Personal information

neuroengineering, neuromodulation, neuroprosthetics
France

Biography

Trained first as an engineer and then as a neuroscientist, I conduct research at the intersection between Neuroscience and Neuroengineering. I am interested in understanding how the dynamics of neuronal networks become altered in neurological disorders or after injury, and how to restore their natural behaviour using neuromodulation approaches. During my Ph.D. at Brown University, I developed new tools to record and stimulate the brain simultaneously and investigated the cortical dynamics that underlie the transition to epileptic seizures in rodent models and epileptic patients. During my postdoctoral work at the Ecole Polytechnique Fédérale de Lausanne (EPFL), I pioneered neuroprosthetic technologies to restore locomotion in non-human primates (Nature 2016; Nature Protocols 2018). I then led a large team of scientists, engineers and clinicians to translate these technologies into patients with spinal cord injury in the context of a first-in-human clinical trial (Nature, 2018; Nature Medicine 2022).

I am currently a tenured researcher at the French National Centre for Scientific Research (CNRS) and a team leader at the Institute of Neurodegenerative Diseases, a joint unit between CNRS and the Neurocampus department at the University of Bordeaux. I am particularly interested in expanding the use of neuroprosthetic systems beyond their current applications in motor disorders, towards neurocognitive disorders such as memory impairments. I recently obtained an ERC starting grant (call 2021) to conduct this project over the next 5 years.

Activities

Employment (4)

French National Centre for Scientific Research (CNRS): Bordeaux, FR

2022-10-01 to present | Tenured Researcher (equivalent to Associate Professor), Team Leader: Neuromodulation and Neuroprosthetics (Institute of Neurodegenerative Diseases - CNRS UMR 5293, Bordeaux Neurocampus)
Employment
Source: Self-asserted source
Fabien B. Wagner

University of Bordeaux: Bordeaux, FR

2020-04-01 to 2022-09-30 | Team leader: Neuromodulation and Neuroprosthetics (Institute of Neurodegenerative Diseases - CNRS UMR 5293, Bordeaux Neurocampus)
Employment
Source: Self-asserted source
Fabien B. Wagner

École Polytechnique Fédérale de Lausanne (EPFL): Lausanne, VD, CH

2015-01-01 to 2020-03-31 | Postdoctoral Fellow (Center for Neuroprosthetics and Brain Mind Institute , School of Life Sciences, Laboratory of Prof. G. Courtine)
Employment
Source: Self-asserted source
Fabien B. Wagner

Brown University: Providence, RI, US

2014-09-01 to 2014-12-31 | Postdoctoral Fellow (Neuroscience, Laboratory of Prof. W. Truccolo)
Employment
Source: Self-asserted source
Fabien B. Wagner

Education and qualifications (2)

Brown University: Providence, RI, US

2009-09-01 to 2014-09-01 | PhD (Neuroscience, Laboratory of Prof. A. Nurmikko)
Education
Source: Self-asserted source
Fabien B. Wagner

Ecole Polytechnique: Paris, FR

2006-09-01 to 2009-09-01 | MS (Engineering)
Education
Source: Self-asserted source
Fabien B. Wagner

Funding (4)

MEMOPROSTHETICS: Neuroprosthetic Modulation of Large-Scale Brain Networks for Treating Memory Disorders

2022-10 to 2027-09 | Grant
European Research Council (Brussels, BE)
Source: Self-asserted source
Fabien B. Wagner

Neurocampus Chair of Excellence for Young Group Leader

2020-03 to 2023-03 | Grant
Région Nouvelle-Aquitaine and University of Bordeaux (Bordeaux, FR)
Source: Self-asserted source
Fabien B. Wagner

From spikes to electrocorticograms: brain-spinal interfaces across cortical spatial scales to restore locomotion after spinal cord injury

2016-04 to 2018-04 | Salary award
EPFL (Lausanne, CH)
GRANT_NUMBER:

H2020-MSCA-COFUND-2015

Source: Self-asserted source
Fabien B. Wagner

Optogenetic control of seizures in a rat model of absence epilepsy

2011-09 to 2012-09 | Salary award
Epilepsy Foundation (Landover, MD, US)
GRANT_NUMBER:

Epilepsy Foundation Meritorious Research Fall2011 FY12

Source: Self-asserted source
Fabien B. Wagner

Works (21)

A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation

eLife
2024-02-14 | Journal article
Contributors: Nikolaos Vardalakis; Amélie Aussel; Nicolas P Rougier; Fabien B Wagner
Source: check_circle
Crossref
grade
Preferred source (of 6)‎

Neuroprosthetics: from sensorimotor to cognitive disorders

Communications Biology
2023-01-06 | Journal article
Contributors: Ankur Gupta; Nikolaos Vardalakis; Fabien B. Wagner
Source: check_circle
Crossref

Spinal Cord Stimulation to Enable Leg Motor Control and Walking in People with Spinal Cord Injury

Neurorehabilitation Technology
2022 | Book chapter
Part of ISBN: 9783031089947
Part of ISBN: 9783031089954
Contributors: Fabien B. Wagner; Ismael Seáñez; Marco Capogrosso; Karen Minassian; Fabien B. Wagner
Source: Self-asserted source
Fabien B. Wagner

The neurons that restore walking after paralysis.

Nature
2022-11-09 | Journal article | Author
Contributors: Claudia Kathe; Michael Skinnider; Thomas Hutson; Regazzi N; MATTHIEU GAUTIER; Robin Demesmaeker; Komi S; Ceto S; Nicholas James; Cho N et al.
Source: Self-asserted source
Fabien B. Wagner

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Nature Medicine
2022-02-07 | Journal article
Part of ISSN: 1078-8956
Part of ISSN: 1546-170X
Source: Self-asserted source
Fabien B. Wagner
grade
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MRI‐Compatible and Conformal Electrocorticography Grids for Translational Research

Advanced Science
2021-05 | Journal article
Contributors: Florian Fallegger; Giuseppe Schiavone; Elvira Pirondini; Fabien B. Wagner; Nicolas Vachicouras; Ludovic Serex; Gregory Zegarek; Adrien May; Paul Constanthin; Marie Palma et al.
Source: check_circle
Crossref
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Preferred source (of 2)‎

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Nature
2021-01-27 | Journal article
Source: Self-asserted source
Fabien B. Wagner
grade
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Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Nature Neuroscience
2018-10 | Journal article
Part of ISSN: 1097-6256
Contributors: Emanuele Formento; Karen Minassian; Fabien Wagner; Jean Baptiste Mignardot; Camille G. Le Goff-Mignardot; Andreas Rowald; Jocelyne Bloch; Silvestro Micera; Marco Capogrosso; Gregoire Courtine
Source: Self-asserted source
Fabien B. Wagner via Crossref Metadata Search
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Targeted neurotechnology restores walking in humans with spinal cord injury

Nature
2018-10 | Journal article
Part of ISSN: 0028-0836
Contributors: Fabien B. Wagner; Jean-Baptiste Mignardot; Camille G. Le Goff-Mignardot; Robin Demesmaeker; Salif Komi; Marco Capogrosso; Andreas Rowald; Ismael Seáñez; Miroslav Caban; Elvira Pirondini et al.
Source: Self-asserted source
Fabien B. Wagner via Crossref Metadata Search
grade
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Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.

Nature protocols
2018-09 | Journal article
Contributors: Capogrosso M; Wagner FB; Gandar J; Moraud EM; Wenger N; Milekovic T; Shkorbatova P; Pavlova N; Musienko P; Bezard E et al.
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
2018-07 | Journal article
Contributors: Schiavone G; Wagner F; Fallegger F; Kang X; Vachicouras N; Barra B; Capogrosso M; Bloch J; Courtine G; Lacour SP
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Erratum: Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications (Journal of Neural Engineering (2012) 9 (016001))

Journal of Neural Engineering
2016 | Journal article
EID:

2-s2.0-84970021141

Part of ISSN: 17412552 17412560
Contributors: Wang, J.; Wagner, F.; Mohamed, D.; Borton, D.A.; Zhang, J.; Ozden, I.; Burwell, R.D.; Nurmikko, A.V.; Van Wagenen, R.; Diester, I. et al.
Source: Self-asserted source
Fabien B. Wagner via Scopus - Elsevier

A brain-spine interface alleviating gait deficits after spinal cord injury in primates.

Nature
2016-11 | Journal article
Contributors: Capogrosso M; Milekovic T; Borton D; Wagner F; Moraud EM; Mignardot JB; Buse N; Gandar J; Barraud Q; Xing D et al.
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Microscale spatiotemporal dynamics during neocortical propagation of human focal seizures.

NeuroImage
2015-08 | Journal article
Contributors: Wagner FB; Eskandar EN; Cosgrove GR; Madsen JR; Blum AS; Potter NS; Hochberg LR; Cash SS; Truccolo W
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury.

Annals of physical and rehabilitation medicine
2015-06 | Journal article
Contributors: van den Brand R; Mignardot JB; von Zitzewitz J; Le Goff C; Fumeaux N; Wagner F; Capogrosso M; Martin Moraud E; Micera S; Schurch B et al.
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Modified toolbox for optogenetics in the nonhuman primate.

Neurophotonics
2015-05 | Journal article
Contributors: Dai J; Ozden I; Brooks DI; Wagner F; May T; Agha NS; Brush B; Borton D; Nurmikko AV; Sheinberg DL
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
grade
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Optogenetically induced spatiotemporal gamma oscillations and neuronal spiking activity in primate motor cortex.

Journal of neurophysiology
2015-03 | Journal article
Contributors: Lu Y; Truccolo W; Wagner FB; Vargas-Irwin CE; Ozden I; Zimmermann JB; May T; Agha NS; Wang J; Nurmikko AV
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Detection of optogenetic stimulation in somatosensory cortex by non-human primates--towards artificial tactile sensation.

PloS one
2014-12 | Journal article
Contributors: May T; Ozden I; Brush B; Borton D; Wagner F; Agha N; Sheinberg DL; Nurmikko AV
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
grade
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Spatiotemporal dynamics of optogenetically induced and spontaneous seizure transitions in primary generalized epilepsy.

Journal of neurophysiology
2014-12 | Journal article
Contributors: Wagner FB; Truccolo W; Wang J; Nurmikko AV
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
grade
Preferred source (of 2)‎

Integrated device for combined optical neuromodulation and electrical recording for chronic in vivo applications.

Journal of neural engineering
2011-12 | Journal article
Contributors: Wang J; Wagner F; Borton DA; Zhang J; Ozden I; Burwell RD; Nurmikko AV; van Wagenen R; Diester I; Deisseroth K
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Approaches to optical neuromodulation from rodents to non-human primates by integrated optoelectronic devices.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
2011-01 | Journal article
Contributors: Wang J; Ozden I; Diagne M; Wagner F; Borton D; Brush B; Agha N; Burwell R; Sheinberg D; Diester I et al.
Source: Self-asserted source
Fabien B. Wagner via Europe PubMed Central
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Peer review (1 review for 1 publication/grant)

Review activity for Advanced science. (1)