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Organelle biogenesis and homeostasis Group

Other IDs

Scopus Author ID: 55458114600

Keywords

Biogenesis of secretory proteins and homeostasis of the endoplasmic reticulum; cell biology; biochem

Countries

United Kingdom

Activities

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Employment (4)

University of Oxford: Oxford, Oxfordshire, GB

(Lincoln College; Sir William Dunn School of Pathology)
Employment
Source: check_circle
ORCID Integration at the University of Oxford

Centre for Genomic Regulation-CRG: Barcelona, ES

2010-07-01 to 2016-07-31 | Principal Investigator (Cell & Developmental Biology Program)
Employment
Source: Self-asserted source
Pedro Carvalho

Harvard Medical School: Boston, MA, US

2005 to 2010 | Postdoctoral fellow
Employment
Source: Self-asserted source
Pedro Carvalho

Dana Farber Cancer Institute: Boston, MA, US

2000 to 2005 | Graduate student
Employment
Source: Self-asserted source
Pedro Carvalho

Education and qualifications (3)

Harvard Medical School: Boston, MA, US

2005 to 2010 | Post-doctoral Fellow (Cell Biology Department)
Education
Source: Self-asserted source
Pedro Carvalho

University of Porto: Porto, PT

1999 to 2005 | Phil in Biological Sciences (Dana-Farber Cancer Institute, USA)
Education
Source: Self-asserted source
Pedro Carvalho

University of Coimbra: Coimbra, PT

1993 to 1998 | B.Sc in Biochemistry
Education
Source: Self-asserted source
Pedro Carvalho

Funding (3)

Starting grant

2014 to 2016 | Grant
Generalitat de Catalunya (Barcelona, ES)
GRANT_NUMBER:

2014 SGR 1008
Source: Self-asserted source
Pedro Carvalho

International early career scientist

2012 to 2016 | Grant
Howard Hughes Medical Institute (MD, MD, US)
GRANT_NUMBER:

55007414
Source: Self-asserted source
Pedro Carvalho

International early career scientist

2012 to 2016 | Grant
Howard Hughes Medical Institute (MD, MD, US)
GRANT_NUMBER:

2626
Source: Self-asserted source
Pedro Carvalho
grade
Preferred source (of 3)‎

Works (40)

Pex30-dependent membrane contacts sites maintain ER lipid homeostasis

2025-03-12 | Other
DOI: 10.1083/jcb.202409039
Contributors: Joana Veríssimo Ferreira; Yara Ahmed; Tiaan Heunis; Aamna Jain; Errin Johnson; Markus Räschle; Robert Ernst; Stefano Vanni; Pedro Carvalho
Source: check_circle
Crossref

Topology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase

Journal of Cell Science
2024-12-01 | Journal article
DOI: 10.1242/jcs.262333
Contributors: Nikita Sergejevs; Dönem Avci; Michael L. van de Weijer; Robin A. Corey; Marius K. Lemberg; Pedro Carvalho
Source: check_circle
Crossref

A unifying mechanism for seipin‐mediated lipid droplet formation

FEBS Letters
2024-05 | Journal article
DOI: 10.1002/1873-3468.14825
Contributors: Yoel A. Klug; Joana V. Ferreira; Pedro Carvalho
Source: check_circle
Crossref

The derlin Dfm1 couples retrotranslocation of a folded protein domain to its proteasomal degradation

Journal of Cell Biology
2024-05-06 | Journal article
DOI: 10.1083/jcb.202308074
Contributors: Daniela G. Vitali; Daniel Fonseca; Pedro Carvalho
Source: check_circle
Crossref

Regulated degradation of the inner nuclear membrane protein SUN2 maintains nuclear envelope architecture and function

eLife
2022-11-01 | Journal article
DOI: 10.7554/eLife.81573
Contributors: Logesvaran Krshnan; Wingyan Skyla Siu; Michael Van de Weijer; Daniel Hayward; Elena Navarro Guerrero; Ulrike Gruneberg; Pedro Carvalho
Source: check_circle
Crossref

Seipin concentrates distinct neutral lipids via interactions with their acyl chain carboxyl esters

Journal of Cell Biology
2022-09-05 | Journal article
DOI: 10.1083/jcb.202112068
Contributors: Mike F. Renne; Robin A. Corey; Joana Veríssimo Ferreira; Phillip J. Stansfeld; Pedro Carvalho
Source: check_circle
Crossref

Regulated Degradation of the Inner Nuclear Membrane Protein SUN2 Maintains Nuclear Envelope Architecture and Function

2022-07-16 | Preprint
DOI: 10.1101/2022.07.15.500172
Contributors: Logesvaran Krshnan; Wingyan Skyla Siu; Michael Van de Weijer; Daniel Hayward; Elena Navarro Guerrero; Ulrike Gruneberg; Pedro Carvalho
Source: check_circle
Crossref

Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis

The EMBO Journal
2022-03-15 | Journal article
DOI: 10.15252/embj.2021109845
Contributors: John C Christianson; Pedro Carvalho
Source: check_circle
Crossref

Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex

Nature Communications
2021-10-08 | Journal article
DOI: 10.1038/s41467-021-26162-6
Contributors: Yoel A. Klug; Justin C. Deme; Robin A. Corey; Mike F. Renne; Phillip J. Stansfeld; Susan M. Lea; Pedro Carvalho
Source: check_circle
Crossref

Pex30-like proteins function as adaptors at distinct ER membrane contact sites

Journal of Cell Biology
2021-10-04 | Journal article
DOI: 10.1083/jcb.202103176
Contributors: Joana Veríssimo Ferreira; Pedro Carvalho
Source: check_circle
Crossref

Lipid droplet biogenesis: A mystery “unmixing”?

Seminars in Cell & Developmental Biology
2020-12 | Journal article
DOI: 10.1016/j.semcdb.2020.03.001
Contributors: Mike F. Renne; Yoel A. Klug; Pedro Carvalho
Source: check_circle
Crossref

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.

Molecular cell
2020-07-31 | Journal article
DOI: 10.1016/j.molcel.2020.07.009
PMID: 32738194
PMC: PMC7482433
Source: Self-asserted source
Pedro Carvalho

The derlin Dfm1 promotes retrotranslocation of folded protein domains from the endoplasmic reticulum

2020-06-03 | Preprint
DOI: 10.1101/2020.06.02.131128
Contributors: Daniel Fonseca; Pedro Carvalho
Source: check_circle
Crossref

Principles of organelle spatial organization and interactions.

Molecular biology of the cell
2020-03-01 | Journal article
DOI: 10.1091/mbc.e20-01-0007
PMID: 32163349
Source: Self-asserted source
Pedro Carvalho

Quality Control of Protein Complex Assembly by a Transmembrane Recognition Factor.

Molecular cell
2019-10-31 | Journal article
DOI: 10.1016/j.molcel.2019.10.003
PMID: 31679820
PMC: PMC6941229
Source: Self-asserted source
Pedro Carvalho

EGAD ! There is an ERAD doppelganger in the Golgi

The EMBO Journal
2019-08 | Journal article
DOI: 10.15252/embj.2019102679
Contributors: Daniel Fonseca; Pedro Carvalho
Source: check_circle
Crossref

Membrane Asymmetry Imposes Directionality on Lipid Droplet Emergence from the ER.

Developmental cell
2019-05-30 | Journal article
DOI: 10.1016/j.devcel.2019.05.003
PMID: 31155466
Source: Self-asserted source
Pedro Carvalho

Dynamics and functions of lipid droplets

Nature Reviews Molecular Cell Biology
2019-03-06 | Journal article
DOI: 10.1038/s41580-018-0085-z
Contributors: James A. Olzmann; Pedro Carvalho
Source: check_circle
Crossref

Life of proteins: from nascent chain to degradation.

Nature structural & molecular biology
2018-11-01 | Journal article
DOI: 10.1038/s41594-018-0150-5
PMID: 30374085
Source: Self-asserted source
Pedro Carvalho

Here, there, and everywhere: The importance of ER membrane contact sites

Science
2018-08-03 | Journal article
DOI: 10.1126/science.aan5835
Contributors: Haoxi Wu; Pedro Carvalho; Gia K. Voeltz
Source: check_circle
Crossref

Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum

Nature Communications
2018-07-27 | Journal article
DOI: 10.1038/s41467-018-05278-2
Contributors: Sihui Wang; Fatima-Zahra Idrissi; Martin Hermansson; Alexandra Grippa; Christer S. Ejsing; Pedro Carvalho
Source: check_circle
Crossref

Regulation of lipid droplets by metabolically controlled Ldo isoforms

Journal of Cell Biology
2018-01-02 | Journal article
DOI: 10.1083/jcb.201704115
Contributors: Vitor Teixeira; Lisa Johnsen; Fernando Martínez-Montañés; Alexandra Grippa; Laura Buxó; Fatima-Zahra Idrissi; Christer S. Ejsing; Pedro Carvalho
Source: check_circle
Crossref

Spatial control of lipid droplet proteins by the ERAD ubiquitin ligase Doa10

The EMBO Journal
2016-08 | Journal article
DOI: 10.15252/embj.201593106
Contributors: Annamaria Ruggiano; Gabriel Mora; Laura Buxó; Pedro Carvalho
Source: check_circle
Crossref

ER-associated degradation: Protein quality control and beyond

Journal of Cell Biology
2014 | Journal article
DOI: 10.1083/jcb.201312042
EID:

2-s2.0-84896270715
Contributors: Ruggiano, A.; Foresti, O.; Carvalho, P.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Key steps in ERAD of luminal ER proteins reconstituted with purified components

Cell
2014 | Journal article
DOI: 10.1016/j.cell.2014.07.050
EID:

2-s2.0-84908072286
Contributors: Stein, A.; Ruggiano, A.; Carvalho, P.; Rapoport, T.A.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Quality control of inner nuclear membrane proteins by the Asi complex

Science
2014 | Journal article
DOI: 10.1126/science.1255638
EID:

2-s2.0-84909962081
Contributors: Foresti, O.; Rodriguez-Vaello, V.; Funaya, C.; Carvalho, P.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

eLife
2013 | Journal article
DOI: 10.7554/eLife.00953
EID:

2-s2.0-84880707873
Contributors: Foresti, O.; Ruggiano, A.; Hannibal-Bach, H.K.; Ejsing, C.S.; Carvalho, P.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

A Complex of Pdi1p and the Mannosidase Htm1p Initiates Clearance of Unfolded Glycoproteins from the Endoplasmic Reticulum

Molecular Cell
2011 | Journal article
DOI: 10.1016/j.molcel.2011.04.027
EID:

2-s2.0-79959357020
Contributors: Gauss, R.; Kanehara, K.; Carvalho, P.; Ng, D.; Aebi, M.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Recognition of an ERAD-L substrate analyzed by site-specific in vivo photocrosslinking

FEBS Letters
2011 | Journal article
DOI: 10.1016/j.febslet.2011.04.009
EID:

2-s2.0-79955611686
Contributors: Stanley, A.M.; Carvalho, P.; Rapoport, T.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase hrd1p

Cell
2010 | Journal article
DOI: 10.1016/j.cell.2010.10.028
EID:

2-s2.0-78149482323
Contributors: Carvalho, P.; Stanley, A.M.; Rapoport, T.A.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

FEBS Letters
2008 | Journal article
DOI: 10.1016/j.febslet.2008.03.056
EID:

2-s2.0-42749085043
Contributors: Goder, V.; Carvalho, P.; Rapoport, T.A.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Distinct Ubiquitin-Ligase Complexes Define Convergent Pathways for the Degradation of ER Proteins

Cell
2006 | Journal article
DOI: 10.1016/j.cell.2006.05.043
EID:

2-s2.0-33746228127
Contributors: Carvalho, P.; Goder, V.; Rapoport, T.A.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle

Nature Cell Biology
2006 | Journal article
DOI: 10.1038/ncb1457
EID:

2-s2.0-33748158378
Contributors: Gupta Jr., M.L.; Carvalho, P.; Roof, D.M.; Pellman, D.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation

Developmental Cell
2004 | Journal article
DOI: 10.1016/j.devcel.2004.05.001
EID:

2-s2.0-2942617092
Contributors: Carvalho, P.; Gupta Jr., M.L.; Hoyt, M.A.; Pellman, D.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Mitotic spindle: Laser microsurgery in yeast cells

Current Biology
2004 | Journal article
DOI: 10.1016/j.cub.2004.09.010
EID:

2-s2.0-4544350984
Contributors: Carvalho, P.; Pellman, D.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Determinants of S. cerevisiae dynein localization and activation: Implications for the mechanism of spindle positioning

Current Biology
2003 | Journal article
DOI: 10.1016/S0960-9822(03)00013-7
EID:

2-s2.0-0037418576
Contributors: Sheeman, B.; Carvalho, P.; Sagot, I.; Geiser, J.; Kho, D.; Hoyt, M.A.; Pellman, D.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Surfing on microtubule ends

Trends in Cell Biology
2003 | Journal article
DOI: 10.1016/S0962-8924(03)00074-6
EID:

2-s2.0-0037725028
Contributors: Carvalho, P.; Tirnauer, J.S.; Pellman, D.
Source: Self-asserted source
Pedro Carvalho via Scopus - Elsevier

Polyploids require Bik1 for kinetochore-microtubule attachment

JOURNAL OF CELL BIOLOGY
Journal article
DOI: {10.1083/jcb.200108119}
Source: Self-asserted source
Pedro Carvalho
grade
Preferred source (of 2)‎

The pan-inhibitor of VEGF receptors, GW654652 blocks growth and migration of multiple myeloma cells in the bone marrow microenvironment.

BLOOD
Journal article
Source: Self-asserted source
Pedro Carvalho

The pan-inhibitor of VEGF receptors, GW654652 blocks growth and migration of multiple myeloma cells in the bone marrow microenvironment.

BLOOD
Journal article
Source: Self-asserted source
Pedro Carvalho
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