Personal information

Orthopedic Surgery, Human Genetics, Congenital Vertebral Malformation
China

Biography

As a physician-scientist, Dr. Wu showed great interest in deciphering the genetic underpins of spinal and related diseases. With the mutual collaboration with a group of physicians, he established a large cohort of scoliosis and associated disorders with specimen bio-bank containing the detailed data of epidemiology, clinical documents, imaging and biological samples (>20,000 DNA samples) etc. He initiated and is now the leading scientist of the Deciphering disorders Involving Scoliosis and COmorbidities (DISCO, http://www.discostudy.org/) project, which uses the genomic approaches to decipher the genetic landscape of scoliosis and associated disorders. What’s more, he is leading a combined group including bioinformatic scientists, geneticists and clinicians, and established an integrated analytic pipeline to interpret the genomic data produced from large scale of humans.
Based on the above resource and infrastructure, Dr. Wu expanded his research area to genome-wide years ago and carried out a number of genetic studies of scoliosis and related disorders. He published the largest cohort of congenital scoliosis, from which one of the most important disease-causing gene (TBX6) of congenital scoliosis and the genetic model of rare null mutations compound with common hypomorphic allele was identified. Dr. Wu has published over 80 original research papers with an IF>400. He is now serving as active members in seven international and domestic groups, such as ICSGDD (International Consortium for Spinal Genetics, Development, and Disease, COA (Chinese Orthopedic Association) and CSOBMR (Chinese Association of Osteoporosis and Bone Mineral Research) etc. He achieved fourteen prizes, including the winner of the first prize of Outstanding Achievement Award in Natural Science from Ministry of Education, and Edward Zhao Orthopaedic Foundation Research Award (the highest prize of Chinese basic research of orthopedics) etc.

Activities

Employment (6)

Peking Union Medical College Hospital: Dongcheng-qu, Beijing, CN

2019-10 to present | Associate chief surgeon (Department of orthopedic surgery)
Employment
Source: Self-asserted source
Nan Wu

Peking Union Medical College, Chinese Academy of Medical Sciences: Beijing, Beijing, CN

2019-05 to present | PI (Tenure-track faculty)
Employment
Source: Self-asserted source
Nan Wu

Baylor College of Medicine: Houston, Texas, US

2018-09 to present | Assistant Professor (Department of Molecular and Human Genetics)
Employment
Source: Self-asserted source
Nan Wu

Baylor College of Medicine: Houston, TX, US

2017-03 to 2018-08 | Postdoc Associate (Department of Molecular and Human Genetics)
Employment
Source: Self-asserted source
Nan Wu

Peking Union Medical College Hospital: Dongcheng-qu, Beijing, CN

2016-01 to 2017-03 | Attending physician (Department of orthopedic surgery)
Employment
Source: Self-asserted source
Nan Wu

Peking Union Medical College Hospital: Dongcheng-qu, Beijing, CN

2012-08 to 2015-12 | Resident (Department of surgery)
Employment
Source: Self-asserted source
Nan Wu

Professional activities (11)

Scoliosis Research Society: International, CN

2020-03-01 to present | Candidate Fellow/Global Outreach Committee
Membership
Source: Self-asserted source
Nan Wu

Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Sciences: Beijing, Beijing, CN

2020-01 to present | Chief director
Service
Source: Self-asserted source
Nan Wu

Genetics Society of China: NA, CN

2019-10 to present | Youth committee member
Membership
Source: Self-asserted source
Nan Wu

International Consortium for Spinal Genetics, Development, and Disease (ICSGDD): NA, CN

2019-09 to present | Secretary (NA)
Service
Source: Self-asserted source
Nan Wu

Basic Research Group, Branch of Geriatric Orthopaedics, Chinese Society: NA, CN

2019-09 to present | Committee member
Membership
Source: Self-asserted source
Nan Wu

Branch of Prevention of Bone and Joint Deformity and Disability, Chinese Association of Orthopaedic Surgeons: NA, CN

2019-07 to present | Committee member
Membership
Source: Self-asserted source
Nan Wu

Chinese Association of Osteoporosis and Bone Mineral Research (CSOBMR): NA, CN

2019-05 to present | National youth committee member
Membership
Source: Self-asserted source
Nan Wu

Branch of Prevention and Control for Spinal Diseases Committee, Chinese Preventive Medicine Association: NA, CN

2019-03 to present | Committee member
Membership
Source: Self-asserted source
Nan Wu

Branch of Innovation and Translational Medicine, Chinese Orthopedic Association: N A, CN

2017-11 to present | Youth committee member
Membership
Source: Self-asserted source
Nan Wu

Beijing Key Laboratory for Genetic Research of Skeletal Deformity: Beijing, Beijing, CN

2016-10 to present | Secretary
Service
Source: Self-asserted source
Nan Wu

China Chapter, SICOT (International Society of Orthopaedic Surgery and Traumatology): NA, CN

2015-09 to present | Youth committee member
Membership
Source: Self-asserted source
Nan Wu

Funding (1)

PUMC Nova program

2016 to 2017 | Award
Peking Union Medical College, Chinese Academy of Medical Sciences (Beijing, CN)
Source: Self-asserted source
Nan Wu

Works (50 of 77)

Items per page:
Page 1 of 2

Landscape of Secondary Findings in Chinese Population: A Practice of ACMG SF v3.0 List

Journal of Personalized Medicine
2022-09 | Journal article | Author
Contributors: Yingzhao Huang; Bowen Liu; Jile Shi; Sen Zhao; Kexin Xu; Liying Sun; Na Chen; Wen Tian; Jianguo Zhang; Nan Wu
Source: check_circle
Multidisciplinary Digital Publishing Institute

Perturbations of genes essential for Müllerian duct and Wölffian duct development in Mayer-Rokitansky-Küster-Hauser syndrome

American Journal of Human Genetics
2021 | Journal article
Source: Self-asserted source
Nan Wu

The Mutational Landscape of <i>PTK7</i> in Congenital Scoliosis and Adolescent Idiopathic Scoliosis

Genes
2021-11 | Journal article | Author
Contributors: Zhe Su; Yang Yang; Shengru Wang; Sen Zhao; Hengqiang Zhao; Xiaoxin Li; Yuchen Niu; Deciphering Disorders Involving Scoliosis and COmorbidities (DISCO) Study Group; Guixing Qiu; Zhihong Wu et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Disruptive <i>NADSYN1</i> Variants Implicated in Congenital Vertebral Malformations

Genes
2021-10 | Journal article | Author
Contributors: Jiachen Lin; Lina Zhao; Sen Zhao; Shengjie Li; Zhengye Zhao; Zefu Chen; Zhifa Zheng; Jiashen Shao; Yuchen Niu; Xiaoxin Li et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Novel <i>FGFR1</i> Variants Are Associated with Congenital Scoliosis

Genes
2021-07 | Journal article | Author
Contributors: Shengru Wang; Xiran Chai; Zihui Yan; Sen Zhao; Yang Yang; Xiaoxin Li; Yuchen Niu; Guanfeng Lin; Zhe Su; Zhihong Wu et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

A novel COMP mutation in a Chinese family with multiple epiphyseal dysplasia

BMC Medical Genetics
2020 | Journal article
Source: Self-asserted source
Nan Wu

Clinical characteristics of pediatric synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: the first Chinese case series from a single center

Clinical Rheumatology
2020 | Journal article
Source: Self-asserted source
Nan Wu

Cost-effectiveness analysis of using the TBX6-associated congenital scoliosis risk score (TACScore) in genetic diagnosis of congenital scoliosis

Orphanet Journal of Rare Diseases
2020 | Journal article
Source: Self-asserted source
Nan Wu

Demographic, clinical, and scintigraphic comparison of patients affected by palmoplantar pustulosis and severe acne: a retrospective study

Clinical Rheumatology
2020 | Journal article
Source: Self-asserted source
Nan Wu

Diagnostic yield and clinical impact of exome sequencing in early-onset scoliosis (EOS)

Journal of Medical Genetics
2020 | Journal article
Source: Self-asserted source
Nan Wu

Exome sequencing reveals a novel variant in NFX1 causing intracranial aneurysm in a Chinese family

Journal of NeuroInterventional Surgery
2020 | Journal article
Source: Self-asserted source
Nan Wu

Genetic and molecular mechanism for distinct clinical phenotypes conveyed by allelic truncating mutations implicated in FBN1

Molecular Genetics & Genomic Medicine
2020 | Journal article
Source: Self-asserted source
Nan Wu

Human and mouse studies establish TBX6 in Mendelian CAKUT and as a potential driver of kidney defects associated with the 16p11.2 microdeletion syndrome

Kidney International
2020 | Journal article
Source: Self-asserted source
Nan Wu

Identification of novel FBN1 variations implicated in congenital scoliosis

Journal of Human Genetics
2020 | Journal article
Source: Self-asserted source
Nan Wu

Mutational burden and potential oligogenic model of TBX6-mediated genes in congenital scoliosis

Molecular Genetics & Genomic Medicine
2020 | Journal article
Source: Self-asserted source
Nan Wu

Mutational landscape and genetic signatures of cell-free DNA in tumour-induced osteomalaci

Journal of Cellular and Molecular Medicine
2020 | Journal article
Source: Self-asserted source
Nan Wu

Phenotypic and genetic spectrum of isolated macrodactyly: somatic mosaicism of PIK3CA and AKT1 oncogenic variants

Orphanet Journal of Rare Diseases
2020 | Journal article
Source: Self-asserted source
Nan Wu

Progress and Future Trends in PET/CT and PET/MRI Molecular Imaging Approaches for Breast Cancer

Frontiers in Oncology
2020 | Journal article
Source: Self-asserted source
Nan Wu

TBX6 missense variants expand the mutational spectrum in a non‐Mendelian inheritance disease

Human Mutation
2020 | Journal article
Source: Self-asserted source
Nan Wu

The mutational burden and oligogenic inheritance in Klippel-Feil syndrome

BMC Musculoskeletal Disorders
2020 | Journal article
Source: Self-asserted source
Nan Wu

A novel multiplex fluorescent competitive PCR for copy number variation detection

Genomics
2019 | Journal article
Source: Self-asserted source
Nan Wu

A Recurrent Rare SOX9 Variant (M469V) is Associated with Congenital Vertebral Malformations

Current Gene Therapy
2019 | Journal article
Source: Self-asserted source
Nan Wu

Genetic polymorphisms of PAX1 are functionally associated with different PUMC types of adolescent idiopathic scoliosis in a northern Chinese Han population

Gene
2019 | Journal article
Source: Self-asserted source
Nan Wu
grade
Preferred source (of 2)‎

Increased TBX6 gene dosages induce congenital cervical vertebral malformations in humans and mice

Journal of Medical Genetics
2019 | Journal article
Source: Self-asserted source
Nan Wu
grade
Preferred source (of 2)‎

Serum IgG4 elevation in SAPHO syndrome: does it unmask a disease activity marker?

Clinical and experimental rheumatology
2019 | Journal article
Source: Self-asserted source
Nan Wu

Spinal and sacroiliac involvement in SAPHO syndrome: A single center study of a cohort of 354 patients

Seminars in Arthritis and Rheumatism
2019 | Journal article
Source: Self-asserted source
Nan Wu

TBX6 compound inheritance leads to congenital vertebral malformations in humans and mice

Human Molecular Genetics
2019 | Journal article
Source: Self-asserted source
Nan Wu

TBX6-associated congenital scoliosis (TACS) as a clinically distinguishable subtype of congenital scoliosis: further evidence supporting the compound inheritance and TBX6 gene dosage model

Genetics in Medicine
2019 | Journal article
Source: Self-asserted source
Nan Wu
grade
Preferred source (of 2)‎

The Progress of CRISPR/Cas9-Mediated Gene Editing in Generating Mouse/Zebrafish Models of Human Skeletal Diseases

Computational and Structural Biotechnology Journal
2019 | Journal article
Source: Self-asserted source
Nan Wu

Three patterns of osteoarticular involvement in SAPHO syndrome: a cluster analysis based on whole body bone scintigraphy of 157 patients

Rheumatology
2019 | Journal article
Source: Self-asserted source
Nan Wu

Whole-Genome Methylation Analysis of Phenotype Discordant Monozygotic Twins Reveals Novel Epigenetic Perturbation Contributing to the Pathogenesis of Adolescent Idiopathic Scoliosis

Frontiers in Bioengineering and Biotechnology
2019 | Journal article
Source: Self-asserted source
Nan Wu

A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis

Scientific Reports
2018 | Journal article
Source: Self-asserted source
Nan Wu

An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis

Scientific Reports
2018 | Journal article
Source: Self-asserted source
Nan Wu

F-18 FDG PET/CT in 26 patients with SAPHO syndrome: a new vision of clinical and bone scintigraphy correlation

Journal of Orthopaedic Surgery and Research
2018 | Journal article
Source: Self-asserted source
Nan Wu

Fat Mass and Obesity-Associated (FTO) Gene Polymorphisms Are Associated with Risk of Intervertebral Disc Degeneration in Chinese Han Population: A Case Control Study

Medical Science Monitor
2018 | Journal article
Source: Self-asserted source
Nan Wu

Genetic polymorphisms of GPR126 are functionally associated with PUMC classifications of adolescent idiopathic scoliosis in a Northern Han population

Journal of Cellular and Molecular Medicine
2018 | Journal article
Source: Self-asserted source
Nan Wu

Identification of likely pathogenic and known variants in TSPEAR, LAMB3, BCOR, and WNT10A in four Turkish families with tooth agenesis

Human Genetics
2018 | Journal article
Source: Self-asserted source
Nan Wu

Identification of two novel null variants in CLN8 by targeted next-generation sequencing: first report of a Chinese patient with neuronal ceroid lipofuscinosis due to CLN8 variants

BMC Medical Genetics
2018 | Journal article
Source: Self-asserted source
Nan Wu

Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM)

Journal of Medical Genetics
2018 | Journal article
Source: Self-asserted source
Nan Wu

Phenotypic heterogeneity of intellectual disability in patients with congenital insensitivity to pain with anhidrosis: A case report and literature review

Journal of International Medical Research
2018 | Journal article
Source: Self-asserted source
Nan Wu

Recurrence-Associated Long Non-coding RNA Signature for Determining the Risk of Recurrence in Patients with Colon Cancer

Molecular Therapy - Nucleic Acids
2018 | Journal article
Source: Self-asserted source
Nan Wu

The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease

Human Genetics
2018 | Journal article
Source: Self-asserted source
Nan Wu

Whole-exome sequencing reveals known and novel variants in a cohort of intracranial vertebral–basilar artery dissection (IVAD)

Journal of Human Genetics
2018 | Journal article
Source: Self-asserted source
Nan Wu

Comparative analysis of serum proteome in congenital scoliosis patients with TBX6 haploinsufficiency - a first report pointing to lipid metabolism

J Cell Mol Med
2017 | Journal article
Contributors: Zhu, Q.; Wu, N.; Liu, G.; Zhou, Y.; Liu, S.; Chen, J.; Liu, J.; Zuo, Y.; Liu, Z.; Chen, W. et al.
Source: Self-asserted source
Nan Wu via ResearcherID

Cover Image, Volume 118, Number 10, October 2017

J Cell Biochem
2017 | Journal article
Contributors: Lin, J.; Zhou, Y.; Liu, J.; Chen, J.; Chen, W.; Zhao, S.; Wu, Z.; Wu, N.
Source: Self-asserted source
Nan Wu via ResearcherID

CRISPR/Cas9 in zebrafish: an efficient combination for human genetic diseases modeling

Human Genetics
2017 | Journal article
WOSUID:

WOS:000392030900001

Contributors: Liu, J. Q.; Zhou, Y. Z.; Qi, X. L.; Chen, J.; Chen, W. S.; Qiu, G. X.; Wu, Z. H.; Wu, N.
Source: Self-asserted source
Nan Wu via ResearcherID

Evaluation of a novel poly(amidoamine) with pendant aminobutyl group on the cellular properties of transfected bone marrow mesenchymal stem cells

J Biomed Mater Res A
2017 | Journal article
Contributors: Chen, L.; Long, D.; Huang, S.; Yang, Q.; Hao, J.; Wu, N.; Peng, L.
Source: Self-asserted source
Nan Wu via ResearcherID

Filamin B: The next hotspot in skeletal research?

Journal of Genetics and Genomics
2017 | Journal article
WOSUID:

WOS:000406933500001

Contributors: Xu, Q. M.; Wu, N.; Cui, L. J.; Wu, Z. H.; Qiu, G. X.
Source: Self-asserted source
Nan Wu via ResearcherID

Genetic Polymorphism of LBX1 Is Associated With Adolescent Idiopathic Scoliosis in Northern Chinese Han Population

SPINE
2017 | Journal article
Source: Self-asserted source
Nan Wu
grade
Preferred source (of 2)‎

Molecular therapeutic strategies for FGFR3 gene-related skeletal dysplasia

J Mol Med (Berl)
2017 | Journal article
Contributors: Chen, J.; Liu, J.; Zhou, Y.; Liu, S.; Liu, G.; Zuo, Y.; Wu, Z.; Wu, N.; Qiu, G.
Source: Self-asserted source
Nan Wu via ResearcherID
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Peer review (16 reviews for 10 publications/grants)

Review activity for American journal of human genetics. (2)
Review activity for BMC musculoskeletal disorders (1)
Review activity for BMJ case reports. (1)
Review activity for European journal of pediatrics (1)
Review activity for Genetics in medicine open. (6)
Review activity for Journal of nanobiotechnology (1)
Review activity for Molecular genetics and genomics. (1)
Review activity for Molecular psychiatry. (1)
Review activity for Orphanet journal of rare diseases. (1)
Review activity for Spine deformity. (1)