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bioinformatics, computatinal biochemistry, docking, molecular dynamics, QSAR, protein kinases
Chile

Biography

Julio Caballero was born in 1977 in Matanzas, Cuba. He studied Chemistry at Universidad de La Habana, where he graduated with a Gold Diploma in 2001. In 2002-2004 he worked on protein engineering in the Enzyme Technology Group at Universidad de Matanzas. He began to work on pharmaceutical modeling and artificial intelligence in 2004 and founded the Molecular Modeling Group at the same university. In 2006 he moved to Talca, Chile and began to work at Universidad de Talca. He was incorporated into the Ph.D. program in Applied Sciences in 2008. He completed his Ph.D. degree working in computational biochemistry in 2012 and was appointed as Assistant Professor at Universidad de Talca. In 2013 he was promoted to associate professor at the same university. At this moment Julio Caballero is member of the regular academic staff of Universidad de Talca, head of the department of Applied Sciences, member of ‘Centro de Bioinformática y Simulación Molecular’ (CBSM), and lecturer of the school of Bioinformatics at the Faculty of Engineering at the same university. His current research is focused on ligand-biomolecules interactions, pharmaceutical modeling, protein structures and function, enzyme reactivity and selectivity, and his main contributions are focused to medicinal chemistry topics.

Activities

Funding (14)

Understanding the molecular function of the papain-like proteases (PLPs) from zoonotic coronaviruses (CoVs): computational approaches to study the catalytic mechanism and interactions with inhibitors.

2021 to 2025 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

1210138

Source: Self-asserted source
Julio Caballero

Diseño racional, síntesis y evaluación de nuevas nanoformulaciones basadas en polímeros para liberación controlada de feromonas sexuales de Lobesia botrana a través de una estrategia híbrida in-silico/experimental

2017-03 to 2020-02 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

3170909

Source: Self-asserted source
Julio Caballero

Diseño, síntesis y evaluación biológica de una nueva librería de compuestos fosfono-peptidomiméticos como inhibidores de la enzima Pseudomona elastasa (LasB)

2017-03 to 2020-02 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

3170003

Source: Self-asserted source
Julio Caballero

Modelación computacional de capacidades para la producción fotosensibilizada de oxígeno singlete en rodopsinas mutantes asociadas a degeneración retiniana

2017-03 to 2020-02 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

3170107

Source: Self-asserted source
Julio Caballero

Design and synthesis of angiotensin-converting enzyme inhibitors using molecular modeling and multicomponent reactions

2017 to 2021 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, Ragion Metropolitana, CL)
GRANT_NUMBER:

1170718

Source: Self-asserted source
Julio Caballero

Use and improvement of the SIRAH force field for Coarse-Grained Simulations applied to intermolecular interactions of proteins

2016 to 2017 | Grant
Comisión Nacional de Investigación Científica y Tecnológica (Santiago, CL)
GRANT_NUMBER:

REDES150151

Source: Self-asserted source
Julio Caballero

Renovación del Clúster de Cómputo del Centro de Bioinformática y Simulación Molecular (CBSM) de la Universidad de Talca

2016 to 2016 | Grant
FONDEQUIP (Santiago, CL)
GRANT_NUMBER:

EQM160063

Source: Self-asserted source
Julio Caballero

Estudio catalítico e inhibitorio en la proteína Fosfofructoquinasa-2

2014-11 to 2017-11 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

3150041

Source: Self-asserted source
Julio Caballero

Modelación de las estructuras tridimensionales de las proteínas quinasas involucradas en tuberculosis y la malaria: búsqueda del farmacóforo de sus inhibidores ATP competitivos

2014-11 to 2017-11 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

3150035

Source: Self-asserted source
Julio Caballero

Study of the structural determinants that control the operation of the Na+/ K+ pump

2013-11 to 2015-11 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

3140288

Source: Self-asserted source
Julio Caballero

Insights into the structural basis of the interactions between cAMP-dependent protein kinase (PKA) and its substrates. Development of predictive molecular models and testing in the study of the interactions between PKA and potassium channel AKT2

2013-03 to 2016-03 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

1130141

Source: Self-asserted source
Julio Caballero

Research on Mechanisms of Antiplatelet Action of Adenosine and other Bioactive Compounds from Solanum lycopersicum L

2013-03 to 2016-03 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

1130216

Source: Self-asserted source
Julio Caballero

Molecular modeling of late embryogenesis abundant (LEA) proteins in plants

2013 to 2014 | Grant
Consejo Nacional de Ciencia y Tecnología (Santiago, CL)
GRANT_NUMBER:

REDES120019

Source: Self-asserted source
Julio Caballero

Catálisis enzimatica en la proteina quinasa PKA

2012-11 to 2013-11 | Grant
Fondo Nacional de Desarrollo Científico y Tecnológico (Santiago, CL)
GRANT_NUMBER:

3130500

Source: Self-asserted source
Julio Caballero

Peer review (265 reviews for 67 publications/grants)

Review activity for ACS medicinal chemistry letters. (3)
Review activity for ACS omega. (6)
Review activity for Arabian journal of chemistry. (5)
Review activity for Artificial cells, nanomedicine, and biotechnology. (1)
Review activity for Biochimica et biophysica acta. (1)
Review activity for Biochimica et biophysica acta. (2)
Review activity for Bioinformatics (2)
Review activity for Bioinorganic Chemistry and Applications (1)
Review activity for Biomolecules. (4)
Review activity for Bioorganic chemistry. (1)
Review activity for Biophysical reviews. (1)
Review activity for BMC bioinformatics (6)
Review activity for BMC structural biology. (1)
Review activity for Chemical biology & drug design. (19)
Review activity for Chemical science. (2)
Review activity for Chemistry & biodiversity. (3)
Review activity for ChemistryOpen (1)
Review activity for ChemistrySelect (3)
Review activity for ChemPhysChem. (5)
Review activity for Combinatorial chemistry & high throughput screening. (1)
Review activity for Computational biology and chemistry (2)
Review activity for Computer methods and programs in biomedicine. (1)
Review activity for Computers in biology and medicine. (1)
Review activity for Computers in biology and medicine. (1)
Review activity for Current computer-aided drug design. (2)
Review activity for European journal of biochemistry. (2)
Review activity for European journal of medicinal chemistry. (4)
Review activity for Expert opinion on drug discovery (5)
Review activity for Frontiers in chemistry. (2)
Review activity for Informatics in medicine unlocked. (1)
Review activity for International journal of biological macromolecules. (4)
Review activity for International journal of environmental research and public health (2)
Review activity for Journal of biomolecular structure and dynamics. (1)
Review activity for Journal of chemical information and modeling. (35)
Review activity for Journal of chemical information and modeling. (20)
Review activity for Journal of chemical theory and computation : (2)
Review activity for Journal of computational biophysics and chemistry. (1)
Review activity for Journal of computational chemistry. (3)
Review activity for Journal of enzyme inhibition and medicinal chemistry. (2)
Review activity for Journal of ethnopharmacology. (2)
Review activity for Journal of medicinal chemistry. (17)
Review activity for Journal of molecular graphics and modelling. (1)
Review activity for Journal of molecular modeling. (3)
Review activity for Journal of molecular structure. (5)
Review activity for Journal of polymer research. (1)
Review activity for Journal of polymer research. (1)
Review activity for Journal of proteome research. (1)
Review activity for Journal of the Brazilian Chemical Society. (3)
Review activity for Medicinal chemistry research. (1)
Review activity for Molecular diversity. (19)
Review activity for Molecular informatics (2)
Review activity for Molecules. (13)
Review activity for Nature communications (2)
Review activity for New journal of chemistry. (2)
Review activity for Organic & biomolecular chemistry. (2)
Review activity for Phosphorus, sulfur, and silicon and the related elements. (1)
Review activity for Physical chemistry chemical physics. (4)
Review activity for Phytochemistry. (1)
Review activity for PloS one. (3)
Review activity for Prostaglandins & other lipid mediators. (2)
Review activity for RSC advances (1)
Review activity for RSC medicinal chemistry. (1)
Review activity for SAR and QSAR in environmental research. (3)
Review activity for Scientia pharmaceutica. (3)
Review activity for Scientific reports. (6)
Review activity for The journal of physical chemistry. (3)
Review activity for The journal of physical chemistry. (3)