Sarah Hainer (0000-0003-0503-1183)

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My research interests focus on the similarities and differences in chromatin structure among different cell types and how chromatin remodeling factors that modulate these differences regulate cell fate. The long-term goals of my laboratory are to comprehensively understand the functions, targets, regulation, and mechanisms of action of non-coding RNAs (ncRNAs) and chromatin regulatory factors with critical functions in the embryonic stem (ES) cell gene regulatory network, through development, and in disease states. Enabling these studies, my research spans the disciplines of genomics, cell and molecular biology, biochemistry, and genetics.

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University of Pittsburgh: Pittsburgh, PA, US

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Sarah Hainer

https://orcid.org/0000-0003-0503-1183

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Biography

Activities

Employment (2)

University of Pittsburgh: Pittsburgh, PA, US

University of Massachusetts Medical School: Worcester, MA, US

Education and qualifications (1)

University of Pittsburgh: Pittsburgh, PA, US

Professional activities (12)

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

University of Pittsburgh: Pittsburgh, PA, US

Funding (16)

Elucidating Regulatory Mechanisms of Lamin B1 Expression in Autosomal Dominant Leukodystrophy

Signaling-regulated establishment of pluripotency in vivo

Tools4Cells: Machine-learning aided morphodynamics characterization of stem cell differentiation using label-free microscopies

Co-Regulation of Alternative Lengthening of Telomeres and Chromatin Dynamics in ATRX-DAXX deficient cancer cells

Using nanobodies to increase the sensitivity and resolution of chromatin profiling through uliCUT&RUN

The Prognostic Significance and Mechanistic Determination of Chromatin Remodeling Biomarkers in Non-Functional Pancreatic Neuroendocrine Tumor

Determining gene expression control during neural differentiation through coupled protein localization and RNA-seq in single cells

Imaging nanoscale chromatin folding in early carcinogenesis

Role of FBXO24 mediated ubiquitination of FoxP1 protein in the pathogenesis and treatment of COPD

Chromatin-mediated mechanisms of transcription regulation in ES cells

Determining BAF complex function during neural development

Investigating the role of overlapping dinucleosomes in gene regulation

Building a network of ncRNA regulation

Determining the Role of the Essential Elongation Factor Spt16 in Embryonic Stem Cell Pluripotency

Role of Nucleosome Remodeling Factors in Regulating eRNA-mediated Gene Expression and Antisense Transcription in ESCs

Role of Nucleosome Remodeling Factors in Regulating eRNA-mediated Gene Expression

Works (50 of 75)

A direct interaction between the Chd1 CHCT domain and Rtf1 controls Chd1 distribution and nucleosome positioning on active genes

Widespread impact of nucleosome remodelers on transcription at cis-regulatory elements

Data from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Data from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 1 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 1 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 2 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 2 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 3 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 3 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 4 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 4 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 5 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 5 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 6 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

FIGURE 6 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 1 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 1 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 2 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 2 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 3 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 3 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 4 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 4 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 5 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 5 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 6 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 6 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 7 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Supplementary Figure 7 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

TABLE 1 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

TABLE 1 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

TABLE 2 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

TABLE 2 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9

Table S1 from The ncBAF Complex Regulates Transcription in AML Through H3K27ac Sensing by BRD9