Personal information

Activities

Employment (2)

Fimbrion Therapeutics, Inc.: Saint Louis, MO, US

2016-02-01 to present | Chief Scientific Officer
Employment
Source: Self-asserted source
Thomas Hannan

Washington University in Saint Louis School of Medicine: Saint Louis, MO, US

2009-04-01 to present | Research Instructor (Pathology and Immunology)
Employment
Source: Self-asserted source
Thomas Hannan

Education and qualifications (3)

Washington University in Saint Louis: Saint Louis, MO, US

2003-07 to 2008-08 | Ph.D. in Molecular MIcrobiology and Microbial Pathogenesis
Education
Source: Self-asserted source
Thomas Hannan

Tufts University Cummings School of Veterinary Medicine: North Grafton, MA, US

1991-08 to 1995-05 | D.V.M.
Education
Source: Self-asserted source
Thomas Hannan

Georgetown University: Washington, DC, US

1985-08 to 1989-05 | B.S. in Biology and History
Education
Source: Self-asserted source
Thomas Hannan

Funding (7)

Thiazolino-Pyridone Compounds as Novel Drugs for Tuberculosis

2023-03-10 to 2025-02-28 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R43AI172559
Source: Self-asserted source
Thomas Hannan via DimensionsWizard

Mucosal Immune Defense Mechanisms of the Urinary Bladder

2023-02-15 to 2027-12-31 | Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
GRANT_NUMBER: R01DK132327
Source: Self-asserted source
Thomas Hannan via DimensionsWizard

Heterocyclic Inhibitors of QcrB as Novel Drugs for Tuberculosis

2019-12-13 to 2024-11-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R44AI149833
Source: Self-asserted source
Thomas Hannan via DimensionsWizard

Anti-Virulence FimH Inhibitors for the Treatment and Prevention of UTIs

2014-07-18 to 2019-02-28 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R44AI106112
Source: Self-asserted source
Thomas Hannan via DimensionsWizard

Anti-virulence FimH inhibitors for the treatment and prevention of UTIs

2014-07-18 to 2016-06-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: R43AI106112
Source: Self-asserted source
Thomas Hannan via DimensionsWizard

Mucosal Immune Defense Mechanisms of the Urinary Bladder

2011-07-01 to 2021-06-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 2U01AI095542-06
Source: Self-asserted source
Thomas Hannan via DimensionsWizard

Mucosal Immune Checkpoints in Chronic Bacterial Cystitis

2009-09-15 to 2012-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: K08AI083746
Source: Self-asserted source
Thomas Hannan via DimensionsWizard

Works (27)

Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract

Science Advances
2025-01-31 | Journal article
Contributors: Philippe N. Azimzadeh; George M. Birchenough; Nathaniel C. Gualbuerto; Jerome S. Pinkner; Kevin O. Tamadonfar; Wandy Beatty; Thomas J. Hannan; Karen W. Dodson; Enid C. Ibarra; Seonyoung Kim et al.
Source: check_circle
Crossref

Chronic urinary tract infections cause persistent microglial changes in a humanized ɑ-synuclein mouse model

Journal of Parkinson’s Disease
2024-11 | Journal article
Contributors: Gabriela Mercado; Ann-Céline Clabout; Vanessa Howland; Ehsan Arkin; Anna Barber Janer; Dieter Plessers; Jennifer A Steiner; Wanli W Smith; Tom Hannan; Patrik Brundin et al.
Source: check_circle
Crossref

Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome.

Nature Microbiology
2023-04-10 | Journal article | Author
Contributors: Seongmi Russell; Jessica Harrison; Benjamin Olson; Hyung Joo Lee; O'Brien VP; Xiaoyun Xing; Jonathan Livny; Yu L; Elisha D.O. Roberson; Bomjan R et al.
Source: Self-asserted source
Thomas Hannan

Urinary tract infections trigger synucleinopathy via the innate immune response.

Acta neuropathologica
2023-03 | Journal article
Contributors: Peelaerts W; Mercado G; George S; Villumsen M; Kasen A; Aguileta M; Linstow C; Sutter AB; Kuhn E; Stetzik L et al.
Source: Self-asserted source
Thomas Hannan via Europe PubMed Central

Longitudinal multi-omics analyses link gut microbiome dysbiosis with recurrent urinary tract infections in women.

Nature Microbiology
2022-05-02 | Journal article | Author
Contributors: Colin Worby; Schreiber HL 4th; Timothy J Straub; Lucas van Dijk; Bronson RA; Benjamin Olson; Pinkner JS; Obernuefemann CLP; Muñoz VL; Paharik AE et al.
Source: Self-asserted source
Thomas Hannan

Mucosal infection rewires TNFɑ signaling dynamics to skew susceptibility to recurrence

eLife
2019-08-20 | Journal article
Contributors: Lu Yu; Valerie P O'Brien; Jonathan Livny; Denise Dorsey; Nirmalya Bandyopadhyay; Marco Colonna; Michael G Caparon; Elisha DO Roberson; Scott J Hultgren; Thomas J Hannan
Source: check_circle
Crossref

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner

PLOS Pathogens
2018-12-13 | Journal article
Contributors: Valerie P. O’Brien; Dana J. Philpott; Denise A. Dorsey; Thomas J. Hannan; Scott J. Hultgren
Source: check_circle
Crossref

Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections

Science Translational Medicine
2017-03-22 | Journal article
Contributors: Henry L. Schreiber, IV; Matt S. Conover; Wen-Chi Chou; Michael E. Hibbing; Abigail L. Manson; Karen W. Dodson; Thomas J. Hannan; Pacita L. Roberts; Ann E. Stapleton; Thomas M. Hooton et al.
Source: check_circle
Crossref

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions

Science Advances
2017-02-03 | Journal article
Contributors: Vasilios Kalas; Jerome S. Pinkner; Thomas J. Hannan; Michael E. Hibbing; Karen W. Dodson; Alex S. Holehouse; Hao Zhang; Niraj H. Tolia; Michael L. Gross; Rohit V. Pappu et al.
Source: check_circle
Crossref

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease

Nature Microbiology
2016 | Journal article
EID:

2-s2.0-84993940187

Contributors: O'Brien, V.P.; Hannan, T.J.; Yu, L.; Livny, J.; Roberson, E.D.O.; Schwartz, D.J.; Souza, S.; Mendelsohn, C.L.; Colonna, M.; Lewis, A.L. et al.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

A murine model for escherichia coli urinary tract infection

Methods in Molecular Biology
2016 | Book
EID:

2-s2.0-84945208957

Contributors: Hannan, T.J.; Hunstad, D.A.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84994045694

Contributors: Mydock-McGrane, L.; Cusumano, Z.; Han, Z.; Binkley, J.; Kostakioti, M.; Hannan, T.; Pinkner, J.S.; Klein, R.; Kalas, V.; Crowley, J. et al.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Drug and vaccine development for the treatment and prevention of urinary tract infections

Microbiology Spectrum
2016 | Journal article
EID:

2-s2.0-84992702916

Contributors: O'Brien, V.P.; Hannan, T.J.; Nielsen, H.V.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Are you experienced? Understanding bladder innate immunity in the context of recurrent urinary tract infection

Current Opinion in Infectious Diseases
2015 | Journal article
EID:

2-s2.0-84920923272

Contributors: O'Brien, V.P.; Hannan, T.J.; Schaeffer, A.J.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Dysregulation of escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
EID:

2-s2.0-84923676032

Contributors: Nagamatsu, K.; Hannan, T.J.; Guest, R.L.; Kostakioti, M.; Hadjifrangiskou, M.; Binkley, J.; Dodson, K.; Raivio, T.L.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

PLoS Pathogens
2015 | Journal article
EID:

2-s2.0-84929485232

Contributors: Lin, A.E.; Beasley, F.C.; Olson, J.; Keller, N.; Shalwitz, R.A.; Hannan, T.J.; Hultgren, S.J.; Nizet, V.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity

mBio
2015 | Journal article
EID:

2-s2.0-84928794873

Contributors: Goneau, L.W.; Hannan, T.J.; Macphee, R.A.; Schwartz, D.J.; Macklaim, J.M.; Gloor, G.B.; Razvi, H.; Reid, G.; Hultgren, S.J.; Burton, J.P.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection

PLoS pathogens
2015 | Journal article
EID:

2-s2.0-84964313567

Contributors: Schwartz, D.J.; Conover, M.S.; Hannan, T.J.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Inhibition of cyclooxygenase-2 prevents chronic and recurrent cystitis

EBioMedicine
2014 | Journal article
EID:

2-s2.0-84920927285

Contributors: Hannan, T.J.; Roberts, P.L.; Riehl, T.E.; van der Post, S.; Binkley, J.M.; Schwartz, D.J.; Miyoshi, H.; Mack, M.; Schwendener, R.A.; Hooton, T.M. et al.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic escherichia coli ST131

Journal of Infectious Diseases
2013 | Journal article
EID:

2-s2.0-84883237676

Contributors: Totsika, M.; Kostakioti, M.; Hannan, T.J.; Upton, M.; Beatson, S.A.; Janetka, J.W.; Hultgren, S.J.; Schembri, M.A.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections

Infection and Immunity
2013 | Journal article
EID:

2-s2.0-84871858863

Contributors: Guiton, P.S.; Hannan, T.J.; Ford, B.; Caparon, M.G.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Estrogen and recurrent UTI: What are the facts?

Science Translational Medicine
2013 | Journal article
EID:

2-s2.0-84880553442

Contributors: Hannan, T.J.; Hooton, T.M.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection

Infection and Immunity
2012 | Journal article
EID:

2-s2.0-84864820786

Contributors: Kostakioti, M.; Hadjifrangiskou, M.; Cusumano, C.K.; Hannan, T.J.; Janetka, J.W.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection

FEMS Microbiology Reviews
2012 | Journal article
EID:

2-s2.0-84859323814

Contributors: Hannan, T.J.; Totsika, M.; Mansfield, K.J.; Moore, K.H.; Schembri, M.A.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection

PLoS Pathogens
2010 | Journal article
EID:

2-s2.0-77958148066

Contributors: Hannan, T.J.; Mysorekar, I.U.; Hung, C.S.; Isaacson-Schmid, M.L.; Hultgren, S.J.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis

Molecular Microbiology
2008 | Journal article
EID:

2-s2.0-36849024456

Contributors: Hannan, T.J.; Mysorekar, I.U.; Chen, S.L.; Walker, J.N.; Jones, J.M.; Pinkner, J.S.; Hultgren, S.J.; Seed, P.C.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds through a Concerted β Strand Displacement Mechanism

Molecular Cell
2006 | Journal article
EID:

2-s2.0-33745195658

Contributors: Remaut, H.; Rose, R.J.; Hannan, T.J.; Hultgren, S.J.; Radford, S.E.; Ashcroft, A.E.; Waksman, G.
Source: Self-asserted source
Thomas Hannan via Scopus - Elsevier

Peer review (9 reviews for 6 publications/grants)

Review activity for ACS infectious diseases. (1)
Review activity for Immunity. (3)
Review activity for Nature biotechnology. (1)
Review activity for Nature communications (2)
Review activity for Nature microbiology. (1)
Review activity for PLOS pathogens : (1)