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Scopus Author ID: 7005952042
SciProfiles: 54941

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Employment (2)

Sapienza University: Rome, IT

2005-01-01 to present | associate professor (cardiology)
Employment
Source: Self-asserted source
Speranza Rubattu

Sapienza University: Rome, IT

2005-01-01 to present | associate professor (cardiology)
Employment
Source: Self-asserted source
Speranza Rubattu

Education and qualifications (1)

University: Sassari, IT

1977-11-01 to 1983-11-07 | MD (cardiology)
Education
Source: Self-asserted source
Speranza Rubattu

Works (50 of 176)

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Page 1 of 4

The Balance Between the Natriuretic Peptides and the Renin-Angiotensin-Aldosterone System in the Preservation of Ideal Cardiovascular Health

Journal of Clinical Medicine
2025-01-19 | Journal article
DOI: 10.3390/jcm14020626
Contributors: Speranza Rubattu; Giovanna Gallo; Massimo Volpe
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Unveiling the Spectrum of Minor Genes in Cardiomyopathies: A Narrative Review

International Journal of Molecular Sciences
2024-09-10 | Journal article
DOI: 10.3390/ijms25189787
Contributors: Caterina Micolonghi; Federica Perrone; Marco Fabiani; Silvia Caroselli; Camilla Savio; Antonio Pizzuti; Aldo Germani; Vincenzo Visco; Simona Petrucci; Speranza Rubattu et al.
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UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles

Biomedicines
2024-06-13 | Journal article
DOI: 10.3390/biomedicines12061307
Contributors: Salvatore Nesci; Speranza Rubattu
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Mitochondrial Dysfunction in Heart Failure: From Pathophysiological Mechanisms to Therapeutic Opportunities

International Journal of Molecular Sciences
2024-02-25 | Journal article
DOI: 10.3390/ijms25052667
Contributors: Giovanna Gallo; Speranza Rubattu; Massimo Volpe
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A Novel Nonsense Pathogenic <i>TTN</i> Variant Identified in a Patient with Severe Dilated Cardiomyopathy

Current Issues in Molecular Biology
2023-03 | Journal article | Author
DOI: 10.3390/cimb45030157
Contributors: Caterina Micolonghi; Marco Fabiani; Erika Pagannone; Camilla Savio; Marta Ricci; Silvia Caroselli; Vittoria Gambioli; Beatrice Musumeci; Aldo Germani; Giacomo Tini Melato et al.
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Multidisciplinary Digital Publishing Institute

Beneficial Effects of Citrus Bergamia Polyphenolic Fraction on Saline Load-Induced Injury in Primary Cerebral Endothelial Cells from the Stroke-Prone Spontaneously Hypertensive Rat Model

Nutrients
2023-03-09 | Journal article
DOI: 10.3390/nu15061334
Contributors: Rosita Stanzione; Maurizio Forte; Maria Cotugno; Francesca Oppedisano; Cristina Carresi; Simona Marchitti; Vincenzo Mollace; Massimo Volpe; Speranza Rubattu
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Natriuretic Peptides: It Is Time for Guided Therapeutic Strategies Based on Their Molecular Mechanisms

International Journal of Molecular Sciences
2023-03-07 | Journal article
DOI: 10.3390/ijms24065131
Contributors: Giovanna Gallo; Speranza Rubattu; Camillo Autore; Massimo Volpe
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Elabela Peptide: A New Player in Hypertension and Vascular Damage

High Blood Pressure & Cardiovascular Prevention
2022-12-12 | Journal article
DOI: 10.1007/s40292-022-00556-z
Contributors: Speranza Rubattu
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Crossref

Natural Activators of Autophagy Increase Maximal Walking Distance and Reduce Oxidative Stress in Patients with Peripheral Artery Disease: A Pilot Study

Antioxidants
2022-09-18 | Journal article
DOI: 10.3390/antiox11091836
Contributors: Ombretta Martinelli; Mariangela Peruzzi; Simona Bartimoccia; Alessandra D’Amico; Simona Marchitti; Speranza Rubattu; Giovanni Chiariello; Luca D’Ambrosio; Sonia Schiavon; Fabio Miraldi et al.
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Role of DAMPs and of Leukocytes Infiltration in Ischemic Stroke: Insights from Animal Models and Translation to the Human Disease

Cellular and Molecular Neurobiology
2022-04 | Journal article
DOI: 10.1007/s10571-020-00966-4
Contributors: Rosita Stanzione; Maurizio Forte; Maria Cotugno; Franca Bianchi; Simona Marchitti; Speranza Rubattu
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Crossref

The Natriuretic Peptides for Hypertension Treatment

High Blood Pressure & Cardiovascular Prevention
2022-01 | Journal article
DOI: 10.1007/s40292-021-00483-5
Contributors: Speranza Rubattu; Giovanna Gallo
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Crossref

Novel ANP (Atrial Natriuretic Peptide)-Based Therapy for Hypertension: The Promising Role of a Disease Mechanism Targeted Approach

Hypertension
2021-12 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.121.18264
Contributors: Massimo Volpe; Giovanna Gallo; Speranza Rubattu
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Crossref

Epigenetic control of natriuretic peptides: implications for health and disease

Cellular and Molecular Life Sciences
2020-12-18 | Journal article
DOI: 10.1007/s00018-020-03573-0
Contributors: Speranza Rubattu; Rosita Stanzione; Maria Cotugno; Franca Bianchi; Simona Marchitti; Maurizio Forte
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Crossref

Circulating Leukocytes and Oxidative Stress in Cardiovascular Diseases: A State of the Art

Oxidative Medicine and Cellular Longevity
2019-10-15 | Journal article
DOI: 10.1155/2019/2650429
Contributors: Speranza Rubattu; Maurizio Forte; Salvatore Raffa
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Crossref

A Decrease of Brain MicroRNA-122 Level Is an Early Marker of Cerebrovascular Disease in the Stroke-Prone Spontaneously Hypertensive Rat

Oxidative Medicine and Cellular Longevity
2017 | Journal article
DOI: 10.1155/2017/1206420
EID:

2-s2.0-85022034681
Contributors: Stanzione, R.; Bianchi, F.; Cotugno, M.; Marchitti, S.; Forte, M.; Busceti, C.; Ryskalin, L.; Fornai, F.; Volpe, M.; Rubattu, S.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier
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A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines

Journal of Hypertension
2017 | Journal article
DOI: 10.1097/HJH.0000000000001374
EID:

2-s2.0-85017433757
Contributors: Rubattu, S.; Cotugno, M.; Bianchi, F.; Sironi, L.; Gelosa, P.; Stanzione, R.; Forte, M.; De Sanctis, C.; Madonna, M.; Marchitti, S. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

C2238 ANP gene variant promotes increased platelet aggregation through the activation of Nox2 and the reduction of cAMP

Scientific Reports
2017 | Journal article
DOI: 10.1038/s41598-017-03679-9
EID:

2-s2.0-85021049687
Contributors: Carnevale, R.; Pignatelli, P.; Frati, G.; Nocella, C.; Stanzione, R.; Pastori, D.; Marchitti, S.; Valenti, V.; Santulli, M.; Barbato, E. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Dickkopf-3 upregulates VEGF in cultured human endothelial cells by activating activin receptor-like kinase 1 (ALK1) pathway

Frontiers in Pharmacology
2017 | Journal article
DOI: 10.3389/fphar.2017.00111
EID:

2-s2.0-85016156918
Contributors: Busceti, C.L.; Marchitti, S.; Bianchi, F.; Di Pietro, P.; Riozzi, B.; Stanzione, R.; Cannella, M.; Battaglia, G.; Bruno, V.; Volpe, M. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat

Cell Death and Disease
2017 | Journal article
DOI: 10.1038/cddis.2017.278
EID:

2-s2.0-85032589336
Contributors: Rubattu, S.; Stanzione, R.; Bianchi, F.; Cotugno, M.; Forte, M.; Ragione, F.D.; Fioriniello, S.; D'Esposito, M.; Marchitti, S.; Madonna, M. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Resetting the neurohormonal balance in heart failure (HF): the relevance of the natriuretic peptide (NP) system to the clinical management of patients with HF

Heart Failure Reviews
2017 | Journal article
DOI: 10.1007/s10741-017-9605-8
EID:

2-s2.0-85017190265
Contributors: Rubattu, S.; Triposkiadis, F.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier
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T2238C Atrial Natriuretic Peptide Gene Variant and the Response to Antiplatelet Therapy in Stable Ischemic Heart Disease Patients

Journal of Cardiovascular Translational Research
2017 | Journal article
DOI: 10.1007/s12265-017-9774-9
EID:

2-s2.0-85037632958
Contributors: Strisciuglio, T.; Barbato, E.; de Biase, C.; Di Gioia, G.; Cotugno, M.; Stanzione, R.; Trimarco, B.; Sciarretta, S.; Volpe, M.; Wijns, W. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases

Oxidative Medicine and Cellular Longevity
2017-01 | Journal article
DOI: 10.1155/2017/7348372
Contributors: Giorgia Pierelli; Rosita Stanzione; Maurizio Forte; Serena Migliarino; Marika Perelli; Massimo Volpe; Speranza Rubattu; Ryuichi Morishita
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A Next-Generation Sequencing Approach to Identify Gene Mutations in Early- and Late-Onset Hypertrophic Cardiomyopathy Patients of an Italian Cohort

International journal of molecular sciences
2016 | Journal article
DOI: 10.3390/ijms17081239
EID:

2-s2.0-85017060276
Contributors: Rubattu, S.; Bozzao, C.; Pennacchini, E.; Pagannone, E.; Musumeci, B.M.; Piane, M.; Germani, A.; Savio, C.; Francia, P.; Volpe, M. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis

The Lancet Diabetes and Endocrinology
2016 | Journal article
DOI: 10.1016/S2213-8587(16)30196-6
EID:

2-s2.0-84990052413
Contributors: Nambi, V.; Ballantyne, C.M.; Hoogeveen, R.C.; Agarwal, S.K.; Panagiotakos, D.B.; Wannamethee, S.G.; Whincup, P.H.; Kiechl, S.; Willeit, J.; Schett, G. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Ndufc2 gene inhibition is associated with mitochondrial dysfunction and increased stroke susceptibility in an animal model of complex human disease

Journal of the American Heart Association
2016 | Journal article
DOI: 10.1161/JAHA.115.002701
EID:

2-s2.0-84995488392
Contributors: Rubattu, S.; Di Castro, S.; Schulz, H.; Geurts, A.M.; Cotugno, M.; Bianchi, F.; Maatz, H.; Hummel, O.; Falak, S.; Stanzione, R. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

New therapies for arterial hypertension

Panminerva Medica
2016 | Journal article
EID:

2-s2.0-84992533413
Contributors: Pagliaro, B.; Santolamazza, C.; Rubattu, S.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Novel Insights into the Mechanisms Regulating Pro-Atrial Natriuretic Peptide Cleavage in the Heart and Blood Pressure Regulation: Proprotein Convertase Subtilisin/Kexin 6 Is the Corin Activating Enzyme

Circulation Research
2016 | Journal article
DOI: 10.1161/CIRCRESAHA.115.307875
EID:

2-s2.0-84955305295
Contributors: Volpe, M.; Rubattu, S.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

NT-proANP and NT-proBNP circulating levels as predictors of cardiovascular outcome following coronary stent implantation

Cardiovascular Revascularization Medicine
2016 | Journal article
DOI: 10.1016/j.carrev.2016.02.012
EID:

2-s2.0-84960532798
Contributors: Niccoli, G.; Conte, M.; Marchitti, S.; Montone, R.A.; Fracassi, F.; Grippo, R.; Roberto, M.; Burzotta, F.; Trani, C.; Leone, A.M. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Role of NOX2 in mediating doxorubicin-induced senescence in human endothelial progenitor cells

Mechanisms of Ageing and Development
2016 | Journal article
DOI: 10.1016/j.mad.2016.05.004
EID:

2-s2.0-84971668376
Contributors: De Falco, E.; Carnevale, R.; Pagano, F.; Chimenti, I.; Fianchini, L.; Bordin, A.; Siciliano, C.; Monticolo, R.; Equitani, F.; Carrizzo, A. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

T2238C ANP gene variant and risk of recurrent acute coronary syndromes in an Italian cohort of ischemic heart disease patients

Journal of Cardiovascular Medicine
2016 | Journal article
DOI: 10.2459/JCM.0000000000000195
EID:

2-s2.0-84913538081
Contributors: Rubattu, S.; De Giusti, M.; Farcomeni, A.; Abbolito, S.; Comito, F.; Cangianiello, S.; Greco, E.S.; Dito, E.; Pagliaro, B.; Cotugno, M. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Mitochondrial Dysfunction Contributes to Hypertensive Target Organ Damage: Lessons from an Animal Model of Human Disease

Oxidative Medicine and Cellular Longevity
2016-01 | Journal article
DOI: 10.1155/2016/1067801
Contributors: Speranza Rubattu; Rosita Stanzione; Massimo Volpe; Mahmood Khan
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An easy and reproducible parameter for the assessment of the pressure gradient in patients with aortic stenosis disease: A magnetic resonance study

Journal of Cardiology
2015 | Journal article
DOI: 10.1016/j.jjcc.2014.07.015
EID:

2-s2.0-84928887879
Contributors: Valenti, V.; Sciarretta, S.; Levin, M.; Shubayev, L.; Edelstein, S.; Zia, M.I.; Rubattu, S.; Volpe, M.; Uretsky, S.; Wolff, S.D.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Angiotensin II Receptor Blocker Neprilysin Inhibitor (ARNI): New Avenues in Cardiovascular Therapy

High Blood Pressure and Cardiovascular Prevention
2015 | Journal article
DOI: 10.1007/s40292-015-0112-5
EID:

2-s2.0-84941068456
Contributors: Volpe, M.; Tocci, G.; Battistoni, A.; Rubattu, S.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

C2238/αANP modulates apolipoprotein E through Egr-1/miR199a in vascular smooth muscle cells in vitro

Cell Death and Disease
2015 | Journal article
DOI: 10.1038/cddis.2015.370
EID:

2-s2.0-84994642916
Contributors: Stanzione, R.; Sciarretta, S.; Marchitti, S.; Bianchi, F.; Di Castro, S.; Scarpino, S.; Cotugno, M.; Frati, G.; Volpe, M.; Rubattu, S.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Differential modulation of AMPK/PPARα/UCP2 axis in relation to hypertension and aging in the brain, kidneys and heart of two closely related spontaneously hypertensive rat strains

Oncotarget
2015 | Journal article
EID:

2-s2.0-84938867968
Contributors: Rubattu, S.; Bianchi, F.; Busceti, C.L.; Cotugno, M.; Stanzione, R.; Marchitti, S.; Di Castro, S.; Madonna, M.; Nicoletti, F.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Hypovitaminosis D and Organ Damage In Patients With Arterial Hypertension: A Multicenter Double Blind Randomised Controlled Trial of Cholecalciferol Supplementation (HYPODD): Study Design, Clinical Procedures and Treatment Protocol

High Blood Pressure and Cardiovascular Prevention
2015 | Journal article
DOI: 10.1007/s40292-015-0080-9
EID:

2-s2.0-84930945818
Contributors: Rendina, D.; Ippolito, R.; D’Elia, L.; Giacchetti, G.; Lonati, C.; Gianfrancesco, F.; Fallo, F.; Rebellato, A.; Ruggiero, C.; Rubattu, S. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Pathogenesis of target organ damage in hypertension: Role of mitochondrial oxidative stress

International Journal of Molecular Sciences
2015 | Journal article
DOI: 10.3390/ijms16010823
EID:

2-s2.0-84920156971
Contributors: Rubattu, S.; Pagliaro, B.; Pierelli, G.; Santolamazza, C.; Di Castro, S.; Mennuni, S.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Phytochemical Compounds and Protection from Cardiovascular Diseases: A State of the Art

BioMed Research International
2015 | Journal article
DOI: 10.1155/2015/918069
EID:

2-s2.0-84945346213
Contributors: Pagliaro, B.; Santolamazza, C.; Simonelli, F.; Rubattu, S.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Protective effects of Brassica oleracea sprouts extract toward renal damage in high-salt-fed SHRSP: Role of AMPK/PPARa/UCP2 axis

Journal of Hypertension
2015 | Journal article
DOI: 10.1097/HJH.0000000000000562
EID:

2-s2.0-84938865951
Contributors: Rubattu, S.; Di Castro, S.; Cotugno, M.; Bianchi, F.; Mattioli, R.; Baima, S.; Stanzione, R.; Madonna, M.; Bozzao, C.; Marchitti, S. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

RyR2 common gene variant G1886S and the risk of ventricular arrhythmias in ICD patients with heart failure

Journal of Cardiovascular Electrophysiology
2015 | Journal article
DOI: 10.1111/jce.12658
EID:

2-s2.0-84930763629
Contributors: Francia, P.; Adduci, C.; Semprini, L.; Stanzione, R.; Serdoz, A.; Caprinozzi, M.; Santini, D.; Cotugno, M.; Palano, F.; Musumeci, M.B. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Atrial natriuretic peptide gene variants and circulating levels: Implications in cardiovascular diseases

Clinical Science
2014 | Journal article
DOI: 10.1042/CS20130427
EID:

2-s2.0-84896039537
Contributors: Rubattu, S.; Sciarretta, S.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

High natriuretic peptide levels and low DBP: Companion markers of cardiovascular risk?

Journal of Hypertension
2014 | Journal article
DOI: 10.1097/HJH.0000000000000365
EID:

2-s2.0-84927590213
Contributors: Rubattu, S.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Hypertension and kidneys: Unraveling complex molecular mechanisms underlying hypertensive renal damage

Journal of Human Hypertension
2014 | Journal article
DOI: 10.1038/jhh.2013.55
EID:

2-s2.0-84891845736
Contributors: Mennuni, S.; Rubattu, S.; Pierelli, G.; Tocci, G.; Fofi, C.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Natriuretic peptides in cardiovascular diseases: Current use and perspectives

European Heart Journal
2014 | Journal article
DOI: 10.1093/eurheartj/eht466
EID:

2-s2.0-84894256771
Contributors: Volpe, M.; Rubattu, S.; Burnett, J.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Natriuretic peptides: Predictive, diagnostic and prognostic implications in cardiovascular diseases with particular regard to acute cardiovascular events

Natriuretic Peptides: Physiology, Molecular Biology, and Clinical Implications
2014 | Book
EID:

2-s2.0-84956804229
Contributors: Rubattu, S.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart

Oxidative Medicine and Cellular Longevity
2014 | Journal article
DOI: 10.1155/2014/210934
EID:

2-s2.0-84922209831
Contributors: Ikeda, Y.; Sciarretta, S.; Nagarajan, N.; Rubattu, S.; Volpe, M.; Frati, G.; Sadoshima, J.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Polypharmacy in heart failure patients

Current Heart Failure Reports
2014 | Journal article
DOI: 10.1007/s11897-014-0186-8
EID:

2-s2.0-84903631465
Contributors: Mastromarino, V.; Casenghi, M.; Testa, M.; Gabriele, E.; Coluccia, R.; Rubattu, S.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Pulmonary embolism in pregnancy

Journal of Thrombosis and Thrombolysis
2014 | Journal article
DOI: 10.1007/s11239-013-0941-9
EID:

2-s2.0-84898486557
Contributors: Conti, E.; Zezza, L.; Ralli, E.; Comito, C.; Sada, L.; Passerini, J.; Caserta, D.; Rubattu, S.; Autore, C.; Moscarini, M. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

The C2238/αANP variant is a negative modulator of both viability and function of coronary artery smooth muscle cells

PLoS ONE
2014 | Journal article
DOI: 10.1371/journal.pone.0113108
EID:

2-s2.0-84913598340
Contributors: Rubattu, S.; Marchitti, S.; Bianchi, F.; Di Castro, S.; Stanzione, R.; Cotugno, M.; Bozzao, C.; Sciarretta, S.; Volpe, M.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier

Association of a single nucleotide polymorphism of the NPR3 gene promoter with early onset ischemic stroke in an Italian cohort

European Journal of Internal Medicine
2013 | Journal article
DOI: 10.1016/j.ejim.2012.09.002
EID:

2-s2.0-84871411207
Contributors: Rubattu, S.; Giusti, B.; Lotta, L.A.; Peyvandi, F.; Cotugno, M.; Stanzione, R.; Marchitti, S.; Palombella, A.M.; Di Castro, S.; Rasura, M. et al.
Source: Self-asserted source
Speranza Rubattu via Scopus - Elsevier
Items per page:
Page 1 of 4

Peer review (13 reviews for 6 publications/grants)

Review activity for BMC medical genomics. (1)
Review activity for High blood pressure & cardiovascular prevention. (7)
Review activity for Journal of cardiovascular translational research. (1)
Review activity for Molecular genetics and genomics. (1)
Review activity for Pflügers Archiv. (1)
Review activity for Pharmacological research. (2)
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