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Lechun Lyu

Other IDs

Scopus Author ID: 55575821500
Loop profile: 2918612
Loop profile: 822406

Keywords

Keloid, Wound healing, microRNA, Psoriasis, Pulmonary fibrosis, Yeast

Countries

China

Activities

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Employment (4)

Kunming Medical University: Kunming, CN

2024-08 to present (School of Rehabilitation)
Employment
Source: Self-asserted source
Lechun Lyu

Kunming Medical University: Kunming, Yunnan, CN

2019-06-01 to present | Professor (Science and Technology Achievement Incubation Center)
Employment
Source: Self-asserted source
Lechun Lyu

Kunming Medical University: Kunming, Yunnan, CN

2018-01-01 to present | Associate Prof. (Technology Transfer Center)
Employment
Source: Self-asserted source
Lechun Lyu

Kunming Medical University: Kunming, Yunnan, CN

2007-06 to 2017-12 | Associate Prof. (Department of Physiology)
Employment
Source: Self-asserted source
Lechun Lyu

Education and qualifications (1)

First Affiliated Hospital of Kunming Medical University: Kunming, CN

2014-09-01 to 2017-06-01 | MD & PhD (Department of Dermatology)
Education
Source: Self-asserted source
Lechun Lyu

Works (47)

Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells by Periplaneta americana extract

Frontiers in Pharmacology
2025-03-04 | Journal article
DOI: 10.3389/fphar.2025.1517491
Part of ISSN: 1663-9812
Contributors: Ying Fang; Ye Liu; Dingchun Li; Yi Miu; Kexuan Chen; Jv Zhou; Lijuan Xie; Xinting Chen; Jingyan Wu; Ying Zhu et al.
Source: Self-asserted source
Lechun Lyu

Cannabidiol-loaded hydrogel microneedle patches inhibit TRIM14/TRAF3/ NF-κB axis for the treatment of psoriasis

International Journal of Biological Macromolecules
2025-02 | Journal article
DOI: 10.1016/j.ijbiomac.2025.140825
Part of ISSN: 0141-8130
Contributors: Mengyan Li; Die Li; Yu Zhang; Juan Wang; Shenglan Wang; Hao Zhao; Hanying Wang; Xiaofeng Zeng; Dan Xu; Lechun Lyu
Source: Self-asserted source
Lechun Lyu

Novel Thermosensitive Hydrogel Encapsulated Carvedilol for the Treatment of Rosacea

ACS Omega
2025-02-19 | Journal article
DOI: 10.1021/acsomega.4c08884
Part of ISSN: 2470-1343
Part of ISSN: 2470-1343
Contributors: Huiya Chen; Zhigang Zhang; Jue Qi; Can Cao; Min Lin; Lechun Lyu; Dan Xu
Source: Self-asserted source
Lechun Lyu

Identification of a metabolism-linked genomic signature for prognosis and immunotherapeutic efficiency in metastatic skin cutaneous melanoma

Medicine (United States)
2024 | Journal article
DOI: 10.1097/MD.0000000000038347
EID:

2-s2.0-85195438760

Part of ISSN: 15365964 00257974
Contributors: He, Z.; Lyu, J.; Lyu, L.; Long, X.; Xu, B.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

MiRNA-224-5p regulates the defective permeability barrier in sensitive skin by targeting claudin-5

Skin Research and Technology
2024 | Journal article
DOI: 10.1111/srt.13720
EID:

2-s2.0-85192884787

Part of ISSN: 16000846 0909752X
Contributors: Yang, L.; Wu, W.-J.; Lyu, L.-C.; Tu, Y.; Gu, H.; Chen, X.-F.; Chai, Y.-J.; Man, M.-Q.; He, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

Nanocarrier-Mediated Delivery of MicroRNAs for Fibrotic Diseases

Molecular Diagnosis and Therapy
2024 | Journal article
DOI: 10.1007/s40291-023-00681-y
EID:

2-s2.0-85174929099

Part of ISSN: 11792000 11771062
Contributors: Guo, Y.; Wang, H.; Lyu, R.; Wang, J.; Wang, T.; Shi, J.; Lyu, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

DTL promotes head and neck squamous cell carcinoma progression by mediating the degradation of ARGLU1 to regulate the Notch signaling pathway

International Journal of Biological Macromolecules
2024-01 | Journal article
DOI: 10.1016/j.ijbiomac.2023.129184
Part of ISSN: 0141-8130
Contributors: Jingpei Shi; Xiaonan Yu; Guoyu Li; Xiaoyu Zhao; Jiwen Chen; Ying Fang; Yan Yang; Ting Wang; Tianyong Xu; Li Bian et al.
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Deletion of YJL218W reduces salt tolerance of Saccharomyces cerevisiae

Journal of Basic Microbiology
2022 | Journal article
DOI: 10.1002/jobm.202200029
EID:

2-s2.0-85131548845

Part of ISSN: 15214028 0233111X
Contributors: Li, M.; Zhang, Y.; Deng, J.; Wang, H.; Ma, J.; Wang, W.; Lyu, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

Deletion of YLR358C Contributes to Reduce Cell Wall Integrity in Saccharomyces Cerevisiae

Research Square
2022 | Other
DOI: 10.21203/rs.3.rs-1235133/v1
EID:

2-s2.0-85166889340
Contributors: Zhang, Y.; Li, M.; Wang, H.; Deng, J.; Liu, J.; Zhang, L.; Lyu, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

Transcriptome Analysis Reveals that MAPK Signaling Pathway Mediates Salt Tolerance of YMR253C ORF in Saccharomyces cerevisiae

Current Microbiology
2022 | Journal article
DOI: 10.1007/s00284-022-02818-4
EID:

2-s2.0-85126262048

Part of ISSN: 14320991 03438651
Contributors: Zhang, Y.; Li, M.; Deng, J.; Bai, C.; Ma, J.; Lyu, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

The ubiquitin‐proteasome system in melanin metabolism

Journal of Cosmetic Dermatology
2022-10-25 | Journal article
DOI: 10.1111/jocd.15433
Part of ISSN: 1473-2130
Part of ISSN: 1473-2165
Contributors: Jingpei Shi; Yanfang Guo; Hanying Wang; Yun Xiao; Weimin Liu; Lechun Lyu
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Localized delivery of curcumin by thermosensitive hydrogels for promoting wound healing

Journal of Cosmetic Dermatology
2022-04-12 | Journal article
DOI: 10.1111/jocd.14967
Part of ISSN: 1473-2130
Part of ISSN: 1473-2165
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Role of miRNAs in melanin metabolism: Implications in melanin‐related diseases

Journal of Cosmetic Dermatology
2022-01-18 | Journal article
DOI: 10.1111/jocd.14762
Part of ISSN: 1473-2130
Part of ISSN: 1473-2165
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

The Ubiquitin Proteasome System and Skin Fibrosis

Molecular Diagnosis and Therapy
2021 | Journal article
DOI: 10.1007/s40291-020-00509-z
EID:

2-s2.0-85099209083

Part of ISSN: 11792000 11771062
Contributors: Shen, W.; Zhang, Z.; Ma, J.; Lu, D.; Lyu, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

Bioactive Chemical Constituents of Pleione yunnanensis

Chemistry of Natural Compounds
2020 | Journal article
DOI: 10.1007/s10600-020-03075-2
EID:

2-s2.0-85086041519

Part of ISSN: 15738388 00093130
Contributors: Xu, J.-J.; Chen, Y.-P.; Dong, W.-X.; Teng, Q.; Lyu, L.-C.; Li, Y.-P.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

Critical role and potential therapeutic efficacy of interleukin-37 in the pathogenesis of keloid scarring

Journal of Cosmetic Dermatology
2020 | Journal article
DOI: 10.1111/jocd.13357
EID:

2-s2.0-85080966274

Part of ISSN: 14732165 14732130
Contributors: Zhao, Y.; Shi, J.; Lyu, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

Current insight into the roles of microRNA in vitiligo

Molecular Biology Reports
2020 | Journal article
DOI: 10.1007/s11033-020-05336-3
EID:

2-s2.0-85080853938

Part of ISSN: 15734978 03014851
Contributors: Yan, S.; Shi, J.; Sun, D.; Lyu, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

The integrative regulatory network of circRNA and microRNA in keloid scarring

Molecular Biology Reports
2020 | Journal article
DOI: 10.1007/s11033-019-05120-y
EID:

2-s2.0-85074026652

Part of ISSN: 15734978 03014851
Contributors: Shi, J.; Yao, S.; Chen, P.; Yang, Y.; Qian, M.; Han, Y.; Wang, N.; Zhao, Y.; He, Y.; Lyu, L. et al.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2

Biochemical and Biophysical Research Communications
2020-01 | Journal article
DOI: 10.1016/j.bbrc.2020.01.028
Part of ISSN: 0006-291X
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 3)‎

Gastrodin ameliorates microvascular reperfusion injury–induced pyroptosis by regulating the NLRP3/caspase-1 pathway

Journal of Physiology and Biochemistry
2019 | Journal article
DOI: 10.1007/s13105-019-00702-7
EID:

2-s2.0-85071480099

Part of ISSN: 18778755 11387548
Contributors: Sun, W.; Lu, H.; Lyu, L.; Yang, P.; Lin, Z.; Li, L.; Sun, L.; Lu, D.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

Systematic evaluation of positivity rates to antibiotic resistance of Propionibacterium acnes isolated from lesions of patients with acne in China,我国痤疮患者皮损中痤疮丙酸杆菌对抗生素耐药性的 Meta 分析

China Journal of Leprosy and Skin Diseases
2019 | Journal article
DOI: 10.12144/zgmfskin201909515
EID:

2-s2.0-85191080833

Part of ISSN: 10091157
Contributors: Zhang, L.; Wang, Q.; Zhu, W.; Lyu, L.; Yang, F.; Yan, S.; Li, G.; Wang, Y.; Li, Y.; Liu, J. et al.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

Integrated Interaction Network of MicroRNA Target Genes in Keloid Scarring

2019-02 | Journal article
DOI: 10.1007/s40291-018-0378-0
Part of ISSN: 1177-1062
Part of ISSN: 1179-2000
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Identification and integrated analysis of microRNA expression profiles in keloid

Journal of Cosmetic Dermatology
2018 | Journal article
DOI: 10.1111/jocd.12706
EID:

2-s2.0-85050724895

Part of ISSN: 14732165 14732130
Contributors: Zhong, L.; Bian, L.; Lyu, J.; Jin, H.; Liu, Z.; Lyu, L.; Lu, D.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier
grade
Preferred source (of 2)‎

From genetics to epigenetics: new insights into keloid scarring

Cell Proliferation
2017 | Journal article
DOI: 10.1111/cpr.12326
EID:

2-s2.0-85008145398

Part of ISSN: 13652184 09607722
Contributors: He, Y.; Deng, Z.; Alghamdi, M.; Lu, L.; Fear, M.W.; He, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

Genome-Wide Analysis of mRNA and Long Noncoding RNA Profiles in Chronic Actinic Dermatitis

2017 | Journal article
DOI: 10.1155/2017/7479523
Part of ISSN: 2314-6133
Part of ISSN: 2314-6141
Source: Self-asserted source
Lechun Lyu

MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

Molecular Diagnosis and Therapy
2017 | Journal article
DOI: 10.1007/s40291-017-0294-8
EID:

2-s2.0-85025102032

Part of ISSN: 11792000 11771062
Contributors: Li, Y.; Zhang, J.; Lei, Y.; Lyu, L.; Zuo, R.; Chen, T.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

MicroRNA-29: A Crucial Player in Fibrotic Disease

Molecular Diagnosis and Therapy
2017 | Journal article
DOI: 10.1007/s40291-016-0253-9
EID:

2-s2.0-85010716507

Part of ISSN: 11792000 11771062
Contributors: Deng, Z.; He, Y.; Yang, X.; Shi, H.; Shi, A.; Lu, L.; He, L.
Source: Self-asserted source
Lechun Lyu via Scopus - Elsevier

Genome-wide identification of long non-coding RNA and mRNA profiling using RNA sequencing in subjects with sensitive skin

2017-12-29 | Journal article
DOI: 10.18632/oncotarget.23147
Part of ISSN: 1949-2553
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

Mol Diagn Ther.
2017-12-02 | Journal article
Source: Self-asserted source
Lechun Lyu

Insight into immunocytes infiltrations in polymorphous light eruption

2017-11 | Journal article
DOI: 10.1016/j.biotechadv.2017.07.006
Part of ISSN: 0734-9750
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Downregulation of microRNA-31 inhibits proliferation and induces apoptosis by targeting <i>HIF1AN</i> in human keloid

2017-09-26 | Journal article
DOI: 10.18632/oncotarget.20284
Part of ISSN: 1949-2553
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

MicroRNA-29: A Crucial Player in Fibrotic Disease

Mol Diagn Ther.
2017-05 | Journal article
Source: Self-asserted source
Lechun Lyu

Angiotensin-converting enzyme gene polymorphisms might be associated with childhood asthma in East Asia

2017-05-28 | Journal article
DOI: 10.1080/02770903.2016.1236943
Part of ISSN: 0277-0903
Part of ISSN: 1532-4303
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

From genetics to epigenetics: new insights into keloid scarring

Cell Prolif.
2017-04 | Journal article
Source: Self-asserted source
Lechun Lyu

Pivotal MicroRNAs in Melanoma: A Mini-Review

2016-10 | Journal article
DOI: 10.1007/s40291-016-0219-y
Part of ISSN: 1177-1062
Part of ISSN: 1179-2000
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Gut-Brain Axis Dysfunction May Be Associated With Psoriatic Arthritis: Comment on the Article by Scher et al

2015-05 | Journal article
DOI: 10.1002/art.39151
Part of ISSN: 2326-5191
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson’s disease

2015-04 | Journal article
DOI: 10.1007/s10072-014-1998-8
Part of ISSN: 1590-1874
Part of ISSN: 1590-3478
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

The Null Polymorphism of the GSTM1/T1 Gene Is Not Associated with Susceptibility to Systemic Lupus Erythematosus: A Meta-Analysis

2015-02 | Journal article
DOI: 10.1007/s40291-015-0131-x
Part of ISSN: 1177-1062
Part of ISSN: 1179-2000
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Val158Met polymorphism of COMT gene and Parkinson’s disease risk in Asians

2015-01 | Journal article
DOI: 10.1007/s10072-014-1896-0
Part of ISSN: 1590-1874
Part of ISSN: 1590-3478
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Angiotensin-converting enzyme gene insertion/deletion polymorphisms and the susceptibility to allergic rhinitis

2014-11 | Journal article
DOI: 10.1016/j.aller.2013.09.008
Part of ISSN: 0301-0546
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Association of the 389 C/T polymorphism of the catalase gene with susceptibility to vitiligo: a meta-analysis

2014-06 | Journal article
DOI: 10.1111/ced.12340
Part of ISSN: 0307-6938
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

MicroRNA-499 rs3746444 Polymorphism and Autoimmune Diseases Risk: A Meta-Analysis

2014-04 | Journal article
DOI: 10.1007/s40291-013-0073-0
Part of ISSN: 1177-1062
Part of ISSN: 1179-2000
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo

2014-02 | Journal article
DOI: 10.1016/j.gene.2013.11.024
Part of ISSN: 0378-1119
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

The COMT Val158Met polymorphism as an associated risk factor for Parkinson′s disease in Asian rather than Caucasian populations

2013 | Journal article
DOI: 10.4103/0028-3886.108121
Part of ISSN: 0028-3886
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Angiotensin-converting enzyme gene polymorphisms and the risk of psoriasis: a meta-analysis.

Clinical and experimental dermatology
2013-06-01 | Journal article
DOI: 10.1111/ced.12106
PMID: 23621089
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Apolipoprotein E Gene Polymorphism in Psoriasis: A Meta-analysis

2013-01 | Journal article
DOI: 10.1016/j.arcmed.2012.10.009
Part of ISSN: 0188-4409
Source: Self-asserted source
Lechun Lyu
grade
Preferred source (of 2)‎

Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells by Periplaneta americana extract

Journal article
Contributors: Lechun Lyu
Source: Self-asserted source
Lechun Lyu

Peer review (2 reviews for 2 publications/grants)

Review activity for Advanced science. (1)
Review activity for World journal of surgical oncology (1)
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