Personal information

No personal information available

Activities

Collapse all

Employment (1)

Washington University in St Louis School of Medicine: St Louis, MO, US

2009-03-02 to present | Associate Professor (Department of Cell Biology and Physiology)
Employment
Source: Self-asserted source
Zhongsheng You

Education and qualifications (1)

University of California, San Diego: CA, CA, US

1997-09 to 2002-06 | PhD (Division of Biological Sciences)
Education
Source: Self-asserted source
Zhongsheng You

Works (38)

ACSS2: Tumor-promoting lactyl-CoA synthetase that drives histone lactylation

hLife
2025-01 | Journal article
DOI: 10.1016/j.hlife.2024.12.007
Contributors: Katherine L. Wang; Zhongsheng You
Source: check_circle
Crossref

Distinct regulation of ATM signaling by DNA single-strand breaks and APE1

Nature Communications
2024-08-07 | Journal article
DOI: 10.1038/s41467-024-50836-6
Contributors: Haichao Zhao; Jia Li; Zhongsheng You; Howard D. Lindsay; Shan Yan
Source: check_circle
Crossref

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

eLife
2023-09-06 | Journal article
DOI: 10.7554/eLife.86976.3
Contributors: Yanqiu Li; Feifei Wang; Xin Li; Ling Wang; Zheng Yang; Zhongsheng You; Aimin Peng
Source: check_circle
Crossref

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

eLife
2023-09-06 | Journal article
DOI: 10.7554/eLife.86976
Contributors: Yanqiu Li; Feifei Wang; Xin Li; Ling Wang; Zheng Yang; Zhongsheng You; Aimin Peng
Source: check_circle
Crossref

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

2023-07-12 | Preprint
DOI: 10.7554/eLife.86976.2
Contributors: Yanqiu Li; Feifei Wang; Xin Li; Ling Wang; Zheng Yang; Zhongsheng You; Aimin Peng
Source: check_circle
Crossref

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

2023-04-25 | Preprint
DOI: 10.7554/eLife.86976.1
Contributors: Yanqiu Li; Feifei Wang; Xin Li; Ling Wang; Zheng Yang; Zhongsheng You; Aimin Peng
Source: check_circle
Crossref

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

2023-02-22 | Preprint
DOI: 10.1101/2023.02.22.529521
Contributors: Yanqiu Li; Feifei Wang; Xin Li; Ling Wang; Zheng Yang; Zhongsheng You; Aimin Peng
Source: check_circle
Crossref

Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring <i>SF3B1</i> or <i>U2AF1</i> Mutations

Cancer Research
2021-09-01 | Journal article
DOI: 10.1158/0008-5472.can-20-4016
Part of ISSN: 0008-5472
Part of ISSN: 1538-7445
Source: Self-asserted source
Zhongsheng You

Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Cell Reports
2020-06 | Journal article
DOI: 10.1016/j.celrep.2020.107745
Part of ISSN: 2211-1247
Source: Self-asserted source
Zhongsheng You

Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

Molecular Cell
2019-06 | Journal article
DOI: 10.1016/j.molcel.2019.04.003
Part of ISSN: 1097-2765
Source: Self-asserted source
Zhongsheng You

Repair of protein-linked DNA double strand breaks: Using the adenovirus genome as a model substrate in cell-based assays

DNA Repair
2019-02 | Journal article
DOI: 10.1016/j.dnarep.2018.12.001
Part of ISSN: 1568-7864
Source: Self-asserted source
Zhongsheng You
grade
Preferred source (of 2)‎

Studying Nonsense-Mediated mRNA Decay in Mammalian Cells Using a Multicolored Bioluminescence-Based Reporter System

mRNA Decay
2018 | Book chapter
DOI: 10.1007/978-1-4939-7540-2_16
Part of ISBN: 9781493975396
Part of ISBN: 9781493975402
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Source: Self-asserted source
Zhongsheng You

Compound C inhibits nonsense-mediated RNA decay independently of AMPK

PLOS ONE
2018-10-05 | Journal article
DOI: 10.1371/journal.pone.0204978
Part of ISSN: 1932-6203
Source: Self-asserted source
Zhongsheng You
grade
Preferred source (of 2)‎

Control of gene expression through the nonsense-mediated RNA decay pathway

Cell &amp; Bioscience
2017-12 | Journal article
DOI: 10.1186/s13578-017-0153-7
Part of ISSN: 2045-3701
Source: Self-asserted source
Zhongsheng You
grade
Preferred source (of 2)‎

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

Nature Communications
2017-12 | Journal article
DOI: 10.1038/s41467-017-01180-5
Part of ISSN: 2041-1723
Source: Self-asserted source
Zhongsheng You

Dna2 initiates resection at clean DNA double-strand breaks

Nucleic Acids Research
2017-11-16 | Journal article
DOI: 10.1093/nar/gkx830
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Zhongsheng You

p38 MAPK inhibits nonsense-mediated RNA decay in response to persistent DNA damage in noncycling cells

Journal of Biological Chemistry
2017-09 | Journal article
DOI: 10.1074/jbc.m117.787846
Part of ISSN: 0021-9258
Source: Self-asserted source
Zhongsheng You

Sharpening the ends for repair: mechanisms and regulation of DNA resection

Acta Biochimica et Biophysica Sinica
2016-07 | Journal article
DOI: 10.1093/abbs/gmw043
Part of ISSN: 1672-9145
Part of ISSN: 1745-7270
Source: Self-asserted source
Zhongsheng You

A cell cycle-dependent BRCA1–UHRF1 cascade regulates DNA double-strand break repair pathway choice

Nature Communications
2016-04 | Journal article
DOI: 10.1038/ncomms10201
Part of ISSN: 2041-1723
Source: Self-asserted source
Zhongsheng You

USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response

Genes &amp; Development
2016-04-15 | Journal article
DOI: 10.1101/gad.271841.115
Part of ISSN: 0890-9369
Part of ISSN: 1549-5477
Source: Self-asserted source
Zhongsheng You

Poly(ADP-ribose)-binding promotes Exo1 damage recruitment and suppresses its nuclease activities

DNA Repair
2015-11 | Journal article
DOI: 10.1016/j.dnarep.2015.09.021
Part of ISSN: 1568-7864
Source: Self-asserted source
Zhongsheng You

14-3-3 Proteins Restrain the Exo1 Nuclease to Prevent Overresection

Journal of Biological Chemistry
2015-05 | Journal article
DOI: 10.1074/jbc.m115.644005
Part of ISSN: 0021-9258
Source: Self-asserted source
Zhongsheng You

Intracellular calcium regulates nonsense-mediated mRNA decay

Nature Medicine
2014-08 | Journal article
DOI: 10.1038/nm.3620
Part of ISSN: 1078-8956
Part of ISSN: 1546-170X
Source: Self-asserted source
Zhongsheng You

PCNA promotes processive DNA end resection by Exo1

Nucleic Acids Research
2013-11 | Journal article
DOI: 10.1093/nar/gkt672
Part of ISSN: 1362-4962
Part of ISSN: 0305-1048
Source: Self-asserted source
Zhongsheng You

CHFR is important for the first wave of ubiquitination at DNA damage sites

Nucleic Acids Research
2013-02 | Journal article
DOI: 10.1093/nar/gks1278
Part of ISSN: 1362-4962
Part of ISSN: 0305-1048
Source: Self-asserted source
Zhongsheng You

Loss of ATM kinase activity leads to embryonic lethality in mice

Journal of Cell Biology
2012-08-06 | Journal article
DOI: 10.1083/jcb.201204035
Part of ISSN: 1540-8140
Part of ISSN: 0021-9525
Source: Self-asserted source
Zhongsheng You

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Nature
2011-02 | Journal article
DOI: 10.1038/nature09658
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Zhongsheng You

Analysis of DNA double-strand break response and chromatin structure in mitosis using laser microirradiation

Nucleic Acids Research
2010-12-01 | Journal article
DOI: 10.1093/nar/gkq836
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Zhongsheng You

DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints

Trends in Cell Biology
2010-07 | Journal article
DOI: 10.1016/j.tcb.2010.04.002
Part of ISSN: 0962-8924
Source: Self-asserted source
Zhongsheng You

CtIP Links DNA Double-Strand Break Sensing to Resection

Molecular Cell
2009-12 | Journal article
DOI: 10.1016/j.molcel.2009.12.002
Part of ISSN: 1097-2765
Source: Self-asserted source
Zhongsheng You

The F Box Protein Fbx6 Regulates Chk1 Stability and Cellular Sensitivity to Replication Stress

Molecular Cell
2009-08 | Journal article
DOI: 10.1016/j.molcel.2009.06.030
Part of ISSN: 1097-2765
Source: Self-asserted source
Zhongsheng You

Rapid activation of ATM on DNA flanking double-strand breaks

Nature Cell Biology
2007-11 | Journal article
DOI: 10.1038/ncb1651
Part of ISSN: 1465-7392
Part of ISSN: 1476-4679
Source: Self-asserted source
Zhongsheng You

Monitoring ATM kinase activity in living cells

DNA Repair
2007-09-01 | Journal article
DOI: 10.1016/j.dnarep.2007.02.025
Part of ISSN: 1568-7864
Source: Self-asserted source
Zhongsheng You

Protein Phosphatase 2A Antagonizes ATM and ATR in a Cdk2- and Cdc7-Independent DNA Damage Checkpoint

Molecular and Cellular Biology
2006-03 | Journal article
DOI: 10.1128/mcb.26.5.1997-2011.2006
Part of ISSN: 0270-7306
Part of ISSN: 1098-5549
Source: Self-asserted source
Zhongsheng You

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

Molecular and Cellular Biology
2005-07 | Journal article
DOI: 10.1128/mcb.25.13.5363-5379.2005
Part of ISSN: 0270-7306
Part of ISSN: 1098-5549
Source: Self-asserted source
Zhongsheng You

The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint

Journal of Biological Chemistry
2002-07 | Journal article
DOI: 10.1074/jbc.m204120200
Part of ISSN: 0021-9258
Source: Self-asserted source
Zhongsheng You

Xic1 degradation in <i>Xenopus</i> egg extracts is coupled to initiation of DNA replication

Genes &amp; Development
2002-05-15 | Journal article
DOI: 10.1101/gad.985302
Part of ISSN: 0890-9369
Part of ISSN: 1549-5477
Source: Self-asserted source
Zhongsheng You

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

Current Biology
2000-12 | Journal article
DOI: 10.1016/s0960-9822(00)00855-1
Part of ISSN: 0960-9822
Source: Self-asserted source
Zhongsheng You

Peer review (4 reviews for 4 publications/grants)

Review activity for Cell & bioscience. (1)
Review activity for Nature communications (1)
Review activity for PLOS genetics. (1)
Review activity for Science advances. (1)
How many people are using ORCID?