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SciProfiles: 1609814
Scopus Author ID: 10438911500

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Poland

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Medical University of Silesia: Katowice, PL

(Department of Internal Medicine and Clinical Pharmacology)
Employment
Source: Self-asserted source
Grzegorz Machnik

Works (50 of 128)

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Page 1 of 3

Effect of tofacitinib on the phenotype and activity of Caco-2 cells in a model of inflammatory bowel disease.

Exp.Ther.Med.
2024 | Journal article
DOI: 10.3892/etm.2024.12440
Contributors: Skudrzyk Estera; Bułdak Łukasz; Machnik Grzegorz; Okopień Bogusław
Source: Self-asserted source
Grzegorz Machnik

A Dot-Blot Screening for Identifying the Temozolomide-Regulated Proteins as Potential Targets for Glioma Multi-OMICS Studies

Frontiers in Bioscience-Landmark
2024-10-22 | Journal article
DOI: 10.31083/j.fbl2910364
Contributors: Anna Maria Bielecka-Wajdman; Grzegorz Machnik; Christina Linnebacher; Michael Linnebacher; Katarzyna Stec-Grosman; Ewa Obuchowicz
Source: check_circle
Crossref

Liraglutide Therapy in Obese Patients Alters Macrophage Phenotype and Decreases Their Tumor Necrosis Factor Alpha Release and Oxidative Stress Markers—A Pilot Study

Metabolites
2024-10-16 | Journal article
DOI: 10.3390/metabo14100554
Contributors: Łukasz Bułdak; Aleksandra Bołdys; Estera Skudrzyk; Grzegorz Machnik; Bogusław Okopień
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Analysis of furin (FURIN) gene expression in the U-87 MG cell line as a potential target for gene inhibiting therapies in (auto-) immune diseases

Acta Universitatis Lodziensis. Folia Biologica et Oecologica
2024-09-18 | Journal article
DOI: 10.18778/1730-2366.18.16
Contributors: Karolina Zapletal-Pudełko; Grzegorz Machnik; Katarzyna Stec-Grosman; Łukasz Bułdak; Bogusław Okopień
Source: check_circle
Crossref

The impact of wound-healing assay, phorbol myristate acetate (PMA) stimulation and siRNA-mediated FURIN gene silencing on endogenous retroviral ERVW-1 expression level in U87-MG astrocytoma cells

Advances in Medical Sciences
2024-03 | Journal article
DOI: 10.1016/j.advms.2024.02.007
Contributors: Grzegorz Machnik; Łukasz Bułdak; Karolina Zapletal-Pudełko; Beniamin Oskar Grabarek; Rafał Staszkiewicz; Dawid Sobański; Bogusław Okopień
Source: check_circle
Crossref

The Application of Peptide Nucleic Acids (PNA) in the Inhibition of Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Gene Expression in a Cell-Free Transcription/Translation System

International Journal of Molecular Sciences
2024-01-25 | Journal article
DOI: 10.3390/ijms25031463
Part of ISSN: 1422-0067
Contributors: Agnieszka Polak; Grzegorz Machnik; Lukasz Buldak; Jaroslaw Ruczynski; Katarzyna Prochera; Oliwia Bujak; Piotr Mucha; Piotr Rekowski; Bogusław Okopień
Source: Self-asserted source
Grzegorz Machnik

The Effect of PCSK9 Inhibition on the Stabilization of Atherosclerotic Plaque Determined by Biochemical and Diagnostic Imaging Methods

Molecules
2023-08-07 | Journal article
DOI: 10.3390/molecules28155928
Part of ISSN: 1420-3049
Contributors: Marcin Basiak; Marcin Hachuła; Michał Kosowski; Grzegorz Machnik; Mateusz Maligłówka; Maria Dziubinska-Basiak; Robert Krysiak; Bogusław Okopień
Source: Self-asserted source
Grzegorz Machnik

Impaired Gonadotropin-Lowering Effects of Metformin in Postmenopausal Women with Autoimmune Thyroiditis: A Pilot Study

Pharmaceuticals
2023-06-24 | Journal article
DOI: 10.3390/ph16070922
Part of ISSN: 1424-8247
Contributors: Robert Krysiak; Marcin Basiak; Grzegorz Machnik; Bogusław Okopień
Source: Self-asserted source
Grzegorz Machnik

Vitamin D Status Determines Cardiometabolic Effects of Cabergoline in Women with Elevated Prolactin Levels: A Pilot Study

Nutrients
2023-05-14 | Journal article
DOI: 10.3390/nu15102303
Part of ISSN: 2072-6643
Contributors: Robert Krysiak; Marcin Basiak; Grzegorz Machnik; Witold Szkróbka; Bogusław Okopień
Source: Self-asserted source
Grzegorz Machnik

Exenatide prevents statin-related LDL receptor increase and improves insulin secretion in pancreatic beta cells (1.1E7) in a protein kinase A-dependent manner

Journal of Applied Biomedicine
2022-12-20 | Journal article
DOI: 10.32725/jab.2022.015
Part of ISSN: 1214-021X
Part of ISSN: 1214-0287
Contributors: Łukasz Bułdak; Grzegorz Machnik; Estera Skudrzyk; Aleksandra Bołdys; Mateusz Maligłówka; Michał Kosowski; Marcin Basiak; Rafał Jakub Bułdak; Bogusław Okopień
Source: Self-asserted source
Grzegorz Machnik
grade
Preferred source (of 2)‎

Phage therapy: An old concept with new perspectives

Journal of Applied Pharmaceutical Science
2022-05-05 | Journal article
DOI: 10.7324/japs.2022.120502
Part of ISSN: 2231-3354
Contributors: Izabela Durbas; Grzegorz Machnik
Source: Self-asserted source
Grzegorz Machnik

Insight into the Evolving Role of PCSK9.

Metabolites
2022-03 | Journal article
DOI: 10.3390/metabo12030256
PMID: 35323699
PMC: PMC8951079
Contributors: Maligłówka M; Kosowski M; Hachuła M; Cyrnek M; Bułdak Ł; Basiak M; Bołdys A; Machnik G; Bułdak RJ; Okopień B
Source: Self-asserted source
Grzegorz Machnik via Europe PubMed Central

Exenatide improves antioxidant capacity and reduces the expression of LDL receptors and PCSK9 in human insulin-secreting 1.1E7 cell line subjected to hyperglycemia and oxidative stress

Postępy Higieny i Medycyny Doświadczalnej
2022-01-01 | Journal article
DOI: 10.2478/ahem-2021-0037
Contributors: Łukasz Bułdak; Estera Skudrzyk; Grzegorz Machnik; Aleksandra Bołdys; Rafał Jakub Bułdak; Bogusław Okopień
Source: check_circle
Crossref

Polyphenols of Antibacterial Potential - May They Help in Resolving Some Present Hurdles in Medicine?

Folia biologica
2022-01-01 | Journal article | Author
PMID: 36689315
Contributors: Zapletal K; Grzegorz Machnik; Bogusław Okopień
Source: Self-asserted source
Grzegorz Machnik
grade
Preferred source (of 2)‎

Epicardial, pericardial fat and glucagon-like peptide-1 and 2 receptors expression in stable patients with multivessel coronary artery disease: an association with renin-angiotensin-aldosterone.

Pol.Arch.Med.Wewn.
2021 | Journal article
DOI: 10.20452/pamw.15797
Source: Self-asserted source
Grzegorz Machnik

Pleiotropic effects of PCSK-9 inhibitors.

Int.J.Mol.Sci.
2021 | Journal article
DOI: 10.3390/ijms22063144
Source: Self-asserted source
Grzegorz Machnik
grade
Preferred source (of 2)‎

The effects of statins on neurotransmission and their neuroprotective role in neurological and psychiatric disorders.

Molecules
2021 | Journal article
DOI: 10.3390/molecules26102838
Source: Self-asserted source
Grzegorz Machnik
grade
Preferred source (of 2)‎

Ekspresja receptorow glukagonopodobnego peptydu 1 i 2 oraz osi renina-angiotensyna-aldosteron w epikardialnej i perikardialnej tkance tłuszczowej.

Kardiol.Pol.
2020 | Journal article
Source: Self-asserted source
Grzegorz Machnik

Imipramine and venlafaxine differentially affect primary glial cultures of prenatally stressed rats.

Front.Pharmacol.
2020 | Journal article
DOI: 10.3389/fphar.2019.01687
Source: Self-asserted source
Grzegorz Machnik

Okołonaczyniowa tkanka tłuszczowa tętnicy piersiowej wewnętrznej u pacjentów z ciężką miażdżycą naczyń wieńcowych.

Kardiol.Pol.
2020 | Journal article
Source: Self-asserted source
Grzegorz Machnik

Perivascular adipose tissue from the internal mammary artery in patients with severe coronary artery atherosclerosis.

Kardiol.Pol.
2020 | Journal article
DOI: 10.33963/KP.15645
Source: Self-asserted source
Grzegorz Machnik

Sulodexide up-regulates glutathione S-transferase P1 by enhancing Nrf2 expression and translocation in human umbilical vein endothelial cells injured by oxygen glucose deprivation.

Arch.Med.Sci.
2020 | Journal article
DOI: 10.5114/aoms.2019.82818
Source: Self-asserted source
Grzegorz Machnik

Epicardial, paracardial and perivascular fat quantity, genes expression and serum cytokines in coronary artery disease and diabetes.

Pol.Arch.Med.Wewn.
2019 | Journal article
DOI: 10.20452/pamw.14961
Source: Self-asserted source
Grzegorz Machnik

Imipramine and venlafaxine given prenatally cause different alterations in microglia activity - ex vivo study.

20th International Congress of the Polish Pharmacological Society, Lublin [Poland] 5-7.06.2019, abstracts
2019 | Book chapter
Source: Self-asserted source
Grzegorz Machnik

The impact of exenatide (a GLP-1 agonist) on markers of inflammation and oxidative stress in normal human astrocytes subjected to various glycemic conditions.

Exp.Ther.Med.
2019 | Journal article
DOI: 10.3892/etm.2019.7245
Source: Self-asserted source
Grzegorz Machnik

Tkanka tłuszczowa epikardialna, perikardialna i okołonaczyniowa: ekspresja genów i osoczowe stężenia cytokin oraz ocena ilościowa u pacjentów z cukrzycą i chorobą wieńcową.

Kardiol.Pol.
2019 | Journal article
Source: Self-asserted source
Grzegorz Machnik

Tofacytynib - nowy lek w terapii wrzodziejącego zapalenia jelit.

Gastroenterol.Prakt.
2019 | Journal article
URI:

https://gastroenterologia-praktyczna.pl/magazine/shownumber/395/3-2019.html/
Source: Self-asserted source
Grzegorz Machnik

Influence of PCSK9 inhibition on the stabilization of atherosclerotic plaque determined by biochemical methods and magnetic resonance imaging.

Atherosclerosis
2018 | Journal article
Source: Self-asserted source
Grzegorz Machnik

Monitoring the transcriptional activity of human endogenous retroviral HERV-W family using PNA strand invasion into double-stranded DNA.

Mol.Biotechnol.
2018 | Journal article
DOI: 10.1007/s12033-017-0057-0
Source: Self-asserted source
Grzegorz Machnik

The effect of PCSK9 inhibition on biomarkers of atherosclerotic plaque destabilization release in hypertensive patients with dyslipidemia.

J.Hypertens.
2018 | Journal article
Source: Self-asserted source
Grzegorz Machnik

The effect of PCSK9 inhibition on biomarkers of atherosclerotic plaque destabilization release in patient with dyslipidemia.

Atherosclerosis
2018 | Journal article
Source: Self-asserted source
Grzegorz Machnik

Treatment based on cinacalcet reduces oxidative stress in hemodialysis patients with secondary hyperparathyroidism.

Nephron
2018 | Journal article
DOI: 10.1159/000489278
Source: Self-asserted source
Grzegorz Machnik

Tricyclic antidepressants modulate stressed mitochondria in glioblastoma multiforme cells.

Cancer Control
2018 | Journal article
DOI: 10.1177/1073274818798594
Source: Self-asserted source
Grzegorz Machnik

Ekspresja receptorów kinin w raku jelita grubego.

68 Kongres Towarzystwa Chirurgów Polskich, Kraków 27-30.09.2017, streszczenia
2017 | Book chapter
Source: Self-asserted source
Grzegorz Machnik

Leczenie Cynakalcetem zmniejsza nasilenie stresu oksydacyjnego u hemodializowanych chorych z wtórną nadczynnością przytarczyc.

23 Konferencja Naukowo-Szkoleniowa Polskiego Towarzystwa Nefrologicznego, Białystok 17-19.05.2017, streszczenia
2017 | Book chapter
Source: Self-asserted source
Grzegorz Machnik

The application of strand invasion phenomenon, directed by peptide nucleic acid (PNA) and single-stranded DNA binding protein (SSB) for the recognition of specific sequences of human endogenous retroviral HERV-W family.

J.Mol.Recognit.
2017 | Journal article
DOI: 10.1002/jmr.2600
Source: Self-asserted source
Grzegorz Machnik
grade
Preferred source (of 2)‎

Time-dependent changes in apoptosis upon autophagy inhibition in astrocytes exposed to oxygen and glucose deprivation.

Cell.Mol.Neurobiol.
2017 | Journal article
DOI: 10.1007/s10571-016-0363-2
Source: Self-asserted source
Grzegorz Machnik

Antidepressant drugs - friends or enemies in adjuvant anticancer glioma therapy.

3rd Annual Meeting of the International Society of Cancer Metabolism, Brussels [Belgium] 26-29.10.2016, abstracts.
2016 | Book chapter
Source: Self-asserted source
Grzegorz Machnik

Exenatide (a GLP-1 agonist) expresses anti-inflammatory properties in cultured human monocytes/macrophages in a protein kinase A and B/Akt manner.

Pharmacol.Rep.
2016 | Journal article
DOI: 10.1016/j.pharep.2015.10.008
Source: Self-asserted source
Grzegorz Machnik

Exenatide and metformin express their anti-inflammatory effects on human monocytes/macrophages by the attenuation of MAPKs and NFκB signaling.

Naunyn-Schmiedeberg's Arch.Pharmacol.
2016 | Journal article
DOI: 10.1007/s00210-016-1277-8
Source: Self-asserted source
Grzegorz Machnik

Glucose and hypoxia: critical players in maintaining glioma malignancy.

3rd Annual Meeting of the International Society of Cancer Metabolism, Brussels [Belgium] 26-29.10.2016, abstracts.
2016 | Book chapter
Source: Self-asserted source
Grzegorz Machnik

Is malignancy of tumor cells alone responsible for variable efficacy of temozolomide treatment in glioblastoma multiforme patients? In vitro versus retrospective studies.

EMBO Conference Series - Cellular signalling and cancer therapy, Cavtat-Dubrovnik [Croatia], 27-31.05.2016, abstracts.
2016 | Book chapter
Source: Self-asserted source
Grzegorz Machnik

Superoxide dismutase 1 and glutathione peroxidase 1 are involved in the protective effect of sulodexide on vascular endothelial cells exposed to oxygen-glucose deprivation.

Microvasc.Res.
2016 | Journal article
DOI: 10.1016/j.mvr.2015.10.001
Source: Self-asserted source
Grzegorz Machnik

A novel, highly selective RT-QPCR method for quantification of MSRV using PNA clamping syncytin-1 (ERVWE1).

Mol.Biotechnol.
2015 | Journal article
DOI: 10.1007/s12033-015-9873-2
Source: Self-asserted source
Grzegorz Machnik

Exenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages.

Naunyn-Schmiedeberg's Arch.Pharmacol.
2015 | Journal article
DOI: 10.1007/s00210-015-1124-3
Source: Self-asserted source
Grzegorz Machnik

Peptide nucleic acid (PNA) probe effectively clamps amplification of Multiple Sclerosis Retrovirus (MSRV) sequences and its action relies on reciprocal probe-to-primer localization.

Ann.Acad.Med.Siles.
2015 | Journal article
Source: Self-asserted source
Grzegorz Machnik

The influence of in vitro exenatide, novel antidiabetic drug utilising incretin mimetic features, on expression of major antioxidative enzymes in monocytes/macrophages isolted from peripheral blood of patients with diabetes.

Ann.Acad.Med.Siles.
2015 | Journal article
Source: Self-asserted source
Grzegorz Machnik

Treatment with cinacalcet increases plasma adiponectin concentration in hemodialysed patients with chronic kidney disease and secondary hyperparathyroidism.

Endocr.Pract.
2015 | Journal article
DOI: 10.4158/EP14483.OR
Source: Self-asserted source
Grzegorz Machnik

Treatment with cinacalcet increases plasma adiponectin concentration in hemodialysed patients with chronic kidney disease and secondary hyperparathyroidism.

Nephrol.Dial.Transplant.
2015 | Journal article
Source: Self-asserted source
Grzegorz Machnik

A peptide nucleic acid (PNA)-mediated polymerase chain reaction clamping allows the selective inhibition of the ERVWE1 gene amplification.

Mol.Cell.Probes
2014 | Journal article
DOI: 10.1016/j.mcp.2014.04.003
Source: Self-asserted source
Grzegorz Machnik
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