Personal information

high-content screening, machine learning, artificial intelligence, liver diseases, iPSC-derived organoids, drug induced liver injury, covid19, sars-cov-2
United States

Activities

Education and qualifications (3)

University of Michigan: Ann Arbor, MI, US

2018-08 to 2023-08-28 | PhD in Medicinal Chemistry (College of Pharmacy)
Education
Source: Self-asserted source
Charles Zhang

Western University of Health Sciences: Pomona, CA, US

2016-08 to 2018-07 | MS in Pharmaceutical Sciences (College of Pharmacy)
Education
Source: Self-asserted source
Charles Zhang

California State Polytechnic University: Pomona, California, US

2012-09 to 2016-06 | BS in Biotechnology, Minor in Chemistry (Department of Biological Sciences)
Education
Source: Self-asserted source
Charles Zhang

Funding (2)

UMCGR Single Cell Pilot Grant

2020-03 to 2020-12 | Grant
University of Michigan Center for Gastrointestinal Research (MI, MI, US)
Source: Self-asserted source
Charles Zhang

Rackham Merit Fellowship

2018-08 to 2023-05 | Award
Horace H. Rackham School of Graduate Studies, University of Michigan (MI, MI, US)
Source: Self-asserted source
Charles Zhang

Works (15)

A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids

Gastro Hep Advances
2024 | Journal article
Contributors: Sophia R. Meyer; Charles J. Zhang; Max A. Garcia; Megan C. Procario; Sanghee Yoo; Amber L. Jolly; Sumin Kim; Jiho Kim; Kyusuk Baek; Roland D. Kersten et al.
Source: check_circle
Crossref

A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids

2023-12-04 | Preprint
Contributors: Charles J. Zhang; Sophia R. Meyer; Max A. Garcia; Megan C. Procario; Sanghee Yoo; Amber L. Jolly; Sumin Kim; Jiho Kim; Kyusuk Baek; Roland D. Kersten et al.
Source: check_circle
Crossref

A human liver organoid screening platform for DILI risk prediction

Journal of Hepatology
2023-05 | Journal article
Contributors: Charles J. Zhang; Sophia R. Meyer; Matthew J. O’Meara; Sha Huang; Meghan M. Capeling; Daysha Ferrer-Torres; Charlie J. Childs; Jason R. Spence; Robert J. Fontana; Jonathan Z. Sexton
Source: check_circle
Crossref

Opposing roles for TGFβ- and BMP-signaling during nascent alveolar differentiation in the developing human lung

2023-05-05 | Preprint
Contributors: Tristan Frum; Peggy P. Hsu; Renee F.C. Hein; Ansley S. Conchola; Charles J. Zhang; Olivia R. Utter; Abhinav Anand; Yi Zhang; Sydney G. Clark; Ian Glass et al.
Source: check_circle
Crossref

Mapping the adult human esophagus in vivo and in vitro

Development
2022-10-15 | Journal article
Contributors: Daysha Ferrer-Torres; Joshua H. Wu; Charles J. Zhang; Max A. Hammer; Michael K. Dame; Angeline Wu; Emily M. Holloway; Kateryna Karpoff; Caroline L. McCarthy; Margaret S. Bohm et al.
Source: check_circle
Crossref

In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 Treatment

Vaccines
2022-08-09 | Journal article
Contributors: Jesse W. Wotring; Sean M. McCarty; Khadija Shafiq; Charles J. Zhang; Theophilus Nguyen; Sophia R. Meyer; Reid Fursmidt; Carmen Mirabelli; Martin C. Clasby; Christiane E. Wobus et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

In Vitro Evaluation and Mitigation of Niclosamide’s Liabilities as a COVID-19 Treatment

2022-06-24 | Preprint
Contributors: Jesse W. Wotring; Sean M. McCarty; Khadija Shafiq; Charles J. Zhang; Theophilus Nguyen; Sophia R. Meyer; Reid Fursmidt; Carmen Mirabelli; Martin C. Clasby; Christiane E. Wobus et al.
Source: check_circle
Crossref

A Human Liver Organoid Screening Platform for DILI Risk Prediction

2021-08-28 | Preprint
Contributors: Charles J. Zhang; Sophia R. Meyer; Matthew J. O’Meara; Sha Huang; Meghan M. Capeling; Daysha Ferrer-Torres; Charlie J. Childs; Jason R. Spence; Robert J. Fontana; Jonathan Z. Sexton
Source: check_circle
Crossref

In vitro models of the human esophagus reveal ancestrally diverse response to injury

[]
2021-05-20 | Preprint
Source: Self-asserted source
Charles Zhang

Role of Synonymous Mutations in the Evolution of TEM β-Lactamase Genes

Antimicrobial Agents and Chemotherapy
2021-05-18 | Journal article
Contributors: Mohammad Faheem; Charles J. Zhang; Monica N. Morris; Juergen Pleiss; Peter Oelschlaeger
Source: check_circle
Crossref

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

Science Immunology
2021-04-02 | Journal article
Contributors: Bingyu Yan; Tilo Freiwald; Daniel Chauss; Luopin Wang; Erin West; Carmen Mirabelli; Charles J. Zhang; Eva-Maria Nichols; Nazish Malik; Richard Gregory et al.
Source: check_circle
Crossref

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

2020-05-27 | Journal article
Source: Self-asserted source
Charles Zhang
grade
Preferred source (of 2)‎

Mutation S115T in IMP-Type Metallo-β-Lactamases Compensates for Decreased Expression Levels Caused by Mutation S119G.

Biomolecules
2019-11-11 | Journal article
Source: Self-asserted source
Charles Zhang
grade
Preferred source (of 2)‎

Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy.

Acta Pharmaceutica Sinica. B
2018-12-08 | Journal article
Source: Self-asserted source
Charles Zhang

Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors.

Journal of Chemical Information and Modeling
2018-08-29 | Journal article
Source: Self-asserted source
Charles Zhang