Personal information

Websites & social links

Google Scholar
LinkedIn

Other IDs

Scopus Author ID: 57202545254
Loop profile: 2180504
SciProfiles: 1950079

Keywords

molecular dynamics, NMR, intrinsically disordered proteins, cyclic peptides, computer-aided drug design

Countries

United States

Activities

Collapse all

Employment (4)

Pinnacle Medicines US Inc.: Doylestown, Pennsylvania, US

2024-05-06 to present | Senior Scientist
Employment
Source: Self-asserted source
Lei Yu

Janssen Research and Development: Spring House, Pennsylvania, US

2022-06-13 to 2024-05-03 | Postdoctoral Fellow (Computational Chemistry)
Employment
Source: Self-asserted source
Lei Yu

University of California, Berkeley: Berkeley, California, US

2022-02 to 2022-06 | Postdoctoral Scholar (Chemistry)
Employment
Source: Self-asserted source
Lei Yu

The Ohio State University: Columbus, Ohio, US

2016-08 to 2021-12 | Graduate Research Associate (Chemistry and Biochemistry)
Employment
Source: Self-asserted source
Lei Yu

Education and qualifications (2)

The Ohio State University: Columbus, OH, US

2016 to 2021
Education
Source: Self-asserted source
Lei Yu

University of Science and Technology of China: Hefei, Anhui, CN

2012 to 2016
Education
Source: Self-asserted source
Lei Yu

Professional activities (1)

American Chemical Society: Washington, DC, US

Membership
Source: Self-asserted source
Lei Yu

Works (11)

Cyclic Peptide Linker Design and Optimization by Molecular Dynamics Simulations

Journal of Chemical Information and Modeling
2023-11-13 | Journal article
DOI: 10.1021/acs.jcim.3c01359
Contributors: Lei Yu; Stephanie A. Barros; Chengzao Sun; Sandeep Somani
Source: check_circle
Crossref

Quantitative prediction of ensemble dynamics, shapes and contact propensities of intrinsically disordered proteins

PLOS Computational Biology
2022-09-09 | Journal article
DOI: 10.1371/journal.pcbi.1010036
Contributors: Lei Yu; Bert L. de Groot; Rafael Brüschweiler
Source: check_circle
Crossref

IDPConformerGenerator: A Flexible Software Suite for Sampling the Conformational Space of Disordered Protein States

The Journal of Physical Chemistry A
2022-09-08 | Journal article
DOI: 10.1021/acs.jpca.2c03726
Contributors: João M. C. Teixeira; Zi Hao Liu; Ashley Namini; Jie Li; Robert M. Vernon; Mickaël Krzeminski; Alaa A. Shamandy; Oufan Zhang; Mojtaba Haghighatlari; Lei Yu et al.
Source: check_circle
Crossref

Quantitative prediction of ensemble dynamics, shapes and contact propensities of intrinsically disordered proteins

2022-03-22 | Preprint
DOI: 10.1101/2022.03.21.485081
Contributors: Lei Yu; Rafael Brüschweiler
Source: check_circle
Crossref

Observation of Sub-Microsecond Protein Methyl-Side Chain Dynamics by Nanoparticle-Assisted NMR Spin Relaxation

Journal of the American Chemical Society
2021-09-01 | Journal article
DOI: 10.1021/jacs.1c04687
Contributors: Xinyao Xiang; Alexandar L. Hansen; Lei Yu; Gregory Jameson; Lei Bruschweiler-Li; Chunhua Yuan; Rafael Brüschweiler
Source: check_circle
Crossref

Systematic Differences between Current Molecular Dynamics Force Fields To Represent Local Properties of Intrinsically Disordered Proteins

The Journal of Physical Chemistry B
2021-01-28 | Journal article
DOI: 10.1021/acs.jpcb.0c10078
Contributors: Lei Yu; Da-Wei Li; Rafael Brüschweiler
Source: check_circle
Crossref

Broadband Dynamics of Ubiquitin by Anionic and Cationic Nanoparticle Assisted NMR Spin Relaxation

Angewandte Chemie International Edition
2021-01-04 | Journal article
DOI: 10.1002/anie.202007205
Contributors: Stacey Wardenfelt; Xinyao Xiang; Mouzhe Xie; Lei Yu; Lei Bruschweiler‐Li; Rafael Brüschweiler
Source: check_circle
Crossref

Broadband Dynamics of Ubiquitin by Anionic and Cationic Nanoparticle Assisted NMR Spin Relaxation

Angewandte Chemie
2021-01-04 | Journal article
DOI: 10.1002/ange.202007205
Contributors: Stacey Wardenfelt; Xinyao Xiang; Mouzhe Xie; Lei Yu; Lei Bruschweiler‐Li; Rafael Brüschweiler
Source: check_circle
Crossref

Balanced Amino-Acid-Specific Molecular Dynamics Force Field for the Realistic Simulation of Both Folded and Disordered Proteins

Journal of Chemical Theory and Computation
2020-02-11 | Journal article
DOI: 10.1021/acs.jctc.9b01062
Contributors: Lei Yu; Da-Wei Li; Rafael Brüschweiler
Source: check_circle
Crossref

Functional protein dynamics on uncharted time scales detected by nanoparticle-assisted NMR spin relaxation

Science Advances
2019-08-02 | Journal article
DOI: 10.1126/sciadv.aax5560
Contributors: Mouzhe Xie; Lei Yu; Lei Bruschweiler-Li; Xinyao Xiang; Alexandar L. Hansen; Rafael Brüschweiler
Source: check_circle
Crossref

The Intracellular Loop of the Na+/Ca2+ Exchanger Contains an “Awareness Ribbon”-Shaped Two-Helix Bundle Domain

Biochemistry
2018-08-28 | Journal article
DOI: 10.1021/acs.biochem.8b00300
Part of ISSN: 0006-2960
Part of ISSN: 1520-4995
Source: Self-asserted source
Lei Yu

Peer review (19 reviews for 9 publications/grants)

Review activity for ACS omega. (2)
Review activity for Biomolecules. (6)
Review activity for Current issues in molecular biology. (1)
Review activity for International journal of biological macromolecules. (1)
Review activity for International journal of molecular sciences. (3)
Review activity for Molecules. (2)
Review activity for STAR protocols. (2)
Review activity for The journal of physical chemistry. (1)
Review activity for Zoonotic diseases. (1)
How many people are using ORCID?