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Activities

Employment (3)

F. Hoffmann - LaRoche AG: Basel, Basel Stadt, CH

2012-05 to present | Group Head (Analytical Development & QC, Biologics)
Employment
Source: Self-asserted source
Atanas Koulov

Novartis Pharma AG: Basel, Basel-Stadt, CH

2008-08 to 2012-05 | Lab Head (Analytical Development, Biologics)
Employment
Source: Self-asserted source
Atanas Koulov

The Scripps Research Institute: La Jolla, CA, US

2004-06 to 2008-07 | Postdoctoral Fellow (Cell Biology)
Employment
Source: Self-asserted source
Atanas Koulov

Education and qualifications (1)

University of Notre Dame: Notre Dame, IN, US

1999-08-28 to 2004-05-01 | PhD (Chemistry and Biochemistry)
Education
Source: Self-asserted source
Atanas Koulov

Works (25)

The immunogenicity of antibody aggregates in a novel transgenic mouse model.

2015-07 | Journal article
DOI:

10.1007/s11095-015-1627-0

PMID:

25630815

Contributors: Bessa J; Boeckle S; Beck H; Buckel T; Schlicht S; Ebeling M; Kiialainen A; Koulov A; Boll B; Weiser T et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Subvisible (2-100 μm) Particle Analysis During Biotherapeutic Drug Product Development: Part 1, Considerations and Strategy.

2015-06 | Journal article
DOI:

10.1002/jps.24437

PMID:

25832583

Contributors: Narhi LO; Corvari V; Ripple DC; Afonina N; Cecchini I; Defelippis MR; Garidel P; Herre A; Koulov AV; Lubiniecki T et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Measuring Sub-Visible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities.

2015-05 | Journal article
DOI:

10.1021/acs.analchem.5b00688

PMID:

26001042

Contributors: Rios Quiroz A; Québatte G; Stump F; Finkler C; Huwyler J; Schmidt R; Mahler HC; Koulov AV; Adler M
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule.

2015-05 | Journal article
DOI:

10.1002/jps.24509

PMID:

26010344

Contributors: Folzer E; Diepold K; Bomans K; Finkler C; Schmidt R; Bulau P; Huwyler J; Mahler HC; Koulov AV
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Aggregation of human recombinant monoclonal antibodies influences the capacity of dendritic cells to stimulate adaptive T-cell responses in vitro.

2014 | Journal article
DOI:

10.1371/journal.pone.0086322

PMID:

24466023

PMC:

PMC3897673

Contributors: Rombach-Riegraf V; Karle AC; Wolf B; Sordé L; Koepke S; Gottlieb S; Krieg J; Djidja MC; Baban A; Spindeldreher S et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Size fractionation of microscopic protein aggregates using a preparative fluorescence-activated cell sorter.

2013-07 | Journal article
DOI:

10.1002/jps.23532

PMID:

23695958

Contributors: Rombach-Riegraf V; Allard C; Angevaare E; Matter A; Ossuli B; Strehl R; Raulf F; Bluemel M; Egodage K; Jeschke M et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

A chaperone trap contributes to the onset of cystic fibrosis.

2012 | Journal article
DOI:

10.1371/journal.pone.0037682

PMID:

22701530

PMC:

PMC3365120

Contributors: Coppinger JA; Hutt DM; Razvi A; Koulov AV; Pankow S; Yates JR 3rd; Balch WE
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Discrimination between silicone oil droplets and protein aggregates in biopharmaceuticals: a novel multiparametric image filter for sub-visible particles in microflow imaging analysis.

2012-02 | Journal article
DOI:

10.1007/s11095-011-0590-7

PMID:

21948455

Contributors: Strehl R; Rombach-Riegraf V; Diez M; Egodage K; Bluemel M; Jeschke M; Koulov AV
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis.

2010-03 | Journal article
DOI:

10.1091/mbc.E09-12-1017

PMID:

20089831

PMC:

PMC2836968

Contributors: Koulov AV; LaPointe P; Lu B; Razvi A; Coppinger J; Dong MQ; Matteson J; Laister R; Arrowsmith C; Yates JR 3rd et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Structure-activity relationships in cholapod anion carriers: enhanced transmembrane chloride transport through substituent tuning.

2008 | Journal article
DOI:

10.1002/chem.200801163

PMID:

18773409

PMC:

PMC2849112

Contributors: McNally BA; Koulov AV; Lambert TN; Smith BD; Joos JB; Sisson AL; Clare JP; Sgarlata V; Judd LW; Magro G et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Chemical and biological folding contribute to temperature-sensitive DeltaF508 CFTR trafficking.

2008-11 | Journal article
DOI:

10.1111/j.1600-0854.2008.00806.x

PMID:

18764821

PMC:

PMC2683680

Contributors: Wang X; Koulov AV; Kellner WA; Riordan JR; Balch WE
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

An evolutionary perspective on eukaryotic membrane trafficking.

2007 | Journal article
PMID:

17977460

Contributors: Gurkan C; Koulov AV; Balch WE
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Semen-derived amyloid fibrils drastically enhance HIV infection.

2007-12 | Journal article
DOI:

10.1016/j.cell.2007.10.014

PMID:

18083097

Contributors: Münch J; Rücker E; Ständker L; Adermann K; Goffinet C; Schindler M; Wildum S; Chinnadurai R; Rajan D; Specht A et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Protein energetics in maturation of the early secretory pathway.

2007-08 | Journal article
DOI:

10.1016/j.ceb.2007.05.005

PMID:

17686625

PMC:

PMC2094714

Contributors: Wiseman RL; Koulov A; Powers E; Kelly JW; Balch WE
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Functional amyloid--from bacteria to humans.

2007-05 | Journal article
DOI:

10.1016/j.tibs.2007.03.003

PMID:

17412596

Contributors: Fowler DM; Koulov AV; Balch WE; Kelly JW
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

2006-11 | Journal article
DOI:

10.1016/j.cell.2006.09.043

PMID:

17110338

Contributors: Wang X; Venable J; LaPointe P; Hutt DM; Koulov AV; Coppinger J; Gurkan C; Kellner W; Matteson J; Plutner H et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Functional amyloid formation within mammalian tissue.

2006-01 | Journal article
DOI:

10.1371/journal.pbio.0040006

PMID:

16300414

PMC:

PMC1288039

Contributors: Fowler DM; Koulov AV; Alory-Jost C; Marks MS; Balch WE; Kelly JW
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

A fluorescent assay for chloride transport; identification of a synthetic anionophore with improved activity.

2005-02 | Journal article
DOI:

10.1039/b414589e

PMID:

15719125

Contributors: McNally BA; Koulov AV; Smith BD; Joos JB; Davis AP
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Apoptosis of human breast carcinoma cells in the presence of disialosyl gangliosides: II. Treatment of SKBR3 cells with GD3 and GD1b gangliosides.

2004 | Journal article
DOI:

10.1023/B:GLYC.0000033628.39302.ae

PMID:

15229396

Contributors: Ma R; Koulov A; Moulton C; Basu M; Banerjee S; Goodson H; Basu S
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Detection of apoptotic cells using a synthetic fluorescent sensor for membrane surfaces that contain phosphatidylserine.

2003-12 | Journal article
DOI:

10.1038/sj.cdd.4401315

PMID:

12970674

Contributors: Koulov AV; Stucker KA; Lakshmi C; Robinson JP; Smith BD
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Synthesis and supramolecular properties of conformationally restricted and flexible phospholipids.

2003-12 | Journal article
DOI:

10.1021/jo034843v

PMID:

14682702

Contributors: Vares L; Koulov AV; Smith BD
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Chloride transport across vesicle and cell membranes by steroid-based receptors.

2003-10 | Journal article
DOI:

10.1002/anie.200351957

PMID:

14579442

Contributors: Koulov AV; Lambert TN; Shukla R; Jain M; Boon JM; Smith BD; Li H; Sheppard DN; Joos JB; Clare JP et al.
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Facilitated transport of sodium or potassium chloride across vesicle membranes using a ditopic salt-binding macrobicycle.

2003-01 | Journal article
DOI:

10.1039/b208873h

PMID:

12929384

Contributors: Koulov AV; Mahoney JM; Smith BD
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues.

2002-08 | Journal article
DOI:

10.1016/S0005-2736(02)00496-0

PMID:

12175929

Contributors: Koulov AV; Vares L; Jain M; Smith BD
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central

Highly impermeable vesicles composed of conformationally restricted phosphatidylethanolamine.

2002-07 | Journal article
DOI:

10.1039/b203640a

PMID:

12189854

Contributors: Vares L; Koulov AV; Smith BD
Source: Self-asserted source
Atanas Koulov via Europe PubMed Central