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I studied biology and bioinformatics at the University of Turin, Italy before completing a PhD on the role of integrin signalling in cell adhesion. I then joined Matthias Mann's group at the Max-Planck Institute of Biochemistry, Germany, where I used SILAC-based mass spectrometry to interrogate the phosphoproteome of mouse models of cancer. I was recruited to the CRUK Beatson Institute in 2010 where I have established an independent research group and manage the Proteomics Facility.
The focus of my research is on understanding the role of cancer associated fibroblasts (CAFs) in invasion in breast and ovarian cancers. Specifically, the aim of my research group is to identify and characterise novel molecular mechanisms through which CAFs create a pro-invasive and pro-angiogenic tumour microenvironment, and explore the possibility of targeting these cells.
To achieve this, we develop and utilise in vitro and in vivo models using a unique combination of cell and molecular biology approaches together with state-of-the-art quantitative mass spectrometry-based proteomics.