B.S. degree in Biology from the University of Science and Technology of China in 1992 and his Ph.D. degree in Chemistry from the California Institute of Technology in 1998 under the guidance of Nobel Laureate Dr. Frances Arnold. Prior to joining UIUC in 2000, he was a project leader at the Industrial Biotechnology Laboratory of the Dow Chemical Company. He was promoted to full professor in 2008. Dr. Zhao has authored and co-authored over 420 research articles and over 30 issued and pending patent applications. In addition, he has given over 470 plenary, keynote, or invited lectures. Thirty-six (36) of his former graduate students and postdocs became professors or principal investigators around the world. Dr. Zhao received numerous research and teaching awards and honors such as AIChE FP&B Division Award, ECI Enzyme Engineering Award, ACS Marvin Johnson Award, and SIMB Charles Thom Award. His primary research interests are in the development and applications of synthetic biology, machine learning, and laboratory automation tools to address society’s most daunting challenges in health, energy, and sustainability.

Activities

Employment (1)

University of Illinois Urbana-Champaign: Urbana, IL, US

2000-07 to present | Professor (Chemical and Biomolecular Engineering)
Employment
Source: Self-asserted source
Huimin Zhao

Education and qualifications (1)

California Institute of Technology: Pasadena, CA, US

1992 to 1998 | Ph.D. (Chemistry)
Education
Source: Self-asserted source
Huimin Zhao

Works (50 of 130)

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Page 1 of 3

A simple room-temperature refurbishment method for sulfated lead-acid batteries using ammonium acetate treatment

Journal of Power Sources
2025-01 | Journal article
Contributors: Aravind Baby; Abdelilah Asserghine; Elizabeth Gao; Huimin Zhao; Joaquín Rodríguez-López
Source: check_circle
Crossref

Chemoenzymatic Synthesis Planning Guided by Reaction Type Score

Journal of Chemical Information and Modeling
2024-12-23 | Journal article
Contributors: Hongxiang Li; Xuan Liu; Guangde Jiang; Huimin Zhao
Source: check_circle
Crossref

A Plug-and-Play T7 Expression System for Heterologous Production of Lanthipeptides in Bacillus subtilis

ACS Synthetic Biology
2024-11-15 | Journal article
Contributors: Chengyou Shi; Huimin Zhao
Source: check_circle
Crossref

Metabolic Engineering of Nonmodel Yeast Issatchenkia orientalis SD108 for 5‐Aminolevulinic Acid Production

Biotechnology and Bioengineering
2024-11-06 | Journal article
Contributors: Shih‐I Tan; I‐Son Ng; Huimin Zhao
Source: check_circle
Crossref

Chemoenzymatic Synthesis Planning Guided by Reaction Type Score

2024-10-29 | Preprint
Contributors: Hongxiang Li; Xuan Liu; Guangde Jiang; Huimin Zhao
Source: check_circle
Crossref

Impact of Chromatin Organization and Epigenetics on CRISPR-Cas and TALEN Genome Editing

ACS Synthetic Biology
2024-10-18 | Journal article
Contributors: Surbhi Jain; Guanhua Xun; Huimin Zhao
Source: check_circle
Crossref

Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides

Nature Chemistry
2024-08 | Journal article
Contributors: Hengqian Ren; Chunshuai Huang; Yuwei Pan; Shravan R. Dommaraju; Haiyang Cui; Maolin Li; Mayuresh G. Gadgil; Douglas A. Mitchell; Huimin Zhao
Source: check_circle
Crossref

Chemoenzymatic synthesis planning by evaluating the synthetic potential in biocatalysis and chemocatalysis

2024-08-30 | Preprint
Contributors: Xuan Liu; Hongxiang Li; Huimin Zhao
Source: check_circle
Crossref

Biochemical Investigation and Engineering of a Tardigrade X Family DNA Polymerase for Template-Independent DNA Synthesis

ACS Catalysis
2024-08-16 | Journal article
Contributors: Yee-Song Law; Nazreen Abdul Muthaliff; Yifeng Wei; Fu Lin; Huimin Zhao; Ee Lui Ang
Source: check_circle
Crossref

Asymmetric photoenzymatic incorporation of fluorinated motifs into olefins

Science
2024-07-26 | Journal article
Contributors: Maolin Li; Yujie Yuan; Wesley Harrison; Zhengyi Zhang; Huimin Zhao
Source: check_circle
Crossref

Prokaryotic RNA N1-Methyladenosine Erasers Maintain tRNA m1A Modification Levels in Streptomyces venezuelae

ACS Chemical Biology
2024-07-19 | Journal article
Contributors: Marcus Foo; Luke R. Frietze; Behnam Enghiad; Yujie Yuan; Christopher D. Katanski; Huimin Zhao; Tao Pan
Source: check_circle
Crossref

Enterolyin S, a Polythiazole‐containing Hemolytic Peptide from Enterococcus caccae

ChemBioChem
2024-06-17 | Journal article
Contributors: Chengyou Shi; Varshal A. Patel; Douglas A. Mitchell; Huimin Zhao
Source: check_circle
Crossref

Self-Buffering system for Cost-Effective production of lactic acid from glucose and xylose using Acid-Tolerant Issatchenkia orientalis

Bioresource Technology
2024-05 | Journal article
Contributors: Ye-Gi Lee; Nam Kyu Kang; Chanwoo Kim; Vinh G. Tran; Mingfeng Cao; Yasuo Yoshikuni; Huimin Zhao; Yong-Su Jin
Source: check_circle
Crossref

Harnessing noncanonical crRNA for highly efficient genome editing

Nature Communications
2024-05-07 | Journal article
Contributors: Guanhua Xun; Zhixin Zhu; Nilmani Singh; Jingxia Lu; Piyush K. Jain; Huimin Zhao
Source: check_circle
Crossref

Multifunctional Glucose Dehydrogenase Enabled Synthesis of Chiral-Bridged Bicyclic Nitrogen Heterocycles

ACS Catalysis
2024-05-03 | Journal article
Contributors: Guangde Jiang; Jingxia Lu; Megan Zhou; Wesley Harrison; Huimin Zhao
Source: check_circle
Crossref

Photoenzymatic Asymmetric Hydroamination for Chiral Alkyl Amine Synthesis

Journal of the American Chemical Society
2024-04-17 | Journal article
Contributors: Wesley Harrison; Guangde Jiang; Zhengyi Zhang; Maolin Li; Haoyu Chen; Huimin Zhao
Source: check_circle
Crossref

CRISPR-COPIES: an in silico platform for discovery of neutral integration sites for CRISPR/Cas-facilitated gene integration

Nucleic Acids Research
2024-04-12 | Journal article
Contributors: Aashutosh Girish Boob; Zhixin Zhu; Pattarawan Intasian; Manan Jain; Vassily Andrew Petrov; Stephan Thomas Lane; Shih-I Tan; Guanhua Xun; Huimin Zhao
Source: check_circle
Crossref

Molecule Maker Lab Institute: Accelerating, advancing, and democratizing molecular innovation

AI Magazine
2024-03 | Journal article
Contributors: Martin D. Burke; Scott E. Denmark; Ying Diao; Jiawei Han; Rachel Switzky; Huimin Zhao
Source: check_circle
Crossref

Remote stereocontrol with azaarenes via enzymatic hydrogen atom transfer

Nature Chemistry
2024-02 | Journal article
Contributors: Maolin Li; Wesley Harrison; Zhengyi Zhang; Yujie Yuan; Huimin Zhao
Source: check_circle
Crossref

Special Issue on Artificial Intelligence for Synthetic Biology

ACS Synthetic Biology
2024-02-16 | Journal article
Contributors: Hector García Martín; Stanislav Mazurenko; Huimin Zhao
Source: check_circle
Crossref

Amino acid based ionic liquids for revitalization of sulfated lead anodes

Journal of Power Sources
2024-01 | Journal article
Contributors: Jingxia Lu; Aravind Baby; Abdelilah Asserghine; Joaquín Rodríguez-López; Huimin Zhao
Source: check_circle
Crossref

Enabling pathway design by multiplex experimentation and machine learning

Metabolic Engineering
2024-01 | Journal article
Contributors: Aashutosh Girish Boob; Junyu Chen; Huimin Zhao
Source: check_circle
Crossref

Inducing and real-time monitoring of lead (de)sulfation processes using scanning electrochemical microscopy for applications in the refurbishment of lead-acid batteries

Electrochimica Acta
2024-01 | Journal article
Contributors: Abdelilah Asserghine; Aravind Baby; Elizabeth Gao; Huimin Zhao; Joaquín Rodríguez-López
Source: check_circle
Crossref

Synthetic Biology Continues to Grow

ACS Synthetic Biology
2024-01-19 | Journal article
Contributors: Huimin Zhao
Source: check_circle
Crossref

In situ detection of reactive oxygen species spontaneously generated on lead acid battery anodes: a pathway for degradation and self-discharge at open circuit

Chemical Science
2023 | Journal article
Contributors: Abdelilah Asserghine; Aravind Baby; Seth T. Putnam; Peisen Qian; Elizabeth Gao; Huimin Zhao; Joaquín Rodríguez-López
Source: check_circle
Crossref

To cut or not to cut: Next-generation genome editors for precision genome engineering

Current Opinion in Biomedical Engineering
2023-12 | Journal article
Contributors: Meng Zhang; Zhixin Zhu; Guanhua Xun; Huimin Zhao
Source: check_circle
Crossref

Multiplexed CRISPR-Based Nucleic Acid Detection Using a Single Cas Protein

Analytical Chemistry
2023-11-07 | Journal article
Contributors: Jinyu Fu; Linghao Zhang; Yanlin Long; Zihe Liu; Geng Meng; Huimin Zhao; Xin Su; Shuobo Shi
Source: check_circle
Crossref

Incorporation of noncanonical base Z yields modified mRNA with minimal immunogenicity and improved translational capacity in mammalian cells

iScience
2023-10 | Journal article
Contributors: Meng Zhang; Nilmani Singh; Mary Elisabeth Ehmann; Lining Zheng; Huimin Zhao
Source: check_circle
Crossref

Machine Learning-Enabled Genome Mining and Bioactivity Prediction of Natural Products

ACS Synthetic Biology
2023-09-15 | Journal article
Contributors: Yujie Yuan; Chengyou Shi; Huimin Zhao
Source: check_circle
Crossref

SHIELD: a platform for high-throughput screening of barrier-type DNA elements in human cells

Nature Communications
2023-09-12 | Journal article
Contributors: Meng Zhang; Mary Elisabeth Ehmann; Srija Matukumalli; Aashutosh Girish Boob; David M. Gilbert; Huimin Zhao
Source: check_circle
Crossref

CRISPR-COPIES: Anin silicoplatform for discovery of neutral integration sites for CRISPR/Cas-facilitated gene integration

2023-09-06 | Preprint
Contributors: Aashutosh Girish Boob; Zhixin Zhu; Pattarawan Intasian; Manan Jain; Vassily Andrew Petrov; Shih-I Tan; Guanhua Xun; Huimin Zhao
Source: check_circle
Crossref

In vitro continuous protein evolution empowered by machine learning and automation

Cell Systems
2023-08 | Journal article
Contributors: Tianhao Yu; Aashutosh Girish Boob; Nilmani Singh; Yufeng Su; Huimin Zhao
Source: check_circle
Crossref

A landing pad system for multicopy gene integration in Issatchenkia orientalis

Metabolic Engineering
2023-07 | Journal article
Contributors: Zia Fatma; Shih-I Tan; Aashutosh Girish Boob; Huimin Zhao
Source: check_circle
Crossref

Further Characterization of Fungal Halogenase RadH and Its Homologs

Biomolecules
2023-07 | Journal article | Author
Contributors: GuangRong Peh; Gregory A. Gunawan; Terence Tay; Elaine Tiong; Lee Ling Tan; Shimin Jiang; Yi Ling Goh; Suming Ye; Joel Wong; Christopher J. Brown et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Photoenzymatic enantioselective intermolecular radical hydroamination

Nature Catalysis
2023-07-31 | Journal article
Contributors: Zhengyi Zhang; Jianqiang Feng; Chao Yang; Haiyang Cui; Wesley Harrison; Dongping Zhong; Binju Wang; Huimin Zhao
Source: check_circle
Crossref

Ene Reductase Enabled Intramolecular β‐C−H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds

Angewandte Chemie
2023-05-22 | Journal article
Contributors: Guangde Jiang; Chunshuai Huang; Wesley Harrison; Hongxiang Li; Megan Zhou; Huimin Zhao
Source: check_circle
Crossref

Ene Reductase Enabled Intramolecular β‐C−H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds

Angewandte Chemie International Edition
2023-05-22 | Journal article
Contributors: Guangde Jiang; Chunshuai Huang; Wesley Harrison; Hongxiang Li; Megan Zhou; Huimin Zhao
Source: check_circle
Crossref

A landing pad system for multicopy gene integration inIssatchenkia orientalis

2023-05-21 | Preprint
Contributors: Zia Fatma; Shih-I Tan; Aashutosh Girish Boob; Huimin Zhao
Source: check_circle
Crossref

CMI: CRISPR/Cas9 Based Efficient Multiplexed Integration in Saccharomyces cerevisiae

ACS Synthetic Biology
2023-05-19 | Journal article
Contributors: Jie Meng; Yue Qiu; Yueping Zhang; Huimin Zhao; Shuobo Shi
Source: check_circle
Crossref

Imaging Method Using CRISPR/dCas9 and Engineered gRNA Scaffolds Can Perturb Replication Timing at the HSPA1 Locus

ACS Synthetic Biology
2023-05-19 | Journal article
Contributors: Xiong Xiong; Ipek Tasan; Che Yang; Meng Zhang; Gabriela A. Hernandez Gonzalez; Shuting Liu; Pankaj Chaturvedi; Andrew S. Belmont; Huimin Zhao
Source: check_circle
Crossref

Metabolic Engineering: Methodologies and Applications

Chemical Reviews
2023-05-10 | Journal article
Contributors: Michael J. Volk; Vinh G. Tran; Shih-I Tan; Shekhar Mishra; Zia Fatma; Aashutosh Boob; Hongxiang Li; Pu Xue; Teresa A. Martin; Huimin Zhao
Source: check_circle
Crossref

Enzyme function prediction using contrastive learning

Science
2023-03-31 | Journal article
Contributors: Tianhao Yu; Haiyang Cui; Jianan Canal Li; Yunan Luo; Guangde Jiang; Huimin Zhao
Source: check_circle
Crossref

Genome mining unveils a class of ribosomal peptides with two amino termini

Nature Communications
2023-03-23 | Journal article
Contributors: Hengqian Ren; Shravan R. Dommaraju; Chunshuai Huang; Haiyang Cui; Yuwei Pan; Marko Nesic; Lingyang Zhu; David Sarlah; Douglas A. Mitchell; Huimin Zhao
Source: check_circle
Crossref

Mass Spectrometry-Based High-Throughput Quantification of Bioproducts in Liquid Culture

Analytical Chemistry
2023-02-28 | Journal article
Contributors: Shuaizhen Zhou; Zia Fatma; Pu Xue; Shekhar Mishra; Mingfeng Cao; Huimin Zhao; Jonathan V. Sweedler
Source: check_circle
Crossref

Machine learning-enabled retrobiosynthesis of molecules

Nature Catalysis
2023-02-16 | Journal article
Contributors: Tianhao Yu; Aashutosh Girish Boob; Michael J. Volk; Xuan Liu; Haiyang Cui; Huimin Zhao
Source: check_circle
Crossref

Design and application of a kinetic model of lipid metabolism in Saccharomyces cerevisiae

Metabolic Engineering
2023-01 | Journal article
Contributors: Shekhar Mishra; Ziyu Wang; Michael J. Volk; Huimin Zhao
Source: check_circle
Crossref

Investigation of the Biosynthetic Mechanism of Bipentaromycin Featuring an Unprecedented Cyclic Head-to-Tail Dimeric Scaffold

JACS Au
2023-01-23 | Journal article
Contributors: Chunshuai Huang; Haiyang Cui; Hengqian Ren; Huimin Zhao
Source: check_circle
Crossref

A Spirobicyclo[3.1.0]Terpene from the Investigation of Sesquiterpene Synthases from Lactarius deliciosus

ACS Chemical Biology
2023-01-20 | Journal article
Contributors: Choon Boon Cheong; GuangRong Peh; Yifeng Wei; Rehka T; Ee Lui Ang; Huimin Zhao; Congqiang Zhang; Yee Hwee Lim
Source: check_circle
Crossref

Metabolic engineering of Rhodotorula toruloides IFO0880 improves C16 and C18 fatty alcohol production from synthetic media

Microbial Cell Factories
2022-12 | Journal article
Contributors: J. Carl Schultz; Shekhar Mishra; Emily Gaither; Andrea Mejia; Hoang Dinh; Costas Maranas; Huimin Zhao
Source: check_circle
Crossref

Identification and Characterization of the Biosynthetic Pathway of the Sulfonolipid Capnine

Biochemistry
2022-12-20 | Journal article
Contributors: Yinbo Liu; Yifeng Wei; Tong Mei Teh; Dazhi Liu; Yan Zhou; Suwen Zhao; Ee Lui Ang; Huimin Zhao; Yan Zhang
Source: check_circle
Crossref
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Peer review (29 reviews for 12 publications/grants)

Review activity for ACS catalysis. (2)
Review activity for ACS central science. (1)
Review activity for ACS synthetic biology. (4)
Review activity for Journal of chemical information and modeling. (1)
Review activity for Journal of the American Chemical Society. (2)
Review activity for Nature (1)
Review activity for Nature biotechnology. (1)
Review activity for Nature Catalysis. (2)
Review activity for Nature chemical biology. (2)
Review activity for Nature communications (11)
Review activity for Nature synthesis. (1)
Review activity for Science. (1)