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Scopus Author ID: 56963390800
Loop profile: 1263606
SciProfiles: 2549221

Keywords

metabolism; pluripotency; stem cells; cardiovascular disease; Friedreich's ataxia; autonomic nerves

Activities

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Employment (6)

Monash University: Melbourne, AU

2023-10 to present | Adjunct Senior Research Fellow (Monash Institute of Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Jarmon G. Lees

University of Melbourne: Melbourne, VIC, AU

2019 to present | Honourary Fellow (Department Of Medicine at St Vincent's Hospital, Melbourne Medical School)
Employment
Source: Self-asserted source
Jarmon G. Lees

St Vincent's institute of Medical Research: Fitzroy, VIC, AU

2018-08 to present | Senior Research Officer (Team Leader) (O'Brien Institute Department)
Employment
Source: Self-asserted source
Jarmon G. Lees

University of Melbourne: Melbourne, VIC, AU

2018 to 2018 | Research Assistant (Gardner Laboratories)
Employment
Source: Self-asserted source
Jarmon G. Lees

University of Melbourne: Melbourne, VIC, AU

2018 to 2018 | Lecturer (BioSciences)
Employment
Source: Self-asserted source
Jarmon G. Lees

University of Melbourne: Melbourne, VIC, AU

2012 to 2018 | Academic Tutor (Zoology/BioSciences)
Employment
Source: Self-asserted source
Jarmon G. Lees

Education and qualifications (4)

The University of Melbourne: Melbourne, VIC, AU

2014 to 2018-03-13 | PhD (School of BioSciences)
Education
Source: Self-asserted source
Jarmon G. Lees

University of Melbourne: Melbourne, VIC, AU

2012 to 2013 | Master of Science (MSc) (Zoolgy)
Education
Source: Self-asserted source
Jarmon G. Lees

University of Melbourne: Melbourne, VIC, AU

2009 to 2011 | Bachelor of Science (BSc) (Zoology)
Education
Source: Self-asserted source
Jarmon G. Lees

University of Melbourne: Melbourne, VIC, AU

2009 to 2011 | Diploma of Modern Languages (French) (Faculty of Arts)
Education
Source: Self-asserted source
Jarmon G. Lees

Professional activities (9)

International Society for Heart Research: Durham, North Carolina, US

2024-04 | Chair - International Early Career Investigator Committee (International Section)
Distinction
Source: Self-asserted source
Jarmon G. Lees

THE MARIAN AND E.H. FLACK TRUST: Melbourne, VIC, AU

2023 | EH Flack Fellowship
Distinction
Source: Self-asserted source
Jarmon G. Lees

International Society for Heart Research: Durham, North Carolina, US

2023 | Early Career Investigator People's Choice Oral Award (Australasian Section)
Distinction
Source: Self-asserted source
Jarmon G. Lees

International Society for Heart Research: Durham, North Carolina, US

2023 | Postdoctoral Publication Prize (Australasian Section)
Distinction
Source: Self-asserted source
Jarmon G. Lees

Australasian Society for Stem Cell Research: Sydney, AU

2023 | Rising Star Award
Distinction
Source: Self-asserted source
Jarmon G. Lees

O'Brien Institute: Melbourne, Victoria, AU

2022 | Shirley Keon Hummingbird Fellowship
Distinction
Source: Self-asserted source
Jarmon G. Lees

St Vincent's Institute of Medical Research: Fitzroy, VIC, AU

2021 | SVI Rising Star Award
Distinction
Source: Self-asserted source
Jarmon G. Lees

Aikenhead Centre for Medical Discovery: Fitzroy, VIC, AU

2021 | Senior Medical Staff Best Oral Prize
Distinction
Source: Self-asserted source
Jarmon G. Lees

Australasian Society for Stem Cell Research: Sydney, AU

2019 | Early Career Researcher Oral Award
Distinction
Source: Self-asserted source
Jarmon G. Lees

Funding (20)

Advancing new therapies for Friedreich ataxia heart disease (Ideas grant)

2024-01 to 2027-01 | Grant
National Health and Medical Research Council (ACT, ACT, AU)
GRANT_NUMBER:

2028004
Source: Self-asserted source
Jarmon G. Lees

Restoring metabolic flexibility as a therapeutic strategy for diabetic heart disease

2024-01 to 2024-12 | Grant
St Vincent's Hospital Melbourne (Research Endowment Fund) (Melbourne, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

EH Flack Fellowship

2023-09 to 2026-09 | Salary award
THE MARIAN AND E.H. FLACK TRUST (Melbourne, Victoria, AU)
Source: Self-asserted source
Jarmon G. Lees

MEG3 and TRIM4 as novel therapeutic targets for vascular dysfunction in Friedreich ataxia

2023-03 to 2024-03 | Grant
National Ataxia Foundation (USA) (Minneapolis, Minesota, US)
Source: Self-asserted source
Jarmon G. Lees

Repurposing approved drugs for Friedreich’s ataxia heart disease (MRFF; Relinquished)

2023-01 to 2025-12 | Grant
Medical Research Future Fund (ACT, ACT, AU)
GRANT_NUMBER:

2023474
Source: Self-asserted source
Jarmon G. Lees

Repurposing Clinical Grade Medications for Treatment of Friedreich Ataxia Heart Disease (MRFF)

2023-01 to 2025-12 | Grant
Medical Research Future Fund (ACT, ACT, AU)
GRANT_NUMBER:

2022018
Source: Self-asserted source
Jarmon G. Lees

Mitochondrial-targeted therapies to limit the structural and functional changes in diabetic cardiomyopathy

2023-01 to 2024-01 | Grant
Diabetes Australia (Canberra, Australian Capital Territory, AU)
Source: Self-asserted source
Jarmon G. Lees

Targeting MEG3 for cardiac repair in Friedreich ataxia

2023-01 to 2024-01 | Award
St Vincent's Institute of Medical Research (Fitzroy, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Testing new treatments for heart attack using human cardiac organoids

2023-01 to 2024-01 | Award
Sir Edward 'Weary' Dunlop Medical Research Foundation (Heidelberg West, AU)
Source: Self-asserted source
Jarmon G. Lees

Cardio-oncology in a dish: Microfluidic organoids-on-a-chip to study chemotherapy-related heart injury and for novel drug discovery

2023-01 to 2023-12 | Grant
St Vincent's Hospital Melbourne (Research Endowment Fund) (Melbourne, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Novel SMART AAV vectors for gene therapy for Friedreich's Ataxia (MRFF)

2022-01 to 2025-12 | Grant
Medical Research Future Fund (ACT, ACT, AU)
GRANT_NUMBER:

2007421
Source: Self-asserted source
Jarmon G. Lees

Shirley Keon Hummingbirds Fellowship

2022-01 to 2023-12 | Salary award
O'Brien Foundation (Fitzroy, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Investigating sympathetic nervous dysregulation in the pathogenesis of the cardiomyopathy of Friedreich’s ataxia

2021-01 to 2022-12 | Grant
Friedreich Ataxia Research Alliance (USA) (PA, PA, US)
Source: Self-asserted source
Jarmon G. Lees

Boosting NAD+ to improve metabolism and treat diabetic heart disease

2021-01 to 2021-12 | Grant
St Vincent's Institute of Medical Research (Fitzroy, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Drp1 inhibitors: a new class of drug with cardioprotective and anitcancer dual therapeutic properties

2021-01 to 2021-12 | Grant
St Vincent's Hospital Melbourne (Research Endowment Fund) (Melbourne, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Beating human hearts with a nervous system

2019-01 to 2019-12 | Grant
Cass Foundation (VIC, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Engineering human cardiac organoids with an autonomic nervous system

2019-01 to 2019-12 | Grant
St Vincent's Hospital Melbourne (Research Endowment Fund) (Melbourne, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Investigating vascular disease in Friedreich’s ataxia with human stem cells

2019-01 to 2019-12 | Grant
National Ataxia Foundation (USA) (Minneapolis, Minesota, US)
Source: Self-asserted source
Jarmon G. Lees

Probing the metabolome of human pluripotent stem cells

2016-01 to 2016-12 | Grant
University of Melbourne (VIC, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Micro-electrode array analysis of neurons derived from human pluripotent stem cells

2014-01 to 2014-12 | Grant
University of Melbourne (VIC, VIC, AU)
Source: Self-asserted source
Jarmon G. Lees

Works (36)

Omaveloxolone for the Treatment of Friedreich Ataxia: Efficacy, Safety, and Future Perspectives

Movement Disorders
2025-02 | Journal article
DOI: 10.1002/mds.30070
Contributors: Saba Naghipour; Louise A. Corben; Amy J. Hulme; Mirella Dottori; Martin B. Delatycki; Jarmon G. Lees; Shiang Y. Lim
Source: check_circle
Crossref

Real-time electro-mechanical profiling of dynamically beating human cardiac organoids by coupling resistive skins with microelectrode arrays

Biosensors and Bioelectronics
2025-01 | Journal article
DOI: 10.1016/j.bios.2024.116752
Contributors: Jialiang Yin; Jarmon G. Lees; Shu Gong; John Tan Nguyen; Ren Jie Phang; Qianqian Shi; Yifeng Huang; Anne M. Kong; Jennifer M. Dyson; Shiang Y. Lim et al.
Source: check_circle
Crossref

NOS3 regulates angiogenic potential of human induced pluripotent stem cell-derived endothelial cells

Biochemistry and Biophysics Reports
2024-12 | Journal article
DOI: 10.1016/j.bbrep.2024.101876
Contributors: Anne M. Kong; Zulhusni A. Idris; Daniel Urrutia-Cabrera; Jarmon G. Lees; Ren Jie Phang; Geraldine M. Mitchell; Raymond C.B. Wong; Shiang Y. Lim
Source: check_circle
Crossref

Cardiomyocyte intercellular signalling increases oxidative stress and reprograms the global‐ and phospho‐proteome of cardiac fibroblasts

Journal of Extracellular Biology
2023-11-30 | Journal article
DOI: 10.1002/jex2.125
Part of ISSN: 2768-2811
Contributors: Bethany Claridge; Alin Rai; Jarmon G. Lees; Haoyun Fang; Shiang Y. Lim; David Greening
Source: Self-asserted source
Jarmon G. Lees via Crossref Metadata Search

Mini hearts to fight Friedreich ataxia

Freight on Board fundraiser for Friedreich ataxia
2023-08-25 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Patient-specific iPSCs reveal vascular dysfunction in Friedreich ataxia

71st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand & the International Society of Heart Research
2023-08-04 | Conference abstract
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy

Cardiovascular Research
2023-05-02 | Journal article
DOI: 10.1093/cvr/cvac049
Contributors: Ren Jie Phang; Rebecca H Ritchie; Derek J Hausenloy; Jarmon G Lees; Shiang Y Lim
Source: check_circle
Crossref

Human iPSC-derived vascularised and innervated cardiac organoids for modelling heart disease in a dish

Drug Discovery Biology (DDB) series, Monash University
2023-03-06 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells

Aging
2023-02-16 | Journal article
DOI: 10.18632/aging.204522
Part of ISSN: 1945-4589
Contributors: Tu Nguyen; Daniel Urrutia-Cabrera; Luozixian Wang; Jarmon G. Lees; Jiang-Hui Wang; Sandy S.C. Hung; Alex W. Hewitt; Thomas L. Edwards; Sam McLenachan; Fred K. Chen et al.
Source: Self-asserted source
Jarmon G. Lees via Crossref Metadata Search

Development of a CRISPRi Human Retinal Pigmented Epithelium Model for Functional Study of Age-Related Macular Degeneration Genes

International Journal of Molecular Sciences
2023-02-08 | Journal article
DOI: 10.3390/ijms24043417
Contributors: Jiang-Hui Wang; Daniel Urrutia-Cabrera; Jarmon G. Lees; Santiago Mesa Mora; Tu Nguyen; Sandy S. C. Hung; Alex W. Hewitt; Shiang Y. Lim; Thomas L. Edwards; Raymond C. B. Wong
Source: check_circle
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Mitochondrial Dynamin-Related Protein Drp1: a New Player in Cardio-oncology

Current Oncology Reports
2022-12 | Journal article
DOI: 10.1007/s11912-022-01333-w
Contributors: Yali Deng; Doan T. M. Ngo; Jessica K. Holien; Jarmon G. Lees; Shiang Y. Lim
Source: check_circle
Crossref

A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly

Nature Communications
2022-11-25 | Journal article
DOI: 10.1038/s41467-022-34860-y
Contributors: Quanxia Lyu; Shu Gong; Jarmon G. Lees; Jialiang Yin; Lim Wei Yap; Anne M. Kong; Qianqian Shi; Runfang Fu; Qiang Zhu; Ash Dyer et al.
Source: check_circle
Crossref

Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair

International Journal of Molecular Sciences
2022-11-18 | Journal article
DOI: 10.3390/ijms232214334
Contributors: Jonathan Lozano; Alin Rai; Jarmon G. Lees; Haoyun Fang; Bethany Claridge; Shiang Y. Lim; David W. Greening
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Restoring blood flow to the heart in Friedreich ataxia

International Congress for Ataxia Research
2022-11-04 | Conference abstract
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Patient-specific iPSCs reveal vascular dysfunction in Friedreich’s Ataxia

International Congress for Ataxia Research
2022-11-03 | Conference abstract
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma

Cell Genomics
2022-06 | Journal article
DOI: 10.1016/j.xgen.2022.100142
Contributors: Maciej Daniszewski; Anne Senabouth; Helena H. Liang; Xikun Han; Grace E. Lidgerwood; Damián Hernández; Priyadharshini Sivakumaran; Jordan E. Clarke; Shiang Y. Lim; Jarmon G. Lees et al.
Source: check_circle
Crossref

Getting to the heart of the matter in Friedreich ataxia

Friedreich ataxia Patient and Family Information Forum
2022-02-24 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Pathological phenotypes of cardiomyocytes, vascular cells and autonomic neurons derived from Friedreich ataxia-iPSCs

Friedreich Ataxia Research Alliance Forum (USA)
2022-02-16 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Cellular pathophysiology of Friedreich's ataxia cardiomyopathy

International Journal of Cardiology
2022-01 | Journal article
DOI: 10.1016/j.ijcard.2021.11.033
Part of ISSN: 0167-5273
Contributors: Jarmon G. Lees; Marek Napierala; Alice Pébay; Mirella Dottori; Shiang Y. Lim
Source: Self-asserted source
Jarmon G. Lees via Crossref Metadata Search

Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart

Cardiovascular Research
2022-01-07 | Journal article
DOI: 10.1093/cvr/cvab043
Contributors: Darnel Prakoso; Shiang Y Lim; Jeffrey R Erickson; Rachel S Wallace; Jarmon G Lees; Mitchel Tate; Helen Kiriazis; Daniel G Donner; Darren C Henstridge; Jonathan R Davey et al.
Source: check_circle
Crossref

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

Cardiovascular Research
2022-01-07 | Journal article
DOI: 10.1093/cvr/cvaa343
Contributors: Siavash Beikoghli Kalkhoran; Janos Kriston-Vizi; Sauri Hernandez-Resendiz; Gustavo E Crespo-Avilan; Ayeshah A Rosdah; Jarmon G Lees; Joana Rodrigues Simoes Da Costa; Naomi X Y Ling; Jessica K Holien; Parisa Samangouei et al.
Source: check_circle
Crossref

Using organoids to study diabetic cardiomyopathy

Aikenhead Centre for Medical Discovery (ACMD) Research Week (NSW)
2021-10-19 | Conference abstract
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Stem cell metabolism: from embryonic development to stem cell differentiation

Conditioning Medicine
2021-06-08 | Journal article
Contributors: Jarmon G. Lees; Shiang Y Lim; David K Gardner; Alexandra J Harvey
Source: Self-asserted source
Jarmon G. Lees

Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction

Cardiovascular Research
2021-02-22 | Journal article
DOI: 10.1093/cvr/cvaa088
Contributors: Andrew R Kompa; David W Greening; Anne M Kong; Paul J McMillan; Haoyun Fang; Ritika Saxena; Raymond C B Wong; Jarmon G Lees; Priyadharshini Sivakumaran; Andrew E Newcomb et al.
Source: check_circle
Crossref

Exploring heart disease in Friedreich ataxia

Friedreich ataxia Research Association Australia Patient Information Forum
2020-11-25 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Heart disease in a dish: human iPSC-derived multicellular cardiac organoids

Gibco™ 5 Days of Stem Cells Virtual Event
2020-10-12 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Human iPSC-derived vascularised and innervated cardiac organoids for modelling heart diseases in a dish

International Society for Heart Research (ISHR) Asia-Pacific Cardiovascular Webinar Series
2020-07-01 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes

Particle and Fibre Toxicology
2020-05-07 | Journal article
DOI: 10.1186/s12989-020-00346-2
Part of ISSN: 1743-8977
Contributors: Omar Lozano; Christian Silva-Platas; Héctor Chapoy-Villanueva; Baruc E. Pérez; Jarmon G. Lees; Chrishan J. A. Ramachandra; Flavio F. Contreras-Torres; Anay Lázaro-Alfaro; Estefanía Luna-Figueroa; Judith Bernal-Ramírez et al.
Source: Self-asserted source
Jarmon G. Lees via Crossref Metadata Search

Nicotinamide adenine dinucleotide induces a bivalent metabolism and maintains pluripotency in human embryonic stem cells

Stem Cells
2020-05-01 | Journal article
DOI: 10.1002/stem.3152
Contributors: Jarmon G. Lees; David K. Gardner; Alexandra J. Harvey
Source: check_circle
Crossref

Mitochondrial Fusion by M1 Promotes Embryoid Body Cardiac Differentiation of Human Pluripotent Stem Cells

Stem Cells International
2019-09-19 | Journal article
DOI: 10.1155/2019/6380135
Contributors: Jarmon G. Lees; Anne M. Kong; Yi C. Chen; Priyadharshini Sivakumaran; Damián Hernández; Alice Pébay; Alexandra J. Harvey; David K. Gardner; Shiang Y. Lim
Source: check_circle
Crossref

Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle.

Acta biomaterialia
2019-05-30 | Journal article
DOI: 10.1016/j.actbio.2019.05.067
PMID: 31152943
Source: Self-asserted source
Jarmon G. Lees

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

Stem Cells International
2019-05-19 | Journal article
DOI: 10.1155/2019/8195614
Contributors: Jarmon G. Lees; Timothy S. Cliff; Amanda Gammilonghi; James G. Ryall; Stephen Dalton; David K. Gardner; Alexandra J. Harvey
Source: check_circle
Crossref

Taking stem cells into the 3rd dimension

FameLab
2019-03-27 | Lecture
Contributors: Jarmon G. Lees
Source: Self-asserted source
Jarmon G. Lees

Mitochondrial and glycolytic remodeling during nascent neural differentiation of human pluripotent stem cells

Development
2018-10-15 | Journal article
DOI: 10.1242/dev.168997
Contributors: Jarmon G. Lees; David K. Gardner; Alexandra J. Harvey
Source: check_circle
Crossref
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Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

Stem Cells International
2017 | Journal article
DOI: 10.1155/2017/2874283
Part of ISSN: 1687-966X
Contributors: Jarmon G. Lees; David K. Gardner; Alexandra J. Harvey
Source: Self-asserted source
Jarmon G. Lees via Crossref Metadata Search
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Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen

REPRODUCTION
2015-10 | Journal article
DOI: 10.1530/rep-14-0633
Part of ISSN: 1470-1626
Contributors: Jarmon G Lees; Joy Rathjen; John R Sheedy; David K Gardner; Alexandra J Harvey
Source: Self-asserted source
Jarmon G. Lees via Crossref Metadata Search
grade
Preferred source (of 2)‎

Peer review (4 reviews for 3 publications/grants)

Review activity for Acta biomaterialia. (1)
Review activity for Cardiovascular research. (2)
Review activity for Journal of Molecular and Cellular Cardiology. (1)
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