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Employment (1)

UW Medicine: Seattle, WA, US

1994 to present | Professor (Neurobiology & Biophysics)
Employment
Source: Self-asserted source
Linda Wordeman

Education and qualifications (3)

UCSF Medical Center: San Francisco, CA, US

1993 | Postdoctoral Fellow (Pharmacology)
Education
Source: Self-asserted source
Linda Wordeman

University of California Berkeley UC Data: Berkeley, CA, US

1988 | PhD (Zoology)
Education
Source: Self-asserted source
Linda Wordeman

University of California Berkeley UC Data: Berkeley, CA, US

1982 | BA (Molecular Biology)
Education
Source: Self-asserted source
Linda Wordeman

Professional activities (3)

National Institutes of Health: Bethesda, Maryland, US

2019-01-01 to present | Board of Scientific Counselors (NIBIB)
Service
Source: Self-asserted source
Linda Wordeman

University of Washington: Seattle, WA, US

2015-07-01 to present | Adjunct Professor (Biology)
Invited position
Source: Self-asserted source
Linda Wordeman

John Simon Guggenheim Memorial Foundation: Seattle, WA, US

2009-09-01 | Fellowship
Distinction
Source: Self-asserted source
Linda Wordeman

Works (50 of 98)

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Page 1 of 2

MCAK/Kif2C centromeric activity level tunes K-fiber stability

2025-02-17 | Preprint
Contributors: Linda Wordeman; Mike Wagenbach; Juan Jesus Vicente
Source: check_circle
Crossref

Production of CRISPR‐Cas9 Transgenic Cell Lines for Knocksideways Studies

Current Protocols
2023-12 | Journal article
Contributors: Michael Wagenbach; Juan Jesus Vicente; Wren Wagenbach; Linda Wordeman
Source: check_circle
Crossref

GTP-tubulin loves microtubule plus ends but marries the minus ends

Journal of Cell Biology
2019-09-02 | Journal article
Contributors: Linda Wordeman
Source: check_circle
Crossref

GPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation

Glia
2019-08 | Journal article
Contributors: Allison E. Cherry; Juan Jesus Vicente; Cong Xu; Richard S. Morrison; Shao‐En Ong; Linda Wordeman; Nephi Stella
Source: check_circle
Crossref

β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells

Life Science Alliance
2018-05 | Journal article
Contributors: Amelia L Parker; Wee Siang Teo; Elvis Pandzic; Juan Jesus Vicente; Joshua A McCarroll; Linda Wordeman; Maria Kavallaris
Source: check_circle
Crossref
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Corrigendum: The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation

Nature Cell Biology
2017-05 | Journal article
Part of ISSN: 1465-7392
Contributors: Justin Decarreau; Michael Wagenbach; Eric Lynch; Aaron R. Halpern; Joshua C. Vaughan; Justin Kollman; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Arf GAPs and molecular motors

Small GTPases
2017-04 | Journal article
Part of ISSN: 2154-1248
Contributors: Ruibai Luo; Christine E. Reed; Jeffrey A. Sload; Linda Wordeman; Paul A. Randazzo; Pei-Wen Chen
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search
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The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation

Nature Cell Biology
2017-03-06 | Journal article
Part of ISSN: 1465-7392
Contributors: Justin Decarreau; Michael Wagenbach; Eric Lynch; Aaron R. Halpern; Joshua C. Vaughan; Justin Kollman; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Direct functional interaction of the kinesin-13 family member kinesin-like protein 2A (Kif2A) and Arf GAP with GTP-binding protein-like, ankyrin repeats and PH domains 1 (AGAP1).

Journal of Biological Chemistry
2016 | Journal article
Part of ISSN: 0021-9258
Contributors: Ruibai Luo; Pei-Wen Chen; Michael Wagenbach; Xiaoying Jian; Lisa Jenkins; Linda Wordeman; Paul A. Randazzo
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Direct Functional Interaction of the Kinesin-13 Family Membrane Kinesin-like Protein 2A (Kif2A) and Arf GAP with GTP-binding Protein-like, Ankyrin Repeats and PH Domains1 (AGAP1)

Journal of Biological Chemistry
2016-08 | Journal article
Contributors: Ruibai Luo; Pei-Wen Chen; Michael Wagenbach; Xiaoying Jian; Lisa Jenkins; Linda Wordeman; Paul A. Randazzo
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme

Molecular Cancer Therapeutics
2016-06 | Journal article
Contributors: A. E. Cherry; B. R. Haas; A. V. Naydenov; S. Fung; C. Xu; K. Swinney; M. Wagenbach; J. Freeling; D. A. Canton; J. Coy et al.
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Molecular insight into the regulation and function of MCAK

Critical Reviews in Biochemistry and Molecular Biology
2016-05-05 | Journal article
Contributors: Andreas Ritter; Nina-Naomi Kreis; Frank Louwen; Linda Wordeman; Juping Yuan
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Oxidative stress decreases microtubule growth and stability in ventricular myocytes

Journal of Molecular and Cellular Cardiology
2016-04 | Journal article
Contributors: Benjamin M.L. Drum; Can Yuan; Lei Li; Qinghang Liu; Linda Wordeman; L. Fernando Santana
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Divergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins

Molecular Biology of the Cell
2016-02 | Journal article
Contributors: L. Wordeman; J. Decarreau; J. J. Vicente; M. Wagenbach
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Oxidative Stress in Myocardial Infarction Disrupts Microtubule Trafficking, Reducing Transient Outward Current Density

Biophysical Journal
2016-02 | Journal article
Contributors: Benjamin Drum; Can Yuan; Lei Li; Linda Wordeman; L. Fernando Santana
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Revisiting Actin's role in early centrosome separation

Cell Cycle
2015 | Journal article
Contributors: Linda Wordeman; Justin Decarreau
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

ATPS-06BRAIN-PENETRANT ALKYLINDOLE COMPOUNDS PROMOTE APOPTOSIS IN GLIOMA CELLS THROUGH MICROTUBULE DESTABILIZATION

Neuro Oncol
2015-11 | Journal article
Contributors: Allison Cherry; Brian Haas; Alipi Naydenov; Susan Fung; Cong Xu; Katie Swinney; Michael Wagenbach; Jennifer Freeling; David Canton; Jonathan Coy et al.
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

A mitotic kinase scaffold depleted in testicular seminomas impacts spindle orientation in germ line stem cells

eLife
2015-09 | Journal article
Contributors: Heidi Hehnly; David Canton; Paula Bucko; Lorene K Langeberg; Leah Ogier; Irwin Gelman; L Fernando Santana; Linda Wordeman; John D Scott
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

HX-MS2 for high performance conformational analysis of complex protein states

Protein Science
2015-05 | Journal article
Contributors: Kyle M. Burns; Vladimir Sarpe; Mike Wagenbach; Linda Wordeman; David C. Schriemer
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Mitosis, microtubule dynamics and the evolution of kinesins

Experimental Cell Research
2015-05 | Journal article
Contributors: Juan Jesus Vicente; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Rapid Measurement of Mitotic Spindle Orientation in Cultured Mammalian Cells

Mitosis
2014 | Other
Contributors: Justin Decarreau; Jonathan Driver; Charles Asbury; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Mass Spec Studio for Integrative Structural Biology

Structure
2014-10 | Journal article
Contributors: Martial Rey; Vladimir Sarpe; Kyle M. Burns; Joshua Buse; Charles A.H. Baker; Marc van Dijk; Linda Wordeman; Alexandre M.J.J. Bonvin; David C. Schriemer
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Nucleotide Exchange in Dimeric MCAK Induces Longitudinal and Lateral Stress at Microtubule Ends to Support Depolymerization

Structure
2014-08 | Journal article
Contributors: Kyle M. Burns; Mike Wagenbach; Linda Wordeman; David C. Schriemer
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

Nat Cell Biol
2014-06 | Journal article
Contributors: Norman Ertych; Ailine Stolz; Albrecht Stenzinger; Wilko Weichert; Silke Kaulfuß; Peter Burfeind; Achim Aigner; Linda Wordeman; Holger Bastians
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Kinesins as Microtubule Disassembly Enzymes

Encyclopedia of Biological Chemistry
2013 | Other
Contributors: R. Ohi; L. Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo

Mechanisms of Development
2013-04 | Journal article
Contributors: Brenda Schumpert; María Guadalupe García; Gary M. Wessel; Linda Wordeman; Merrill B. Hille
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

The Kinesin Superfamily

Cytoskeleton and Human Disease
2012 | Other
Contributors: Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Gravin Is a Transitory Effector of Polo-like Kinase 1 during Cell Division

Molecular Cell
2012-11 | Journal article
Contributors: David A. Canton; C. Dirk Keene; Katie Swinney; Lorene K. Langeberg; Vivian Nguyen; Laurence Pelletier; Tony Pawson; Linda Wordeman; Nephi Stella; John D. Scott
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility

Science Signaling
2012-09-04 | Journal article
Contributors: P. F. Siesser; M. Motolese; M. P. Walker; D. Goldfarb; K. Gewain; F. Yan; R. M. Kulikauskas; A. J. Chien; L. Wordeman; M. B. Major
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Kif18A and Chromokinesins Confine Centromere Movements via Microtubule Growth Suppression and Spatial Control of Kinetochore Tension

Developmental Cell
2012-05 | Journal article
Contributors: Jason Stumpff; Michael Wagenbach; Andrew Franck; Charles L. Asbury; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment

J Cell Biol
2012-04-09 | Journal article
Contributors: Sarah B. Domnitz; Michael Wagenbach; Justin Decarreau; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target

Oncotarget
2011 | Journal article
Contributors: Mourad Sanhaji; Claire T Friel; Linda Wordeman; Frank Louwen; Juping Yuan
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A

Molecular Cell
2011-09 | Journal article
Contributors: Jason Stumpff; Yaqing Du; Chauca A. English; Zoltan Maliga; Michael Wagenbach; Charles L. Asbury; Linda Wordeman; Ryoma Ohi
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

AKAP220 Protein Organizes Signaling Elements That Impact Cell Migration

Journal of Biological Chemistry
2011-09-02 | Journal article
Contributors: J. S. Logue; J. L. Whiting; B. Tunquist; D. B. Sacks; L. K. Langeberg; L. Wordeman; J. D. Scott
Source: Self-asserted source
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Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning

Cell Cycle
2011-03 | Journal article
Contributors: Christopher P. Mattison; Jason Stumpff; Linda Wordeman; Mark Winey
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Reconstitution and Functional Analysis of Kinetochore Subcomplexes

Microtubules, in vitro
2010 | Other
Contributors: Daniel R. Gestaut; Jeremy Cooper; Charles L. Asbury; Trisha N. Davis; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

In Vitro Reconstitution of the Functional Interplay between MCAK and EB3 at Microtubule Plus Ends

Current Biology
2010-10 | Journal article
Contributors: Susana Montenegro Gouveia; Kris Leslie; Lukas C. Kapitein; Rubén M. Buey; Ilya Grigoriev; Michael Wagenbach; Ihor Smal; Erik Meijering; Casper C. Hoogenraad; Linda Wordeman et al.
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Long astral microtubules uncouple mitotic spindles from the cytokinetic furrow

J Cell Biol
2010-07-05 | Journal article
Contributors: Kathleen E. Rankin; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Session 68: Oocyte Maturation

Human Reproduction
2010-06-01 | Journal article
Contributors: H. Clarke; E. Shalom-Paz; A. K. M. Streiff; S. El-Khabouri; E. Mahrous; I. Demeestere; U. Eichenlaub-Ritter; W. Klein; N. Staubach; E. Vogt et al.
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B

J Cell Biol
2010-05 | Journal article
Contributors: Jerry F. Tien; Neil T. Umbreit; Daniel R. Gestaut; Andrew D. Franck; Jeremy Cooper; Linda Wordeman; Tamir Gonen; Charles L. Asbury; Trisha N. Davis
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays

Seminars in Cell & Developmental Biology
2010-05 | Journal article
Contributors: Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes

Molecular Human Reproduction
2010-04 | Journal article
Contributors: E. Vogt; M. Sanhaji; W. Klein; T. Seidel; L. Wordeman; U. Eichenlaub-Ritter
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK

Nat Struct Mol Biol
2009 | Journal article
Contributors: Jeremy R Cooper; Michael Wagenbach; Charles L Asbury; Linda Wordeman
Source: Self-asserted source
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Microtubule Length Control, a Team Sport?

Developmental Cell
2009-10 | Journal article
Contributors: Linda Wordeman; Jason Stumpff
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

Motor-dependent microtubule disassembly driven by tubulin tyrosination

J Cell Biol
2009-06 | Journal article
Contributors: Leticia Peris; Michael Wagenbach; Laurence Lafanechère; Jacques Brocard; Ayana T. Moore; Frank Kozielski; Didier Job; Linda Wordeman; Annie Andrieux
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

TIP150 interacts with and targets MCAK at the microtubule plus ends

EMBO reports
2009-06 | Journal article
Contributors: Kai Jiang; Jianyu Wang; Jing Liu; Tarsha Ward; Linda Wordeman; Alec Davidson; Fengsong Wang; Xuebiao Yao
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search

A new model for binding of kinesin 13 to curved microtubule protofilaments

J Cell Biol
2009-03 | Journal article
Contributors: Anke M. Mulder; Alex Glavis-Bloom; Carolyn A. Moores; Michael Wagenbach; Bridget Carragher; Linda Wordeman; Ronald A. Milligan
Source: Self-asserted source
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The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion

Cell
2009-03 | Journal article
Contributors: Andrew F. Powers; Andrew D. Franck; Daniel R. Gestaut; Jeremy Cooper; Beth Gracyzk; Ronnie R. Wei; Linda Wordeman; Trisha N. Davis; Charles L. Asbury
Source: Self-asserted source
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Reconstitution Of Microtubule-driven Movement and Force Production by the Ndc80 Kinetochore Complex

Biophysical Journal
2009-02 | Journal article
Contributors: Andrew D. Franck; Andrew F. Powers; Daniel R. Gestaut; Jeremy Cooper; Beth Gracyzk; Ronnie R. Wei; Linda Wordeman; Trisha N. Davis; Charles L. Asbury
Source: Self-asserted source
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The diffusive interaction of microtubule binding proteins

Current Opinion in Cell Biology
2009-02 | Journal article
Contributors: Jeremy R Cooper; Linda Wordeman
Source: Self-asserted source
Linda Wordeman via Crossref Metadata Search
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