TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets.
Cytoskeletal and scaffolding proteins as structural and functional determinants of TRP channels.
The TRPV1 ion channel is expressed in human but not mouse platelets.
The canonical transient receptor potential 6 (TRPC6) channel is sensitive to extracellular pH in mouse platelets.
Transient receptor potential ankyrin-1 (TRPA1) modulates store-operated Ca(2+) entry by regulation of STIM1-Orai1 association.
Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation.
The membrane potential modulates thrombin-stimulated Ca²⁺ mobilization and platelet aggregation.
Recent advances in cardiovascular and circulatory signalling.
Pharmacology of TRP channels in the vasculature.
Molecular interplay between platelets and the vascular wall in thrombosis and hemostasis.
Homer proteins in Ca²⁺ entry.
The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium.
Long-term mTOR inhibitors administration evokes altered calcium homeostasis and platelet dysfunction in kidney transplant patients.
FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells.
Immunophilins are involved in the altered platelet aggregation observed in patients with type 2 diabetes mellitus.
Unraveling STIM2 function.
Transient receptor potential channels in human platelets: expression and functional role.
Two-pore channel 2 (TPC2) modulates store-operated Ca(2+) entry.
Capacitative and non-capacitative signaling complexes in human platelets.
Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1.
STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets.
Urotensin-II signaling mechanism in rat coronary artery: role of STIM1 and Orai1-dependent store operated calcium influx in vasoconstriction.
Orais and STIMs: physiological mechanisms and disease.
Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep.
Store-operated Ca(2+) entry.
Functional role of the calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) site of TRPC6 in human platelet activation.
The cytoskeleton plays a modulatory role in the association between STIM1 and the Ca2+ channel subunits Orai1 and TRPC1.
Acidic NAADP-releasable Ca(2+) compartments in the megakaryoblastic cell line MEG01.
Acidic Ca(2+) stores in platelets.
Two distinct calcium pools in the endoplasmic reticulum of HEK-293T cells.
STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets.
Lipid rafts are essential for the regulation of SOCE by plasma membrane resident STIM1 in human platelets.
Attenuated store-operated divalent cation entry and association between STIM1, Orai1, hTRPC1 and hTRPC6 in platelets from type 2 diabetic patients.
Modulation of platelet function and signaling by flavonoids.
The TRPC ion channels: association with Orai1 and STIM1 proteins and participation in capacitative and non-capacitative calcium entry.
Immunophilins and thrombotic disorders.
Immunophilin dysfunction and neuropathology.
Ca2+ leakage rate from agonist-sensitive intracellular pools is altered in platelets from patients with type 2 diabetes.
Lipid rafts modulate the activation but not the maintenance of store-operated Ca(2+) entry.
Synthesis and evaluation of the platelet antiaggregant properties of phenolic antioxidants structurally related to rosmarinic acid.
Homocysteine induces caspase activation by endoplasmic reticulum stress in platelets from type 2 diabetics and healthy donors.
TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.
SERCA2b activity is regulated by cyclophilins in human platelets.
Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: Evidence for the involvement of mitochondria and Bax activation.
Role of oxidant scavengers in the prevention of Ca²+ homeostasis disorders.
Homocysteine, intracellular signaling and thrombotic disorders.
Store-operated Ca2+ entry is sensitive to the extracellular Ca2+ concentration through plasma membrane STIM1.
STIM1, Orai1 and hTRPC1 are important for thrombin- and ADP-induced aggregation in human platelets.
Acidic-store depletion is required for human platelet aggregation.
Role of Calcium Signals on Hydrogen Peroxide-Induced Apoptosis in Human Myeloid HL-60 Cells.
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress.
Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca(2+) entry pathways.
Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells.
Hepatitis C virus NS5A and core proteins induce oxidative stress-mediated calcium signalling alterations in hepatocytes.
Melatonin, as an adjuvant-like agent, enhances platelet responsiveness.
Melatonin enhances the immune response to vaccination against A1 and C strains of Dichelobacter nodosus.
TRPC channels and store-operated Ca(2+) entry.
Platelet function in hypertension.
Olive tree wood phenolic compounds with human platelet antiaggregant properties.
Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus.
Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus.
Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets.
Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus.
Protein complex immunological separation assay (ProCISA): a technique for investigating single protein properties.
Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels.
STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets.
Intracellular Ca2+ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP3 receptor and SERCA3 in human platelets.
Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca2+ store depletion.
Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor.
Physical properties of two types of calcium stores and SERCAs in human platelets.
Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets.
SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.
Intracellular calcium release from human platelets: different messengers for multiple stores.
Phosphatidylinositol 4,5-bisphosphate enhances store-operated calcium entry through hTRPC6 channel in human platelets.
Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1.
Platelet signalling abnormalities in patients with type 2 diabetes mellitus: a review.
Natriuretic peptides in vascular physiology and pathology.
hTRPC1-associated alpha-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation.
Dual role of tubulin-cytoskeleton in store-operated calcium entry in human platelets.
Involvement of SNARE proteins in thrombin-induced platelet aggregation: evidence for the relevance of Ca2+ entry.
Antiaggregant effects of Arbutus unedo extracts in human platelets.
Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets.
Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets.
Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets.
Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets.
Altered calcium signalling in platelets from bile-duct-ligated rats.
Differential involvement of thrombin receptors in Ca2+ release from two different intracellular stores in human platelets.
Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients.
Transient receptor potential channels and intracellular signaling.
Renal atrial natriuretic peptide receptors binding properties and function are resistant to DOCA-salt-induced hypertension in rats.
Discovering the mechanism of capacitative calcium entry.
Early caspase-3 activation independent of apoptosis is required for cellular function.
Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores.
Inhibitory effect of Ca(2+) on ATP-mediated stimulation of NPR-A-coupled guanylyl cyclase in renal glomeruli from spontaneously hypertensive and normotensive rats.
Intracellular Ca2+ homeostasis and aggregation in platelets are impaired by ethanol through the generation of H2O2 and oxidation of sulphydryl groups.
Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus.
Caspases 3 and 9 are translocated to the cytoskeleton and activated by thrombin in human platelets. Evidence for the involvement of PKC and the actin filament polymerization.
Involvement of ryanodine-operated channels in tert-butylhydroperoxide-evoked Ca2+ mobilisation in pancreatic acinar cells.
Calcium signalling and reactive oxygen species in non-excitable cells.
Two distinct Ca2+ compartments show differential sensitivity to thrombin, ADP and vasopressin in human platelets.
Alterations in intracellular calcium homeostasis and platelet aggregation induced by ethanol.
A role for cofilin in the activation of store-operated calcium entry by de novo conformational coupling in human platelets.
A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets.
Thrombin-induced caspases 3 and 9 translocation to the cytoskeleton is independent of changes in cytosolic calcium in human platelets.
Different effect of ATP on ANP receptor guanylyl cyclase in spontaneously hypertensive and normotensive rats.
Collaborative effect of SERCA and PMCA in cytosolic calcium homeostasis in human platelets.
Characteristics of the renal C-type natriuretic peptide receptor in hypertrophied and developing rat kidney.
Store-operated Ca2+ entry: vesicle fusion or reversible trafficking and de novo conformational coupling?
Dynamics of calcium fluxes in human platelets assessed in calcium-free medium.
Hydrogen peroxide and peroxynitrite enhance Ca2+ mobilization and aggregation in platelets from type 2 diabetic patients.
Ca2+-independent activation of Bruton's tyrosine kinase is required for store-mediated Ca2+ entry in human platelets.
Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets.
Disruption of the filamentous actin cytoskeleton is necessary for the activation of capacitative calcium entry in naive smooth muscle cells.
Cleavage of SNAP-25 and VAMP-2 impairs store-operated Ca2+ entry in mouse pancreatic acinar cells.
G-protein coupled receptors and calcium signaling in development.
Store-operated Ca(2+) entry and tyrosine kinase pp60(src) hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus.
Water deprivation enhances the inhibitory effect of natriuretic peptides on cAMP synthesis in rat renal glomeruli.
Reduced plasma membrane Ca2+-ATPase function in platelets from patients with non-insulin-dependent diabetes mellitus.
Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets.
A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets.
Patterning of renal cGMP production by the natriuretic peptide receptor type A and blood pressure in spontaneously hypertensive rats.
Dietary virgin olive oil enhances secretagogue-evoked calcium signaling in rat pancreatic acinar cells.
Dual effect of hydrogen peroxide on store-mediated calcium entry in human platelets.
Effect of hydrogen peroxide on Ca2+ mobilisation in human platelets through sulphydryl oxidation dependent and independent mechanisms.
Hydrogen peroxide generation induces pp60src activation in human platelets: evidence for the involvement of this pathway in store-mediated calcium entry.
Differences between natriuretic peptide receptors in the olfactory bulb and hypothalamus from spontaneously hypertensive and normotensive rat brain.
Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells.
TRP channels and calcium entry in human platelets.
Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets.
The ERK cascade, a new pathway involved in the activation of store-mediated calcium entry in human platelets.
Effects of reactive oxygen species on actin filament polymerisation and amylase secretion in mouse pancreatic acinar cells.
Expression and control of C-type natriuretic peptide in rat vascular smooth muscle cells.
Dendroaspis natriuretic peptide-like immunoreactivity and its regulation in rat aortic vascular smooth muscle.
The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: cautions for its use in studying Ca2+ influx.
Tumor necrosis factor-alpha inhibits store-mediated Ca2+ entry in the human hepatocellular carcinoma cell line HepG2.
Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets.
Fibrinogen binding to the integrin alpha(IIb)beta(3) modulates store-mediated calcium entry in human platelets.
Cyclic nucleotides modulate store-mediated calcium entry through the activation of protein-tyrosine phosphatases and altered actin polymerization in human platelets.
Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets.
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets.
Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton.
Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted.
Regulation of plasma membrane Ca2+-ATPase by small GTPases and phosphoinositides in human platelets.
Activation of m3 muscarinic receptors induces rapid tyrosine phosphorylation of p125(FAK), p130(cas), and paxillin in rat pancreatic acini.
Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton.
Phosphoinositides are required for store-mediated calcium entry in human platelets.
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling.
A role for phosphoinositides in tyrosine phosphorylation of p125 focal adhesion kinase in rat pancreatic acini.
Are tyrosine phosphorylation of p125(FAK) and paxillin or the small GTP binding protein, rho, needed for CCK-stimulated pancreatic amylase secretion?
Cholecystokinin-stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho.
CCK causes rapid tyrosine phosphorylation of p125FAK focal adhesion kinase and paxillin in rat pancreatic acini.
Ionic requirements in histamine-evoked potassium efflux in guinea pig pancreas.
Acetylcholine-evoked potassium transport in the isolated guinea-pig pancreas.
Secretin potentiates guinea pig pancreatic response to cholecystokinin by a cholinergic mechanism.
Histamine-evoked potassium release in the mouse and guinea pig pancreas.
The actin cytoskeleton in store-mediated calcium entry
Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1
Receptor subtypes for vasonatrin peptide in renal glomeruli and arteries
Recent advances in natriuretic peptide research
Protein kinase C activates non-capacitative calcium entry in human platelets
Editorial [Hot Topic: A Role for Immunophilins in Cellular Signalling in Health and Disease (Guest Editors: Juan Antonio Rosado Dionisio and Pedro Cosme Redondo Liberal)]
Biochemical and functional properties of the store-operated Ca2+ channels
A-type natriuretic peptide receptor in the spontaneously hypertensive rat kidney