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Biography
As a physician-scientist, Dr. Wu showed great interest in deciphering the genetic underpins of spinal and related diseases. With the mutual collaboration with a group of physicians, he established a large cohort of scoliosis and associated disorders with specimen bio-bank containing the detailed data of epidemiology, clinical documents, imaging and biological samples (>20,000 DNA samples) etc. He initiated and is now the leading scientist of the Deciphering disorders Involving Scoliosis and COmorbidities (DISCO, http://www.discostudy.org/) project, which uses the genomic approaches to decipher the genetic landscape of scoliosis and associated disorders. What’s more, he is leading a combined group including bioinformatic scientists, geneticists and clinicians, and established an integrated analytic pipeline to interpret the genomic data produced from large scale of humans.
Based on the above resource and infrastructure, Dr. Wu expanded his research area to genome-wide years ago and carried out a number of genetic studies of scoliosis and related disorders. He published the largest cohort of congenital scoliosis, from which one of the most important disease-causing gene (TBX6) of congenital scoliosis and the genetic model of rare null mutations compound with common hypomorphic allele was identified. Dr. Wu has published over 80 original research papers with an IF>400. He is now serving as active members in seven international and domestic groups, such as ICSGDD (International Consortium for Spinal Genetics, Development, and Disease, COA (Chinese Orthopedic Association) and CSOBMR (Chinese Association of Osteoporosis and Bone Mineral Research) etc. He achieved fourteen prizes, including the winner of the first prize of Outstanding Achievement Award in Natural Science from Ministry of Education, and Edward Zhao Orthopaedic Foundation Research Award (the highest prize of Chinese basic research of orthopedics) etc.
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