Personal information

Dendritic Cells, T Cells, Vaccines, Asthma
United Kingdom

Biography

Timothy Powell's research career included working in the UK and USA in different immunology projects and areas mostly focusing on T cell responses and infectious diseases. He also worked within comparative immunology and respiratory immunology.

Activities

Works (24)

A single cycle influenza virus coated in H7 haemagglutinin generates neutralizing antibody responses to haemagglutinin and neuraminidase glycoproteins and protection from heterotypic challenge.

The Journal of general virology
2019-02 | Journal article
Contributors: Powell TJ; Rijal P; McEwen-Smith RM; Byun H; Hardwick M; Schimanski LM; Huang KA; Daniels RS; Townsend ARM
Source: Self-asserted source
Timothy J Powell via Europe PubMed Central

Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.

Nature microbiology
2018-11 | Journal article
Contributors: Huang KA; Rijal P; Jiang H; Wang B; Schimanski L; Dong T; Liu YM; Chang P; Iqbal M; Wang MC et al.
Source: Self-asserted source
Timothy J Powell via Europe PubMed Central

Synergistic activation of pro-inflammatory type-2 CD8+ T lymphocytes by lipid mediators in severe eosinophilic asthma.

Mucosal immunology
2018-06 | Journal article
Contributors: Hilvering B; Hinks TSC; Stöger L; Marchi E; Salimi M; Shrimanker R; Liu W; Chen W; Luo J; Go S et al.
Source: Self-asserted source
Timothy J Powell via Europe PubMed Central

A single cycle influenza virus coated in H7 hemagglutinin provides heterotypic protection and neutralising antibody responses to both glycoproteins

2017-11-27 | Other
Contributors: Timothy J Powell; Pramila Rijal; Rosanna M McEwen-Smith; Haewon Byun; Marc Hardwick; Lisa M Schimanski; Kuan-Ying A Huang; Rodney S Daniels; Alain R M Townsend
Source: check_circle
Crossref

M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza.

JCI insight
2017-04 | Journal article
Source: Self-asserted source
Timothy J Powell via Europe PubMed Central

Boosted influenza-specific T cell responses after H5N1 pandemic live attenuated influenza virus vaccination

Frontiers in Immunology
2015 | Journal article
EID:

2-s2.0-84935076872

Contributors: Peng, Y.; Wang, B.; Talaat, K.; Karron, R.; Powell, T.J.; Zeng, H.; Dong, D.; Luke, C.J.; McMichael, A.; Subbarao, K. et al.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Focused antibody response to influenza linked to antigenic drift

Journal of Clinical Investigation
2015 | Journal article
EID:

2-s2.0-84936797201

Contributors: Huang, K.-Y.A.; Rijal, P.; Schimanski, L.; Powell, T.J.; Lin, T.-Y.; McCauley, J.W.; Daniels, R.S.; Townsend, A.R.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Nonreplicating influenza a virus vaccines confer broad protection against lethal challenge

mBio
2015 | Journal article
EID:

2-s2.0-84946595399

Contributors: Baz, M.; Boonnak, K.; Paskel, M.; Santos, C.; Powell, T.; Townsend, A.; Subbarao, K.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

The Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice.

Clinical and vaccine immunology : CVI
2015-09 | Journal article
Source: Self-asserted source
Timothy J Powell via Europe PubMed Central

Autophagy is a critical regulator of memory CD8<sup>+</sup> T cell formation

eLife
2014 | Journal article
EID:

2-s2.0-84928489717

Contributors: Puleston, D.J.; Zhang, H.; Powell, T.J.; Lipina, E.; Sims, S.; Panse, I.; Watson, A.S.; Cerundolo, V.; Townsend, A.R.M.; Klenerman, P. et al.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Examination of Influenza Specific T Cell Responses after Influenza Virus Challenge in Individuals Vaccinated with MVA-NP+M1 Vaccine

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84877038783

Contributors: Powell, T.J.; Peng, Y.; Berthoud, T.K.; Blais, M.-E.; Lillie, P.J.; Hill, A.V.S.; Rowland-Jones, S.L.; McMichael, A.J.; Gilbert, S.C.; Dong, T.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

High levels of virus-specific CD4+ T cells predict severe pandemic influenza A virus infection

American Journal of Respiratory and Critical Care Medicine
2012 | Journal article
EID:

2-s2.0-84871764994

Contributors: Zhao, Y.; Zhang, Y.-H.; Denney, L.; Young, D.; Powell, T.J.; Peng, Y.-C.; Li, N.; Yan, H.-P.; Wang, D.-Y.; Shu, Y.-L. et al.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Identification of H5N1-specific T-Cell responses in a high-risk cohort in Vietnam indicates the existence of potential asymptomatic infections

Journal of Infectious Diseases
2012 | Journal article
EID:

2-s2.0-84555195647

Contributors: Powell, T.J.; Fox, A.; Peng, Y.; Mai, L.T.Q.; Lien, V.T.K.; Hang, N.L.K.; Wang, L.; Lee, L.Y.-H.; Simmons, C.P.; McMichael, A.J. et al.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Preliminary assessment of the efficacy of a T-cell-based influenza vaccine, MVA-NP+M1, in humans

Clinical Infectious Diseases
2012 | Journal article
EID:

2-s2.0-84862219175

Contributors: Lillie, P.J.; Berthoud, T.K.; Powell, T.J.; Lambe, T.; Mullarkey, C.; Spencer, A.J.; Hamill, M.; Peng, Y.; Blais, M.-E.; Duncan, C.J.A. et al.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Pseudotyped influenza A virus as a vaccine for the induction of heterotypic immunity

Journal of Virology
2012 | Journal article
EID:

2-s2.0-84870676890

Contributors: Powell, T.J.; Silk, J.D.; Sharps, J.; Fodor, E.; Townsend, A.R.M.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Multilayered defense in HLA-B51-associated HIV viral control

Journal of Immunology
2011 | Journal article
EID:

2-s2.0-79960488721

Contributors: Zhang, Y.; Peng, Y.; Yan, H.; Xu, K.; Saito, M.; Wu, H.; Chen, X.; Ranasinghe, S.; Kuse, N.; Powell, T. et al.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Different evolutionary histories of the two classical class I genes BF1 and BF2 illustrate drift and selection within the stable MHC haplotypes of chickens

Journal of Immunology
2007 | Journal article
EID:

2-s2.0-34247641675

Contributors: Shaw, I.; Powell, T.J.; Marston, D.A.; Baker, K.; Van Hateren, A.; Riegert, P.; Wiles, M.V.; Milne, S.; Beck, S.; Kaufman, J.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Priming with cold-adapted influenza A does not prevent infection but elicits long-lived protection against supralethal challenge with heterosubtypic virus

Journal of Immunology
2007 | Journal article
EID:

2-s2.0-33846219152

Contributors: Powell, T.J.; Strutt, T.; Reome, J.; Hollenbaugh, J.A.; Roberts, A.D.; Woodland, D.L.; Swain, S.L.; Dutton, R.W.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Peptide motifs of the single dominantly expressed class I molecule explain the striking MHC-determined response to Rous sarcoma virus in chickens

Proceedings of the National Academy of Sciences of the United States of America
2006 | Journal article
EID:

2-s2.0-31944444235

Contributors: Wallny, H.-J.; Avila, D.; Hunt, L.G.; Powell, T.J.; Riegert, P.; Salomonsen, J.; Skjødt, K.; Vainio, O.; Vilbois, F.; Wiles, M.V. et al.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

The immune system provides a strong response to even a low exposure to virus

Clinical Immunology
2006 | Journal article
EID:

2-s2.0-33644752618

Contributors: Powell, T.J.; Dwyer, D.W.; Morgan, T.; Hollenbaugh, J.A.; Dutton, R.W.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

CD8 + T cells responding to influenza infection reach and persist at higher numbers than CD4 + T cells independently of precursor frequency

Clinical Immunology
2004 | Journal article
EID:

2-s2.0-6044253358

Contributors: Powell, T.J.; Brown, D.M.; Hollenbaugh, J.A.; Charbonneau, T.; Kemp, R.A.; Swain, S.L.; Dutton, R.W.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Cutting edge: Regulation of CD8+ T cell effector population size

Journal of Immunology
2004 | Journal article
EID:

2-s2.0-4344562815

Contributors: Kemp, R.A.; Powell, T.J.; Dwyer, D.W.; Dutton, R.W.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

Rat bone marrow-derived dendritic cells, but not ex vivo dendritic cells, secrete nitric oxide and can inhibit T-cell proliferation

Immunology
2003 | Journal article
EID:

2-s2.0-0037843104

Contributors: Powell, T.J.; Jenkins, C.D.; Hattori, R.; Macpherson, G.G.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier

A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes

Journal of Experimental Medicine
2000 | Journal article
EID:

2-s2.0-0034614894

Contributors: Huang, F.-P.; Platt, N.; Wykes, M.; Major, J.R.; Powell, T.J.; Jenkins, C.D.; MacPherson, G.G.
Source: Self-asserted source
Timothy J Powell via Scopus - Elsevier