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Activities

Employment (3)

The University of Queensland: Brisbane, Queensland, AU

2015 to present | Lab Head (Institute for Molecular Bioscience)
Employment
Source: Self-asserted source
Nathan Palpant

University of Washington: Seattle, Washington, US

2014 to 2015 | Acting Instructor (Pathology)
Employment
Source: Self-asserted source
Nathan Palpant

University of Washington: Seattle, Washington, US

2009 to 2014 | Postdoctoral Research Fellow (Pathology)
Employment
Source: Self-asserted source
Nathan Palpant

Education and qualifications (2)

University of Michigan: Ann Arbor, Michigan, US

2004 to 2009 | PhD (Molecular and Integrative Physiology)
Education
Source: Self-asserted source
Nathan Palpant

Whitworth University: Spokane, Washington, US

1997 to 2001 | BS (Biology)
Education
Source: Self-asserted source
Nathan Palpant

Works (50 of 79)

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TRIAGE: an R package for regulatory gene analysis

Briefings in Bioinformatics
2024-11-22 | Journal article
Contributors: Qiongyi Zhao; Woo Jun Shim; Yuliangzi Sun; Enakshi Sinniah; Sophie Shen; Mikael Boden; Nathan J Palpant
Source: check_circle
Crossref

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

2024-09-27 | Preprint
Contributors: Nathan Palpant; Yuanzhao Cao; Woo Jun Shim; James Hudson; Shaine Chenxin Bao; Sumedha Negi; Chen Fang; Chris Siu Yeung Chow
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Crossref

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

Toxicon: X
2024-03 | Journal article
Part of ISSN: 2590-1710
Contributors: Simon Kramer; Charan Kotapati; Yuanzhao Cao; Bryan G. Fry; Nathan J. Palpant; Glenn F. King; Fernanda C. Cardoso
Source: Self-asserted source
Nathan Palpant

How the Australian Functional Genomics Network (AFGN) contributes to improved patient care

Pathology
2024-02 | Journal article
Part of ISSN: 0031-3025
Contributors: Hamish S. Scott; Ebony Matotek; Tessa Mattiske; Robert J. Bryson-Richardson; Ian Smyth; Jozef Gecz; John Christodoulou; Nathan Palpant; Kelly Smith; Coral Warr et al.
Source: Self-asserted source
Nathan Palpant

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

Developmental Cell
2024-02 | Journal article | Author
Part of ISSN: 1534-5807
Contributors: Zhixuan Wu; Sophie Shen; Dalia Mizikovsky; Yuanzhao Cao; Marina Naval-Sanchez; Siew Zhuan Tan; Yanina D. Alvarez; Yuliangzi Sun; Xiaoli Chen; Qiongyi Zhao et al.
Source: Self-asserted source
Nathan Palpant

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Nature Cardiovascular Research
2024-02-06 | Journal article | Author
Part of ISSN: 2731-0590
Contributors: Dinesh Selvakumar; Zoe E. Clayton; Andrew Prowse; Steve Dingwall; Sul Ki Kim; Leila Reyes; Jacob George; Haisam Shah; Siqi Chen; Halina H. L. Leung et al.
Source: Self-asserted source
Nathan Palpant
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HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

Developmental Cell
2024-01 | Journal article | Author
Part of ISSN: 1534-5807
Contributors: Clayton E. Friedman; Seth W. Cheetham; Sumedha Negi; Richard J. Mills; Masahito Ogawa; Meredith A. Redd; Han Sheng Chiu; Sophie Shen; Yuliangzi Sun; Dalia Mizikovsky et al.
Source: Self-asserted source
Nathan Palpant
grade
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Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation

Stem Cell Reports
2023 | Journal article
Contributors: Alavattam, Kris G.; Mitzelfelt, Katie A.; Bonora, Giancarlo; Fields, Paul A.; Yang, Xiulan; Chiu, Han Sheng; Pabon, Lil; Bertero, Alessandro; Palpant, Nathan J.; Noble, William S. et al.
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PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction

JACC: Basic to Translational Science
2023 | Journal article
Contributors: Hume, Robert D.; Deshmukh, Tejas; Doan, Tram; Shim, Woo Jun; Kanagalingam, Shaan; Tallapragada, Vikram; Rashid, Fairooj; Marcuello, Maria; Blessing, Daniel; Selvakumar, Dinesh et al.
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The ins and outs of cellular pH during cardiac ischemia

Journal of Molecular and Cellular Cardiology
2023 | Journal article
Contributors: Cao, Yuanzhao; Palpant, Nathan J.
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Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

2023-11-20 | Other
Contributors: Nathan Palpant; Meredith A. Redd; Yusuke Yoshikawa; Nemat Khan; Maleeha Waqar; Natalie J. Saez; Jennifer Outhwaite; Jake S. Russell; Amy Hanna; Han S. Chiu et al.
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New Drug Targets and Preclinical Modelling Recommendations for Treating Acute Myocardial Infarction

Heart, Lung and Circulation
2023-07 | Journal article
Contributors: Yuanzhao Cao; Meredith A. Redd; Chen Fang; Dalia Mizikovsky; Xichun Li; Peter S. Macdonald; Glenn F. King; Nathan J. Palpant
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Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity

Nucleic Acids Research
2023-06-23 | Journal article | Author
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Yuliangzi Sun; Woo Jun Shim; Sophie Shen; Enakshi Sinniah; Duy Pham; Zezhuo Su; Dalia Mizikovsky; Melanie D White; Joshua W K Ho; Quan Nguyen et al.
Source: Self-asserted source
Nathan Palpant
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A village in a dish model system for population-scale hiPSC studies

Nature Communications
2023-06-09 | Journal article | Author
Part of ISSN: 2041-1723
Contributors: Drew Neavin; Angela M. Steinmann; Nona Farbehi; Han Sheng Chiu; Maciej Daniszewski; Himanshi Arora; Yasmin Bermudez; Cátia Moutinho; Chia-Ling Chan; Monique Bax et al.
Source: Self-asserted source
Nathan Palpant
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Vascular cells improve functionality of human cardiac organoids

Cell Reports
2023-05 | Journal article
Part of ISSN: 2211-1247
Contributors: Holly K. Voges; Simon R. Foster; Liam Reynolds; Benjamin L. Parker; Lynn Devilée; Gregory A. Quaife-Ryan; Patrick R.J. Fortuna; Ellen Mathieson; Rebecca Fitzsimmons; Mary Lor et al.
Source: Self-asserted source
Nathan Palpant
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An integrated cell barcoding and computational analysis pipeline for scalable analysis of differentiation at single-cell resolution

BioRxiv
2022 | Journal article
Contributors: Shen, S.; Werner, T.; Sun, Y.L.; Shim, W. J.; Lukowski, S.; Andersen, S.; Chiu, H. S.; Xia, D.; Chen, X.L.; Pham, D. et al.
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Defining the Fetal Gene Program at Single-Cell Resolution in Pediatric Dilated Cardiomyopathy

Circulation
2022 | Journal article
Contributors: Mehdiabadi, Neda R. R.; Sim, Choon Boon; Phipson, Belinda; Kalathur, Ravi K. R.; Sun, Yuliangzi; Vivien, Celine J. J.; ter Huurne, Menno; Piers, Adam T. T.; Hudson, James E. E.; Oshlack, Alicia et al.
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Organisation of gene programs revealed by unsupervised analysis of diverse gene-trait associations

BioRxiv
2022 | Journal article
Contributors: Mizikovsky, D.; Sanchez, Marina Naval; Nefzger, C. M.; Partida, Gabriel Cuellar; Palpant, Nathan J.
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Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1-3 in mesendoderm cell differentiation

Cell Reports
2022 | Journal article
Contributors: Sinniah, Enakshi; Wu, Zhixuan; Shen, Sophie; Naval-Sanchez, Marina; Chen, Xiaoli; Lim, Junxian; Helfer, Abbigail; Iyer, Abishek; Tng, Jiahui; Lucke, Andrew J. et al.
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A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification

2022-12-16 | Other
Contributors: Thierry Pedrazzini; Nathan Palpant; Francesca Rochais; Panagiotis Chouvardas
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Don’t Turn Off the Tap! The Importance of Discovery Science to the Australian Cardiovascular Sector and Improving Clinical Outcomes Into the Future

Heart, Lung and Circulation
2022-10 | Journal article
Contributors: Christina A. Bursill; Nicola J. Smith; Nathan Palpant; Isabella Tan; Margaret Sunde; Richard P. Harvey; Benjamin Lewis; Gemma A. Figtree; Jamie I. Vandenberg
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Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations

Nucleic Acids Research
2022-08-26 | Journal article
Contributors: Dalia Mizikovsky; Marina Naval Sanchez; Christian M Nefzger; Gabriel Cuellar Partida; Nathan J Palpant
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Crossref
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Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation

2022-04-16 | Preprint
Contributors: Kris G Alavattam; Katie A Mitzelfelt; Giancarlo Bonora; Paul A Fields; Xiulan Yang; Han Sheng Chiu; Lil Pabon; Alessandro Bertero; Nathan J Palpant; William S Noble et al.
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Crossref

<i>Elp2</i> mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype

Nature Communications
2021 | Journal article
Contributors: Kojic, Marija; Gawda, Tomasz; Gaik, Monika; Begg, Alexander; Salerno-Kochan, Anna; Kurniawan, Nyoman D.; Jones, Alun; Drozdzyk, Katarzyna; Koscielniak, Anna; Chramiec-Glabik, Andrzej et al.
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Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

The Journal of Cell Biology
2021 | Journal article
Contributors: Lo, Harriet P.; Lim, Ye-Wheen; Xiong, Zherui; Martel, Nick; Ferguson, Charles; Ariotti, Nicholas; Giacomotto, Jean; Rae, James; Floetenmeyer, Matthias; Moradi, Shayli Varasteh et al.
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scGPS: Determining Cell States and Global Fate Potential of Subpopulations

Frontiers in Genetics
2021 | Journal article
Contributors: Thompson, Michael; Matsumoto, Maika; Ma, Tianqi; Senabouth, Anne; Palpant, Nathan J.; Powell, Joseph E.; Quan Nguyen
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Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury (vol 144, pg 947, 2021)

Circulation
2021 | Journal article
Contributors: Redd, Meredith A.; Scheuer, Sarah E.; Saez, Natalie J.; Yoshikawa, Yusuke; Chiu, Han Sheng; Gao, Ling; Hicks, Mark; Villanueva, Jeanette E.; Joshi, Yashutosh; Chow, Chun Yuen et al.
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Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

Circulation
2021 | Journal article
Contributors: Redd, Meredith A.; Scheuer, Sarah E.; Saez, Natalie J.; Yoshikawa, Yusuke; Chiu, Han Sheng; Gao, Ling; Hicks, Mark; Villanueva, Jeanette E.; Joshi, Yashutosh; Chow, Chun Yuen et al.
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Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation

Trends in Molecular Medicine
2021-10 | Journal article
Contributors: Sophie Shen; Yuliangzi Sun; Maika Matsumoto; Woo Jun Shim; Sean B. Wilson; Melissa H. Little; Joseph Powell; Quan Nguyen; Nathan J. Palpant
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Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells.

Genome biology
2021-03-05 | Journal article
Source: Self-asserted source
Nathan Palpant
grade
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A SPIDER-VENOM PEPTIDE FOR PREVENTING ISCHEMIC INJURIES OF THJE HEART: APPLICATION TO HEART TRANSPLANT AND MYOCARDIAL INFARCTION

Toxicon
2020 | Journal article
Contributors: Redd, M. A.; Scheuer, S. E.; Saez, N. J.; Macdonald, P. S.; Palpant, N. J.; King, G. F.
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Combined Mesenchymal Stromal Cell Therapy and Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome. A Randomized Controlled Trial in Sheep

American journal of respiratory and critical care medicine
2020 | Journal article
EID:

2-s2.0-85089129264

Part of ISBN:

15354970

Contributors: Millar, J.E.; Bartnikowski, N.; Passmore, M.R.; Obonyo, N.G.; Malfertheiner, M.V.; von Bahr, V.; Redd, M.A.; See Hoe, L.; Ki, K.K.; Pedersen, S. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity.

Cell systems
2020-12-04 | Journal article
Source: Self-asserted source
Nathan Palpant
grade
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Genotype-free demultiplexing of pooled single-cell RNA-seq

Genome Biology
2019 | Journal article
EID:

2-s2.0-85077007816

Part of ISBN:

1474760X 14747596

Contributors: Xu, J.; Falconer, C.; Nguyen, Q.; Crawford, J.; McKinnon, B.D.; Mortlock, S.; Senabouth, A.; Andersen, S.; Chiu, H.S.; Jiang, L. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells

iScience
2018 | Journal article
EID:

2-s2.0-85066304839

Part of ISBN:

25890042

Contributors: Hofsteen, P.; Robitaille, A.M.; Strash, N.; Palpant, N.; Moon, R.T.; Pabon, L.; Murry, C.E.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Evidence for minimal cardiogenic potential of Sca-1 positive cells in the adult mouse heart

BioRxiv
2018 | Journal article
Contributors: Neidig, L. E.; Weinberger, F.; Palpant, N. J.; Mignone, J.; Martinson, A. M.; Sorensen, D.; Bender, I.; Nemoto, N.; Reinecke, H.; Pabon, L. et al.
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Evidence for minimal cardiogenic potential of stem cell antigen 1-positive cells in the adult mouse heart

Circulation
2018 | Journal article
EID:

2-s2.0-85058879716

Contributors: Neidig, L.E.; Weinberger, F.; Palpant, N.J.; Mignone, J.; Martinson, A.M.; Sorensen, D.W.; Bender, I.; Nemoto, N.; Reinecke, H.; Pabon, L. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Genetic lineage tracing of Sca-1+ cells reveals endothelial but not myogenic contribution to the murine heart

Circulation
2018 | Journal article
EID:

2-s2.0-85057126786

Source: Self-asserted source
Nathan Palpant
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Genetic networks modulating cell fate specification and contributing to cardiac disease risk in hiPSC-derived cardiomyocytes at single cell resolution

Human Genomics
2018 | Journal article
Contributors: Nguyen, Quan H.; Lukowski, Samuel W.; Chiu, Han S.; Friedman, Clayton E.; Senabouth, Anne; Crowhurst, Liam; Bruxner, Timothy J. C.; Christ, Angelika N.; Hudson, James; Ding, Jun et al.
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Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal

Cell Cycle
2018 | Journal article
EID:

2-s2.0-85045044149

Contributors: Ferreccio, A.; Mathieu, J.; Detraux, D.; Somasundaram, L.; Cavanaugh, C.; Sopher, B.; Fischer, K.; Bello, T.; M. Hussein, A.; Levy, S. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations

Genome Research
2018 | Journal article
EID:

2-s2.0-85049237664

Contributors: Nguyen, Q.H.; Lukowski, S.W.; Chiu, H.S.; Senabouth, A.; Bruxner, T.J.C.; Christ, A.N.; Palpant, N.J.; Powell, J.E.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation

Cell Stem Cell
2018 | Journal article
EID:

2-s2.0-85054085289

Contributors: Friedman, C.E.; Nguyen, Q.; Lukowski, S.W.; Helfer, A.; Chiu, H.S.; Miklas, J.; Levy, S.; Suo, S.; Han, J.-D.J.; Osteil, P. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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A transcribed enhancer dictates mesendoderm specification in pluripotency

Nature Communications
2017 | Journal article
EID:

2-s2.0-85035774964

Contributors: Alexanian, M.; Maric, D.; Jenkinson, S.P.; Mina, M.; Friedman, C.E.; Ting, C.-C.; Micheletti, R.; Plaisance, I.; Nemir, M.; Maison, D. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis

Cell Reports
2017 | Journal article
EID:

2-s2.0-85027867517

Contributors: Palpant, N.J.; Wang, Y.; Hadland, B.; Zaunbrecher, R.J.; Redd, M.; Jones, D.; Pabon, L.; Jain, R.; Epstein, J.; Ruzzo, W.L. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Epigenetic and transcriptional analysis of mesoderm progenitor cells identifies HOPX as a novel regulator of hemogenic endothelium

Mechanisms of Development
2017 | Journal article
Contributors: Palpant, Nathan; Wang, Yuliang; Hadland, Brandon; Zaunbrecher, Rebecca; Redd, Meredith; Pabon, Lil; Jain, Rajan; Epstein, Jonathan; Zheng, Ying; Bernstein, Irwin et al.
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Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells

Nature Protocols
2017 | Journal article
EID:

2-s2.0-85000786709

Contributors: Palpant, N.J.; Pabon, L.; Friedman, C.E.; Roberts, M.; Hadland, B.; Zaunbrecher, R.J.; Bernstein, I.; Zheng, Y.; Murry, C.E.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta

eLife
2017 | Journal article
EID:

2-s2.0-85018461920

Contributors: Zamir, L.; Singh, R.; Nathan, E.; Patrick, R.; Yifa, O.; Yahalom-Ronen, Y.; Arraf, A.A.; Schultheiss, T.M.; Suo, S.; Han, J.-D.J. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Science Signaling
2017 | Journal article
EID:

2-s2.0-85037630978

Contributors: Muttenthaler, M.; Andersson, Å.; Vetter, I.; Menon, R.; Busnelli, M.; Ragnarsson, L.; Bergmayr, C.; Arrowsmith, S.; Deuis, J.R.; Chiu, H.S. et al.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development (vol 16, 126, 2016)

Genome Biology
2016 | Journal article
Contributors: Szabo, Linda; Morey, Robert; Palpant, Nathan J.; Wang, Peter L.; Afari, Nastaran; Jiang, Chuan; Parast, Mana M.; Murry, Charles E.; Laurent, Louise C.; Salzman, Julia
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The developmental origins and lineage contributions of endocardial endothelium

Biochimica et Biophysica Acta - Molecular Cell Research
2016 | Journal article
EID:

2-s2.0-84957684902

Contributors: Nakano, A.; Nakano, H.; Smith, K.A.; Palpant, N.J.
Source: Self-asserted source
Nathan Palpant via Scopus - Elsevier
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Page 1 of 2

Peer review (19 reviews for 12 publications/grants)

Review activity for Biophysical reviews. (1)
Review activity for Cell genomics. (2)
Review activity for Cell stem cell. (4)
Review activity for Development. (1)
Review activity for Developmental cell. (2)
Review activity for Journal of Molecular and Cellular Cardiology. (2)
Review activity for Nature (1)
Review activity for Nature cardiovascular research. (2)
Review activity for Nature cell biology (1)
Review activity for Nature communications (1)
Review activity for Nature methods. (1)
Review activity for Stem cells. (1)