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malaria, transcriptomics, genomics, proteomics, Plasmodium falciparum, Drug resistance

Activities

Employment (5)

Columbia University Irving Medical Center: New York, NY, US

2022-10-01 to present | Assistant Professor of Medical Sciences (Medicine)
Employment
Source: Self-asserted source
Sachel Mok

Columbia University Irving Medical Center: New York, NY, US

2021-08-01 to 2022-09-30 | Assistant Professor (Microbiology and Immunology)
Employment
Source: Self-asserted source
Sachel Mok

Columbia University Irving Medical Center: New York, NY, US

2019-12-01 to 2021-07-31 | Associate Research Scientist (Microbiology and Immunology)
Employment
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Sachel Mok

Columbia University Irving Medical Center: New York, NY, US

2016-06-01 to 2019-11-30 | Postdoctoral Research Fellow
Employment
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Sachel Mok

Nanyang Technological University School of Biological Sciences: Singapore, SG

2013-08-01 to 2016-03-31 | Postdoctoral Research Fellow
Employment
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Sachel Mok

Education and qualifications (2)

Nanyang Technological University School of Biological Sciences: Singapore, SG

2013 | PhD
Education
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Sachel Mok

Nanyang Technological University School of Biological Sciences: Singapore, SG

2002-07 to 2006-07 | BSc (Hon) with Minor in Business
Education
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Sachel Mok

Professional activities (2)

American Society of Tropical Medicine and Hygiene: Oakbrook Terrace, IL, US

2017 to present | member
Membership
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Sachel Mok

Human Frontier Science Program: Strasbourg, FR

2016-05-01 | Long-term Fellowship
Distinction
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Sachel Mok

Funding (2)

The genetic basis of emerging multidrug resistance in Plasmodium falciparum African malaria

2024-03-11 to 2029-01-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI182318
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Sachel Mok via DimensionsWizard

Defining the genetic basis of piperaquine resistance in P. falciparum to support malaria elimination

2016-05-01 to 2019-04-30 | Grant
International Human Frontier Science Program Organization (Strasbourg, FR)
GRANT_NUMBER:

grant.2d88e39d

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Works (50 of 64)

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Effects of recombination on multi-drug resistance evolution inPlasmodium falciparummalaria

2024-12-21 | Preprint
Contributors: Kien Trung Tran; Tran Dang Nguyen; Daniel B Weissman; Eric Zhewen Li; Sachel Mok; Jennifer L Small-Saunders; Teun Bousema; Robert J Zupko; Thu Nguyen-Anh Tran; Maciej F Boni
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Generation of a mutator parasite to drive resistome discovery in <i>Plasmodium falciparum</i>

Nature Communications
2023 | Journal article
Contributors: Kumpornsin, Krittikorn; Kochakarn, Theerarat; Yeo, Tomas; Okombo, John; Luth, Madeline R.; Hoshizaki, Johanna; Rawat, Mukul; Pearson, Richard D.; Schindler, Kyra A.; Mok, Sachel et al.
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Mapping the genomic landscape of multidrug resistance in <i>Plasmodium falciparum</i> and its impact on parasite fitness

Science Advances
2023 | Journal article
Contributors: Mok, Sachel; Yeo, Tomas; Hong, Davin; Shears, Melanie J.; Ross, Leila S.; Ward, Kurt E.; Dhingra, Satish K.; Kanai, Mariko; Bridgford, Jessica L.; Tripathi, Abhai K. et al.
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Potent acyl-CoA synthetase 10 inhibitors kill <i>Plasmodium falciparum</i> by disrupting triglyceride formation

Nature Communications
2023 | Journal article
Contributors: Bopp, Selina; Pasaje, Charisse Flerida A.; Summers, Robert L.; Magistrado-Coxen, Pamela; Schindler, Kyra A.; Corpas-Lopez, Victoriano; Yeo, Tomas; Mok, Sachel; Dey, Sumanta; Smick, Sebastian et al.
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Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite <i>Plasmodium falciparum</i>

PLOS Pathogens
2023 | Journal article
Contributors: Kucharski, Michal; Wirjanata, Grennady; Nayak, Sourav; Boentoro, Josephine; Dziekan, Jerzy Michal; Assisi, Christina; van der Pluijm, Rob W.; Miotto, Olivo; Mok, Sachel; Dondorp, Arjen M. et al.
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Determinants of piperaquine-resistant malaria in South America.

The Lancet. Infectious diseases
2023-10-16 | Journal article
Contributors: Mok S; Fidock DA
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Mapping the genomic landscape of multidrug resistance inPlasmodium falciparumand its impact on parasite fitness

2023-06-03 | Preprint
Contributors: Sachel Mok; Tomas Yeo; Davin Hong; Melanie J. Shears; Leila S. Ross; Kurt E. Ward; Satish K. Dhingra; Mariko Kanai; Jessica L. Bridgford; Abhai K. Tripathi et al.
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Comparative Analysis of <i>Plasmodium falciparum</i> Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing

Antimicrobial Agents and Chemotherapy
2022 | Journal article
Contributors: Kanai, Mariko; Yeo, Tomas; Asua, Victor; Rosenthal, Philip J.; Fidock, David A.; Mok, Sachel
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Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

bioRxiv
2022 | Other
EID:

2-s2.0-85141166344

Part of ISSN: 26928205
Contributors: Kümpornsin, K.; Kochakarn, T.; Yeo, T.; Luth, M.R.; Pearson, R.D.; Hoshizaki, J.; Schindler, K.A.; Mok, S.; Park, H.; Uhlemann, A.-C. et al.
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Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials

The Journal of Infectious Diseases
2022 | Journal article
Contributors: Wicht, Kathryn J.; Small-Saunders, Jennifer L.; Hagenah, Laura M.; Mok, Sachel; Fidock, David A.
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Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study

The Lancet Infectious Diseases
2022 | Journal article
Contributors: Barber, Bridget E.; Fernandez, Melissa; Patel, Hardik Babubhai; Barcelo, Catalina; Woolley, Stephen D.; Patel, Harilal; Llewellyn, Stacey; Abd-Rahman, Azrin N.; Sharma, Sunil; Jain, Mukul et al.
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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

Cell Chemical Biology
2022 | Journal article
Contributors: Murithi, James M.; Deni, Ioanna; Pasaje, Charisse Flerida A.; Okombo, John; Bridgford, Jessica L.; Gnadig, Nina F.; Edwards, Rachel L.; Yeo, Tomas; Mok, Sachel; Burkhard, Anna Y. et al.
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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.

PLoS pathogens
2022-10-28 | Journal article
Contributors: Okombo J; Mok S; Qahash T; Yeo T; Bath J; Orchard LM; Owens E; Koo I; Albert I; Llinás M et al.
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3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum

Journal of Medicinal Chemistry
2021 | Journal article
Contributors: Knaab, Tanja C.; Held, Jana; Burckhardt, Bjoern B.; Rubiano, Kelly; Okombo, John; Yeo, Tomas; Mok, Sachel; Uhlemann, Anne-Catrin; Lungerich, Beate; Fischli, Christoph et al.
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<i>Plasmodium falciparum</i> K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

eLife
2021 | Journal article
Contributors: Stokes, Barbara H.; Dhingra, Satish K.; Rubiano, Kelly; Mok, Sachel; Straimer, Judith; Gnadig, Nina F.; Deni, Ioanna; Schindler, Kyra A.; Bath, Jade R.; Ward, Kurt E. et al.
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A NOVEL K13 MUTATION MEDIATES PLASMODIUM FALCIPARUM RESISTANCE TO OZ439

The American Journal of Tropical Medicine and Hygiene
2021 | Journal article
Contributors: Mok, Sachel; Stokes, Barbara H.; Burkhard, Anna Y.; Yeo, Tomas; Small-Saunders, Jennifer; Okombo, John; Llinas, Manuel; Fidock, David A.
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Artemisinin-resistant K13 mutations rewire <i>Plasmodium falciparum</i>'<i>s</i> intra-erythrocytic metabolic program to enhance survival

Nature Communications
2021 | Journal article
Contributors: Mok, Sachel; Stokes, Barbara H.; Gnaedig, Nina F.; Ross, Leila S.; Yeo, Tomas; Amaratunga, Chanaki; Allman, Erik; Solyakov, Lev; Bottrill, Andrew R.; Tripathi, Jaishree et al.
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Chemoprotective antimalarials identified through quantitative high-throughput screening of <i>Plasmodium</i> blood and liver stage parasites

Scientific Reports
2021 | Journal article
Contributors: Dorjsuren, Dorjbal; Eastman, Richard T.; Wicht, Kathryn J.; Jansen, Daniel; Talley, Daniel C.; Sigmon, Benjamin A.; Zakharov, Alexey V.; Roncal, Norma; Girvin, Andrew T.; Antonova-Koch, Yevgeniya et al.
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Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite <i>Plasmodium falciparum</i> and Optimization Efforts

Journal of Medicinal Chemistry
2021 | Journal article
Contributors: Le Manach, Claire; Dam, Jean; Woodland, John G.; Kaur, Gurminder; Khonde, Lutete P.; Brunschwig, Christel; Njoroge, Mathew; Wicht, Kathryn J.; Horatscheck, Andre; Paquet, Tanya et al.
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Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in <i>Plasmodium falciparum</i>

Journal of Medicinal Chemistry
2021 | Journal article
Contributors: Lawong, Aloysus; Gahalawat, Suraksha; Okombo, John; Striepen, Josefine; Yeo, Tomas; Mok, Sachel; Deni, Ioanna; Bridgford, Jessica L.; Niederstrasser, Hanspeter; Zhou, Anwu et al.
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Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Journal of Medicinal Chemistry
2021 | Journal article
Contributors: Palmer, Michael J.; Deng, Xiaoyi; Watts, Shawn; Krilov, Goran; Gerasyuto, Aleksey; Kokkonda, Sreekanth; El Mazouni, Farah; White, John; White, Karen L.; Striepen, Josefine et al.
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Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as <i>Plasmodium</i> Cytoplasmic Prolyl-tRNA Synthetase Inhibitors

ACS Infectious Diseases
2021 | Journal article
Contributors: Okaniwa, Masanori; Shibata, Akira; Ochida, Atsuko; Akao, Yuichiro; White, Karen L.; Shackleford, David M.; Duffy, Sandra; Lucantoni, Leonardo; Dey, Sumanta; Striepen, Josefine et al.
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The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to <i>Plasmodium falciparum</i> parasite resistance

Science Translational Medicine
2021 | Journal article
Contributors: Murithi, James M.; Pascal, Cecile; Bath, Jade; Boulenc, Xavier; Gnadig, Nina F.; Pasaje, Charisse Flerida A.; Rubiano, Kelly; Yeo, Tomas; Mok, Sachel; Klieber, Sylvie et al.
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P. falciparumK13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

2021-01-30 | Preprint
Contributors: Barbara H. Stokes; Kelly Rubiano; Satish K. Dhingra; Sachel Mok; Judith Straimer; Nina F. Gnädig; Jade R. Bath; Ioanna Deni; Kurt E. Ward; Josefine Striepen et al.
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Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

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2021-01-05 | Preprint
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Local emergence in Amazonia of <i>Plasmodium falciparum k13</i> C580Y mutants associated with <i>in vitro</i> artemisinin resistance

eLife
2020 | Journal article
Contributors: Mathieu, Luana C.; Cox, Horace; Early, Angela M.; Mok, Sachel; Lazrek, Yassamine; Paquet, Jeanne-Celeste; Ade, Maria-Paz; Lucchi, Naomi W.; Grant, Quacy; Udhayakumar, Venkatachalam et al.
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The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in <i>P</i>. <i>falciparum</i> Parasites

Cell Chemical Biology
2020 | Journal article
Contributors: Yoo, Euna; Schulze, Christopher J.; Stokes, Barbara H.; Onguka, Ouma; Yeo, Tomas; Mok, Sachel; Gnadig, Nina F.; Zhou, Yani; Kurita, Kenji; Foe, Ian T. et al.
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Plasmodium falciparum artemisinin-resistant K13 mutations confer a sexual-stage transmission advantage that can be overcome with atovaquone-proguanil

2020-10-27 | Other
Contributors: Zuleima Pava; Sachel Mok; Katharine A. Collins; Maria Rebelo; Rebecca E. Watts; Gregory J. Robinson; Claire Y.T. Wang; Hayley Mitchell; Sean Lynch; Jeremy Gower et al.
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Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

Annual Review of Microbiology
2020-09-08 | Journal article
Part of ISSN: 0066-4227
Part of ISSN: 1545-3251
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Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

Cell Chemical Biology
2020-07 | Journal article
Part of ISSN: 2451-9456
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Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

PLOS Pathogens
2020-04-20 | Journal article
Part of ISSN: 1553-7374
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EXAMINING QUININE MECHANISM OF ACTION AND RESISTANCE USING A NOVEL <i>PLASMODIUM FALCIPARUM</i> GENETIC CROSS IN HUMANIZED MICE

The American Journal of Tropical Medicine and Hygiene
2019 | Journal article
Contributors: Kanai, Mariko; Ross, Leila S.; Yeo, Tomas; Shears, Melanie J.; Tripathi, Abhai; Mok, Sachel; Sinnis, Photini; Fidock, David A.
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EXAMINING THE EPISTATIC INTERACTION BETWEEN PLASMEPSIN II AND PFCRT IN <i>PLASMODIUM</i>. <i>FALCIPARUM</i> PIPERAQUINE RESISTANCE

The American Journal of Tropical Medicine and Hygiene
2019 | Journal article
Contributors: Mok, Sachel; Ross, Leila; Dhingra, Satish; Yeo, Tomas; Shears, Melanie; Tripathi, Abhai K.; Musset, Lise; Sinnis, Photini; Fidock, David A.
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Global Spread of Mutant PfCRT and Its Pleiotropic Impact on <i>Plasmodium falciparum</i> Multidrug Resistance and Fitness

mBio
2019 | Journal article
Contributors: Dhingra, Satish K.; Gabryszewski, Stanislaw J.; Small-Saunders, Jennifer L.; Yeo, Tomas; Henrich, Philipp P.; Mok, Sachel; Fidock, David A.
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MULTIPLE <i>PLASMODIUM FALCIPARUM</i> K13 MUTATIONS CONFER ARTEMISININ RESISTANCE AND MODULATE PARASITE FITNESS IN ASIAN AND AFRICAN STRAINS

The American Journal of Tropical Medicine and Hygiene
2019 | Journal article
Contributors: Stokes, Barbara H.; Rubiano, Kelly; Gnadig, Nina F.; Straimer, Judith; Anderson, Tim J.; Ariey, Frederic; Menard, Didier; Mok, Sachel; Fidock, David A.
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PIPERAQUINE RESISTANCE IS ASSOCIATED WITH DIFFERENTIAL VACUOLAR ACCUMULATION AND PEPTIDOMIC PROFILES IN <i>PLASMODIUM FALCIPARUM</i>

The American Journal of Tropical Medicine and Hygiene
2019 | Journal article
Contributors: Okombo, John; Mok, Sachel; Owen, Edward; Bozdech, Zbynek; Llinas, Manuel; Fidock, David
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The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

bioRxiv
2019 | Other
EID:

2-s2.0-85095664246

Part of ISSN: 26928205
Contributors: Yoo, E.; Schulze, C.J.; Stokes, B.H.; Onguka, O.; Yeo, T.; Mok, S.; Gnädig, N.F.; Zhou, Y.; Kurita, K.; Foe, I.T. et al.
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The Antimalarial Natural Product Salinipostin a Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. Falciparum Parasites

SSRN
2019 | Other
EID:

2-s2.0-85110808372

Part of ISSN: 15565068
Contributors: Yoo, E.; Schulze, C.J.; Stokes, B.H.; Onguka, O.; Yeo, T.; Mok, S.; Gnädig, N.F.; Zhou, Y.; Kurita, K.; Foe, I.T. et al.
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Adaptation of <i>Plasmodium falciparum</i> to its transmission environment

Nature Ecology & Evolution
2018 | Journal article
Contributors: Rono, Martin K.; Nyonda, Mary A.; Simam, Joan J.; Ngoi, Joyce M.; Mok, Sachel; Kortok, Moses M.; Abdullah, Abdullah S.; Elfaki, Mohammed M.; Waitumbi, John N.; El-Hassan, Ibrahim M. et al.
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Emerging Southeast Asian PfCRT mutations confer <i>Plasmodium</i> <i>falciparum</i> resistance to the first-line antimalarial piperaquine

Nature Communications
2018 | Journal article
Contributors: Ross, Leila S.; Dhingra, Satish K.; Mok, Sachel; Yeo, Tomas; Wicht, Kathryn J.; Kumpornsin, Krittikorn; Takala-Harrison, Shannon; Witkowski, Benoit; Fairhurst, Rick M.; Ariey, Frederic et al.
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EMERGING SOUTHEAST ASIAN PFCRT MUTATIONS CONFER <it>PLASMODIUM FALCIPARUM</it> RESISTANCE TO THE FIRST-LINE ANTIMALARIAL PIPERAQUINE

The American Journal of Tropical Medicine and Hygiene
2018 | Journal article
Contributors: Ross, Leila; Dhingra, Satish; Mok, Sachel; Yeo, Tomas; Kumpornsin, Krittikorn; Takala-Harrison, Shannon; Witkowski, Benoit; Fairhurst, Rick; Ariey, Fred; Menard, Didier et al.
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Gene copy number variation in natural populations of <i>Plasmodium falciparum</i> in Eastern Africa

BMC Genomics
2018 | Journal article
Contributors: Simam, Joan; Rono, Martin; Ngoi, Joyce; Nyonda, Mary; Mok, Sachel; Marsh, Kevin; Bozdech, Zbynek; Mackinnon, Margaret
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Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

PLOS Pathogens
2018 | Journal article
Contributors: Rocamora, Frances; Zhu, Lei; Liong, Kek Yee; Dondorp, Arjen; Miotto, Olivo; Mok, Sachel; Bozdech, Zbynek
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The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

Nature Communications
2018 | Journal article
Contributors: Zhu, Lei; Tripathi, Jaishree; Rocamora, Frances Maureen; Miotto, Olivo; van der Pluijm, Rob; Voss, Till S.; Mok, Sachel; Kwiatkowski, Dominic P.; Nosten, Francois; Day, Nicholas P. J. et al.
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A Variant PfCRT Isoform Can Contribute to <i>Plasmodium falciparum</i> Resistance to the First-Line Partner Drug Piperaquine

mBio
2017 | Journal article
Contributors: Dhingra, Satish K.; Redhi, Devasha; Combrinck, Jill M.; Yeo, Tomas; Okombo, John; Henrich, Philipp P.; Cowell, Annie N.; Gupta, Purva; Stegman, Matthew L.; Hoke, Jonathan M. et al.
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Integrated analysis of the <i>Plasmodium</i> species transcriptome

EBioMedicine
2016 | Journal article
Contributors: Hoo, Regina; Zhu, Lei; Amaladoss, Anburaj; Mok, Sachel; Natalang, Onguma; Lapp, Stacey A.; Hu, Guangan; Liew, Kingsley; Galinski, Mary R.; Bozdech, Zbynek et al.
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New insights into the <i>Plasmodium</i> <i>vivax</i> transcriptome using RNA-Seq

Scientific Reports
2016 | Journal article
Contributors: Zhu, Lei; Mok, Sachel; Imwong, Mallika; Jaidee, Anchalee; Russell, Bruce; Nosten, Francois; Day, Nicholas P.; White, Nicholas J.; Preiser, Peter R.; Bozdech, Zbynek
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<i>Plasmodium knowlesi</i> gene expression differs in <i>ex vivo</i> compared to <i>in vitro</i> blood-stage cultures

Malaria Journal
2015 | Journal article
Contributors: Lapp, Stacey A.; Mok, Sachel; Zhu, Lei; Wu, Hao; Preiser, Peter R.; Bozdech, Zybnek; Galinski, Mary R.
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A crucial piece in the puzzle of the artemisinin resistance mechanism in <i>Plasmodium falciparum</i>

Trends in Parasitology
2015 | Journal article
Contributors: Bozdech, Zbynek; Ferreira, Pedro E.; Mok, Sachel
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Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

Science
2015 | Journal article
Contributors: Mok, Sachel; Ashley, Elizabeth A.; Ferreira, Pedro E.; Zhu, Lei; Lin, Zhaoting; Yeo, Tomas; Chotivanich, Kesinee; Imwong, Mallika; Pukrittayakamee, Sasithon; Dhorda, Mehul et al.
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Peer review (10 reviews for 6 publications/grants)

Review activity for Antimicrobial agents and chemotherapy. (4)
Review activity for Biochemistry. (1)
Review activity for Malaria journal (2)
Review activity for Microbiology spectrum. (1)
Review activity for Nature communications (1)
Review activity for PLOS genetics. (1)