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University of Oxford: Oxford, Oxfordshire, GB

2016-12-01 to present (Chemistry Research Laboratory)
Employment
Source: Self-asserted source
Lennart Brewitz

Works (43)

Biochemical investigations using mass spectrometry to monitor JMJD6-catalysed hydroxylation of multi-lysine containing bromodomain-derived substrates

RSC Chemical Biology
2025 | Journal article
DOI: 10.1039/D4CB00311J
Contributors: Thomas P. Corner; Eidarus Salah; Anthony Tumber; Lennart Brewitz; Christopher J. Schofield
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Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2′ proline of the viral polyprotein

RSC Chemical Biology
2024 | Journal article
DOI: 10.1039/D3CB00128H
Contributors: H. T. Henry Chan; Lennart Brewitz; Petra Lukacik; Claire Strain-Damerell; Martin A. Walsh; Christopher J. Schofield; Fernanda Duarte
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Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation

Chemical Science
2024 | Journal article
DOI: 10.1039/D4SC01027B
Contributors: Gayatri; Lennart Brewitz; Lewis Ibbotson; Eidarus Salah; Shyam Basak; Hani Choudhry; Christopher J. Schofield
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Crystallographic and Selectivity Studies on the Approved HIF Prolyl Hydroxylase Inhibitors Desidustat and Enarodustat

ChemMedChem
2024-12-16 | Journal article
DOI: 10.1002/cmdc.202400504
Contributors: Thomas P. Corner; Eidarus Salah; Anthony Tumber; Samanpreet Kaur; Yu Nakashima; Mark D. Allen; Lara I. Schnaubelt; Giorgia Fiorini; Lennart Brewitz; Christopher J. Schofield
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Human prolyl hydroxylase domain 2 reacts with O2 and 2-oxoglutarate to enable formation of inactive Fe(III).2OG.hypoxia-inducible-factor α complexes

Scientific Reports
2024-10-30 | Journal article
DOI: 10.1038/s41598-024-75761-y
Part of ISSN: 2045-2322
Contributors: Giorgia Fiorini; Stephen A. Marshall; William D. Figg; William K. Myers; Lennart Brewitz; Christopher J. Schofield
Source: Self-asserted source
Lennart Brewitz

Substitution of 2-oxoglutarate alters reaction outcomes of the Pseudomonas savastanoi ethylene-forming enzyme

Journal of Biological Chemistry
2024-08 | Journal article
DOI: 10.1016/j.jbc.2024.107546
Contributors: Siddhant Dhingra; Zhihong Zhang; Christopher T. Lohans; Lennart Brewitz; Christopher J. Schofield
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Fixing the Achilles Heel of Pfizer’s Paxlovid for COVID-19 Treatment

Journal of Medicinal Chemistry
2024-07-25 | Journal article
DOI: 10.1021/acs.jmedchem.4c01342
Contributors: Lennart Brewitz; Christopher J. Schofield
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Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease

Bulletin of the Chemical Society of Japan
2024-05-03 | Journal article
DOI: 10.1093/bulcsj/uoae018
Part of ISSN: 0009-2673
Part of ISSN: 1348-0634
Contributors: Takashi Miura; Tika R Malla; Lennart Brewitz; Anthony Tumber; Eidarus Salah; Kang Ju Lee; Naohiro Terasaka; C David Owen; Claire Strain-Damerell; Petra Lukacik et al.
Source: Self-asserted source
Lennart Brewitz

The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia

Nature Cancer
2024-04-18 | Journal article
DOI: 10.1038/s43018-024-00761-w
Part of ISSN: 2662-1347
Contributors: Hannah Lawson; James P. Holt-Martyn; Vilma Dembitz; Yuka Kabayama; Lydia M. Wang; Aarushi Bellani; Samanpreet Atwal; Nadia Saffoon; Jozef Durko; Louie N. van de Lagemaat et al.
Source: Self-asserted source
Lennart Brewitz

Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5

RSC Chemical Biology
2023 | Journal article
DOI: 10.1039/D2CB00249C
Contributors: Anthony Tumber; Eidarus Salah; Lennart Brewitz; Thomas P. Corner; Christopher J. Schofield
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Structure-guided optimisation of <i>N</i>-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

Chemical Science
2023 | Journal article | Author
DOI: 10.1039/d3sc04253g
Part of ISSN: 2041-6520
Part of ISSN: 2041-6539
Contributors: Thomas P. Corner; Zhao Rong Ryan Teo; Yue Wu; Eidarus Salah; Yu Nakashima; Giorgia Fiorini; Anthony Tumber; Amelia Brasnett; James P. Holt-Martyn; William D. Figg et al.
Source: Self-asserted source
Lennart Brewitz

αβ,α′β′-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes

Chemical Communications
2023 | Journal article
DOI: 10.1039/D3CC02932H
Contributors: Mariska de Munnik; Jasper Lithgow; Lennart Brewitz; Kirsten E. Christensen; Robert H. Bates; Beatriz Rodriguez-Miquel; Christopher J. Schofield
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Mass spectrometric assays monitoring the deubiquitinase activity of the SARS-CoV-2 papain-like protease inform on the basis of substrate selectivity and have utility for substrate identification

Bioorganic &amp; Medicinal Chemistry
2023-11 | Journal article
DOI: 10.1016/j.bmc.2023.117498
Part of ISSN: 0968-0896
Contributors: Lennart Brewitz; H.T. Henry Chan; Petra Lukacik; Claire Strain-Damerell; Martin A. Walsh; Fernanda Duarte; Christopher Schofield
Source: Self-asserted source
Lennart Brewitz

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

Science
2023-11-10 | Journal article
DOI: 10.1126/science.abo7201
Part of ISSN: 0036-8075
Part of ISSN: 1095-9203
Contributors: Melissa L. Boby; Daren Fearon; Matteo Ferla; Mihajlo Filep; Lizbe Koekemoer; Matthew C Robinson; John Chodera; Alpha A. Lee; Nir London; Annette von Delft et al.
Source: Self-asserted source
Lennart Brewitz

5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5

Journal of Medicinal Chemistry
2023-08-10 | Journal article
DOI: 10.1021/acs.jmedchem.3c01114
Contributors: Lennart Brewitz; Yu Nakashima; Sonia K. Piasecka; Eidarus Salah; Sally C. Fletcher; Anthony Tumber; Thomas P. Corner; Tristan J. Kennedy; Giorgia Fiorini; Armin Thalhammer et al.
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In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease

Nature Chemistry
2023-07 | Journal article
DOI: 10.1038/s41557-023-01205-1
Contributors: Takashi Miura; Tika R. Malla; C. David Owen; Anthony Tumber; Lennart Brewitz; Michael A. McDonough; Eidarus Salah; Naohiro Terasaka; Takayuki Katoh; Petra Lukacik et al.
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Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2

Journal of Biological Chemistry
2023-02 | Journal article | Author
DOI: 10.1016/j.jbc.2023.102873
Part of ISSN: 0021-9258
Contributors: XIAO LIU; Raphael Reinbold; Shuang Liu; Ryan A. Herold; Patrick Rabe; Stéphanie Duclos; Rahul B. Yadav; Martine I. Abboud; Sandrine Thieffine; Fraser A. Armstrong et al.
Source: Self-asserted source
Lennart Brewitz

Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine

Journal of Medicinal Chemistry
2023-02-23 | Journal article
DOI: 10.1021/acs.jmedchem.2c01627
Contributors: Lennart Brewitz; Leo Dumjahn; Yilin Zhao; C. David Owen; Stephen M. Laidlaw; Tika R. Malla; Dung Nguyen; Petra Lukacik; Eidarus Salah; Adam D. Crawshaw et al.
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Combined proteomic and biochemical analyses redefine the consensus sequence requirement for epidermal growth factor-like domain hydroxylation

Journal of Biological Chemistry
2022-08 | Journal article
DOI: 10.1016/j.jbc.2022.102129
Contributors: Lennart Brewitz; Bruce C. Onisko; Christopher J. Schofield
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Crossref

Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine

Journal of Medicinal Chemistry
2022-06-09 | Journal article
DOI: 10.1021/acs.jmedchem.1c02214
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Tika R. Malla; Lennart Brewitz; Dorian-Gabriel Muntean; Hiba Aslam; David Owen; Eidarus Salah; Anthony Tumber; Petra Lukacik; Claire Strain-Damerell; Halina Mikolajek et al.
Source: Self-asserted source
Lennart Brewitz

Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS‐CoV‐2 Papain‐Like Protease

ChemMedChem
2022-05-04 | Journal article
DOI: 10.1002/cmdc.202200016
Contributors: Lennart Brewitz; Jos J. A. G. Kamps; Petra Lukacik; Claire Strain‐Damerell; Yilin Zhao; Anthony Tumber; Tika R. Malla; Allen M. Orville; Martin A. Walsh; Christopher J. Schofield
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Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

eLife
2022-02-21 | Journal article
DOI: 10.7554/elife.69348
Part of ISSN: 2050-084X
Contributors: Christopher J Brereton; Liudi Yao; Elizabeth R. Davies; Yilu Zhou; Milica Vukmirovic; Joseph A Bell; Siyuan Wang; Robert A Ridley; Lareb Dean; Orestis G Andriotis et al.
Source: Self-asserted source
Lennart Brewitz

Structure‐Activity Studies Reveal Scope for Optimisation of Ebselen‐Type Inhibition of SARS‐CoV‐2 Main Protease

ChemMedChem
2022-02-16 | Journal article
DOI: 10.1002/cmdc.202100582
Contributors: Siegfried T. D. Thun‐Hohenstein; Timothy F. Suits; Tika R. Malla; Anthony Tumber; Lennart Brewitz; Hani Choudhry; Eidarus Salah; Christopher J. Schofield
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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

Chemical Communications
2021 | Journal article
DOI: 10.1039/D0CC06870E
Contributors: Tika R. Malla; Anthony Tumber; Tobias John; Lennart Brewitz; Claire Strain-Damerell; C David Owen; Petra Lukacik; H. T. Henry Chan; Pratheesh Maheswaran; Eidarus Salah et al.
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Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase

Chemical Science
2021 | Journal article
DOI: 10.1039/D0SC04301J
Contributors: Lennart Brewitz; Yu Nakashima; Christopher J. Schofield
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Crossref

2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases

Nature Communications
2021-11-10 | Journal article
DOI: 10.1038/s41467-021-26673-2
Contributors: Yu Nakashima; Lennart Brewitz; Anthony Tumber; Eidarus Salah; Christopher J. Schofield
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Crossref

Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases

Journal of Fluorine Chemistry
2021-07 | Journal article
DOI: 10.1016/j.jfluchem.2021.109804
Part of ISSN: 0022-1139
Contributors: Lennart Brewitz; Yu Nakashima; Anthony Tumber; Eidarus Salah; Christopher J. Schofield
Source: Self-asserted source
Lennart Brewitz

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19

Scientific Reports
2021-06-24 | Journal article
DOI: 10.1038/s41598-021-92416-4
Part of ISSN: 2045-2322
Contributors: Martin A. Redhead; C. David Owen; Lennart Brewitz; Amelia H. Collette; Petra Lukacik; Claire Strain-Damerell; Sean W. Robinson; Patrick M. Collins; Philipp Schäfer; Mark Swindells et al.
Source: Self-asserted source
Lennart Brewitz

Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active

Angewandte Chemie International Edition
2021-06-21 | Journal article
DOI: 10.1002/anie.202103711
Contributors: Amelia Brasnett; Inga Pfeffer; Lennart Brewitz; Rasheduzzaman Chowdhury; Yu Nakashima; Anthony Tumber; Michael A. McDonough; Christopher J. Schofield
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Crossref

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase

Bioorganic & Medicinal Chemistry
2020-10 | Journal article
DOI: 10.1016/j.bmc.2020.115675
Part of ISSN: 0968-0896
Contributors: Lennart Brewitz; Anthony Tumber; Xiaojin Zhang; Christopher J. Schofield
Source: Self-asserted source
Lennart Brewitz

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase

ChemMedChem
2020-07-03 | Journal article
DOI: 10.1002/cmdc.202000147
Contributors: Lennart Brewitz; Anthony Tumber; Armin Thalhammer; Eidarus Salah; Kirsten E. Christensen; Christopher J. Schofield
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Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing

Journal of Biological Chemistry
2020-06 | Journal article
DOI: 10.1074/jbc.ra119.012202
Part of ISSN: 0021-9258
Contributors: Lennart Brewitz; Anthony Tumber; Christopher Schofield
Source: Self-asserted source
Lennart Brewitz

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

Scientific Reports
2020-05-26 | Journal article
DOI: 10.1038/s41598-020-65123-9
Part of ISSN: 2045-2322
Contributors: Lennart Brewitz; Anthony Tumber; Inga Pfeffer; Michael A. McDonough; Christopher J. Schofield
Source: Self-asserted source
Lennart Brewitz

(2R,3S)-3,4,4,4-Tetrafluorovaline: A Fluorinated Bioisostere of Isoleucine

European Journal of Organic Chemistry
2020-03-05 | Journal article
DOI: 10.1002/ejoc.202000109
Part of ISSN: 1434-193X
Contributors: Lennart Brewitz; Hidetoshi Noda; Naoya Kumagai; Masakatsu Shibasaki
Source: Self-asserted source
Lennart Brewitz via Crossref Metadata Search

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern

Nature Communications
2019-10 | Journal article
DOI: 10.1038/s41467-019-12711-7
Part of ISSN: 2041-1723
Contributors: Inga Pfeffer; Lennart Brewitz; Tobias Krojer; Sacha A. Jensen; Grazyna T. Kochan; Nadia J. Kershaw; Kirsty S. Hewitson; Luke A. McNeill; Holger Kramer; Martin Münzel et al.
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Lennart Brewitz via Crossref Metadata Search

Achiral Trisubstituted Thioureas as Secondary Ligands to CuI Catalysts: Direct Catalytic Asymmetric Addition of α-Fluoronitriles to Imines

Angewandte Chemie International Edition
2018 | Journal article
DOI: 10.1002/anie.201812673
Part of ISSN: 1433-7851
Contributors: Pandur Venkatesan Balaji; Lennart Brewitz; Naoya Kumagai; Masakatsu Shibasaki
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Lennart Brewitz via Crossref Metadata Search

Structural and Computational Investigation of Intramolecular N···H Interactions in α‐ and β‐Fluorinated 7‐Azaindoline Amides

European Journal of Organic Chemistry
2018-02-14 | Journal article
DOI: 10.1002/ejoc.201701083
Contributors: Lennart Brewitz; Hidetoshi Noda; Naoya Kumagai; Masakatsu Shibasaki
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Catalytic asymmetric synthesis of 2,3,3,3-tetrafluoro-2-methyl-1-arylpropan-1-amines as useful building blocks for SAR-studies

Journal of Fluorine Chemistry
2017-02 | Journal article
DOI: 10.1016/j.jfluchem.2016.12.008
Part of ISSN: 0022-1139
Contributors: Lennart Brewitz; Naoya Kumagai; Masakatsu Shibasaki
Source: Self-asserted source
Lennart Brewitz via Crossref Metadata Search

Direct Catalytic Asymmetric Mannich-Type Reaction of Alkylamides

Organic Letters
2016-05 | Journal article
DOI: 10.1021/acs.orglett.6b00879
Part of ISSN: 1523-7060
Contributors: Fernando Arteaga Arteaga; Zijian Liu; Lennart Brewitz; Jianyang Chen; Bo Sun; Naoya Kumagai; Masakatsu Shibasaki
Source: Self-asserted source
Lennart Brewitz via Crossref Metadata Search

Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides

Journal of the American Chemical Society
2015 | Journal article
DOI: 10.1021/jacs.5b11064
Part of ISSN: 0002-7863
Contributors: Lennart Brewitz; Fernando Arteaga Arteaga; Liang Yin; Kaliyamoorthy Alagiri; Naoya Kumagai; Masakatsu Shibasaki
Source: Self-asserted source
Lennart Brewitz via Crossref Metadata Search

Catalytic Generation of α-CF3 Enolate: Direct Catalytic Asymmetric Mannich-Type Reaction of α-CF3 Amide

Journal of the American Chemical Society
2014 | Journal article
DOI: 10.1021/ja511458k
Part of ISSN: 0002-7863
Contributors: Liang Yin; Lennart Brewitz; Naoya Kumagai; Masakatsu Shibasaki
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Lennart Brewitz via Crossref Metadata Search

Formal Total Synthesis of the Algal Toxin (−)-Polycavernoside A

Chemistry - A European Journal
2013-02 | Journal article
DOI: 10.1002/chem.201204551
Part of ISSN: 0947-6539
Contributors: Lennart Brewitz; Josep Llaveria; Akira Yada; Alois Fürstner
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Lennart Brewitz via Crossref Metadata Search

Bridged fac-Tricarbonylrhenium(I)-Biscarbene Complexes: Synthesis, Characterization, and Molecular Dynamics

European Journal of Inorganic Chemistry
2010-10 | Journal article
DOI: 10.1002/ejic.201000690
Part of ISSN: 1434-1948
Contributors: Oliver Hiltner; Florian J. Boch; Lennart Brewitz; Peter Härter; Markus Drees; Eberhardt Herdtweck; Wolfgang A. Herrmann; Fritz E. Kühn
Source: Self-asserted source
Lennart Brewitz via Crossref Metadata Search
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