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Loop profile: 1102535

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Employment (2)

University of South Carolina: Columbia, SC, US

2005-08-16 to present | Professor (Chemistry and Biochemistry)
Employment
Source: Self-asserted source
Franklin Outten

National Institutes of Health: Bethesda, Maryland, US

2001-06-01 to 2005-06-15 | Post-doctoral Fellow (Cell Biology and Metabolism Branch, NICHD)
Employment
Source: Self-asserted source
Franklin Outten

Education and qualifications (2)

Northwestern University: Evanston, IL, US

1995-09-01 to 2001-04-15 | Ph.D. (Molecular Biosciences)
Education
Source: Self-asserted source
Franklin Outten

College of William and Mary: Williamsburg, Virginia, US

1991-09-01 to 1995-05-15 | B.S. (Biology)
Education
Source: Self-asserted source
Franklin Outten

Funding (6)

Unraveling novel roles for iron-sulfur cluster trafficking proteins in Fe-S cluster and cell envelope biogenesis

2024-05 to 2028-04 | Grant
National Science Foundation (Alexandria, US)
URL: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2344561&HistoricalAwards=false
GRANT_NUMBER: MCB 2344561
Source: Self-asserted source
Franklin Outten

Conformational dynamics and allosteric regulation during stress-responsive metallocofactor assembly

2015-01-10 to 2024-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.3859079
GRANT_NUMBER: R01GM112919
Source: Self-asserted source
Franklin Outten via DimensionsWizard

Conformational dynamics and allosteric regulation during stress-responsive metallocofactor assembly

Source: Self-asserted source
Franklin Outten via DimensionsWizard

7th International Conference on Fe-S Cluster Biogenesis and Regulation

2013-04-01 to 2014-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 1R13GM106685-01
GRANT_NUMBER: 1R13GM106685-01
Source: Self-asserted source
Franklin Outten via DimensionsWizard

Characterization of a Novel Nickel Metalloregulatory Protein, YqjI

2010-09-01 to 2015-08-31 | Grant
National Science Foundation (n/a, US)
GRANT_NUMBER: 1022288
GRANT_NUMBER: 1022288
Source: Self-asserted source
Franklin Outten via DimensionsWizard

Characterization of the Suf Fe-S Cluster Biosynthesis Pathway Under Stress

2007-07-02 to 2013-04-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 5R01GM081706-05
GRANT_NUMBER: 5R01GM081706-05
Source: Self-asserted source
Franklin Outten via DimensionsWizard

Works (38)

Escherichia coli monothiol glutaredoxin GrxD replenishes Fe-S clusters to the essential ErpA A-type carrier under low iron stress

Journal of Biological Chemistry
2024-08 | Journal article
DOI: 10.1016/j.jbc.2024.107506
Contributors: Claire E. Fisher; Daniel W. Bak; Kennedy E. Miller; Clorissa L. Washington-Hughes; Anna M. Dickfoss; Eranthie Weerapana; Béatrice Py; F. Wayne Outten
Source: check_circle
Crossref

Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms

Biomaterials
2023-10 | Journal article
DOI: 10.1016/j.biomaterials.2023.122275
Contributors: Leman Buzoglu Kurnaz; Swagatam Barman; Xiaoming Yang; Claire Fisher; F. Wayne Outten; Prakash Nagarkatti; Mitzi Nagarkatti; Chuanbing Tang
Source: check_circle
Crossref

Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues

Journal of Biological Chemistry
2019-08 | Journal article
DOI: 10.1074/jbc.RA119.009471
Contributors: Matthew Blahut; Courtney E. Wise; Michael R. Bruno; Guangchao Dong; Thomas M. Makris; Patrick A. Frantom; Jack A. Dunkle; F. Wayne Outten
Source: check_circle
Crossref

Nickel exposure reduces enterobactin production in Escherichia coli

MicrobiologyOpen
2019-04 | Journal article
DOI: 10.1002/mbo3.691
Contributors: Clorissa L. Washington – Hughes; Geoffrey T. Ford; Alsten D. Jones; Kimberly McRae; F. Wayne Outten
Source: check_circle
Crossref

Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS

Biochemistry
2019-02-12 | Journal article
DOI: 10.1021/acs.biochem.8b01122
Contributors: Jack A. Dunkle; Michael R. Bruno; F. Wayne Outten; Patrick A. Frantom
Source: check_circle
Crossref

Evidence that a respiratory shield in Escherichia coli protects a low-molecular-mass FeII pool from O2-dependent oxidation.

The Journal of biological chemistry
2018-10-18 | Journal article
DOI: 10.1074/jbc.RA118.005233
PMID: 30337367
PMC: PMC6322884
Source: Self-asserted source
Franklin Outten

Changes in Protein Dynamics in Escherichia coli SufS Reveal a Possible Conserved Regulatory Mechanism in Type II Cysteine Desulfurase Systems

Biochemistry
2018-09-04 | Journal article
DOI: 10.1021/acs.biochem.7b01275
Contributors: Dokyong Kim; Harsimran Singh; Yuyuan Dai; Guangchao Dong; Laura S. Busenlehner; F. Wayne Outten; Patrick A. Frantom
Source: check_circle
Crossref

Conserved cysteine residues are necessary for nickel-induced allosteric regulation of the metalloregulatory protein YqjI (NfeR) in E. coli

Journal of Inorganic Biochemistry
2018-07 | Journal article
DOI: 10.1016/j.jinorgbio.2018.04.016
Contributors: Matthew Blahut; Stephen Dzul; Suning Wang; Ashoka Kandegedara; Nicholas E. Grossoehme; Timothy Stemmler; F. Wayne Outten
Source: check_circle
Crossref

Heme dynamics and trafficking factors revealed by genetically encoded fluorescent heme sensors.

Proceedings of the National Academy of Sciences of the United States of America
2016-07 | Journal article
DOI: 10.1073/pnas.1523802113
PMID: 27247412
PMC: PMC4941510
Contributors: Hanna DA; Harvey RM; Martinez-Guzman O; Yuan X; Chandrasekharan B; Raju G; Outten FW; Hamza I; Reddi AR
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Functional Dynamics Revealed by the Structure of the SufBCD Complex, a Novel ATP-binding Cassette (ABC) Protein That Serves as a Scaffold for Iron-Sulfur Cluster Biogenesis.

The Journal of biological chemistry
2015-12 | Journal article
DOI: 10.1074/jbc.m115.680934
PMID: 26472926
PMC: PMC4705970
Contributors: Hirabayashi K; Yuda E; Tanaka N; Katayama S; Iwasaki K; Matsumoto T; Kurisu G; Outten FW; Fukuyama K; Takahashi Y et al.
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

SufE D74R Substitution Alters Active Site Loop Dynamics To Further Enhance SufE Interaction with the SufS Cysteine Desulfurase.

Biochemistry
2015-08 | Journal article
DOI: 10.1021/acs.biochem.5b00663
PMID: 26171726
PMC: PMC4639930
Contributors: Dai Y; Kim D; Dong G; Busenlehner LS; Frantom PA; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Recent advances in the Suf Fe-S cluster biogenesis pathway: Beyond the Proteobacteria.

2014-11 | Journal article
PMID:

25447545
Contributors: Wayne Outten F
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Communication between binding sites is required for YqjI regulation of target promoters within the yqjH-yqjI intergenic region.

2014-09 | Journal article
DOI:

10.1128/JB.01835-14

PMID:

24982304
Contributors: Wang S; Blahut M; Wu Y; Philipkosky KE; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Interplay between oxygen and Fe-S cluster biogenesis: insights from the Suf pathway.

2014-09 | Journal article
DOI:

10.1021/bi500488r

PMID:

25153801
Contributors: Boyd ES; Thomas KM; Dai Y; Boyd JM; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Escherichia coli SufE sulfur transfer protein modulates the SufS cysteine desulfurase through allosteric conformational dynamics.

2013-12 | Journal article
DOI:

10.1074/jbc.M113.525709

PMID:

24196966

PMC:

PMC3868733
Contributors: Singh H; Dai Y; Outten FW; Busenlehner LS
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Lability and liability of endogenous copper pools.

2013-10 | Journal article
DOI:

10.1128/JB.00891-13

PMID:

23913325

PMC:

PMC3807436
Contributors: Outten FW; Munson GP
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Separate FeS scaffold and carrier functions for SufBâ‚‚Câ‚‚ and SufA during in vitro maturation of [2Fe2S] Fdx.

2012-11 | Journal article
DOI:

10.1016/j.jinorgbio.2012.06.008

PMID:

23018275

PMC:

PMC3483452
Contributors: Chahal HK; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

The E. coli SufS-SufE sulfur transfer system is more resistant to oxidative stress than IscS-IscU.

2012-11 | Journal article
DOI:

10.1016/j.febslet.2012.10.001

PMID:

23068614

PMC:

PMC3511050
Contributors: Dai Y; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli.

2011-01 | Journal article
DOI:

10.1128/JB.01062-10

PMID:

21097627

PMC:

PMC3019823
Contributors: Wang S; Wu Y; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

SufD and SufC ATPase activity are required for iron acquisition during in vivo Fe-S cluster formation on SufB.

2010-11 | Journal article
DOI:

10.1021/bi1011546

PMID:

20857974

PMC:

PMC3004146
Contributors: Saini A; Mapolelo DT; Chahal HK; Johnson MK; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

The SufBCD Fe-S scaffold complex interacts with SufA for Fe-S cluster transfer.

2009-11 | Journal article
DOI:

10.1021/bi901518y

PMID:

19810706

PMC:

PMC2783425
Contributors: Chahal HK; Dai Y; Saini A; Ayala-Castro C; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Iron-based redox switches in biology.

2009-05 | Journal article
DOI:

10.1089/ARS.2008.2296

PMID:

19021503

PMC:

PMC2842161
Contributors: Outten FW; Theil EC
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Native Escherichia coli SufA, coexpressed with SufBCDSE, purifies as a [2Fe-2S] protein and acts as an Fe-S transporter to Fe-S target enzymes.

2009-05 | Journal article
DOI:

10.1021/ja807551e

PMID:

19366265

PMC:

PMC2677299
Contributors: Gupta V; Sendra M; Naik SG; Chahal HK; Huynh BH; Outten FW; Fontecave M; Ollagnier de Choudens S
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Molecular dynamism of Fe-S cluster biosynthesis implicated by the structure of the SufC(2)-SufD(2) complex.

2009-03 | Journal article
DOI:

10.1016/j.jmb.2009.01.054

PMID:

19361433

PMC:

PMC2744881
Contributors: Wada K; Sumi N; Nagai R; Iwasaki K; Sato T; Suzuki K; Hasegawa Y; Kitaoka S; Minami Y; Outten FW et al.
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

IscR controls iron-dependent biofilm formation in Escherichia coli by regulating type I fimbria expression.

2009-02 | Journal article
DOI:

10.1128/JB.01086-08

PMID:

19074392

PMC:

PMC2631988
Contributors: Wu Y; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

The impact of O(2) on the Fe-S cluster biogenesis requirements of Escherichia coli FNR.

2008-12 | Journal article
DOI:

10.1016/j.jmb.2008.09.080

PMID:

18938178

PMC:

PMC2648814
Contributors: Mettert EL; Outten FW; Wanta B; Kiley PJ
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Fe-S cluster assembly pathways in bacteria.

2008-03 | Journal article
DOI:

10.1128/MMBR.00034-07

PMID:

18322036

PMC:

PMC2268281
Contributors: Ayala-Castro C; Saini A; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

SufE transfers sulfur from SufS to SufB for iron-sulfur cluster assembly.

2007-05 | Journal article
DOI:

10.1074/jbc.M608555200

PMID:

17350958
Contributors: Layer G; Gaddam SA; Ayala-Castro CN; Ollagnier-de Choudens S; Lascoux D; Fontecave M; Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Iron-sulfur clusters as oxygen-responsive molecular switches.

2007-04 | Journal article
DOI:

10.1038/nchembio0407-206

PMID:

17372605
Contributors: Outten FW
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Mutational analysis to define an activating region on the redox-sensitive transcriptional regulator OxyR.

2006-12 | Journal article
DOI:

10.1128/JB.01318-06

PMID:

17012382

PMC:

PMC1698235
Contributors: Wang X; Mukhopadhyay P; Wood MJ; Outten FW; Opdyke JA; Storz G
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Repair of oxidized iron-sulfur clusters in Escherichia coli.

2004-10 | Journal article
DOI:

10.1074/jbc.M406487200

PMID:

15308657
Contributors: Djaman O; Outten FW; Imlay JA
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

A suf operon requirement for Fe-S cluster assembly during iron starvation in Escherichia coli.

2004-05 | Journal article
DOI:

10.1111/j.1365-2958.2004.04025.x

PMID:

15101990
Contributors: Outten FW; Djaman O; Storz G
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

The SufE protein and the SufBCD complex enhance SufS cysteine desulfurase activity as part of a sulfur transfer pathway for Fe-S cluster assembly in Escherichia coli.

2003-11 | Journal article
DOI:

10.1074/jbc.M308004200

PMID:

12941942
Contributors: Outten FW; Wood MJ; Munoz FM; Storz G
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Spectroscopy of Cu(II)-PcoC and the multicopper oxidase function of PcoA, two essential components of Escherichia coli pco copper resistance operon.

2002-08 | Journal article
DOI:

10.1021/bi0259960

PMID:

12146969
Contributors: Huffman DL; Huyett J; Outten FW; Doan PE; Finney LA; Hoffman BM; O'Halloran TV
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli.

2001-08 | Journal article
DOI:

10.1074/jbc.M104122200

PMID:

11399769
Contributors: Outten FW; Huffman DL; Hale JA; O'Halloran TV
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.

2000-10 | Journal article
DOI:

10.1128/JB.182.20.5864-5871.2000

PMID:

11004187

PMC:

PMC94710
Contributors: Munson GP; Lam DL; Outten FW; O'Halloran TV
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Transcriptional activation of an Escherichia coli copper efflux regulon by the chromosomal MerR homologue, cueR.

2000-10 | Journal article
DOI:

10.1074/jbc.M006508200

PMID:

10915804
Contributors: Outten FW; Outten CE; Hale J; O'Halloran TV
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

DNA distortion mechanism for transcriptional activation by ZntR, a Zn(II)-responsive MerR homologue in Escherichia coli.

1999-12 | Journal article
DOI:

10.1074/jbc.274.53.37517

PMID:

10608803
Contributors: Outten CE; Outten FW; O'Halloran TV
Source: Self-asserted source
Franklin Outten via Europe PubMed Central

Peer review (15 reviews for 8 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for ACS infectious diseases. (1)
Review activity for Biochemistry. (4)
Review activity for Biochimica et biophysica acta. Molecular cell research (2)
Review activity for eLife (1)
Review activity for Journal of inorganic biochemistry. (2)
Review activity for Journal of the American Chemical Society. (3)
Review activity for Nature microbiology. (1)
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