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Employment (1)

AstraZenenca: Cambridge, GB

2019-05-05 to present | Medicinal Chemist
Employment
Source: Self-asserted source
Simon Lucas

Education and qualifications (2)

GSK/University of Strathclyde Industrial PhD Scheme: Stevenage, GB

2015-10 to 2019-03 | PhD (Pure and Applied Chemistry)
Education
Source: Self-asserted source
Simon Lucas

University of York: York, GB

2011-09 to 2015-06 | MChem (Chemistry)
Education
Source: Self-asserted source
Simon Lucas

Works (16)

Discovery of a Series of Covalent Ligands That Bind to Cys77 of the Von Hippel–Lindau Tumor Suppressor Protein (VHL)

ACS Medicinal Chemistry Letters
2025-03-19 | Journal article
DOI: 10.1021/acsmedchemlett.4c00582
Contributors: Simon C. C. Lucas; Yong Xu; Sarah Hewitt; Gavin W. Collie; Lucia Fusani; Ganesh Kadamur; Thomas E. Hadfield; Nancy Su; Caroline Truman; Sylvain Demanze et al.
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Crossref

Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors

Journal of Medicinal Chemistry
2024-09-26 | Journal article
DOI: 10.1021/acs.jmedchem.4c01288
Contributors: Simon C. C. Lucas; J. Henry Blackwell; Ulf Börjesson; David Hargreaves; Alexander G. Milbradt; Mark J. Bostock; Samiyah Ahmed; Kevin Beaumont; Tony Cheung; Sylvain Demanze et al.
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Crossref

Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1

Journal of Medicinal Chemistry
2024-07-11 | Journal article
DOI: 10.1021/acs.jmedchem.4c00781
Contributors: Simon C. C. Lucas; Alexander G. Milbradt; J. Henry Blackwell; Silvia Bonomo; Andrew Brierley; Doyle J. Cassar; Jared Freeman; Thomas E. Hadfield; Lucas A. Morrill; Rick Riemens et al.
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Crossref

Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

ACS Medicinal Chemistry Letters
2024-06-13 | Journal article
DOI: 10.1021/acsmedchemlett.4c00113
Contributors: Simon C. C. Lucas; J. Henry Blackwell; Ulf Börjesson; David Hargreaves; Alexander G. Milbradt; Samiyah Ahmed; Mark J. Bostock; Carine Guerot; Andrea Gohlke; Olaf Kinzel et al.
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Crossref

Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders

Journal of Medicinal Chemistry
2024-04-11 | Journal article
DOI: 10.1021/acs.jmedchem.3c02136
Contributors: Simon C. C. Lucas; Afshan Ahmed; S. Neha Ashraf; Argyrides Argyrou; Matthias R. Bauer; Gian Marco De Donatis; Sylvain Demanze; Frederik Eisele; Lucia Fusani; Andreas Hock et al.
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Crossref

Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates

RSC Medicinal Chemistry
2022 | Journal article
DOI: 10.1039/D2MD00239F
Contributors: S. Paul Jones; James D. Firth; Mary C. Wheldon; Masakazu Atobe; Roderick E. Hubbard; David C. Blakemore; Claudia De Fusco; Simon C. C. Lucas; Stephen D. Roughley; Lewis R. Vidler et al.
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Crossref

Fragment screening at AstraZeneca: developing the next generation biophysics fragment set

RSC Medicinal Chemistry
2022 | Journal article
DOI: 10.1039/D2MD00154C
Contributors: Simon C. C. Lucas; Ulf Börjesson; Mark J. Bostock; John Cuff; Fredrik Edfeldt; Kevin J. Embrey; Per-Olof Eriksson; Andrea Gohlke; Anders Gunnarson; Michael Lainchbury et al.
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Crossref

Synthesis of Benzothiazinones from Benzoyl Thiocarbamates: Application to Clinical Candidates for Tuberculosis Treatment

European Journal of Organic Chemistry
2022-09-13 | Journal article
DOI: 10.1002/ejoc.202200684
Contributors: William Connors; Ryan DeKorte; Simon C. C. Lucas; Ariamala Gopalsamy; Robert E. Ziegler
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Crossref

Put a ring on it: application of small aliphatic rings in medicinal chemistry

RSC Medicinal Chemistry
2021 | Journal article
DOI: 10.1039/D0MD00370K
Contributors: Matthias R. Bauer; Paolo Di Fruscia; Simon C. C. Lucas; Iacovos N. Michaelides; Jennifer E. Nelson; R. Ian Storer; Benjamin C. Whitehurst
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Crossref

Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors

Journal of Medicinal Chemistry
2021-08-12 | Journal article
DOI: 10.1021/acs.jmedchem.1c00344
Contributors: Simon C. C. Lucas; Stephen J. Atkinson; Chun-wa Chung; Rob Davis; Laurie Gordon; Paola Grandi; James J. R. Gray; Thomas Grimes; Alexander Phillipou; Alex G. Preston et al.
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Crossref

Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode

Journal of Medicinal Chemistry
2020-05-28 | Journal article
DOI: 10.1021/acs.jmedchem.0c00021
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Simon Lucas

Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions

SLAS DISCOVERY: Advancing the Science of Drug Discovery
2020-02 | Journal article
DOI: 10.1177/2472555219896278
Part of ISSN: 2472-5552
Part of ISSN: 2472-5560
Source: Self-asserted source
Simon Lucas

A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification

Journal of Medicinal Chemistry
2019-08-22 | Journal article
DOI: 10.1021/acs.jmedchem.9b00673
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Simon Lucas

Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines

The Journal of Organic Chemistry
2018-06-15 | Journal article
DOI: 10.1021/acs.joc.8b00392
Part of ISSN: 0022-3263
Part of ISSN: 1520-6904
Source: Self-asserted source
Simon Lucas

General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Tetrahedron Letters
2016-10 | Journal article
DOI: 10.1016/j.tetlet.2016.09.029
Part of ISSN: 0040-4039
Source: Self-asserted source
Simon Lucas

Synthesis of 4-Arylthieno[2,3-b]pyridines and 4-Aminothieno[2,3-b]pyridines via a Regioselective Bromination of Thieno[2,3-b]pyridine

The Journal of Organic Chemistry
2015-12-18 | Journal article
DOI: 10.1021/acs.joc.5b01735
Part of ISSN: 0022-3263
Part of ISSN: 1520-6904
Source: Self-asserted source
Simon Lucas

Peer review (4 reviews for 2 publications/grants)

Review activity for Journal of medicinal chemistry. (3)
Review activity for Nature communications (1)
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