Personal information

Activities

Employment (2)

Massachusetts General Hospital: Boston, MA, US

1999 to present | Associate Professor of Medicine (Medicine)
Employment
Source: Self-asserted source
Georg Lauer

Harvard Medical School: Boston, MA, US

1999-09-01 to present | Associate Professor of Medicine
Employment
Source: Self-asserted source
Georg Lauer

Funding (9)

T cells in HCV/HIV co-infection

2018-03-01 to 2022-12-31 | Grant
National Institute on Drug Abuse (Bethesda, US)
GRANT_NUMBER: R01DA046277
Source: Self-asserted source
Georg Lauer via DimensionsWizard

Immune Control and Evadion during Acute HCV Infection

2016-08-20 to 2021-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: U01AI131314
Source: Self-asserted source
Georg Lauer via DimensionsWizard

T cell responses at the site of infection

2015-06-15 to 2017-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R21AI115476
Source: Self-asserted source
Georg Lauer via DimensionsWizard

CD4+ T Cells in Acute Versus Chronic HCV Infection

2013-02-01 to 2019-01-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R01AI105035
Source: Self-asserted source
Georg Lauer via DimensionsWizard

CD4+ T Cells in Acute Versus Chronic HCV Infection

2013-02-01 to 2018-01-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5R01AI105035-03
GRANT_NUMBER: 5R01AI105035-03
Source: Self-asserted source
Georg Lauer via DimensionsWizard
grade
Preferred source (of 2)‎

Reversal of Immune Failure with Viral Cure in Chronic HCV Infection

2009-06-08 to 2019-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: U19AI082630
Source: Self-asserted source
Georg Lauer via DimensionsWizard

Immune Control and Evasion during Acute HCV Infection

2005-08-17 to 2016-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: U19AI066345
Source: Self-asserted source
Georg Lauer via DimensionsWizard

Immune Control and Evasion during Acute HCV Infection

2005-08-17 to 2015-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5U19AI066345-10
GRANT_NUMBER: 5U19AI066345-10
Source: Self-asserted source
Georg Lauer via DimensionsWizard
grade
Preferred source (of 2)‎

Tetramer Assay in der Analyse der zytotoxischen T-Zellantwort bei der akuten und chronischen Hepatitis C-Virusinfektion

1999-01-01 to 2002-12-31 | Grant
German Research Foundation (Bonn, DE)
GRANT_NUMBER: 5191266
Source: Self-asserted source
Georg Lauer via DimensionsWizard

Works (50 of 123)

Items per page:
Page 1 of 3

Precision-cut liver slices as an ex vivo model to evaluate antifibrotic therapies for liver fibrosis and cirrhosis

Hepatology Communications
2024-11 | Journal article
Contributors: Yongtao Wang; Ben Leaker; Guoliang Qiao; Mozhdeh Sojoodi; Ibrahim Ragab Eissa; Eliana T. Epstein; Jonathan Eddy; Oizoshimoshiofu Dimowo; Georg M. Lauer; Motaz Qadan et al.
Source: check_circle
Crossref

Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set

Science Advances
2024-04-12 | Journal article
Contributors: Nikolaj Pagh Kristensen; Edoardo Dionisio; Amalie Kai Bentzen; Tripti Tamhane; Janine Sophie Kemming; Grigorii Nos; Lasse Frank Voss; Ulla Kring Hansen; Georg Michael Lauer; Sine Reker Hadrup
Source: check_circle
Crossref

Comment on ‘End-of-treatment HBcrAg and HBsAb levels identify durable functional cure after Peg-IFN-based therapy in patients with CHB’

Journal of Hepatology
2023-11 | Journal article
Contributors: Antonio Bertoletti; Nina Le Bert; Anthony T. Tan; Carolina Boni; Paola Fisicaro; Carlo Ferrari; Kyong-Mi Chang; Adam J. Gehring; Georg Lauer; Mala Maini et al.
Source: check_circle
Crossref

Implementation of a controlled human infection model for evaluation of HCV vaccine candidates

Hepatology
2023-05 | Journal article
Contributors: Eleanor Barnes; Graham S. Cooke; Georg M. Lauer; Raymond T. Chung
Source: check_circle
Crossref

Omics studies in gastroenterological and hepatological patient populations: current impact and future promise exemplified by a large study of HCV-infected livers

Gut
2023-05 | Journal article
Contributors: Georg M Lauer
Source: check_circle
Crossref

Immunological biomarker discovery in cure regimens for chronic hepatitis B virus infection

Journal of Hepatology
2022-08 | Journal article
Contributors: Adam J. Gehring; Patricia Mendez; Kirsten Richter; Hildegund Ertl; Eric F. Donaldson; Poonam Mishra; Mala Maini; Andre Boonstra; Georg Lauer; An de Creus et al.
Source: check_circle
Crossref

Genomic characterization of hepatitis C virus transmitted founder variants with deep sequencing.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2019-03 | Journal article
Contributors: Abayasingam A; Leung P; Eltahla A; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Innocent Spectators, Helping Hands or a Fifth Column? Acute Hepatitis A Infection Reveals Important Insights Into Bystander T Cells.

Hepatology (Baltimore, Md.)
2019-02 | Journal article
Contributors: Hoogeveen RC; Lauer GM
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Dynamic changes in innate immune responses during direct-acting antiviral therapy for HCV infection.

Journal of viral hepatitis
2019-01 | Journal article
Contributors: Holmes JA; Carlton-Smith C; Kim AY; Dumas EO; Brown J; Gustafson JL; Lauer GM; Silva ST; Robidoux M; Kvistad D et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Genomic variability of within-host hepatitis C variants in acute infection.

Journal of viral hepatitis
2019-01 | Journal article
Contributors: Rodrigo C; Leung P; Lloyd AR; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Simultaneous Analysis of HCV-Specific CD4+ and CD8+ T Cells by Multicolor Flow Cytometry.

Methods in molecular biology (Clifton, N.J.)
2019-01 | Journal article
Contributors: Wolski D; Lauer GM
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Genetic and structural insights into broad neutralization of hepatitis C virus by human V H 1-69 antibodies

Science Advances
2019-01-04 | Journal article
Contributors: Netanel Tzarum; Erick Giang; Leopold Kong; Linling He; Jannick Prentoe; Elias Augestad; Yuanzi Hua; Shaun Castillo; Georg M. Lauer; Jens Bukh et al.
Source: check_circle
Crossref

Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus.

Gastroenterology
2018-12 | Journal article
Contributors: Vergara C; Thio CL; Johnson E; Kral AH; O'Brien TR; Goedert JJ; Mangia A; Piazzolla V; Mehta SH; Kirk GD et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection.

Gut
2018-12 | Journal article
Contributors: Hoogeveen RC; Robidoux MP; Schwarz T; Heydmann L; Cheney JA; Kvistad D; Aneja J; Melgaço JG; Fernandes CA; Chung RT et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy.

Frontiers in Medicine
2018-04 | Journal article
Contributors: Fusco DN; Ganova-Raeva L; Khudyakov Y; Punkova L; Mohamed A; Cheon SSY; Koirala P; Andersson KL; Jourdain G; Sureau C et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

ADCC-Mediated CD56DIM NK Cell Responses Are Associated with Early HBsAg Clearance in Acute HBV Infection.

Pathogens & immunity
2018-02 | Journal article
Contributors: Yu WH; Cosgrove C; Berger CT; Cheney PC; Krykbaeva M; Kim AY; Lewis-Ximenez L; Lauer GM; Alter G
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

The Effect of Female Sex on Hepatitis C Incidence Among People Who Inject Drugs: Results From the International Multicohort InC3 Collaborative.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2018-01 | Journal article
Contributors: Esmaeili A; Mirzazadeh A; Morris MD; Hajarizadeh B; Sacks HS; Maher L; Grebely J; Kim AY; Lauer G; Cox AL et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

IFN-free therapy is associated with restoration of type I IFN response in HIV-1 patients with acute HCV infection who achieve SVR.

Journal of viral hepatitis
2017-12 | Journal article
Contributors: Carlton-Smith C; Holmes JA; Naggie S; Lidofsky A; Lauer GM; Kim AY; Chung RT; of the ACTG A5327 study group
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection.

Scientific reports
2017-11 | Journal article
Contributors: Huang H; Duggal P; Thio CL; Latanich R; Goedert JJ; Mangia A; Cox AL; Kirk GD; Mehta S; Aneja J et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Early Transcriptional Divergence Marks Virus-Specific Primary Human CD8+ T Cells in Chronic versus Acute Infection.

Immunity
2017-10 | Journal article
Contributors: Wolski D; Foote PK; Chen DY; Lewis-Ximenez LL; Fauvelle C; Aneja J; Walker A; Tonnerre P; Torres-Cornejo A; Kvistad D et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Hepatitis B virus infection and the immune response: The big questions.

Best practice & research. Clinical gastroenterology
2017-05 | Journal article
Contributors: Boeijen LL; Hoogeveen RC; Boonstra A; Lauer GM
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

2017-04 | Other
OTHER-ID:

PPR21562

Contributors: Huang H; Duggal P; Thio C; Latanich R; Goedert J; Mangia A; Cox A; Kirk G; Mehta S; Blankson J et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Geographic Differences in Temporal Incidence Trends of Hepatitis C Virus Infection Among People Who Inject Drugs: The InC3 Collaboration.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2017-04 | Journal article
Contributors: Morris MD; Shiboski S; Bruneau J; Hahn JA; Hellard M; Prins M; Cox AL; Dore G; Grebely J; Kim AY et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs.

Journal of hepatology
2017-04 | Journal article
Contributors: Thöns C; Senff T; Hydes TJ; Manser AR; Heinemann FM; Heinold A; Heilmann M; Kim AY; Uhrberg M; Scherbaum N et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Hurdles to the Development of Effective HBV Immunotherapies and HCV Vaccines.

Pathogens & immunity
2017-04 | Journal article
Contributors: Torres-Cornejo A; Lauer GM
Source: Self-asserted source
Georg Lauer via Europe PubMed Central
grade
Preferred source (of 2)‎

Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections.

Genes and immunity
2017-03 | Journal article
Contributors: Vergara C; Thio C; Latanich R; Cox AL; Kirk GD; Mehta SH; Busch M; Murphy EL; Villacres MC; Peters MG et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140.

Science immunology
2017-03 | Journal article
Contributors: Mehta S; Cronkite DA; Basavappa M; Saunders TL; Adiliaghdam F; Amatullah H; Morrison SA; Pagan JD; Anthony RM; Tonnerre P et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Limited naturally occurring escape in broadly neutralizing antibody epitopes in hepatitis C glycoprotein E2 and constrained sequence usage in acute infection.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2017-01 | Journal article
Contributors: Rodrigo C; Walker MR; Leung P; Eltahla AA; Grebely J; Dore GJ; Applegate T; Page K; Dwivedi S; Bruneau J et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Phylogenetic analysis of full-length, early infection, hepatitis C virus genomes among people with intravenous drug use: the InC3 Study.

Journal of viral hepatitis
2016-11 | Journal article
Contributors: Rodrigo C; Eltahla AA; Bull RA; Luciani F; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Morris MD et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

The effects of alcohol on spontaneous clearance of acute hepatitis C virus infection in females versus males.

Drug and alcohol dependence
2016-10 | Journal article
Contributors: Tsui JI; Mirzazadeh A; Hahn JA; Maher L; Bruneau J; Grebely J; Hellard M; Kim AY; Shoukry NH; Cox AL et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

The epigenetic landscape of T cell exhaustion.

Science (New York, N.Y.)
2016-10 | Journal article
Contributors: Sen DR; Kaminski J; Barnitz RA; Kurachi M; Gerdemann U; Yates KB; Tsao HW; Godec J; LaFleur MW; Brown FD et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Analysis of resistance-associated substitutions in acute hepatitis C virus infection by deep sequencing across six genotypes and three continents.

Journal of viral hepatitis
2016-09 | Journal article
Contributors: Eltahla AA; Rodrigo C; Betz-Stablein B; Grebely J; Applegate T; Luciani F; Schinkel J; Dore GJ; Page K; Bruneau J et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Historical Trends in the Hepatitis C Virus Epidemics in North America and Australia.

The Journal of infectious diseases
2016-08 | Journal article
Contributors: Rodrigo C; Eltahla AA; Bull RA; Grebely J; Dore GJ; Applegate T; Page K; Bruneau J; Morris MD; Cox AL et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection.

Journal of immunology (Baltimore, Md. : 1950)
2016-07 | Journal article
Contributors: Barnett BE; Staupe RP; Odorizzi PM; Palko O; Tomov VT; Mahan AE; Gunn B; Chen D; Paley MA; Alter G et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Breadth of the HCV-specific CD4+ T-cell response in spontaneous resolvers is independent of the IL-28 haplotype.

Journal of viral hepatitis
2016-06 | Journal article
Contributors: Scheurich C; Schulze Zur Wiesch J; Kim AY; Lewis-Ximenez L; Meyer T; Polywka S; Chung RT; Lauer GM
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Enhanced binding of antibodies generated during chronic HIV infection to mucus component MUC16.

Mucosal immunology
2016-03 | Journal article
Contributors: Gunn B; Schneider J; Shansab M; Bastian AR; Fahrbach K; Smith A; Mahan A; Karim M; Licht A; Zvonar I et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

Open forum infectious diseases
2016-01 | Journal article
Contributors: Page K; Mirzazadeh A; Rice TM; Grebely J; Kim AY; Cox AL; Morris MD; Hellard M; Bruneau J; Shoukry NH et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

PLoS pathogens
2015-10 | Journal article
Contributors: Gupta PK; Godec J; Wolski D; Adland E; Yates K; Pauken KE; Cosgrove C; Ledderose C; Junger WG; Robson SC et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing.

Journal of virology
2015-10 | Journal article
Contributors: Walker A; Skibbe K; Steinmann E; Pfaender S; Kuntzen T; Megger DA; Groten S; Sitek B; Lauer GM; Kim AY et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

The safety and efficacy of ledipasvir/sofosbuvir for the treatment of a nosocomial outbreak of HCV in patients with significant cardiovascular disease.

Antiviral therapy
2015-10 | Journal article
Contributors: Simon TG; Kim AY; Stamm LM; Liu L; Mo H; Doehle B; Pang PS; Brainard DM; McHutchison JG; Gustafson J et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Underascertainment of acute hepatitis C virus infections in the U.S. surveillance system: a case series and chart review.

Annals of internal medicine
2015-08 | Journal article
Contributors: Onofrey S; Aneja J; Haney GA; Nagami EH; DeMaria A; Lauer GM; Hills-Evans K; Barton K; Kulaga S; Bowen MJ et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

The broad assessment of HCV genotypes 1 and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine design.

Gut
2015-06 | Journal article
Contributors: von Delft A; Humphreys IS; Brown A; Pfafferott K; Lucas M; Klenerman P; Lauer GM; Cox AL; Gaudieri S; Barnes E
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection--the InC3 Study.

The Journal of infectious diseases
2015-04 | Journal article
Contributors: Sacks-Davis R; Grebely J; Dore GJ; Osburn W; Cox AL; Rice TM; Spelman T; Bruneau J; Prins M; Kim AY et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Patterns of hepatitis C virus RNA levels during acute infection: the InC3 study.

PloS one
2015-04 | Journal article
Contributors: Hajarizadeh B; Grady B; Page K; Kim AY; McGovern BH; Cox AL; Rice TM; Sacks-Davis R; Bruneau J; Morris M et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

A longitudinal study of hepatitis C virus testing and infection status notification on behaviour change in people who inject drugs.

Journal of epidemiology and community health
2015-03 | Journal article
Contributors: Spelman T; Morris MD; Zang G; Rice T; Page K; Maher L; Lloyd A; Grebely J; Dore GJ; Kim AY et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Factors associated with hepatitis C virus RNA levels in early chronic infection: the InC3 study.

Journal of viral hepatitis
2015-01 | Journal article
Contributors: Hajarizadeh B; Grady B; Page K; Kim AY; McGovern BH; Cox AL; Rice TM; Sacks-Davis R; Bruneau J; Morris M et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

A prophylactic hepatitis C virus vaccine: a distant peak still worth climbing.

Journal of hepatology
2014-11 | Journal article
Contributors: Baumert TF; Fauvelle C; Chen DY; Lauer GM
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Interferon lambda 3 genotype predicts hepatitis C virus RNA levels in early acute infection among people who inject drugs: the InC(3) study.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
2014-09 | Journal article
Contributors: Hajarizadeh B; Grady B; Page K; Kim AY; McGovern BH; Cox AL; Rice TM; Sacks-Davis R; Bruneau J; Morris M et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Chronic HCV infection affects the NK cell phenotype in the blood more than in the liver.

PloS one
2014-08 | Journal article
Contributors: Cosgrove C; Berger CT; Kroy DC; Cheney PC; Ghebremichael M; Aneja J; Tomlinson M; Kim AY; Lauer GM; Alter G
Source: Self-asserted source
Georg Lauer via Europe PubMed Central

Genome-wide association study of hepatitis C virus- and cryoglobulin-related vasculitis.

Genes and immunity
2014-07 | Journal article
Contributors: Zignego AL; Wojcik GL; Cacoub P; Visentini M; Casato M; Mangia A; Latanich R; Charles ED; Gragnani L; Terrier B et al.
Source: Self-asserted source
Georg Lauer via Europe PubMed Central
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Page 1 of 3

Peer review (3 reviews for 2 publications/grants)

Review activity for Journal of hepatology. (2)
Review activity for Nature communications (1)