Personal information

Websites & social links

http://www.nhri.org.tw/NHRI_WEB/nhriw1001Action.do?emp_cd=970531
http://ibpr.nhri.org.tw/zhtw/index.php/ya-hui-chi/

Keywords

Molecular Biology, Cell Biology, Biochemistry, Structural Biology

Activities

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Employment (6)

National Health Research Institutes: Zhunan, TW

2021-10-01 to present | Investigator (Institute of Biotechnology and Pharmaceutical Research)
Employment
Source: Self-asserted source
Ya-Hui Chi

National Health Research Institutes: Zhunan, TW

2014-09 to 2021-09 | Associate Investigator (Institute of Biotechnology and Pharmaceutical Research)
Employment
Source: Self-asserted source
Ya-Hui Chi

National Health Research Institutes: Zhunan, TW

2014-01 to 2014-08 | Associate Investigator (Institute of Cellular and System Medicine)
Employment
Source: Self-asserted source
Ya-Hui Chi

National Health Research Institutes: Zhunan, TW

2008-05 to 2013-12 | Assistant Investigator (Institute of Cellular and System Medicine)
Employment
Source: Self-asserted source
Ya-Hui Chi

National Institute of Allergy and Infectious Diseases: Md., Md., US

2003-07 to 2008-05 | Postdoctoral Fellow (National Institute of Allergy and Infectious Disease)
Employment
Source: Self-asserted source
Ya-Hui Chi

National Health Research Institutes: Zhunan, TW

2003-03 to 2003-07 | Postdoctoral Fellow (Division of Biotechnology and Pharmaceutical Research)
Employment
Source: Self-asserted source
Ya-Hui Chi

Education and qualifications (2)

National Tsing Hua University: Hsinchu, TW

1999-09 to 2002-07 | Ph.D., Chemistry
Education
Source: Self-asserted source
Ya-Hui Chi

National Taiwan Normal University: Taipei, TW

1994-09 to 1998-06 | B.S., Chemistry
Education
Source: Self-asserted source
Ya-Hui Chi

Works (50 of 67)

Items per page:
Page 1 of 2

Orally bioavailable and site-selective covalent STING inhibitor derived from a macrocyclic marine diterpenoid

Journal of Medicinal Chemistry
2025 | Journal article
DOI: http://dx.doi.org/10.1021/acs.jmedchem.4c02665
Part of ISSN: 0022-2623
Contributors: Niu, G. H.; Hsiao, W. C.; Lee, P. H.; Zheng, L. G.; Yang, Y. S.; Huang, W. C.; Hsieh, C. C.; Chiu, T. Y.; Wang, J. Y.; Chen, C. P. et al.
Source: Self-asserted source
Ya-Hui Chi

Discovery of a long half-life AURKA inhibitor to treat MYC-amplified solid tumors as a monotherapy and in combination with everolimus

Molecular Cancer Therapeutics
2024 | Journal article
DOI: http://dx.doi.org/10.1158/1535-7163.Mct-23-0602
Part of ISSN: 1535-7163
Contributors: Chang, C. P.; Yeh, T. K.; Chen, C. T.; Wang, W. P.; Chen, Y. T.; Tsai, C. H.; Chen, Y. F.; Ke, Y. Y.; Wang, J. Y.; Chen, C. P. et al.
Source: Self-asserted source
Ya-Hui Chi

Analysis of structure–activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors

Bioorganic and Medicinal Chemistry
2023 | Journal article
DOI: http://dx.doi.org/10.1016/j.bmc.2023.117502
Part of ISSN: 0968-0896
Contributors: Chang, P. W.; Wang, J. Y.; Wang, W. P.; Huang, W. C.; Wu, M. H.; Song, J. S.; Chen, L. Y.; Tung, C. W.; Chi, Y. H.; Ueng, S. H.
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

Marine diterpenoid targets STING palmitoylation in mammalian cells

Communications Chemistry
2023 | Journal article
DOI: http://dx.doi.org/10.1038/s42004-023-00956-9
Part of ISSN: 2399-3669
Contributors: Hsiao, W. C.; Niu, G. H.; Lo, C. F.; Wang, J. Y.; Chi, Y. H.; Huang, W. C.; Tung, C. W.; Sung, P. J.; Tsou, L. K.; Zhang, M. M.
Source: Self-asserted source
Ya-Hui Chi

AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer

Cell and Bioscience
2022 | Journal article
DOI: http://dx.doi.org/10.1186/s13578-022-00862-y
Part of ISSN: 2045-3701
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

Deformation of the nucleus by TGF beta 1 via the remodeling of nuclear envelope and histone isoforms

Epigenetics and Chromatin
2022 | Journal article
DOI: http://dx.doi.org/10.1186/s13072-021-00434-3
Part of ISSN: 1756-8935
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

Development of a respiratory syncytial virus vaccine using human hepatitis B core-based virus-like particles to induce mucosal immunity

Vaccine
2021 | Journal article
DOI: http://dx.doi.org/10.1016/j.vaccine.2021.04.038
Part of ISSN: 0264-410X
Source: Self-asserted source
Ya-Hui Chi

Discovery and synthesis of a pyrimidine-based aurora kinase inhibitor to reduce levels of MYC oncoproteins

Journal of Medicinal Chemistry
2021 | Journal article
DOI: http://dx.doi.org/10.1021/acs.jmedchem.0c01806
Part of ISSN: 0022-2623
Source: Self-asserted source
Ya-Hui Chi

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal

Scientific Reports
2021 | Journal article
DOI: http://dx.doi.org/10.1038/s41598-021-84750-4
Part of ISSN: 2045-2322
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

Deformation of the Nucleus by TGFβ1 Via the Remodeling of Nuclear Envelope and Histone Isoforms

2021-10-05 | Preprint
DOI: 10.21203/rs.3.rs-944682/v1
Contributors: Ya-Hui Chi; Wan-Ping Wang; Ming-Chun Hung; Gunn-Guang Liou; Jing-Ya Wang; Pen-Hsiu Grace Chao
Source: check_circle
Crossref

Lamin A‐mediated nuclear lamina integrity is required for proper ciliogenesis

EMBO reports
2021-09-06 | Journal article
DOI: 10.15252/embr.202153517
Contributors: Jia‐Rong Fa; Li‐Ru Yo; Won‐Jing Wang; Wei‐Syun Huang; Ching‐Tung Chu; Ya‐Hui Chi; Hong‐Chen Chen
Source: check_circle
Crossref

Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms

2021-07-29 | Preprint
DOI: 10.21203/rs.3.rs-735722/v1
Contributors: Ya-Hui Chi; Wan-Ping Wang; Ming-Chun Hung; Gunn-Guang Liou; Jing-Ya Wang; Pen-Hsiu Grace Chao
Source: check_circle
Crossref

Deformation of the nucleus by TGFβ1 via the remodeling of nuclear envelope and histone isoforms

2021-07-19 | Preprint
DOI: 10.21203/rs.3.rs-702270/v1
Contributors: Ya-Hui Chi; Wan-Ping Wang; Ming-Chun Hung; Gunn-Guang Liou; Jing-Ya Wang; Pen-Hsiu Grace Chao
Source: check_circle
Crossref

BPR6K609: An Aurora kinase inhibitor targeting small cell lung cancer with MYC amplification

Cancer Research
2020 | Journal article
DOI: http://dx.doi.org/10.1158/1538-7445.Am2020-1937
Part of ISSN: 0008-5472
Source: Self-asserted source
Ya-Hui Chi

Exercise and the Cisd2 prolongevity gene: Two promising strategies to delay the aging of skeletal muscle

International Journal of Molecular Sciences
2020 | Journal article
DOI: http://dx.doi.org/10.3390/ijms21239059
Part of ISSN: 1422-0067
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 4)‎

Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis

EMBO Reports
2020 | Journal article
DOI: http://dx.doi.org/10.15252/embr.201949680
Part of ISSN: 1469-221X
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis

Aging Cell
2020 | Journal article
DOI: http://dx.doi.org/10.1111/acel.13090
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

A novel mechanism of miRNA-mediated CBX8 associated with tumorigenesis in head and neck squamous cell carcinoma

Journal of Clinical Oncology
2019 | Journal article
DOI: http://dx.doi.org/10.1200/JCO.2019.37.15_suppl.e17534
Source: Self-asserted source
Ya-Hui Chi

An Aurora kinase inhibitor BPR6K471 inhibits tumor growth and reduces the cancer stem cell-like properties of small cell lung cancer

Cancer Research
2019 | Journal article
DOI: http://dx.doi.org/10.1158/1538-7445.am2019-3851
Source: Self-asserted source
Ya-Hui Chi

Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV

Molecular Therapy-Nucleic Acids
2019 | Journal article
DOI: http://dx.doi.org/10.1016/j.omtn.2018.12.001
Source: Self-asserted source
Ya-Hui Chi

Sun1 Mediates Interkinetic Nuclear Migration and Notch Signaling in the Neurogenesis of Zebrafish

Stem Cells and Development
2019 | Journal article
DOI: http://dx.doi.org/10.1089/scd.2019.0063
Source: Self-asserted source
Ya-Hui Chi

Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition

European Journal of Medicinal Chemistry
2018 | Journal article
DOI: http://dx.doi.org/10.1016/j.ejmech.2018.03.064
Source: Self-asserted source
Ya-Hui Chi

Adaptation of influenza A (H7N9) virus in primary human airway epithelial cells

Scientific Reports
2017 | Journal article
DOI: http://dx.doi.org/10.1038/s41598-017-10749-5
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

In vivo inhibition of influenza A virus replication by RNA interference targeting the PB2 subunit via intratracheal delivery

Plos One
2017 | Journal article
DOI: http://dx.doi.org/10.1371/journal.pone.0174523
Source: Self-asserted source
Ya-Hui Chi

Neural stem cells promote nerve regeneration through IL12-induced Schwann cell differentiation

Molecular and Cellular Neuroscience
2017 | Journal article
DOI: http://dx.doi.org/10.1016/j.mcn.2016.11.007
Source: Self-asserted source
Ya-Hui Chi

Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture

Journal of Cell Biology
2017 | Journal article
DOI: http://dx.doi.org/10.1083/jcb.201606043
Source: Self-asserted source
Ya-Hui Chi

Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis

Scientific Reports
2017 | Journal article
DOI: http://dx.doi.org/10.1038/s41598-017-05993-8
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 2)‎

Activation of FGF1B Promoter and FGF1 Are Involved in Cardiogenesis Through the Signaling of PKC, but Not MAPK

Stem Cells and Development
2015 | Journal article
DOI: http://dx.doi.org/10.1089/scd.2015.0157
Source: Self-asserted source
Ya-Hui Chi

Sun1 deficiency leads to cerebellar ataxia in mice

Disease Models & Mechanisms
2015 | Journal article
DOI: http://dx.doi.org/10.1242/dmm.019240
Source: Self-asserted source
Ya-Hui Chi

Dysregulated affinity of lamin A to SUN1 induces nuclear and endoplasmic reticulum aberrancies in progeric laminopathies

Faseb Journal
2014 | Journal article
DOI: https://doi.org/10.1096/fasebj.28.1_supplement.829.18
Source: Self-asserted source
Ya-Hui Chi

Dysregulated affinity of lamin A to SUN1 induces nuclear and endoplasmic reticulum aberrancies in progeric laminopathies

Faseb Journal
2014 | Journal article
DOI:

http://dx.doi.org/
Source: Self-asserted source
Ya-Hui Chi
grade
Preferred source (of 10)‎

Dysregulated interactions between lamin A and SUN1 induce abnormalities in the nuclear envelope and endoplasmic reticulum in progeric laminopathies

Journal of Cell Science
2014 | Journal article
DOI: http://dx.doi.org/10.1242/jcs.139683
Source: Self-asserted source
Ya-Hui Chi

Large Isoform of Mammalian Relative of DnaJ is a Major Determinant of Human Susceptibility to HIV-1 Infection

Ebiomedicine
2014 | Journal article
DOI: http://dx.doi.org/10.1016/j.ebiom.2014.10.002
Source: Self-asserted source
Ya-Hui Chi

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
DOI: http://dx.doi.org/10.1073/pnas.1220523110
Source: Self-asserted source
Ya-Hui Chi

Optimization of Ligand and Lipophilic Efficiency To Identify an in Vivo Active Furano-Pyrimidine Aurora Kinase Inhibitor

Journal of Medicinal Chemistry
2013 | Journal article
DOI: http://dx.doi.org/10.1021/jm4006059
Source: Self-asserted source
Ya-Hui Chi

14-3-3 sigma Regulates beta-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3 beta

Plos One
2012 | Journal article
DOI: http://dx.doi.org/10.1371/journal.pone.0040193
Source: Self-asserted source
Ya-Hui Chi

Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic Laminopathies

Cell
2012 | Journal article
DOI: http://dx.doi.org/10.1016/j.cell.2012.01.059
Source: Self-asserted source
Ya-Hui Chi

Reversal of laminopathies: the curious case of SUN1

Nucleus
2012 | Journal article
DOI: http://dx.doi.org/10.4161/nucl.21714
Source: Self-asserted source
Ya-Hui Chi

Sun1 and Sun2 are required for nuclear positioning and nuclear migration of neuronal cells in postnatal brain development

Faseb Journal
2012 | Journal article
DOI:

http://www.fasebj.org/content/26/1_Supplement/1035.12
Source: Self-asserted source
Ya-Hui Chi

The EP300, KDM5A, KDM6A and KDM6B Chromatin Regulators Cooperate with KLF4 in the Transcriptional Activation of POU5F1

Plos One
2012 | Journal article
DOI: http://dx.doi.org/10.1371/journal.pone.0052556
Source: Self-asserted source
Ya-Hui Chi

A proteomic study of TAR-RNA binding protein (TRBP)-associated factors

Cell and Bioscience
2011 | Journal article
DOI: http://dx.doi.org/10.1186/2045-3701-1-9
Source: Self-asserted source
Ya-Hui Chi

Argonaute-2 enhances suppression of human cytomegalovirus replication by polycistronic short hairpin RNAs targeting UL46, UL70 and UL122

Antiviral Therapy
2011 | Journal article
DOI: http://dx.doi.org/10.3851/imp1808
Source: Self-asserted source
Ya-Hui Chi

Chromosomal Instability and Human T Cell Leukemia Virus 1 Transformation

Translational Research in Biomedicine
2009 | Journal article
DOI: http://dx.doi.org/10.1159/000141523
Source: Self-asserted source
Ya-Hui Chi

Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA

Development
2009 | Journal article
DOI: http://dx.doi.org/10.1242/dev.029868
Source: Self-asserted source
Ya-Hui Chi

Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

International Journal of Cancer
2009 | Journal article
DOI: http://dx.doi.org/10.1002/ijc.24094
Source: Self-asserted source
Ya-Hui Chi

The nuclear envelopathies and human diseases

Journal of Biomedical Science
2009 | Journal article
DOI: http://dx.doi.org/10.1186/1423-0127-16-96
Source: Self-asserted source
Ya-Hui Chi

Requirements for Protein Phosphorylation and the Kinase Activity of Polo-like Kinase 1 (Plk1) for the Kinetochore Function of Mitotic Arrest Deficiency Protein 1 (Mad1)

Journal of Biological Chemistry
2008 | Journal article
DOI: http://dx.doi.org/10.1074/jbc.M804967200
Source: Self-asserted source
Ya-Hui Chi

Aneuploidy and cancer

Journal of Cellular Biochemistry
2007 | Journal article
DOI: http://dx.doi.org/10.1002/jcb.21484
Source: Self-asserted source
Ya-Hui Chi

Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax

J Virol
2007 | Journal article
DOI: http://dx.doi.org/10.1128/jvi.00555-07
Source: Self-asserted source
Ya-Hui Chi

Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice

Cancer Res
2007 | Journal article
DOI: http://dx.doi.org/10.1158/0008-5472.can-06-3326
Source: Self-asserted source
Ya-Hui Chi
Items per page:
Page 1 of 2

Peer review (10 reviews for 3 publications/grants)

Review activity for Biomolecules. (1)
Review activity for Cell & bioscience. (8)
Review activity for European journal of medicinal chemistry. (1)
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