Personal information

Emails & domains

Verified email domains

Websites & social links

http://www.imb.de/ulrich

Other IDs

Scopus Author ID: 7102525817

Keywords

ubiquitin, SUMO, DNA repair, genome stability, DNA replication, mutagenesis, molecular biology, budding yeast

Countries

Germany

Activities

Collapse all

Employment (2)

Johannes Gutenberg Universität Mainz: Mainz, Rheinland-Pfalz, DE

2013 to present | Full Professor (Department of Biology)
Employment
Source: Self-asserted source
Helle D. Ulrich

Institute of Molecular Biology (IMB): Mainz, DE

2013-01-01 to present | Scientific Director
Employment
Source: Self-asserted source
Helle D. Ulrich

Education and qualifications (2)

University of California Berkeley: Berkeley, CA, US

1992 to 1996 | PhD (Department of Chemistry)
Education
Source: Self-asserted source
Helle D. Ulrich

Georg-August-Universität Göttingen: Göttingen, Niedersachsen, DE

1988 to 1994 | Diplom (Department of Molecular Genetics)
Education
Source: Self-asserted source
Helle D. Ulrich

Professional activities (2)

German National Academy of Sciences Leopoldina: Halle, DE

2021 to present
Membership
Source: Self-asserted source
Helle D. Ulrich

EMBO: Heidelberg, DE

2008 to present
Membership
Source: Self-asserted source
Helle D. Ulrich

Funding (1)

CRC 1361 - Regulation of DNA Repair and Genome Stability

2019-01 to 2022-12 | Grant
German Research Foundation (Bonn, DE)
GRANT_NUMBER: Project-ID 393547839 – SFB 1361
Source: Self-asserted source
Helle D. Ulrich

Works (50 of 103)

Items per page:
Page 1 of 3

Post-replicative lesion processing limits DNA damage-induced mutagenesis

Nucleic Acids Research
2025-03-20 | Journal article
DOI: 10.1093/nar/gkaf198
Contributors: Katarzyna H Masłowska; Ronald P Wong; Helle D Ulrich; Vincent Pagès
Source: check_circle
Crossref

Analysis of cell cycle stage, replicated DNA, and chromatin-associated proteins using high-throughput flow cytometry

Biological Chemistry
2024-10-28 | Journal article
DOI: 10.1515/hsz-2024-0058
Contributors: Marina Bejarano Franco; Safia Boujataoui; Majd Hadji; Louis Hammer; Helle D. Ulrich; L. Maximilian Reuter
Source: check_circle
Crossref

TelAP2 links TelAP1 to the telomere complex inTrypanosoma brucei

2024-05-22 | Preprint
DOI: 10.1101/2024.05.22.595291
Contributors: Nadine Weisert; Verena Majewski; Laura Hartleb; Katarina Luko; Liudmyla Lototska; Nils Christian Krapoth; Helle D. Ulrich; Christian J. Janzen; Falk Butter
Source: check_circle
Crossref

Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

Nature Communications
2024-02-15 | Journal article
DOI: 10.1038/s41467-024-45664-7
Contributors: Kook Son; Vakil Takhaveev; Visesato Mor; Hobin Yu; Emma Dillier; Nicola Zilio; Nikolai J. L. Püllen; Dmitri Ivanov; Helle D. Ulrich; Shana J. Sturla et al.
Source: check_circle
Crossref

Avidity-based biosensors for ubiquitylated PCNA reveal choreography of DNA damage bypass

Science Advances
2023-09-08 | Journal article
DOI: 10.1126/sciadv.adf3041
Contributors: George Yakoub; Yun-Seok Choi; Ronald P. Wong; Tina Strauch; Kezia J. Ann; Robert E. Cohen; Helle D. Ulrich
Source: check_circle
Crossref

Post-replicative lesion processing limits DNA damage-induced mutagenesis

2023-09-04 | Preprint
DOI: 10.1101/2023.09.04.556208
Contributors: Katarzyna H. Maslowska; Ronald P. Wong; Helle D. Ulrich; Vincent Pagès
Source: check_circle
Crossref

Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

2023-07-10 | Preprint
DOI: 10.1101/2023.07.10.548294
Contributors: Kook Son; Vakil Takhaveev; Visesato Mor; Hobin Yu; Emma Dillier; Nicola Zilio; Nikolai J.L. Püllen; Dmitri Ivanov; Helle D. Ulrich; Shana J. Sturla et al.
Source: check_circle
Crossref

SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells

2022-07-21 | Preprint
DOI: 10.1101/2022.07.21.500940
Contributors: Lonnie P. Swift; B. Christoffer Lagerholm; Hannah T. Baddock; Malitha Ratnaweera; Blanka Sengerova; Sook Lee; Helle D. Ulrich; Christian Renz; Dominic Waithe; Christopher J. Schofield et al.
Source: check_circle
Crossref

The Nse5/6-like SIMC1-SLF2 Complex Localizes SMC5/6 to Viral Replication Centers

2022-05-19 | Preprint
DOI: 10.1101/2022.05.17.492321
Contributors: Martina Oravcová; Minghua Nie; Nicola Zilio; Shintaro Maeda; Yasaman Jami-Alahmadi; Eros Lazzerini-Denchi; James A. Wohlschlegel; Helle D. Ulrich; Takanori Otomo; Michael N. Boddy
Source: check_circle
Crossref

Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass

Molecular Cell
2022-04 | Journal article
DOI: 10.1016/j.molcel.2022.02.016
Contributors: Sabrina Wegmann; Cindy Meister; Christian Renz; George Yakoub; Hans-Peter Wollscheid; Diane T. Takahashi; Ivan Mikicic; Petra Beli; Helle D. Ulrich
Source: check_circle
Crossref

Daughter-strand gaps in DNA replication – substrates of lesion processing and initiators of distress signalling

DNA Repair
2021-09 | Journal article
DOI: 10.1016/j.dnarep.2021.103163
Contributors: Ronald P. Wong; Kirill Petriukov; Helle D. Ulrich
Source: check_circle
Crossref

Exploring the SSBreakome: genome‐wide mapping of DNA single‐strand breaks by next‐generation sequencing

The FEBS Journal
2021-07 | Journal article
DOI: 10.1111/febs.15568
Contributors: Nicola Zilio; Helle D. Ulrich
Source: check_circle
Crossref

Non‐recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance

EMBO reports
2021-01-07 | Journal article
DOI: 10.15252/embr.202050410
Contributors: María I Cano‐Linares; Aurora Yáñez‐Vilches; Néstor García‐Rodríguez; Marta Barrientos‐Moreno; Román González‐Prieto; Pedro San‐Segundo; Helle D Ulrich; Félix Prado
Source: check_circle
Crossref

Ubc13–Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting

Journal of Cell Science
2020-05-15 | Journal article
DOI: 10.1242/jcs.244566
Contributors: Christian Renz; Véronique Albanèse; Vera Tröster; Thomas K. Albert; Olivier Santt; Susan C. Jacobs; Anton Khmelinskii; Sébastien Léon; Helle D. Ulrich
Source: check_circle
Crossref

Effects of chain length and geometry on the activation of DNA damage bypass by polyubiquitylated PCNA

Nucleic Acids Research
2020-04-06 | Journal article
DOI: 10.1093/nar/gkaa053
Contributors: Tomio S Takahashi; Hans-Peter Wollscheid; Jonathan Lowther; Helle D Ulrich
Source: check_circle
Crossref

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain

Nature Communications
2019-08-15 | Journal article
DOI: 10.1038/s41467-019-11549-3
Contributors: Annie M. Sriramachandran; Katrin Meyer-Teschendorf; Stefan Pabst; Helle D. Ulrich; Niels H. Gehring; Kay Hofmann; Gerrit J. K. Praefcke; R. Jürgen Dohmen
Source: check_circle
Crossref

PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability

Genes & Development
2019-07-01 | Journal article
DOI: 10.1101/gad.322446.118
Contributors: Ricardo J. Cordeiro Rodrigues; António Miguel de Jesus Domingues; Svenja Hellmann; Sabrina Dietz; Bruno F.M. de Albuquerque; Christian Renz; Helle D. Ulrich; Peter Sarkies; Falk Butter; René F. Ketting
Source: check_circle
Crossref

The ubiquitin-conjugating enzyme Ubc13-Mms2 cooperates with a family of FYVE-type-RING ubiquitin protein ligases in K63-polyubiquitylation at internal membranes

2019-03-12 | Other
DOI: 10.1101/575241
Contributors: Christian Renz; Vera Tröster; Thomas K. Albert; Olivier Santt; Susan C. Jacobs; Anton Khmelinskii; Helle D. Ulrich
Source: check_circle
Crossref

PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability

2018-11-06 | Other
DOI: 10.1101/463711
Contributors: Ricardo J. Cordeiro Rodrigues; António Miguel de Jesus Domingues; Svenja Hellmann; Sabrina Dietz; Bruno F. M. de Albuquerque; Christian Renz; Helle D. Ulrich; Falk Butter; René F. Ketting
Source: check_circle
Crossref

The helicase Pif1 functions in the template switching pathway of DNA damage bypass

Nucleic Acids Research
2018-09-19 | Journal article
DOI: 10.1093/nar/gky648
Contributors: Néstor García-Rodríguez; Ronald P Wong; Helle D Ulrich
Source: check_circle
Crossref

Spatial separation between replisome‐ and template‐induced replication stress signaling

The EMBO Journal
2018-05-02 | Journal article
DOI: 10.15252/embj.201798369
Contributors: Néstor García‐Rodríguez; Magdalena Morawska; Ronald P Wong; Yasukazu Daigaku; Helle D Ulrich
Source: check_circle
Crossref

GTSF-1 is required for the formation of a functional RNA-dependent RNA Polymerase complex in C. elegans

2018-02-25 | Other
DOI: 10.1101/271270
Contributors: Miguel Vasconcelos Almeida; Sabrina Dietz; Stefan Redl; Emil Karaulanov; Andrea Hildebrandt; Christian Renz; Helle D. Ulrich; Julian König; Falk Butter; René F. Ketting
Source: check_circle
Crossref

Functions of SUMO in the Maintenance of Genome Stability.

Advances in experimental medicine and biology
2017 | Journal article
DOI: 10.1007/978-3-319-50044-7_4
PMID: 28197906
Contributors: Zilio N; Eifler-Olivi K; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Monoubiquitylation of histone H2B contributes to the bypass of DNA damage during and after DNA replication.

Proceedings of the National Academy of Sciences of the United States of America
2017-03 | Journal article
DOI: 10.1073/pnas.1612633114
PMID: 28246327
PMC: PMC5358361
Contributors: Hung SH; Wong RP; Ulrich HD; Kao CF
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress.

2016 | Journal article
DOI: 10.3389/fgene.2016.00087
PMID: 27242895
PMC: PMC4865505
Contributors: García-Rodríguez N; Wong RP; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.

2016-07 | Journal article
DOI: 10.1038/onc.2015.500
PMID: 27345393
Contributors: Kanu N; Zhang T; Burrell RA; Chakraborty A; Cronshaw J; DaCosta C; Grönroos E; Pemberton HN; Anderton E; Gonzalez L et al.
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.

2015-11 | Journal article
PMID: 26549024
Contributors: Kanu N; Zhang T; Burrell RA; Chakraborty A; Cronshaw J; Costa CD; Grönroos E; Pemberton HN; Anderton E; Gonzalez L et al.
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Concerted and differential actions of two enzymatic domains underlie Rad5 contributions to DNA damage tolerance.

2015-03 | Journal article
DOI: 10.1093/nar/gkv004
PMID: 25690888
PMC: PMC4357696
Contributors: Choi K; Batke S; Szakal B; Lowther J; Hao F; Sarangi P; Branzei D; Ulrich HD; Zhao X
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Two-way communications between ubiquitin-like modifiers and DNA.

2014-04 | Journal article
DOI: 10.1038/nsmb.2805
PMID: 24699080
Contributors: Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

SIM-dependent enhancement of substrate-specific SUMOylation by a ubiquitin ligase in vitro.

2014-02 | Journal article
DOI: 10.1042/BJ20131381
PMID: 24224485
Contributors: Parker JL; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

New insights into replication clamp unloading.

2013-11 | Journal article
DOI: 10.1016/j.jmb.2013.05.003
PMID: 23688817
Contributors: Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

An expanded tool kit for the auxin-inducible degron system in budding yeast.

2013-09 | Journal article
DOI: 10.1002/yea.2967
PMID: 23836714
PMC: PMC4171812
Contributors: Morawska M; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

DNA-dependent SUMO modification of PARP-1.

2013-09 | Journal article
DOI: 10.1016/j.dnarep.2013.07.001
PMID: 23871147
PMC: PMC3744807
Contributors: Zilio N; Williamson CT; Eustermann S; Shah R; West SC; Neuhaus D; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Readers of PCNA modifications.

2013-08 | Journal article
DOI: 10.1007/s00412-013-0410-4
PMID: 23580141
PMC: PMC3714560
Contributors: Ulrich HD; Takahashi T
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Detection of PCNA modifications in Saccharomyces cerevisiae.

2012 | Journal article
DOI: 10.1007/978-1-61779-998-3_36
PMID: 22941627
Contributors: Davies AA; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

In vitro PCNA modification assays.

2012 | Journal article
DOI: 10.1007/978-1-61779-998-3_37
PMID: 22941628
Contributors: Parker JL; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

A SUMO-interacting motif activates budding yeast ubiquitin ligase Rad18 towards SUMO-modified PCNA.

2012-12 | Journal article
DOI: 10.1093/nar/gks892
PMID: 23034805
PMC: PMC3526273
Contributors: Parker JL; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

The ubiquitin-proteasome system of Saccharomyces cerevisiae.

2012-10 | Journal article
DOI: 10.1534/genetics.112.140467
PMID: 23028185
PMC: PMC3454868
Contributors: Finley D; Ulrich HD; Sommer T; Kaiser P
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Ubiquitin, SUMO, and Phosphate: How a Trio of Posttranslational Modifiers Governs Protein Fate

Molecular Cell
2012-08-10 | Journal article
DOI: 10.1016/j.molcel.2012.07.016
Source: Self-asserted source
Helle D. Ulrich

The genome maintenance factor Mgs1 is targeted to sites of replication stress by ubiquitylated PCNA.

2012-01 | Journal article
DOI: 10.1093/nar/gkr738
PMID: 21911365
PMC: PMC3245944
Contributors: Saugar I; Parker JL; Zhao S; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Ubiquitin and SUMO in DNA repair at a glance.

2012-01 | Journal article
DOI: 10.1242/jcs.091801
PMID: 22357966
Contributors: Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development.

2011-10 | Journal article
DOI: 10.1534/genetics.111.133629
PMID: 21840851
PMC: PMC3189810
Contributors: Brückner S; Kern S; Birke R; Saugar I; Ulrich HD; Mösch HU
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Timing and spacing of ubiquitin-dependent DNA damage bypass

FEBS Letters
2011-05-18 | Journal article
DOI: 10.1016/j.febslet.2011.05.028
Source: Self-asserted source
Helle D. Ulrich

Ubiquitin-dependent DNA damage bypass is separable from genome replication

Nature
2010 | Journal article
DOI: 10.1038/nature09097
Source: Self-asserted source
Helle D. Ulrich

Ubiquitin signalling in DNA replication and repair

Nature Reviews Molecular Cell Biology
2010-07 | Journal article
DOI: 10.1038/nrm2921
Source: Self-asserted source
Helle D. Ulrich

Ubiquitylation of the 9-1-1 checkpoint clamp is independent of rad6-rad18 and DNA damage.

2010-06 | Journal article
DOI: 10.1016/j.cell.2010.04.039
PMID: 20550940
Contributors: Davies AA; Neiss A; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains.

2010-04 | Journal article
DOI: 10.1073/pnas.0908764107
PMID: 20385835
PMC: PMC2867854
Contributors: Zhao S; Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

Functions of SUMO in the maintenance of genome stability

SUMO Regulation of Cellular Processes
2009 | Book
DOI: 10.1007/978-90-481-2649-1_5
EID:

2-s2.0-84880965482
Contributors: Zilio, N.; Ulrich, H.D.
Source: Self-asserted source
Helle D. Ulrich via Scopus - Elsevier

In vivo detection and characterization of sumoylation targets in Saccharomyces cerevisiae.

2009 | Journal article
DOI: 10.1007/978-1-59745-566-4_6
PMID: 19107412
Contributors: Ulrich HD; Davies AA
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central

SUMO Protocols. Preface.

2009 | Journal article
DOI: 10.1007/978-1-59745-566-4
PMID: 19117098
Contributors: Ulrich HD
Source: Self-asserted source
Helle D. Ulrich via Europe PubMed Central
Items per page:
Page 1 of 3

Peer review (25 reviews for 13 publications/grants)

Review activity for Cell reports. (2)
Review activity for Cellular and molecular life sciences (1)
Review activity for EMBO journal. (3)
Review activity for EMBO reports. (2)
Review activity for iScience. (1)
Review activity for Molecular cell. (1)
Review activity for Nature (1)
Review activity for Nature communications (7)
Review activity for Nature protocols (1)
Review activity for PLOS genetics. (2)
Review activity for Review Commons (1)
Review activity for Science. (2)
Review activity for The Journal of cell biology. (1)
How many people are using ORCID?