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Biography

Professor of cell signalling. Johnston Chair of Biochemistry, University of Liverpool

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Employment (3)

University of Liverpool: Liverpool, Merseyside, GB

2020-03-01 to present | Johnston Chair and Head of Department (Biochemistry, Cell and Systems Biology)
Employment
Source: Self-asserted source
Patrick Eyers

University of Liverpool: Liverpool, GB

2017-10-01 to present | Personal Chair (Biochemistry, Cell and Systems Biology)
Employment
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University of Liverpool via ORCID Member Portal

University of Liverpool: Liverpool, England, GB

2013-05-17 to present | Professor of Cell Signalling (Biochemistry)
Employment
Source: Self-asserted source
Patrick Eyers

Education and qualifications (2)

University of Dundee: Dundee, Scotland, GB

1997-09-01 to 2000-09-30 | PhD (Biochemistry)
Education
Source: Self-asserted source
Patrick Eyers

University of Bristol: Bristol, England, GB

1994-10-01 to 1997-06-30 | BSc (Honours) Biochemistry (Biochemistry)
Education
Source: Self-asserted source
Patrick Eyers

Professional activities (1)

Biochemical Society: London, GB

1998-02-05 to present
Membership
Source: Self-asserted source
Patrick Eyers

Works (45)

Searching for Sulfotyrosines (sY) in a HA(pY)STACK

Journal of Proteome Research
2025-03-07 | Journal article
DOI: 10.1021/acs.jproteome.4c00907
Contributors: Jordan Tzvetkov; Claire E. Eyers; Patrick A. Eyers; Kerry A. Ramsbottom; Sally O. Oswald; John A. Harris; Zhi Sun; Eric W. Deutsch; Andrew R. Jones
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Crossref

Applying a conservation-based approach for predicting novel phosphorylation sites in eukaryotes and evaluating their functional relevance

2025-01-13 | Preprint
DOI: 10.1101/2025.01.09.632054
Contributors: Anton Kalyuzhnyy; Patrick A Eyers; Claire E Eyers; Eric W Deutsch; Andrew R Jones
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Crossref

Searching for Sulfotyrosines (sY) in a HA(pY)STACK

2024-10-16 | Preprint
DOI: 10.1101/2024.10.14.618131
Contributors: Jordan Tzvetkov; Claire E Eyers; Patrick A Eyers; Kerry A Ramsbottom; Sally O Oswald; John A Harris; Zhi Sun; Eric W Deutsch; Andrew R Jones
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Crossref

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

2024-05-02 | Preprint
DOI: 10.7554/eLife.92536.3
Contributors: George N. Bendzunas; Dominic P Byrne; Safal Shrestha; Leonard A Daly; Sally O. Oswald; Samiksha Katiyar; Aarya Venkat; Wayland Yeung; Claire E Eyers; Patrick A Eyers et al.
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Crossref

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

2024-05-02 | Preprint
DOI: 10.7554/eLife.92536
Contributors: George N. Bendzunas; Dominic P Byrne; Safal Shrestha; Leonard A Daly; Sally O. Oswald; Samiksha Katiyar; Aarya Venkat; Wayland Yeung; Claire E Eyers; Patrick A Eyers et al.
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Crossref

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

2024-04-19 | Preprint
DOI: 10.7554/eLife.92536.2
Contributors: George N. Bendzunas; Dominic P Byrne; Safal Shrestha; Leonard A Daly; Sally O. Oswald; Samiksha Katiyar; Aarya Venkat; Wayland Yeung; Claire E Eyers; Patrick A Eyers et al.
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Crossref

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

2024-01-08 | Preprint
DOI: 10.7554/eLife.92536.1
Contributors: George N. Bendzunas; Dominic P Byrne; Safal Shrestha; Leonard A Daly; Sally O. Oswald; Samiksha Katiyar; Aarya Venkat; Wayland Yeung; Claire E Eyers; Patrick A Eyers et al.
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Crossref

Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides

Journal of Proteome Research
2023-12-01 | Journal article
DOI: 10.1021/acs.jproteome.3c00425
Contributors: Leonard A. Daly; Dominic P. Byrne; Simon Perkins; Philip J. Brownridge; Euan McDonnell; Andrew R. Jones; Patrick A. Eyers; Claire E. Eyers
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Crossref

Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms

2023-10-06 | Preprint
DOI: 10.1101/2023.10.05.561145
Contributors: George N. Bendzunas; Dominic P Byrne; Safal Shrestha; Leonard A Daly; Sally O. Oswald; Samiksha Katiyar; Aarya Venkat; Wayland Yeung; Claire E Eyers; Patrick A Eyers et al.
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Crossref

A bespoke analytical workflow for the confident identification of sulfopeptides and their discrimination from phosphopeptides

2023-07-15 | Preprint
DOI: 10.1101/2023.07.15.549150
Contributors: Leonard A. Daly; Dominic P. Byrne; Simon Perkins; Philip J Brownridge; Euan McDonnell; Andrew R. Jones; Patrick A. Eyers; Claire E. Eyers
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Crossref

Evolutionary and cellular analysis of the ‘dark’ pseudokinase PSKH2

Biochemical Journal
2023-01-31 | Journal article
DOI: 10.1042/BCJ20220474
Contributors: Dominic P. Byrne; Safal Shrestha; Leonard A. Daly; Vanessa Marensi; Krithika Ramakrishnan; Claire E. Eyers; Natarajan Kannan; Patrick A. Eyers
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Crossref

A Peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms

2022-11-15 | Preprint
DOI: 10.1101/2022.11.15.513554
Contributors: Min Cao; Alison M Day; Martin Galler; Heather Latimer; Dominic P Byrne; Emilia Dwyer; Elise Bennett; Patrick A Eyers; Elizabeth A Veal
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Crossref

Evolutionary and cellular analysis of the dark pseudokinase PSKH2

2022-09-10 | Preprint
DOI: 10.1101/2022.09.10.507278
Contributors: Dominic P Byrne; Safal Shrestha; Leonard A Daly; Vanessa Marensi; Krithika Ramakrishnan; Claire E Eyers; Natarajan Kannan; Patrick A Eyers
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Crossref

Profiling the Human Phosphoproteome to Estimate the True Extent of Protein Phosphorylation

Journal of Proteome Research
2022-06-03 | Journal article
DOI: 10.1021/acs.jproteome.2c00131
Contributors: Anton Kalyuzhnyy; Patrick A. Eyers; Claire E. Eyers; Emily Bowler-Barnett; Maria J. Martin; Zhi Sun; Eric W. Deutsch; Andrew R. Jones
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Crossref

Exploring the Conformational Landscape and Stability of Aurora A Using Ion-Mobility Mass Spectrometry and Molecular Modeling

Journal of the American Society for Mass Spectrometry
2022-03-02 | Journal article
DOI: 10.1021/jasms.1c00271
Contributors: Lauren J. Tomlinson; Matthew Batchelor; Joscelyn Sarsby; Dominic P. Byrne; Philip J. Brownridge; Richard Bayliss; Patrick A. Eyers; Claire E. Eyers
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Crossref

Exploring the conformational landscape and stability of Aurora A using ion-mobility mass spectrometry and molecular modelling

2021-08-31 | Other
DOI: 10.1101/2021.08.30.458190
Contributors: Lauren J. Tomlinson; Matthew Batchelor; Joscelyn Sarsby; Dominic P. Byrne; Philip Brownridge; Richard Bayliss; Patrick A. Eyers; Claire E. Eyers
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Crossref

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota

2021-07-24 | Other
DOI: 10.1101/2021.07.23.453482
Contributors: Ana Luis; Arnaud Baslé; Dominic P Byrne; Gareth SA Wright; James London; Jin Chunsheng; Niclas Karlsson; Gunnar Hansson; Patrick Eyers; Mirjam Czjzek et al.
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Crossref

Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Biochemical Journal
2021-07-16 | Journal article
DOI: 10.1042/BCJ-2020-0952_COR
Contributors: Dominic P. Byrne; James A. London; Patrick A. Eyers; Edwin A. Yates; Alan Cartmell
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Crossref

Profiling the Human Phosphoproteome to Estimate the True Extent of Protein Phosphorylation

2021-04-15 | Other
DOI: 10.1101/2021.04.14.439901
Contributors: Anton Kalyuzhnyy; Patrick A. Eyers; Claire E. Eyers; Zhi Sun; Eric W. Deutsch; Andrew R. Jones
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Crossref

KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases

2021-03-05 | Other
DOI: 10.1101/2021.03.05.434161
Contributors: Liang-Chin Huang; Rahil Taujale; Nathan Gravel; Aarya Venkat; Wayland Yeung; Dominic P Byrne; Patrick A Eyers; Natarajan Kannan
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Crossref

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

Biochemical Journal
2021-02-26 | Journal article
DOI: 10.1042/BCJ20200952
Contributors: Dominic P. Byrne; James A. London; Patrick A. Eyers; Edwin A. Yates; Alan Cartmell
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Crossref

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity

2020-12-02 | Preprint
DOI: 10.1101/2020.12.01.406876
Contributors: Dominic P Byrne; James A London; Patrick A Eyers; Edwin A Yates; Alan Cartmell
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Crossref

Cataloguing the dead: breathing new life into pseudokinase research

The FEBS Journal
2020-10 | Journal article
DOI: 10.1111/febs.15246
Contributors: Safal Shrestha; Dominic P. Byrne; John A. Harris; Natarajan Kannan; Patrick A. Eyers
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Crossref

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets for drug repurposing

2020-09-16 | Other
DOI: 10.1101/2020.09.16.297945
Contributors: Bjoern Meyer; Jeanne Chiaravalli; Philip Brownridge; Dominic P. Bryne; Leonard A. Daly; Fabrice Agou; Claire E. Eyers; Patrick A. Eyers; Marco Vignuzzi; Edward Emmott
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Crossref

Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

Biochemical Journal
2020-07-17 | Journal article
DOI: 10.1042/BCJ20200309
Contributors: Dominic P. Byrne; Christopher J. Clarke; Philip J. Brownridge; Anton Kalyuzhnyy; Simon Perkins; Amy Campbell; David Mason; Andrew R. Jones; Patrick A. Eyers; Claire E. Eyers
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Crossref

Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity

Science Signaling
2020-07-07 | Journal article
DOI: 10.1126/scisignal.aax2713
Contributors: Dominic P. Byrne; Safal Shrestha; Martin Galler; Min Cao; Leonard A. Daly; Amy E. Campbell; Claire E. Eyers; Elizabeth A. Veal; Natarajan Kannan; Patrick A. Eyers
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Crossref

Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors

RSC Advances
2019 | Journal article
DOI: 10.1039/C9RA07567D
Contributors: Neil M. Kershaw; Dominic P. Byrne; Hollie Parsons; Neil G. Berry; David G. Fernig; Patrick A. Eyers; Richard Cosstick
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Crossref
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Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments

Organic & Biomolecular Chemistry
2019 | Journal article
DOI: 10.1039/C8OB03152E
Contributors: Paul R. Mears; Steven Hoekman; Claire E. Rye; Fiona P. Bailey; Dominic P. Byrne; Patrick A. Eyers; Eric J. Thomas
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Crossref

Strong anion exchange‐mediated phosphoproteomics reveals extensive human non‐canonical phosphorylation

The EMBO Journal
2019-11-04 | Journal article
DOI: 10.15252/embj.2018100847
Contributors: Gemma Hardman; Simon Perkins; Philip J Brownridge; Christopher J Clarke; Dominic P Byrne; Amy E Campbell; Anton Kalyuzhnyy; Ashleigh Myall; Patrick A Eyers; Andrew R Jones et al.
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Crossref

Structure-Based Design of Nucleoside-Derived Analogues as Sulfotransferase Inhibitors

2019-10-11 | Other
DOI: 10.26434/chemrxiv.9944243
Contributors: Neil Kershaw; Dominic Byrne; Hollie Parsons; Neil G Berry; David Fernig; Patrick A. Eyers; Richard Cosstick
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Crossref

Structure-Based Design of Nucleoside-Derived Analogues as Sulfotransferase Inhibitors

2019-10-11 | Other
DOI: 10.26434/chemrxiv.9944243.v1
Contributors: Neil Kershaw; Dominic Byrne; Hollie Parsons; Neil G Berry; David Fernig; Patrick A. Eyers; Richard Cosstick
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Crossref

Emerging concepts in pseudoenzyme classification, evolution, and signaling

Science Signaling
2019-08-13 | Journal article
DOI: 10.1126/scisignal.aat9797
Contributors: António J. M. Ribeiro; Sayoni Das; Natalie Dawson; Rossana Zaru; Sandra Orchard; Janet M. Thornton; Christine Orengo; Elton Zeqiraj; James M. Murphy; Patrick A. Eyers
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Crossref

Tracing the origin and evolution of pseudokinases across the tree of life

Science Signaling
2019-04-23 | Journal article
DOI: 10.1126/scisignal.aav3810
Contributors: Annie Kwon; Steven Scott; Rahil Taujale; Wayland Yeung; Krys J. Kochut; Patrick A. Eyers; Natarajan Kannan
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Crossref

An evolutionary-conserved redox regulatory mechanism in human Ser/Thr protein kinases

2019-03-08 | Other
DOI: 10.1101/571844
Contributors: Dominic P. Byrne; Safal Shrestha; Natarajan Kannan; Patrick A. Eyers
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Crossref

Drug repurposing: progress, challenges and recommendations.

Nature reviews. Drug discovery
2019-01 | Journal article
DOI: 10.1038/nrd.2018.168
PMID: 30310233
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Researchfish

A new consensus for evaluating CDKL 5/ STK 9‐dependent signalling mechanisms

The EMBO Journal
2018-12-14 | Journal article
DOI: 10.15252/embj.2018100848
Contributors: Patrick A Eyers
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Crossref

Repurposing covalent EGFR/HER2 inhibitors for on-target degradation of human Tribbles 2 (TRIB2) pseudokinase

2018-04-20 | Other
DOI: 10.1101/305243
Contributors: Daniel M Foulkes; Dominic P Byrne; Fiona P Bailey; Samantha Ferries; Claire E Eyers; Karen Keeshan; Safal Shrestha; Wayland Yeung; Natarajan Kannan; Carrow Wells et al.
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Crossref

New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

2018-04-06 | Other
DOI: 10.1101/296707
Contributors: Patrick Eyers; Dominic Byrne; Pawin Ngamlert; Yong Li; Krithika Ramakrishnan; Claire Eyers; Carrow Wells; David Drewry; William Zuercher; Neil Berry et al.
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Crossref

Kinome‐wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics

Pigment Cell & Melanoma Research
2018-03 | Journal article
DOI: 10.1111/pcmr.12650
Contributors: Fiona P. Bailey; Kim Clarke; Helen Kalirai; Jenna Kenyani; Haleh Shahidipour; Francesco Falciani; Judy M. Coulson; Joseph J. Sacco; Sarah E. Coupland; Patrick A. Eyers
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Crossref

Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes

Journal of Cell Biology
2017-11-06 | Journal article
DOI: 10.1083/jcb.201606077
Contributors: Leah Bury; Paula A. Coelho; Angela Simeone; Samantha Ferries; Claire E. Eyers; Patrick A. Eyers; Magdalena Zernicka-Goetz; David M. Glover
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Crossref

Extensive non-canonical phosphorylation in human cells revealed using strong-anion exchange-mediated phosphoproteomics

2017-10-13 | Other
DOI: 10.1101/202820
Contributors: Gemma Hardman; Simon Perkins; Zheng Ruan; Natarajan Kannan; Philip Brownridge; Dominic P Byrne; Patrick A Eyers; Andrew R Jones; Claire E Eyers
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Crossref

Evaluation of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer

Journal of Proteome Research
2017-09-01 | Journal article
DOI: 10.1021/acs.jproteome.7b00337
Contributors: Samantha Ferries; Simon Perkins; Philip J. Brownridge; Amy Campbell; Patrick A. Eyers; Andrew R. Jones; Claire E. Eyers
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Crossref
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Local protein kinase A action proceeds through intact holoenzymes

Science
2017-06-23 | Journal article
DOI: 10.1126/science.aaj1669
Contributors: F. Donelson Smith; Jessica L. Esseltine; Patrick J. Nygren; David Veesler; Dominic P. Byrne; Matthias Vonderach; Ilya Strashnov; Claire E. Eyers; Patrick A. Eyers; Lorene K. Langeberg et al.
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Crossref

The hVps34‐ SGK 3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC 1 and tumour growth

The EMBO Journal
2016-09 | Journal article
DOI: 10.15252/embj.201693929
Contributors: Ruzica Bago; Eeva Sommer; Pau Castel; Claire Crafter; Fiona P Bailey; Natalia Shpiro; José Baselga; Darren Cross; Patrick A Eyers; Dario R Alessi
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Crossref
grade
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Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C

International Journal of Molecular Sciences
2016-08 | Journal article
DOI: 10.3390/ijms17091378
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Multidisciplinary Digital Publishing Institute
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Peer review (24 reviews for 11 publications/grants)

Review activity for ACS central science. (1)
Review activity for ACS chemical biology. (5)
Review activity for Analytical chemistry. (1)
Review activity for Biochemistry. (2)
Review activity for F1000Research. (1)
Review activity for iScience. (4)
Review activity for Journal of medicinal chemistry. (4)
Review activity for Journal of proteome research. (1)
Review activity for Journal of the American Chemical Society. (1)
Review activity for Nature (1)
Review activity for Nature communications (3)
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