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Biography

I did my PhD training at the Institut Pasteur (Paris, France) and received in 2010 my degree from the University Paris-Saclay. In 2010, I joined the laboratory of Professor David Drubin as a post-doctoral fellow at UC Berkeley (USA). In 2014, I returned at the Institut Pasteur (Paris, France) in the team of Dr. Nathalie Sauvonnet in the laboratory of Professor Philippe Sansonetti where I developed organ-on-chip models for studying intestinal infections caused by the pathogen Shigella. In 2020, I joined the Chinese Academy of Sciences (CAS) as a Professor and established the Bioengineering and Microbiology Laboratory at the Institut Pasteur of Shanghai-CAS. In 2022, I joined as a team leader and ATIP/AVENIR laureate the Center for Infection and Immunity of Lille (a unit from CNRS, INSERM, University of Lille, CHU of Lille and the Institut Pasteur of Lille) . I obtained my tenure track position at INSERM the same year.

Activities

Employment (1)

INSERM: Lille, Hauts-de-France, FR

Principal Investigator (Center for Infection and Immunity of Lille)
Employment
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alexandre grassart

Education and qualifications (1)

University of Paris-Saclay: Gif-sur-Yvette, FR

2006-10-01 to 2010-02-12 | PhD (Institut Pasteur)
Education
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alexandre grassart

Professional activities (1)

SBCF: Paris, FR

Membership
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alexandre grassart

Funding (1)

Atip-Avenir

Award
CNRS -INSERM (Lille, FR)
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alexandre grassart

Works (19)

Gut-on-Chip Methodology Based on 3D-Printed Molds: A Cost-Effective and Accessible Approach

2025-01-29 | Preprint
Contributors: Elise Delannoy; Aurélie Burette; Sébastien Janel; Catherine Daniel; Alexandre Grassart
Source: check_circle
Crossref

4D live imaging and computational modeling of a functional gut-on-a-chip evaluate how peristalsis facilitates enteric pathogen invasion

Science Advances
2022-10-21 | Journal article
Contributors: Aleix Boquet-Pujadas; Thomas Feaugas; Alba Petracchini; Alexandre Grassart; Héloïse Mary; Maria Manich; Samy Gobaa; Jean-Christophe Olivo-Marin; Nathalie Sauvonnet; Elisabeth Labruyère
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Crossref

Cytokine receptor cluster size impacts its endocytosis and signaling.

Proceedings of the National Academy of Sciences of the United States of America
2021-09-01 | Journal article
Source: Self-asserted source
alexandre grassart

Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection.

Cell host & microbe
2019-10-01 | Journal article
Source: Self-asserted source
alexandre grassart

Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection.

Cell host & microbe
2019-09-03 | Journal article
Source: Self-asserted source
alexandre grassart

<i>Shigella</i> promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport.

Proceedings of the National Academy of Sciences of the United States of America
2019-06-17 | Journal article
Source: Self-asserted source
alexandre grassart

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription.

The Journal of cell biology
2018-10-22 | Journal article
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alexandre grassart
grade
Preferred source (of 2)‎

Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics.

Nature communications
2018-02-15 | Journal article
Source: Self-asserted source
alexandre grassart

Quantitative and Statistical Study of the Dynamics of Clathrin-Dependent and -Independent Endocytosis Reveal a Differential Role of EndophilinA2.

Cell reports
2018-02-01 | Journal article
Source: Self-asserted source
alexandre grassart

EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo.

eLife
2017-12-21 | Journal article
Source: Self-asserted source
alexandre grassart

Nanoscale manipulation of membrane curvature for probing endocytosis in live cells.

Nature nanotechnology
2017-06-05 | Journal article
Source: Self-asserted source
alexandre grassart

Casein kinase 1 promotes initiation of clathrin-mediated endocytosis.

Developmental cell
2015-01-01 | Journal article
Source: Self-asserted source
alexandre grassart

Actin and dynamin2 dynamics and interplay during clathrin-mediated endocytosis.

The Journal of cell biology
2014-06-02 | Journal article
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alexandre grassart

Tagging endogenous loci for live-cell fluorescence imaging and molecule counting using ZFNs, TALENs, and Cas9.

Methods in enzymology
2014-01-01 | Journal article
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alexandre grassart

Actin filament elongation in Arp2/3-derived networks is controlled by three distinct mechanisms.

Developmental cell
2013-01-17 | Journal article
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alexandre grassart

Myosin 1E coordinates actin assembly and cargo trafficking during clathrin-mediated endocytosis.

Molecular biology of the cell
2012-06-06 | Journal article
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alexandre grassart

Pak1 phosphorylation enhances cortactin-N-WASP interaction in clathrin-caveolin-independent endocytosis.

Traffic (Copenhagen, Denmark)
2010-04-28 | Journal article
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alexandre grassart

Rac1 inactivation by lethal toxin from Clostridium sordellii modifies focal adhesions upstream of actin depolymerization.

Cellular microbiology
2009-10-13 | Journal article
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alexandre grassart

Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2.

EMBO reports
2008-03-14 | Journal article
Source: Self-asserted source
alexandre grassart