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ResearcherID: I-2685-2017

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Funding (1)

From MIS-C to Kawasaki disease: a new human genetic and immunological approach to tackle a long-standing enigma

2023-07-01 to 2025-06-30 | Grant
American Heart Association (Dallas, US)
DOI: 10.58275/AHA.23IPA1051306.pc.gr.171968
GRANT_NUMBER:

23IPA1051306
Source: check_circle
American Heart Association

Works (49)

T-Cell Responses to HSV-1 in Persons Who Have Survived Childhood Herpes Simplex Encephalitis.

2017-05 | Journal article
DOI: 10.1097/inf.0000000000001631
PMID: 28471862
Contributors: Ott M; Jing L; Lorenzo L; Casanova JL; Zhang SY; Koelle DM
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Autosomal Recessive Cardiomyopathy Presenting as Acute Myocarditis.

2017-04 | Journal article
DOI: 10.1016/j.jacc.2017.01.043
PMID: 28359509
Contributors: Belkaya S; Kontorovich AR; Byun M; Mulero-Navarro S; Bajolle F; Cobat A; Josowitz R; Itan Y; Quint R; Lorenzo L et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

A novel kindred with inherited STAT2 deficiency and severe viral illness.

2017-01 | Journal article
DOI: 10.1016/j.jaci.2016.10.033
PMID: 28087227
Contributors: Moens L; Van Eyck L; Jochmans D; Mitera T; Frans G; Bossuyt X; Matthys P; Neyts J; Ciancanelli M; Zhang SY et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Characterization of Greater Middle Eastern genetic variation for enhanced disease gene discovery.

2016-09 | Journal article
DOI: 10.1038/ng.3592
PMID: 27428751
PMC: PMC5019950
Contributors: Scott EM; Halees A; Itan Y; Spencer EG; He Y; Azab MA; Gabriel SB; Belkadi A; Boisson B; Abel L et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Human TBK1: A Gatekeeper of Neuroinflammation.

2016-06 | Journal article
DOI: 10.1016/j.molmed.2016.04.006
PMID: 27211305
Contributors: Ahmad L; Zhang SY; Casanova JL; Sancho-Shimizu V
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Whole-exome sequencing to analyze population structure, parental inbreeding, and familial linkage.

2016-06 | Journal article
DOI: 10.1073/pnas.1606460113
PMID: 27247391
PMC: PMC4914194
Contributors: Belkadi A; Pedergnana V; Cobat A; Itan Y; Vincent QB; Abhyankar A; Shang L; El Baghdadi J; Bousfiha A; Exome/Array Consortium et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Host genetics of severe influenza: from mouse Mx1 to human IRF7.

2016-02 | Journal article
DOI: 10.1016/j.coi.2015.12.002
PMID: 26761402
PMC: PMC4733643
Contributors: Ciancanelli MJ; Abel L; Zhang SY; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

The mutation significance cutoff: gene-level thresholds for variant predictions.

2016-02 | Journal article
DOI: 10.1038/nmeth.3739
PMID: 26820543
PMC: PMC4980758
Contributors: Itan Y; Shang L; Boisson B; Ciancanelli MJ; Markle JG; Martinez-Barricarte R; Scott E; Shah I; Stenson PD; Gleeson J et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Parsing the Interferon Transcriptional Network and Its Disease Associations.

2016-01 | Journal article
DOI: 10.1016/j.cell.2015.12.032
PMID: 26824662
PMC: PMC4743492
Contributors: Mostafavi S; Yoshida H; Moodley D; LeBoité H; Rothamel K; Raj T; Ye CJ; Chevrier N; Zhang SY; Feng T et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Deciphering Human Cell-Autonomous Anti-HSV-1 Immunity in the Central Nervous System.

2015 | Journal article
DOI: 10.3389/fimmu.2015.00208
PMID: 26005444
PMC: PMC4424875
Contributors: Lafaille FG; Ciancanelli MJ; Studer L; Smith G; Notarangelo L; Casanova JL; Zhang SY
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

The human gene damage index as a gene-level approach to prioritizing exome variants.

2015-11 | Journal article
DOI: 10.1073/pnas.1518646112
PMID: 26483451
PMC: PMC4640721
Contributors: Itan Y; Shang L; Boisson B; Patin E; Bolze A; Moncada-Vélez M; Scott E; Ciancanelli MJ; Lafaille FG; Markle JG et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Inborn errors underlying herpes simplex encephalitis: From TLR3 to IRF3.

2015-08 | Journal article
DOI: 10.1084/jem.2129insight4
PMID: 26304982
PMC: PMC4548049
Contributors: Zhang SY; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections.

2015-06 | Journal article
DOI: 10.1056/nejmoa1413462
PMID: 26083206
PMC: PMC4480434
Contributors: Dobbs K; Domínguez Conde C; Zhang SY; Parolini S; Audry M; Chou J; Haapaniemi E; Keles S; Bilic I; Okada S et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.

2015-04 | Journal article
DOI: 10.1126/science.aaa1578
PMID: 25814066
PMC: PMC4431581
Contributors: Ciancanelli MJ; Huang SX; Luthra P; Garner H; Itan Y; Volpi S; Lafaille FG; Trouillet C; Schmolke M; Albrecht RA et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.

2015-01 | Journal article
DOI: 10.1038/nature13801
PMID: 25307056
PMC: PMC4303590
Contributors: Zhang X; Bogunovic D; Payelle-Brogard B; Francois-Newton V; Speer SD; Yuan C; Volpi S; Li Z; Sanal O; Mansouri D et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

TLR3 deficiency in herpes simplex encephalitis: high allelic heterogeneity and recurrence risk.

2014-11 | Journal article
DOI: 10.1212/wnl.0000000000000999
PMID: 25339207
PMC: PMC4248460
Contributors: Lim HK; Seppänen M; Hautala T; Ciancanelli MJ; Itan Y; Lafaille FG; Dell W; Lorenzo L; Byun M; Pauwels E et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Addressing diagnostic challenges in primary immunodeficiencies: laboratory evaluation of Toll-like receptor- and NF-κB-mediated immune responses.

2014-04 | Journal article
DOI: 10.3109/10408363.2014.881317
PMID: 24533908
Contributors: Frans G; Meyts I; Picard C; Puel A; Zhang SY; Moens L; Wuyts G; Van der Werff Ten Bosch J; Casanova JL; Bossuyt X
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

HGCS: an online tool for prioritizing disease-causing gene variants by biological distance.

2014-04 | Journal article
DOI: 10.1186/1471-2164-15-256
PMID: 24694260
PMC: PMC4051124
Contributors: Itan Y; Mazel M; Mazel B; Abhyankar A; Nitschke P; Quintana-Murci L; Boisson-Dupuis S; Boisson B; Abel L; Zhang SY et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Mendelian predisposition to herpes simplex encephalitis.

2013 | Journal article
DOI: 10.1016/b978-0-444-52910-7.00027-1
PMID: 23622315
Contributors: Zhang SY; Abel L; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

The human gene connectome as a map of short cuts for morbid allele discovery.

2013-04 | Journal article
DOI: 10.1073/pnas.1218167110
PMID: 23509278
PMC: PMC3619280
Contributors: Itan Y; Zhang SY; Vogt G; Abhyankar A; Herman M; Nitschke P; Fried D; Quintana-Murci L; Abel L; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

The proteome of Toll-like receptor 3-stimulated human immortalized fibroblasts: implications for susceptibility to herpes simplex virus encephalitis.

2013-04 | Journal article
DOI: 10.1016/j.jaci.2013.01.008
PMID: 23434283
PMC: PMC3640632
Contributors: Pérez de Diego R; Mulvey C; Crawford M; Trotter MW; Lorenzo L; Sancho-Shimizu V; Abel L; Zhang SY; Casanova JL; Godovac-Zimmermann J
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

TLR3 immunity to infection in mice and humans.

2013-02 | Journal article
DOI: 10.1016/j.coi.2012.11.001
PMID: 23290562
PMC: PMC3594520
Contributors: Zhang SY; Herman M; Ciancanelli MJ; Pérez de Diego R; Sancho-Shimizu V; Abel L; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Cleaved/associated TLR3 represents the primary form of the signaling receptor.

2013-01 | Journal article
DOI: 10.4049/jimmunol.1202173
PMID: 23255358
Contributors: Toscano F; Estornes Y; Virard F; Garcia-Cattaneo A; Pierrot A; Vanbervliet B; Bonnin M; Ciancanelli MJ; Zhang SY; Funami K et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

EVER2 deficiency is associated with mild T-cell abnormalities.

2013-01 | Journal article
DOI: 10.1007/s10875-012-9749-1
PMID: 22903682
PMC: PMC3733103
Contributors: Crequer A; Picard C; Pedergnana V; Lim A; Zhang SY; Abel L; Majewski S; Casanova JL; Jablonska S; Orth G et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Inherited MST1 deficiency underlies susceptibility to EV-HPV infections.

2012 | Journal article
DOI: 10.1371/journal.pone.0044010
PMID: 22952854
PMC: PMC3428299
Contributors: Crequer A; Picard C; Patin E; D'Amico A; Abhyankar A; Munzer M; Debré M; Zhang SY; de Saint-Basile G; Fischer A et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients.

2012-12 | Journal article
DOI: 10.1182/blood-2012-07-440776
PMID: 23002119
PMC: PMC3525023
Contributors: Weller S; Bonnet M; Delagreverie H; Israel L; Chrabieh M; Maródi L; Rodriguez-Gallego C; Garty BZ; Roifman C; Issekutz AC et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.

2012-11 | Journal article
DOI: 10.1038/nature11583
PMID: 23103873
PMC: PMC3527075
Contributors: Lafaille FG; Pessach IM; Zhang SY; Ciancanelli MJ; Herman M; Abhyankar A; Ying SW; Keros S; Goldstein PA; Mostoslavsky G et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.

2012-08 | Journal article
DOI: 10.1084/jem.20111316
PMID: 22851595
PMC: PMC3428952
Contributors: Herman M; Ciancanelli M; Ou YH; Lorenzo L; Klaudel-Dreszler M; Pauwels E; Sancho-Shimizu V; Pérez de Diego R; Abhyankar A; Israelsson E et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.

2011-12 | Journal article
DOI: 10.1172/jci59259
PMID: 22105173
PMC: PMC3226004
Contributors: Sancho-Shimizu V; Pérez de Diego R; Lorenzo L; Halwani R; Alangari A; Israelsson E; Fabrega S; Cardon A; Maluenda J; Tatematsu M et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Inborn errors of anti-viral interferon immunity in humans.

2011-12 | Journal article
DOI: 10.1016/j.coviro.2011.10.016
PMID: 22347990
PMC: PMC3280408
Contributors: Sancho-Shimizu V; Perez de Diego R; Jouanguy E; Zhang SY; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.

2011-09 | Journal article
DOI: 10.1084/jem.20101568
PMID: 21911422
PMC: PMC3182056
Contributors: Guo Y; Audry M; Ciancanelli M; Alsina L; Azevedo J; Herman M; Anguiano E; Sancho-Shimizu V; Lorenzo L; Pauwels E et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.

2011-09 | Journal article
DOI: 10.1016/j.jaci.2011.04.059
PMID: 21722947
PMC: PMC3164951
Contributors: Audry M; Ciancanelli M; Yang K; Cobat A; Chang HH; Sancho-Shimizu V; Lorenzo L; Niehues T; Reichenbach J; Li XX et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies.

2011-06 | Journal article
DOI: 10.1016/j.jaci.2010.11.008
PMID: 21185069
PMC: PMC3081993
Contributors: Pessach IM; Ordovas-Montanes J; Zhang SY; Casanova JL; Giliani S; Gennery AR; Al-Herz W; Manos PD; Schlaeger TM; Park IH et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood.

2010-10 | Journal article
DOI: 10.1016/j.jpeds.2010.04.020
PMID: 20553844
Contributors: Abel L; Plancoulaine S; Jouanguy E; Zhang SY; Mahfoufi N; Nicolas N; Sancho-Shimizu V; Alcaïs A; Guo Y; Cardon A et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors.

2010-09 | Journal article
DOI: 10.1016/j.immuni.2010.08.012
PMID: 20832340
PMC: PMC3063338
Contributors: Cros J; Cagnard N; Woollard K; Patey N; Zhang SY; Senechal B; Puel A; Biswas SK; Moshous D; Picard C et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis.

2010-09 | Journal article
DOI: 10.1016/j.immuni.2010.08.014
PMID: 20832341
PMC: PMC2946444
Contributors: Pérez de Diego R; Sancho-Shimizu V; Lorenzo L; Puel A; Plancoulaine S; Picard C; Herman M; Cardon A; Durandy A; Bustamante J et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Primary immunodeficiencies of protective immunity to primary infections.

2010-05 | Journal article
DOI: 10.1016/j.clim.2010.02.001
PMID: 20236864
Contributors: Bousfiha A; Picard C; Boisson-Dupuis S; Zhang SY; Bustamante J; Puel A; Jouanguy E; Ailal F; El-Baghdadi J; Abel L et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

WITHDRAWN: Genetic infectious susceptibility and TLR defects in human.

2009-10 | Journal article
DOI: 10.1016/j.imlet.2009.09.011
PMID: 19808052
Contributors: Picard C; Puel A; Zhang SY; Jouanguy E; Sancho V; Abel L; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

A partial form of recessive STAT1 deficiency in humans.

2009-06 | Journal article
DOI: 10.1172/jci37083
PMID: 19436109
PMC: PMC2689115
Contributors: Chapgier A; Kong XF; Boisson-Dupuis S; Jouanguy E; Averbuch D; Feinberg J; Zhang SY; Bustamante J; Vogt G; Lejeune J et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense.

2008-12 | Journal article
DOI: 10.1111/j.1600-065x.2008.00698.x
PMID: 19161414
Contributors: Zhang SY; Boisson-Dupuis S; Chapgier A; Yang K; Bustamante J; Puel A; Picard C; Abel L; Jouanguy E; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans.

2008-11 | Journal article
DOI: 10.1016/j.immuni.2008.09.015
PMID: 19006693
PMC: PMC2666307
Contributors: Isnardi I; Ng YS; Srdanovic I; Motaghedi R; Rudchenko S; von Bernuth H; Zhang SY; Puel A; Jouanguy E; Picard C et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Revisiting human primary immunodeficiencies.

2008-08 | Journal article
DOI: 10.1111/j.1365-2796.2008.01971.x
PMID: 18544117
Contributors: Casanova JL; Fieschi C; Zhang SY; Abel L
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

From infectious diseases to primary immunodeficiencies.

2008-05 | Journal article
DOI: 10.1016/j.iac.2008.01.009
PMID: 18424331
Contributors: Bustamante J; Zhang SY; von Bernuth H; Abel L; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Human primary immunodeficiencies of type I interferons.

2007 | Journal article
DOI: 10.1016/j.biochi.2007.04.016
PMID: 17561326
Contributors: Jouanguy E; Zhang SY; Chapgier A; Sancho-Shimizu V; Puel A; Picard C; Boisson-Dupuis S; Abel L; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Genetic susceptibility to herpes simplex virus 1 encephalitis in mice and humans.

2007-12 | Journal article
DOI: 10.1097/aci.0b013e3282f151d2
PMID: 17989525
Contributors: Sancho-Shimizu V; Zhang SY; Abel L; Tardieu M; Rozenberg F; Jouanguy E; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Human Toll-like receptor-dependent induction of interferons in protective immunity to viruses.

2007-12 | Journal article
DOI: 10.1111/j.1600-065x.2007.00564.x
PMID: 17979850
Contributors: Zhang SY; Jouanguy E; Sancho-Shimizu V; von Bernuth H; Yang K; Abel L; Picard C; Puel A; Casanova JL
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

2007-10 | Journal article
DOI: 10.1084/jem.20070628
PMID: 17893200
PMC: PMC2118442
Contributors: Ku CL; von Bernuth H; Picard C; Zhang SY; Chang HH; Yang K; Chrabieh M; Issekutz AC; Cunningham CK; Gallin J et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

TLR3 deficiency in patients with herpes simplex encephalitis.

2007-09 | Journal article
DOI: 10.1126/science.1139522
PMID: 17872438
Contributors: Zhang SY; Jouanguy E; Ugolini S; Smahi A; Elain G; Romero P; Segal D; Sancho-Shimizu V; Lorenzo L; Puel A et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central

Herpes simplex virus encephalitis in human UNC-93B deficiency.

2006-10 | Journal article
DOI: 10.1126/science.1128346
PMID: 16973841
Contributors: Casrouge A; Zhang SY; Eidenschenk C; Jouanguy E; Puel A; Yang K; Alcais A; Picard C; Mahfoufi N; Nicolas N et al.
Source: Self-asserted source
Shen-Ying Zhang via Europe PubMed Central
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