Personal information

Immunologist, immune checkpoint therapy, immuno metabolism,immunophenotyping
United States

Activities

Employment (1)

UCSF : SAN FRANCISCO, CA, US

2019-06-01 to present | Director Disease to Biology CoLab (CoLab)
Employment
Source: Self-asserted source
Alexis Combes

Education and qualifications (2)

UCSF: SAN FRANCISCO, CA, US

2017-07-01 to 2019-05-31 | Post docotoral (Pathology/Krummel lab)
Education
Source: Self-asserted source
Alexis Combes

Aix-Marseille University: Marseille, FR

2012-10-01 to 2016-10-01 | PhD (CIML)
Education
Source: Self-asserted source
Alexis Combes

Funding (2)

Study trafficking of Toll like receptor in plasmacytoid dendritic cells

Grant
French ministry of higher education and research (Marseile, FR)
Source: Self-asserted source
Alexis Combes

Study trafficking of Toll like receptor in plasmacytoid dendritic cells

Salary award
Fondation ARC pour la Recherche sur le Cancer (Marseile, FR)
Source: Self-asserted source
Alexis Combes

Works (34)

A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment

F&S Science
2025-02 | Journal article
Contributors: David Huang; Emily Flynn; Ana Almonte-Loya; Brittany Davidson; Meagan Chan; Amber Casillas; Juan C. Irwin; Gabriela K. Fragiadakis; Hakan Cakmak; Alexis J. Combes et al.
Source: check_circle
Crossref

Targeting CD206+ macrophages disrupts the establishment of a key antitumor immune axis

Journal of Experimental Medicine
2025-01-06 | Journal article
Contributors: Arja Ray; Kenneth H. Hu; Kelly Kersten; Tristan Courau; Nicholas F. Kuhn; Itzia Zaleta-Linares; Bushra Samad; Alexis J. Combes; Matthew F. Krummel
Source: check_circle
Crossref

CD38 expression by neonatal human naïve CD4+T cells shapes their distinct metabolic state and high regulatory T cell potential

2025-01-02 | Preprint
Contributors: Laura R. Dwyer; Sean Clancy; Victoire Gouirand; Charles Chien; Elizabeth E. Rogers; Scott P. Oltman; Laura L. Jelliffe-Pawlowski; Susan V. Lynch; Allon Wagner; Alexis J. Combes et al.
Source: check_circle
Crossref

Data from Polyunsaturated fatty acid-bound alpha-fetoprotein promotes immune suppression by altering human dendritic cell metabolism

2024-09-16 | Preprint
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M. B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Data from Polyunsaturated fatty acid-bound alpha-fetoprotein promotes immune suppression by altering human dendritic cell metabolism

2024-09-16 | Preprint
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M. B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Supplementary Data from Polyunsaturated fatty acid-bound alpha-fetoprotein promotes immune suppression by altering human dendritic cell metabolism

2024-09-16 | Preprint
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M. B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Supplementary Data from Polyunsaturated fatty acid-bound alpha-fetoprotein promotes immune suppression by altering human dendritic cell metabolism

2024-09-16 | Preprint
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M. B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Defining and using immune archetypes to classify and treat cancer

Nature Reviews Cancer
2023-07 | Journal article
Contributors: Alexis J. Combes; Bushra Samad; Matthew F. Krummel
Source: check_circle
Crossref

Data from Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism

2023-05-02 | Preprint
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M.B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism

Cancer Research
2023-05-02 | Journal article
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M.B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Supplementary Data from Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism

2023-05-02 | Preprint
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M.B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Supplementary Data from Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism

2023-05-02 | Preprint
Contributors: Paul V. Munson; Juraj Adamik; Felix J. Hartmann; Patricia M.B. Favaro; Daniel Ho; Sean C. Bendall; Alexis J. Combes; Matthew F. Krummel; Karen Zhang; Robin K. Kelley et al.
Source: check_circle
Crossref

Distinct metabolic states guide maturation of inflammatory and tolerogenic dendritic cells

Nature Communications
2022-09-02 | Journal article
Contributors: Juraj Adamik; Paul V. Munson; Felix J. Hartmann; Alexis J. Combes; Philippe Pierre; Matthew F. Krummel; Sean C. Bendall; Rafael J. Argüello; Lisa H. Butterfield
Source: check_circle
Crossref

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

Cancer Cell
2022-06 | Journal article
Contributors: Kelly Kersten; Kenneth H. Hu; Alexis J. Combes; Bushra Samad; Tory Harwin; Arja Ray; Arjun Arkal Rao; En Cai; Kyle Marchuk; Jordan Artichoker et al.
Source: check_circle
Crossref

Deep Immunophenotyping Reveals Endometriosis is Marked by Dysregulation of the Mononuclear Phagocytic System in Endometrium and Peripheral Blood

2022-02-04 | Preprint
Contributors: Julia Vallve Juanico; Ashley F George; Sushmita Sen; Reuben Thomas; Min-Gyoung Shin; Divyashree Kushnoor; Joshua J Vasquez; Juan C Irwin; Nadia R. Roan; Alexis J Combes et al.
Source: check_circle
Crossref

Discovering dominant tumor immune archetypes in a pan-cancer census

Cell
2022-01 | Journal article
Contributors: Alexis J. Combes; Bushra Samad; Jessica Tsui; Nayvin W. Chew; Peter Yan; Gabriella C. Reeder; Divyashree Kushnoor; Alan Shen; Brittany Davidson; Andrea J. Barczak et al.
Source: check_circle
Crossref

The intersection of COVID-19 and autoimmunity

Journal of Clinical Investigation
2021-12-15 | Journal article
Contributors: Jason S. Knight; Roberto Caricchio; Jean-Laurent Casanova; Alexis J. Combes; Betty Diamond; Sharon E. Fox; David A. Hanauer; Judith A. James; Yogendra Kanthi; Virginia Ladd et al.
Source: check_circle
Crossref

Active surveillance characterizes human intratumoral T cell exhaustion

Journal of Clinical Investigation
2021-09-15 | Journal article
Contributors: Ran You; Jordan Artichoker; Adam Fries; Austin W. Edwards; Alexis J. Combes; Gabriella C. Reeder; Bushra Samad; Matthew F. Krummel
Source: check_circle
Crossref

Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19

Nature
2021-08-19 | Journal article
Contributors: Alexis J. Combes; Tristan Courau; Nicholas F. Kuhn; Kenneth H. Hu; Arja Ray; William S. Chen; Nayvin W. Chew; Simon J. Cleary; Divyashree Kushnoor; Gabriella C. Reeder et al.
Source: check_circle
Crossref

Multiomic Characterization of Stage I Lung Adenocarcinoma Reveals Distinct Genetic and Immunologic Features of Recurrent Disease

2021-05-21 | Other
Contributors: Johannes R. Kratz; Jack Z. Li; Jessica Tsui; Jen C. Lee; Vivianne W. Ding; Arjun A. Rao; Michael J. Mann; Vincent Chan; Alexis J. Combes; Matthew F. Krummel et al.
Source: check_circle
Crossref

A Pan-Cancer Census of Dominant Tumor Immune Archetypes

2021-04-27 | Other
Contributors: Alexis J. Combes; Bushra Samad; Jessica Tsui; Nayvin W. Chew; Peter Yan; Gabriella C. Reeder; Divyashree Kushnoor; Alan Shen; Brittany Davidson; Andrea J. Barczac et al.
Source: check_circle
Crossref

Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures

Communications Biology
2021-04-21 | Journal article
Contributors: Gaia Andreoletti; Cristina M. Lanata; Laura Trupin; Ishan Paranjpe; Tia S. Jain; Joanne Nititham; Kimberly E. Taylor; Alexis J. Combes; Lenka Maliskova; Chun Jimmie Ye et al.
Source: check_circle
Crossref

A tumor-specific mechanism of T reg enrichment mediated by the integrin αvβ8

Science Immunology
2021-03-04 | Journal article
Contributors: Robert I. Seed; Kenji Kobayashi; Saburo Ito; Naoki Takasaka; Anthony Cormier; Jillian M. Jespersen; Jean Publicover; Suprita Trilok; Alexis J. Combes; Nayvin W. Chew et al.
Source: check_circle
Crossref

Global absence and targeting of protective immune states in severe COVID-19

Nature
2021-03-04 | Journal article
Contributors: Alexis J. Combes; Tristan Courau; Nicholas F. Kuhn; Kenneth H. Hu; Arja Ray; William S. Chen; Nayvin W. Chew; Simon J. Cleary; Divyashree Kushnoor; Gabriella C. Reeder et al.
Source: check_circle
Crossref

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution.

Cell metabolism
2020-12-01 | Journal article
Source: Self-asserted source
Alexis Combes

Lessons of COVID-19: A roadmap for post-pandemic science.

The Journal of experimental medicine
2020-09-01 | Journal article
Source: Self-asserted source
Alexis Combes

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity.

Cell
2019-04-04 | Journal article
Source: Self-asserted source
Alexis Combes

A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.

Nature medicine
2018-06-25 | Journal article
Source: Self-asserted source
Alexis Combes

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

Science Signaling
2018-01-23 | Journal article
Contributors: Jessica Perego; Andreia Mendes; Clarisse Bourbon; Voahirana Camosseto; Alexis Combes; Hong Liu; Thien-Phong Vu Manh; Alexandre Dalet; Lionel Chasson; Lionel Spinelli et al.
Source: check_circle
Crossref

BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells.

Nature communications
2017-10-13 | Journal article
Source: Self-asserted source
Alexis Combes

MARCH9-mediated ubiquitination regulates MHC I export from the TGN.

Immunology and cell biology
2017-05-31 | Journal article
Source: Self-asserted source
Alexis Combes

Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.

The EMBO journal
2017-01-18 | Journal article
Source: Self-asserted source
Alexis Combes

LAMP5 Fine-Tunes GABAergic Synaptic Transmission in Defined Circuits of the Mouse Brain.

PloS one
2016-06-07 | Journal article
Source: Self-asserted source
Alexis Combes

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

The Journal of cell biology
2015-09-01 | Journal article
Source: Self-asserted source
Alexis Combes

Peer review (1 review for 1 publication/grant)

Review activity for Communications biology. (1)