Personal information

Madelung's disease, familial multiple lipomatosis, Dercum's disease, Lipoedema, Lipedema
United States

Biography

Board-certified Endocrinologist with a specialization in fat diseases including Dercum disease, lipedema, Madelung disease and familial multiple lipomatosis.

Activities

Employment (4)

Total Lipedema Care: Beverly Hills, California, US

2021-01-03 to present | Research Director
Employment
Source: Self-asserted source
Karen L. Herbst

Karen L. Herbst, MD, PC: Los Angeles, California, US

2020-03-25 to present | President
Employment
Source: Self-asserted source
Karen L. Herbst

Limitless Therapeutics: Los Angeles, California, US

2020-03-11 to 2020-11-15 | Medical Advisor
Employment
Source: Self-asserted source
Karen L. Herbst

University of Arizona: Tucson, AZ, US

2013-08-01 to 2020-02-28 | Associate Professor (Medicine)
Employment
Source: Self-asserted source
Karen L. Herbst

Education and qualifications (5)

University of Washington: Seattle, WA, US

2000-07-01 to 2002-08-31 | Endocrine Fellowship (Medicine)
Education
Source: Self-asserted source
Karen L. Herbst

University of Washington: Seattle, WA, US

1999-07-01 to 2000-06-30 | Chief Residency (Medicine)
Education
Source: Self-asserted source
Karen L. Herbst

University of Washington: Seattle, WA, US

1998-07-01 to 1999-06-30 | Endocrinology Fellowship (Medicine)
Education
Source: Self-asserted source
Karen L. Herbst

University of Washington: Seattle, WA, US

1996-07-01 to 1998-06-30 | Residency (Internship and 2nd Year)
Education
Source: Self-asserted source
Karen L. Herbst

Rush University: Chicago, IL, US

1992-08-01 to 1996-05-05 | MD
Education
Source: Self-asserted source
Karen L. Herbst

Works (43)

Genome-wide association study of a lipedema phenotype among women in the UK Biobank identifies multiple genetic risk factors

European Journal of Human Genetics
2023-03 | Journal article
Contributors: Yann C. Klimentidis; Zhao Chen; Manuel L. Gonzalez-Garay; Dionysios Grigoriadis; Ege Sackey; Alan Pittman; Pia Ostergaard; Karen L. Herbst
Source: check_circle
Crossref

Standard of care for lipedema in the United States

Phlebology: The Journal of Venous Disease
2021-12 | Journal article
Contributors: Karen L Herbst; Linda Anne Kahn; Emily Iker; Chuck Ehrlich; Thomas Wright; Lindy McHutchison; Jaime Schwartz; Molly Sleigh; Paula MC Donahue; Kathleen H Lisson et al.
Source: check_circle
Crossref

Dercum’s Disease: Estimating the Prevalence of a Rare Painful Loose Connective Tissue Disease

Future Rare Diseases
2021-03-31 | Journal article
Contributors: Natalie Munguia; B Robert Mozayeni; Thomas F Wright; Karen L Herbst
Source: check_circle
Crossref

3D Spheroids Derived from Human Lipedema ASCs Demonstrated Similar Adipogenic Differentiation Potential and ECM Remodeling to Non-Lipedema ASCs In Vitro

International Journal of Molecular Sciences
2020-11-07 | Journal article
Contributors: Sara Al-Ghadban; India A. Pursell; Zaidmara T. Diaz; Karen L. Herbst; Bruce A. Bunnell
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Dercum’s Disease: Estimating the prevalence of a rare painful loose connective tissue disease

2020-06-04 | Preprint
Contributors: Natalie Corina Munguia; B. Robert Mozayeni; Thomas Wright; Karen L. Herbst
Source: check_circle
Crossref

Elevated Resting and Postprandial Digestive Proteolytic Activity in Peripheral Blood of Individuals With Type-2 Diabetes Mellitus, With Uncontrolled Cleavage of Insulin Receptors

Journal of the American College of Nutrition
2019-08-18 | Journal article
Contributors: Augusta E. Modestino; Elaine A. Skowronski; Chris Pruitt; Pam R. Taub; Karen Herbst; Geert W. Schmid-Schönbein; Michael J. Heller; Paul J. Mills
Source: check_circle
Crossref

Subcutaneous adipose tissue therapy reduces fat by dual X‐ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease

Clinical Obesity
2018-12 | Journal article
Contributors: M. Ibarra; A. Eekema; C. Ussery; D. Neuhardt; K. Garby; K. L. Herbst
Source: check_circle
Crossref

Pilot study: whole body manual subcutaneous adipose tissue (SAT) therapy improved pain and SAT structure in women with lipedema

Hormone Molecular Biology and Clinical Investigation
2018-02-23 | Journal article
Contributors: Karen L. Herbst; Christopher Ussery; Alyna Eekema
Source: check_circle
Crossref

Lipedema: friend and foe

Hormone Molecular Biology and Clinical Investigation
2018-01-26 | Journal article
Contributors: Yanira Sanchez-De la Torre; Rita Wadeea; Victoria Rosas; Karen L. Herbst
Source: check_circle
Crossref

Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial

Clinical Gastroenterology and Hepatology
2015 | Journal article
EID:

2-s2.0-84939538443

Contributors: Frankwich, K.A.; Egnatios, J.; Kenyon, M.L.; Rutledge, T.R.; Liao, P.S.; Gupta, S.; Herbst, K.L.; Zarrinpar, A.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

An abnormal lymphatic phenotype is associated with subcutaneous adipose tissue deposits in Dercum's disease

Obesity
2014 | Journal article
EID:

2-s2.0-84907689837

Contributors: Rasmussen, J.C.; Herbst, K.L.; Aldrich, M.B.; Darne, C.D.; Tan, I.-C.; Zhu, B.; Guilliod, R.; Fife, C.E.; Maus, E.A.; Sevick-Muraca, E.M.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Testosterone with dutasteride, but not anastrazole, improves insulin sensitivity in young obese men: A randomized controlled trial

Journal of Sexual Medicine
2014 | Journal article
EID:

2-s2.0-84904975710

Contributors: Juang, P.S.; Peng, S.; Allehmazedeh, K.; Shah, A.; Coviello, A.D.; Herbst, K.L.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design

Cancer Causes and Control
2013 | Journal article
EID:

2-s2.0-84876478607

Contributors: Patterson, R.E.; Colditz, G.A.; Hu, F.B.; Schmitz, K.H.; Ahima, R.S.; Brownson, R.C.; Carson, K.R.; Chavarro, J.E.; Chodosh, L.A.; Gehlert, S. et al.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Five-year changes in psychiatric treatment status and weight-related comorbidities following bariatric surgery in a veteran population

Obesity Surgery
2012 | Journal article
EID:

2-s2.0-84868200431

Contributors: Rutledge, T.; Braden, A.L.; Woods, G.; Herbst, K.L.; Groesz, L.M.; Savu, M.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Proof of Concept: Matrix metalloproteinase inhibitor decreases inflammation and improves muscle insulin sensitivity in people with type 2 diabetes

Journal of Inflammation
2012 | Journal article
EID:

2-s2.0-84866789438

Contributors: Frankwich, K.; Tibble, C.; Torres-Gonzalez, M.; Bonner, M.; Lefkowitz, R.; Tyndall, M.; Schmid-Schönbein, G.W.; Villarreal, F.; Heller, M.; Herbst, K.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Subcutaneous adipose tissue fatty acid desaturation in adults with and without rare adipose disorders

Lipids in Health and Disease
2012 | Journal article
EID:

2-s2.0-84856487153

Contributors: Yee, J.K.; Phillips, S.A.; Allamehzadeh, K.; Herbst, K.L.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Rare adipose disorders (RADs) masquerading as obesity

Acta Pharmacologica Sinica
2012-02 | Journal article
Contributors: Karen L Herbst
Source: Self-asserted source
Karen L. Herbst via Crossref Metadata Search
grade
Preferred source (of 2)‎

Behavioural weight management for the primary careprovider

Obesity Reviews
2011 | Journal article
EID:

2-s2.0-79955037006

Contributors: Rutledge, T.; Groesz, L.M.; Linke, S.E.; Woods, G.; Herbst, K.L.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Pilot study: rapidly cycling hypobaric pressure improves pain after 5 days in adiposis dolorosa

Journal of Pain Research
2010-08 | Journal article
Contributors: Karen Herbst
Source: Self-asserted source
Karen L. Herbst via Crossref Metadata Search

Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice

Diabetes
2009 | Journal article
EID:

2-s2.0-68049117225

Contributors: Tu, P.; Bhasin, S.; Hruz, P.W.; Herbst, K.L.; Castellani, L.W.; Hua, N.; Hamilton, J.A.; Guo, W.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Lipomatosis-associated inflammation and excess collagen may contribute to lower relative resting energy expenditure in women with adiposis dolorosa

International Journal of Obesity
2009 | Journal article
EID:

2-s2.0-70349136255

Contributors: Herbst, K.L.; Coviello, A.D.; Chang, A.; Boyle, D.L.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Effects of a supraphysiological dose of testosterone on physical function, muscle performance, mood, and fatigue in men with HIV-associated weight loss

American Journal of Physiology - Endocrinology and Metabolism
2008 | Journal article
EID:

2-s2.0-47549114457

Contributors: Knapp, P.E.; Storer, T.W.; Herbst, K.L.; Singh, A.B.; Dzekov, C.; Dzekov, J.; LaValley, M.; Zhang, A.; Ulloor, J.; Bhasin, S.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Adiposis Dolorosa Is More Than Painful Fat

The Endocrinologist
2007-11 | Journal article
Contributors: Karen L. Herbst; Sheila Asare-Bediako
Source: Self-asserted source
Karen L. Herbst via Crossref Metadata Search
grade
Preferred source (of 2)‎

Effects of transdermal testosterone administration on insulin sensitivity, fat mass and distribution, and markers of inflammation and thrombolysis in human immunodeficiency virus-infected women with mild to moderate weight loss

Fertility and Sterility
2006 | Journal article
EID:

2-s2.0-33744543207

Contributors: Herbst, K.L.; Calof, O.M.; Hsia, S.H.; Sinha-Hikim, I.; Woodhouse, L.J.; Buchanan, T.A.; Bhasin, S.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: A randomized clinical trial

Journal of Andrology
2005 | Journal article
EID:

2-s2.0-18244379028

Contributors: Anawalt, B.D.; Amory, J.K.; Herbst, K.L.; Coviello, A.D.; Page, S.T.; Bremner, W.J.; Matsumoto, A.M.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression

Journal of Clinical Endocrinology and Metabolism
2005 | Journal article
EID:

2-s2.0-21044438748

Contributors: Coviello, A.D.; Matsumoto, A.M.; Bremner, W.J.; Herbst, K.L.; Amory, J.K.; Anawalt, B.D.; Sutton, P.R.; Wright, W.W.; Brown, T.R.; Yan, X. et al.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Testosterone administration suppresses adiponectin levels in men

Journal of Andrology
2005 | Journal article
EID:

2-s2.0-10844259129

Contributors: Page, S.T.; Herbst, K.L.; Amory, J.K.; Coviello, A.D.; Anawalt, B.D.; Matsumoto, A.M.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Tetrahydrogestrinone is an androgenic steroid that stimulates androgen receptor-mediated, myogenic differentiation in C3H10T1/2 multipotent mesenchymal cells and promotes muscle accretion in orchidectomized male rats

Endocrinology
2005 | Journal article
EID:

2-s2.0-24944527415

Contributors: Jasuja, R.; Catlin, D.H.; Miller, A.; Chang, Y.-C.; Herbst, K.L.; Starcevic, B.; Artaza, J.N.; Singh, R.; Datta, G.; Sarkissian, A. et al.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

A single dose of the potent gonadotropin-releasing hormone antagonist acyline suppresses gonadotropins and testosterone for 2 weeks in healthy young men

Journal of Clinical Endocrinology and Metabolism
2004 | Journal article
EID:

2-s2.0-10344247116

Contributors: Herbst, K.L.; Coviello, A.D.; Page, S.; Amory, J.K.; Anawalt, B.D.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Intratesticular testosterone concentrations comparable with serum levels are not sufficient to maintain normal sperm production in men receiving a hormonal contraceptive regimen

Journal of Andrology
2004 | Journal article
EID:

2-s2.0-7044246174

Contributors: Coviello, A.D.; Bremner, W.J.; Matsumoto, A.M.; Herbst, K.L.; Amory, J.K.; Anawalt, B.D.; Yan, X.; Brown, T.R.; Wright, W.W.; Zirkin, B.R. et al.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Testosterone action on skeletal muscle

Current Opinion in Clinical Nutrition and Metabolic Care
2004 | Journal article
EID:

2-s2.0-4544381113

Contributors: Herbst, K.L.; Bhasin, S.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Gonadotropin-releasing hormone antagonists

Current Opinion in Pharmacology
2003 | Journal article
EID:

2-s2.0-0344444706

Contributors: Herbst, K.L.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Köbberling type of familial partial lipodystrophy: An underrecognized syndrome

Diabetes Care
2003 | Journal article
EID:

2-s2.0-0041668112

Contributors: Herbst, K.L.; Tannock, L.R.; Deeb, S.S.; Purnell, J.Q.; Brunzell, J.D.; Chait, A.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Phenotypic and Genetic Heterogeneity in Congenital Generalized Lipodystrophy

Journal of Clinical Endocrinology and Metabolism
2003 | Journal article
EID:

2-s2.0-10744220431

Contributors: Agarwal, A.K.; Simha, V.; Oral, E.A.; Moran, S.A.; Gorden, P.; O'Rahilly, S.; Zaidi, Z.; Gurakan, F.; Arslanian, S.A.; Klar, A. et al.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Testosterone administration to men increases hepatic lipase activity and decreases HDL and LDL size in 3 wk

American Journal of Physiology - Endocrinology and Metabolism
2003 | Journal article
EID:

2-s2.0-0037840433

Contributors: Herbst, K.L.; Amory, J.K.; Brunzell, J.D.; Chansky, H.A.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Testosterone and atherosclerosis progression in men

Diabetes Care
2003 | Journal article
EID:

2-s2.0-0042669927

Contributors: Bhasin, S.; Herbst, K.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

The male contraceptive regimen of testosterone and levonorgestrel significantly increases lean mass in healthy young men in 4 weeks, but attenuates a decrease in fat mass induced by testosterone alone

Journal of Clinical Endocrinology and Metabolism
2003 | Journal article
EID:

2-s2.0-0037340217

Contributors: Herbst, K.L.; Anawalt, B.D.; Amory, J.K.; Matsumoto, A.M.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Acyline: The first study in humans of a potent, new gonadotropin-releasing hormone antagonist

Journal of Clinical Endocrinology and Metabolism
2002 | Journal article
EID:

2-s2.0-0036316840

Contributors: Herbst, K.L.; Anawalt, B.D.; Amory, J.K.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Cognitive effects of short-term manipulation of serum sex steroids in healthy young men

Journal of Clinical Endocrinology and Metabolism
2002 | Journal article
EID:

2-s2.0-0036319140

Contributors: Cherrier, M.M.; Anawalt, B.D.; Herbst, K.L.; Amory, J.K.; Craft, S.; Matsumoto, A.M.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Desogestrel plus testosterone effectively suppresses spermatogenesis but also causes modest weight gain and high-density lipoprotein suppression

Fertility and Sterility
2000 | Journal article
EID:

2-s2.0-0033795352

Contributors: Anawalt, B.D.; Herbst, K.L.; Matsumoto, A.M.; Mulders, T.M.T.; Coelingh-Bennink, H.J.T.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Testosterone (T) administration improves spatial and verbal memory in normal men

Investigative Ophthalmology and Visual Science
1996 | Journal article
EID:

2-s2.0-33750147092

Contributors: Herbst, K.L.; Anawalt, B.D.; Cherrier, M.; Craft, S.; Matsumoto, A.M.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Testosterone administration to normal men decreases truncal and total body fat

Investigative Ophthalmology and Visual Science
1996 | Journal article
EID:

2-s2.0-33750195628

Contributors: Anawalt, B.D.; Amory, J.K.; Herbst, K.L.; Matsumoto, A.M.; Bremner, W.J.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

A mutation in ribosomal protein L9 affects ribosomal hopping during translation of gene 60 from bacteriophage T4

Proceedings of the National Academy of Sciences of the United States of America
1994 | Journal article
EID:

2-s2.0-0028587369

Contributors: Herbst, K.L.; Nichols, L.M.; Gesteland, R.F.; Weiss, R.B.
Source: Self-asserted source
Karen L. Herbst via Scopus - Elsevier

Peer review (21 reviews for 13 publications/grants)

Review activity for Adipocyte. (1)
Review activity for BMC surgery (1)
Review activity for Dermatologic therapy. (2)
Review activity for Diabetes, metabolic syndrome and obesity. (1)
Review activity for Disability and rehabilitation (1)
Review activity for International journal of environmental research and public health (1)
Review activity for Journal of cosmetic dermatology. (2)
Review activity for Life. (1)
Review activity for Medicina. (1)
Review activity for Obesity. (3)
Review activity for Phlebology (5)
Review activity for SpringerPlus. (1)
Review activity for World journal of surgical oncology (1)