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Scopus Author ID: 9942306500

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Employment (1)

Duke University: Durham, North Carolina, US

2002-10-01 to present | Associate Professor with Tenur (Ophthalmology)
Employment
Source: Self-asserted source
Goldis Malek

Funding (2)

The Role Of A Macrophage Chemotactic Factor In AMD

2015-07-01 to 2017-06-30 | Grant
BrightFocus Foundation (Clarksburg, US)
GRANT_NUMBER:

M2015421
Source: check_circle
BrightFocus Foundation - ProposalCentral

Oxidant Activated Nuclear Receptors in AMD Pathogenesis

2010-04-01 to 2013-03-31 | Grant
BrightFocus Foundation (Clarksburg, US)
GRANT_NUMBER:

M2010097
Source: check_circle
BrightFocus Foundation - ProposalCentral

Works (43)

Correction: Peavey et al. Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration. <i>Cells</i> 2022, <i>11</i>, 2386

Cells
2022-12 | Journal article | Author
DOI: 10.3390/cells11243948
Contributors: Jeremy Peavey; vipulkumar parmar; Goldis Malek
Source: check_circle
Multidisciplinary Digital Publishing Institute

Nuclear Receptor Atlases of Choroidal Tissues Reveal Candidate Receptors Associated with Age-Related Macular Degeneration

Cells
2022-08 | Journal article | Author
DOI: 10.3390/cells11152386
Contributors: Jeremy Peavey; vipulkumar parmar; Goldis Malek
Source: check_circle
Multidisciplinary Digital Publishing Institute

Age-Related Macular Degeneration Revisited: From Pathology and Cellular Stress to Potential Therapies

Frontiers in Cell and Developmental Biology
2021 | Journal article
DOI: 10.3389/fcell.2020.612812
EID:

2-s2.0-85100644715

Part of ISSN: 2296634X
Contributors: Hadziahmetovic, M.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

15th Biennial AOPT Scientific Meeting: Restoring Vision through Regeneration Virtual Meeting, March 4th-7th, 2021

Journal of Ocular Pharmacology and Therapeutics
2020 | Journal article
DOI: 10.1089/jop.2020.0136
EID:

2-s2.0-85097955426

Part of ISSN: 15577732 10807683
Contributors: Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Cell line authentication in vision research and beyond: A tale retold

Investigative Ophthalmology and Visual Science
2020 | Journal article
DOI: 10.1167/IOVS.61.6.19
EID:

2-s2.0-85086354351

Part of ISSN: 15525783 01460404
Contributors: Peavey, J.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Leveraging nuclear receptors as targets for pathological ocular vascular diseases

International Journal of Molecular Sciences
2020 | Journal article
DOI: 10.3390/ijms21082889
EID:

2-s2.0-85084007739

Part of ISSN: 14220067 16616596
Contributors: Yao, P.-L.; Peavey, J.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

LXRs regulate features of age-related macular degeneration and may be a potential therapeutic target

JCI Insight
2020 | Journal article
DOI: 10.1172/jci.insight.131928
EID:

2-s2.0-85080853335

Part of ISSN: 23793708
Contributors: Choudhary, M.; Ismail, E.N.; Yao, P.-L.; Tayyari, F.; Radu, R.A.; Nusinowitz, S.; Boulton, M.E.; Apte, R.S.; Ruberti, J.W.; Handa, J.T. et al.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Models of pathologies associated with age-related macular degeneration and their utilities in drug discovery

Topics in Medicinal Chemistry
2020 | Book chapter
DOI: 10.1007/7355_2020_93
EID:

2-s2.0-85091704627

Part of ISSN: 1862247X 18622461
Contributors: Malek, G.; Yao, P.-L.; Choudhary, M.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

The aryl hydrocarbon receptor: A mediator and potential therapeutic target for ocular and non-ocular neurodegenerative diseases

International Journal of Molecular Sciences
2020 | Journal article
DOI: 10.3390/ijms21186777
EID:

2-s2.0-85090976929

Part of ISSN: 14220067 16616596
Contributors: Malek, G.; Choudhary, M.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

A Review of Pathogenic Drivers of Age-Related Macular Degeneration, Beyond Complement, with a Focus on Potential Endpoints for Testing Therapeutic Interventions in Preclinical Studies

Advances in Experimental Medicine and Biology
2019 | Book chapter
DOI: 10.1007/978-3-030-27378-1_2
EID:

2-s2.0-85077303580

Part of ISSN: 22148019 00652598
Contributors: Choudhary, M.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss

JCI insight
2018 | Journal article
DOI: 10.1172/jci.insight.120824
EID:

2-s2.0-85060334675

Part of ISSN: 23793708
Contributors: Ban, N.; Lee, T.J.; Sene, A.; Choudhary, M.; Lekwuwa, M.; Dong, Z.; Santeford, A.; Lin, J.B.; Malek, G.; Ory, D.S. et al.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Models of retinal diseases and their applicability in drug discovery

Expert Opinion on Drug Discovery
2018 | Journal article
DOI: 10.1080/17460441.2018.1430136
EID:

2-s2.0-85043528321

Part of ISSN: 1746045X 17460441
Contributors: Malek, G.; Busik, J.; Grant, M.B.; Choudhary, M.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Suppression of aberrant choroidal neovascularization through activation of the aryl hydrocarbon receptor

Biochimica et Biophysica Acta - Molecular Basis of Disease
2018 | Journal article
DOI: 10.1016/j.bbadis.2018.02.015
EID:

2-s2.0-85042665215

Part of ISSN: 1879260X 09254439
Contributors: Choudhary, M.; Safe, S.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Quick-freeze/deep-etch electron microscopy visualization of the mouse posterior pole

Experimental Eye Research
2017 | Journal article
DOI: 10.1016/j.exer.2017.06.013
EID:

2-s2.0-85024110536

Part of ISSN: 10960007 00144835
Contributors: Ismail, E.N.; Ruberti, J.W.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

The Mechanism of Diabetic Retinopathy Pathogenesis Unifying Key Lipid Regulators, Sirtuin 1 and Liver X Receptor

EBioMedicine
2017 | Journal article
DOI: 10.1016/j.ebiom.2017.07.008
EID:

2-s2.0-85026353637

Part of ISSN: 23523964
Contributors: Hammer, S.S.; Beli, E.; Kady, N.; Wang, Q.; Wood, K.; Lydic, T.A.; Malek, G.; Saban, D.R.; Wang, X.X.; Hazra, S. et al.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

A brief discussion on lipid activated nuclear receptors and their potential role in regulating microglia in age-related macular degeneration (AMD)

Advances in Experimental Medicine and Biology
2016 | Book chapter
DOI: 10.1007/978-3-319-17121-0_7
EID:

2-s2.0-84943328746

Part of ISSN: 22148019 00652598
Contributors: Choudhary, M.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration

Aging
2016 | Journal article
DOI: 10.18632/aging.101031
EID:

2-s2.0-84991451252

Part of ISSN: 19454589
Contributors: Choudhary, M.; Ding, J.; Qi, X.; Boulton, M.E.; Yao, P.-L.; Peters, J.M.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Rethinking Nuclear Receptors as Potential Therapeutic Targets for Retinal Diseases

Journal of Biomolecular Screening
2016 | Journal article
DOI: 10.1177/1087057116659856
EID:

2-s2.0-84994758764

Part of ISSN: 1552454X 10870571
Contributors: Choudhary, M.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Aryl hydrocarbon receptor knock-out exacerbates choroidal neovascularization via multiple pathogenic pathways

Journal of Pathology
2015 | Journal article
DOI: 10.1002/path.4433
EID:

2-s2.0-84916207341

Part of ISSN: 10969896 00223417
Contributors: Choudhary, M.; Kazmin, D.; Hu, P.; Thomas, R.S.; McDonnell, D.P.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration

Cellular and Molecular Life Sciences
2014 | Journal article
DOI: 10.1007/s00018-014-1709-x
EID:

2-s2.0-84911867090

Part of ISSN: 14209071 1420682X
Contributors: Malek, G.; Lad, E.M.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Nuclear receptors as potential therapeutic targets for age-related macular degeneration

Advances in Experimental Medicine and Biology
2014 | Book
DOI: 10.1007/978-1-4614-3209-8_40
EID:

2-s2.0-84904795724

Part of ISSN: 22148019 00652598
Contributors: Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
DOI: 10.1073/pnas.1307574110
EID:

2-s2.0-84886420285

Part of ISSN: 00278424 10916490
Contributors: Hu, P.; Herrmann, R.; Bednar, A.; Saloupis, P.; Dwyer, M.A.; Yang, P.; Qi, X.; Thomas, R.S.; Jaffe, G.J.; Boulton, M.E. et al.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser- induced choroidal neovascularization

Investigative Ophthalmology and Visual Science
2013 | Journal article
DOI: 10.1167/iovs.13-12546
EID:

2-s2.0-84887834514

Part of ISSN: 01460404 15525783
Contributors: Espinosa-Heidmann, D.G.; Malek, G.; Mettu, P.S.; Caicedo, A.; Saloupis, P.; Gach, S.; Dunnon, A.K.; Hu, P.; Spiga, M.-G.; Cousins, S.W.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD

Advances in Experimental Medicine and Biology
2012 | Book
DOI: 10.1007/978-1-4614-0631-0_8
EID:

2-s2.0-84855959099

Part of ISSN: 00652598
Contributors: Malek, G.; Dwyer, M.; McDonnell, D.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Research resource: Nuclear receptor atlas of human retinal pigment epithelial cells: Potential relevance to age-related macular degeneration

Molecular Endocrinology
2011 | Journal article
DOI: 10.1210/me.2010-0392
EID:

2-s2.0-79951715828

Part of ISSN: 08888809
Contributors: Dwyer, M.A.; Kazmin, D.; Hu, P.; McDonnell, D.P.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

PPAR nuclear receptors and altered RPE lipid metabolism in age-related macular degeneration

Advances in Experimental Medicine and Biology
2010 | Book
DOI: 10.1007/978-1-4419-1399-9_49
EID:

2-s2.0-79955580578

Part of ISSN: 00652598
Contributors: Malek, G.; Hu, P.; Wielgus, A.; Dwyer, M.; Cousins, S.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Reticular Pseudodrusen Are Subretinal Drusenoid Deposits

Ophthalmology
2010 | Journal article
DOI: 10.1016/j.ophtha.2009.07.014
EID:

2-s2.0-75449109809

Part of ISSN: 01616420
Contributors: Zweifel, S.A.; Spaide, R.F.; Curcio, C.A.; Malek, G.; Imamura, Y.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

Progress in Retinal and Eye Research
2010 | Journal article
DOI: 10.1016/j.preteyeres.2009.11.003
EID:

2-s2.0-77249147331

Part of ISSN: 13509462
Contributors: Anderson, D.H.; Radeke, M.J.; Gallo, N.B.; Chapin, E.A.; Johnson, P.T.; Curletti, C.R.; Hancox, L.S.; Hu, J.; Ebright, J.N.; Malek, G. et al.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

ERG Responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration

Advances in Experimental Medicine and Biology
2008 | Book
DOI: 10.1007/978-0-387-74904-4_18
EID:

2-s2.0-38949114314

Part of ISSN: 00652598
Contributors: Malek, G.; Jamison, J.A.; MacE, B.; Sullivan, P.; Rickman, C.B.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Recurrent choroidal neovascularization after macular translocation surgery with 360-degree peripheral retinectomy

Retina
2008 | Journal article
DOI: 10.1097/IAE.0b013e31817d5bce
EID:

2-s2.0-67649208336

Part of ISSN: 0275004X
Contributors: Baer, C.A.; Rickman, C.B.; Sri Vastava, S.; Malek, G.; Stinnett, S.; Toth, C.A.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Sub-retinal drusenoid deposits in human retina: Organization and composition

Experimental Eye Research
2008 | Journal article
DOI: 10.1016/j.exer.2008.07.010
EID:

2-s2.0-54449097316

Part of ISSN: 00144835
Contributors: Rudolf, M.; Malek, G.; Messinger, J.D.; Clark, M.E.; Wang, L.; Curcio, C.A.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Molecular genetics of AMD and current animal models

Angiogenesis
2007 | Journal article
DOI: 10.1007/s10456-007-9064-2
EID:

2-s2.0-33947315191

Part of ISSN: 09696970
Contributors: Edwards, A.O.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina

Biochimica et Biophysica Acta - Molecular Cell Research
2007 | Journal article
DOI: 10.1016/j.bbamcr.2007.06.005
EID:

2-s2.0-34548498188

Part of ISSN: 01674889
Contributors: Yu, L.; Kelly, U.; Ebright, J.N.; Malek, G.; Saloupis, P.; Rickman, D.W.; McKay, B.S.; Arshavsky, V.Y.; Bowes Rickman, C.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Is our current clinical classification of AMD up to the job?

British Journal of Ophthalmology
2006 | Journal article
DOI: 10.1136/bjo.2006.098715
EID:

2-s2.0-33748456711

Part of ISSN: 00071161
Contributors: Malek, G.; Cousins, S.W.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Apolipoprotein E allele-dependent pathogenesis: A model for age-related retinal degeneration

Proceedings of the National Academy of Sciences of the United States of America
2005 | Journal article
DOI: 10.1073/pnas.0503015102
EID:

2-s2.0-23844463473

Part of ISSN: 00278424
Contributors: Malek, G.; Johnson, L.V.; Mace, B.E.; Saloupis, P.; Schmechel, D.E.; Rickman, D.W.; Toth, C.A.; Sullivan, P.M.; Rickman, C.B.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy

Experimental Eye Research
2005 | Journal article
DOI: 10.1016/j.exer.2005.04.012
EID:

2-s2.0-28444468904

Part of ISSN: 00144835
Contributors: Curcio, C.A.; Presley, J.B.; Malek, G.; Medeiros, N.E.; Avery, D.V.; Kruth, H.S.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Initial observations of key features of age-related macular degeneration in APOE targeted replacement mice

Advances in Experimental Medicine and Biology
2005 | Book
EID:

2-s2.0-33747394458

Part of ISSN: 00652598
Contributors: Malek, G.; Mace, B.; Saloupis, P.; Schmechel, D.; Rickman, D.; Sullivan, P.; Rickman, C.B.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Lipoprotein-like particles and cholesteryl esters in human Bruch's membrane: Initial characterization

Investigative Ophthalmology and Visual Science
2005 | Journal article
DOI: 10.1167/iovs.05-0034
EID:

2-s2.0-23244467801

Part of ISSN: 01460404
Contributors: Li, C.-M.; Chung, B.H.; Presley, J.B.; Malek, G.; Zhang, X.; Dashti, N.; Li, L.; Chen, J.; Bradley, K.; Kruth, H.S. et al.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells

Biochemical and Biophysical Research Communications
2005 | Journal article
DOI: 10.1016/j.bbrc.2005.09.028
EID:

2-s2.0-25844476124

Part of ISSN: 0006291X
Contributors: Rosenthal, R.; Malek, G.; Salomon, N.; Peill-Meininghaus, M.; Coeppicus, L.; Wohlleben, H.; Wimmers, S.; Bowes Rickman, C.; Strauss, O.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Insulin-like growth factor-1 contributes to neovascularization in age-related macular degeneration

Biochemical and Biophysical Research Communications
2004 | Journal article
DOI: 10.1016/j.bbrc.2004.08.219
EID:

2-s2.0-4644239500

Part of ISSN: 0006291X
Contributors: Rosenthal, R.; Wohlleben, H.; Malek, G.; Schlichting, L.; Thieme, H.; Rickman, C.B.; Strauss, O.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy

American Journal of Pathology
2003 | Journal article
DOI: 10.1016/S0002-9440(10)63836-9
EID:

2-s2.0-0037332052

Part of ISSN: 00029440
Contributors: Malek, G.; Li, C.-M.; Guidry, C.; Medeiros, N.E.; Curcio, C.A.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Dominant late-onset retinal degeneration with regional variation of sub-retinal pigment epithelium deposits, retinal function, and photoreceptor degeneration

Ophthalmology
2000 | Journal article
DOI: 10.1016/S0161-6420(00)00419-X
EID:

2-s2.0-0033659788

Part of ISSN: 01616420
Contributors: Milam, A.H.; Curcio, C.A.; Cideciyan, A.V.; Saxena, S.; John, S.K.; Kruth, H.S.; Malek, G.; Heckenlively, J.R.; Weleber, R.G.; Jacobson, S.G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier

Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss

Ophthalmology
2000 | Journal article
DOI: 10.1016/S0161-6420(99)00037-8
EID:

2-s2.0-0034027664

Part of ISSN: 01616420
Contributors: Curcio, C.A.; Saunders, P.L.; Younger, P.W.; Malek, G.
Source: Self-asserted source
Goldis Malek via Scopus - Elsevier
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