Personal information

Human Genetics, Neuroscience, Next Generation Sequencing, Molecular Biology

Biography

I completed my PhD. and one year Post Doc. from prestigious Gyeongsang National University, South Korea in 2011. I have 16 year of teaching and research experience. My area of expertise are human genetics, includes gene structure and organization, gene expression, mutation detection and analysis, bioinformatics, gene therapy and gene editing, cellular and developmental neuroscience etc. My PhD work was based on the effect of ethanol on siRNA-Mediated GABAB1 receptor expression for downstream signaling pathways, apoptotic neurodegeneration, maternal epileptic seizure and role of GABABR1 receptor expression in early development of pre/postnatal rat brain.
Currently I am actively involved in Neurogenetic research program at CEGMR, working on rare, ulta rare and common neurologic disorders including Epilepsy, Autism, Mental retardation, Microcephaly and other neurodegenerative and neurodevelopmental disorders of Saudi Arabia. I am using microarray platform for array CGH, CNV/SNP analysis and Next generation technology for expression and whole exome/whole genome and Sanger sequencing analysis for identification of novel genes and mutations from rare genetic disorders in the Saudi Arabia. I have more than 16 years of research experience with more than 150 international peer reviewed article published reputed journals.
My aim of the research is to find novel genes and mutations specially the role of different KIFs genes in neurodegenerative disorders in the Saudi Arabia including Epilepsy, Autism, Alzheimer's intellectual disabilities and mental retardations. In addition, I use Knock-in/Knock-out animal models based on the identification of novel mutations/findings related to epileptic patients, rare genetics disorders for known as well as novel genetic aberrations to utilize them for testing novel therapeutic agents in a targeted therapeutic approach for rare, ultra rare genetic disorder, autism, epilepsy and microcephaly.

Activities

Employment (1)

King Abdulaziz University: Jeddah, Makkah, SA

2011-02-23 to present (CEGMR)
Employment
Source: Self-asserted source
Naseer MI

Education and qualifications (3)

Gyeongsang National University: Jinju, KR

2010-02-10 to 2011-02-10 | Post Doc. (Applied Life Science)
Education
Source: Self-asserted source
Naseer MI

Gyeongsang National University: Jinju, KR

2006-09-01 to 2010-02-15 | Ph.D (Applied Life Science)
Education
Source: Self-asserted source
Naseer MI

Quaid-i-Azam University: Islamabad, PK

2003-09-01 to 2005-06-31 | M.phil (Biochemistry/Molecularbiology)
Education
Source: Self-asserted source
Naseer MI

Professional activities (1)

Center of Excellence in Genomic Medicine Research: Jeddah, SA

2024-04-24 | Best Senior Researcher 2023 (Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah)
Distinction
Source: Self-asserted source
Naseer MI

Funding (18)

Application of advanced high-density array technology for mutational analysis to detect genome-wide copy number variations and single nucleotide polymorphisms in Juvenile Myoclonic Epilepsy from Western Saudi Arabia

Grant
King Abdulaziz City for Science and Technology (KACST) (Riyadh, SA)
Source: Self-asserted source
Naseer MI

Association of SNPs in GC and CYP2R1 with total and directly measured free 25-hydroxyvitamin D in multi-ethnic postmenopausal women in Saudi Arabia

Grant
Deanship of Scientific Research (DSR), King Abdulaziz University(KAU) (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Comprehensive molecular analysis of Kinesin superfamily proteins (KIFs) and their role in neurodegenerative disease model in Saudi Arabia

Grant
KAU HiCi grant 1432/6-1 (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Deciphering the therapeutic importance of IL-33/ST2 axis in colonic inflammation and colon carcinoma using cellular, molecular and systems immunological strategies

Grant
IFPRC-012-141-2020 DSR KAU Institutional (National Challenge Grant) (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Developing Strategies to Dissect the Role of IL-33-ST2-Mast Cell Axis in Allergic Disorders: In Vitro, In Vivo and In Silico Approaches

Grant
King Abdulaziz City for Science and Technology (KACST) (Riyadh, SA)
Source: Self-asserted source
Naseer MI

Exome Analysis Identified Novel Homozygous Splice Site Donor Alteration in NT5C2 Gene in a Saudi Family Associated With Spastic Diplegia Cerebral Palsy, Developmental Delay, and Intellectual Disability

Grant
KiDeanship of Scientific Research (DSR), King Abdulaziz Universityng Abdulaziz University (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Exome sequencing reveled a compound heterozygous mutations in RTTN gene causing developmental delay and primary microcephaly

Grant
King Abdulaziz University- Deanship of Scientific Research (DSR) (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Gene Mapping and Molecular Analysis of Hereditary Nonpolyposis Colorectal Cancer (Lynch Syndrome) in Saudi Arabian population

Grant
King Abdulaziz City for Science and Technology (KACST) (Riyadh, SA)
Source: Self-asserted source
Naseer MI

Identification of novel gene and mutations from Epileptic patients

Grant
KiDeanship of Scientific Research (DSR), King Abdulaziz Universityng Abdulaziz University (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Identification of Novel Genes and mutation in the families having Rare Genetics disorders

Grant
Deanship of scientific research (DSR), King Abdulaziz University (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Innovative Gene Therapy for Primary Microcephaly in Saudi Arabia

Grant
Research and Development Office, Ministry of Education RDO-902 (Riyadh, SA)
Source: Self-asserted source
Naseer MI

Neurogenetics Research Program

Grant
King Salman Center for Disability Research (Riyadh, SA)
Source: Self-asserted source
Naseer MI

Next generation sequencing reveals novel homozygous frameshift in PUS7 and splice acceptor variants in AASS gene leading to intellectual disability, developmental delay, dysmorphic feature and microcephaly

Grant
Deanship of Scientific Research (DSR), King Abdulaziz University(KAU) (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Novel Missense Variant in Heterozygous State in the BRPF1 Gene Leading to Intellectual Developmental Disorder With Dysmorphic Facies and Ptosis

Grant
Deanship of Scientific Research (DSR), King Abdulaziz University(KAU) (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Study of novel gene and mutations from primary Microcephaly in Saudi Arabia using advanced high-density array technology to detect genome-wide copy number variations and single nucleotide polymorphisms

Grant
King Abdulaziz City for Science and Technology` (Riyadh, SA)
Source: Self-asserted source
Naseer MI

Use of Whole Exome Sequencing for Identification of Genetic Variants Related to Growth Hormone Deficiency and Short Stature: Family-Based Study

Grant
KiDeanship of Scientific Research (DSR), King Abdulaziz Universityng Abdulaziz University (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Whole exome sequencing reveals a homozygous nonsense mutation in HEXA gene leading to Tay-Sachs disease in Saudi Family

Grant
King Abdulaziz University- Deanship of Scientific Research (DSR) (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Whole exome sequencing technique to identify of novel genes and mutation from Primary Microcephaly families in Saudi Arabia

Grant
Deanship of Scientific Research (DSR), King Abdulaziz University(KAU) (Jeddah, SA)
Source: Self-asserted source
Naseer MI

Peer review (8 reviews for 4 publications/grants)

Review activity for European journal of medical genetics. (1)
Review activity for Heliyon. (4)
Review activity for PloS one. (2)
Review activity for Progress in neuro-psychopharmacology & biological psychiatry. (1)