Personal information

Other IDs

Scopus Author ID: 7406295783

Keywords

cell death, cardiac remodeling, programmed necrosis, heart failure, cardiac hypertrophy, signal transduction, protein kinases, protein phosphatase

Activities

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Employment (1)

University of Washington: Seattle, WA, US

2011-01-02 to present | Associate Professor (Physiology & Biophysics)
Employment
Source: Self-asserted source
Qinghang Liu

Education and qualifications (1)

University of Tennessee Health Science Center: Memphis, Tennessee, US

1999-09-01 to 2004-05-01 | PhD (Physiology)
Education
Source: Self-asserted source
Qinghang Liu

Funding (6)

A K63-Ubiquitination Dependent Necroptosis Signaling Network in the Heart

2021-01-08 to 2025-12-31 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.9560382
GRANT_NUMBER: R01HL155035
Source: Self-asserted source
Qinghang Liu via DimensionsWizard

Molecular regulation of programmed necrosis in the heart

2019-07-01 to 2022-06-30 | Grant
American Heart Association (Dallas, US)
URL: https://app.dimensions.ai/details/grant/grant.100073608
GRANT_NUMBER:

19TPA34850148
Source: Self-asserted source
Qinghang Liu via DimensionsWizard
grade
Preferred source (of 2)‎

A Critical TAK1 Signaling Network in Myocardial Survival and Remodeling

2013-01-17 to 2018-11-30 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2543988
GRANT_NUMBER: R01HL116507
Source: Self-asserted source
Qinghang Liu via DimensionsWizard

Role of TAK1 Signaling Network in Cardiac Hypertrophy

2011-03-04 to 2015-02-28 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2442080
GRANT_NUMBER: R00HL098076
Source: Self-asserted source
Qinghang Liu via DimensionsWizard

Role of TAK1 Signaling Network in Cardiac Hypertrophy

2010-03-01 to 2011-02-28 | Grant
National Heart Lung and Blood Institute (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2422850
GRANT_NUMBER: K99HL098076
Source: Self-asserted source
Qinghang Liu via DimensionsWizard

The role of apoptosis signal-regulating kinase-1 in regulation of cardiac growth and cell death in adult heart in vivo

2006-07-01 to 2008-06-30 | Grant
American Heart Association (Dallas, US)
URL: https://app.dimensions.ai/details/grant/grant.100058245
GRANT_NUMBER:

0625543B
Source: Self-asserted source
Qinghang Liu via DimensionsWizard

Works (27)

Anchored PKA synchronizes adrenergic phosphoregulation of cardiac Cav1.2 channels

Journal of Biological Chemistry
2024-09 | Journal article
DOI: 10.1016/j.jbc.2024.107656
Contributors: Lipeng Wang; Yi Chen; Jin Li; Ruth Westenbroek; Travis Philyaw; Ning Zheng; John D. Scott; Qinghang Liu; William A. Catterall
Source: check_circle
Crossref

Ferroptosis contributes to catecholamine-induced cardiotoxicity and pathological remodeling

Free Radical Biology and Medicine
2023-10 | Journal article
DOI: 10.1016/j.freeradbiomed.2023.07.025
Contributors: Yi Chen; Xiaoyun Guo; Yachang Zeng; Xiaoliang Mo; Siqi Hong; Hui He; Jing Li; Rachel Steinmetz; Qinghang Liu
Source: check_circle
Crossref

Necroptosis in heart disease: Molecular mechanisms and therapeutic implications

Journal of Molecular and Cellular Cardiology
2022 | Journal article
DOI: 10.1016/j.yjmcc.2022.05.006
EID:

2-s2.0-85130456517

Part of ISSN: 10958584 00222828
Contributors: Guo, X.; Chen, Y.; Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis

Journal of Clinical Investigation
2022-02-15 | Journal article
DOI: 10.1172/JCI152297
Contributors: Haifeng Yin; Xiaoyun Guo; Yi Chen; Yachang Zeng; Xiaoliang Mo; Siqi Hong; Hui He; Jing Li; Rachel Steinmetz; Qinghang Liu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

Journal of Molecular and Cellular Cardiology
2020 | Journal article
DOI: 10.1016/j.yjmcc.2020.06.004
EID:

2-s2.0-85086729638

Part of ISSN: 10958584 00222828
Contributors: Qi, L.; Zang, H.; Wu, W.; Nagarkatti, P.; Nagarkatti, M.; Liu, Q.; Robbins, J.; Wang, X.; Cui, T.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

NFκB promotes oxidative stress-induced necrosis and ischemia/reperfusion injury by inhibiting Nrf2-ARE pathway

Free Radical Biology and Medicine
2020 | Journal article
DOI: 10.1016/j.freeradbiomed.2020.07.031
EID:

2-s2.0-85089383002

Part of ISSN: 18734596 08915849
Contributors: Guo, X.; Hong, S.; He, H.; Zeng, Y.; Chen, Y.; Mo, X.; Li, J.; Li, L.; Steinmetz, R.; Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling

Biomedicines
2020-05-30 | Journal article
DOI: 10.3390/biomedicines8060144
Contributors: Theresa Aliwarga; Xiaoyun Guo; Eric A. Evangelista; Rozenn N. Lemaitre; Nona Sotoodehnia; Sina A. Gharib; Darryl C. Zeldin; Qinghang Liu; Rheem A. Totah
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Response by Liu to Letter Regarding Article, "Cardioprotective Role of Tumor Necrosis Factor Receptor-Associated Factor 2 by Suppressing Apoptosis and Necroptosis"

Circulation
2018 | Journal article
DOI: 10.1161/CIRCULATIONAHA.117.032339
EID:

2-s2.0-85064987412

Part of ISSN: 15244539
Contributors: Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Cardioprotective role of tumor necrosis factor receptor-associated factor 2 by suppressing apoptosis and necroptosis

Circulation
2017 | Journal article
DOI: 10.1161/CIRCULATIONAHA.116.026240
EID:

2-s2.0-85021795206

Part of ISSN: 15244539 00097322
Contributors: Guo, X.; Yin, H.; Li, L.; Chen, Y.; Li, J.; Doan, J.; Steinmetz, R.; Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Loss of AKAP150 promotes pathological remodelling and heart failure propensity by disrupting calcium cycling and contractile reserve

Cardiovascular Research
2017 | Journal article
DOI: 10.1093/cvr/cvw221
EID:

2-s2.0-85015236014

Part of ISSN: 17553245 00086363
Contributors: Li, L.; Li, J.; Drum, B.M.; Chen, Y.; Yin, H.; Guo, X.; Luckey, S.W.; Gilbert, M.L.; Stanley McKnight, G.; Scott, J.D. et al.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Assessment of cardiac morphological and functional changes in mouse model of transverse aortic constriction by echocardiographic imaging

Journal of Visualized Experiments
2016 | Journal article
DOI: 10.3791/54101
EID:

2-s2.0-84977577989

Part of ISSN: 1940087X
Contributors: Li, L.; Guo, X.; Chen, Y.; Yin, H.; Li, J.; Doan, J.; Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Oxidative stress decreases microtubule growth and stability in ventricular myocytes

Journal of Molecular and Cellular Cardiology
2016 | Journal article
DOI: 10.1016/j.yjmcc.2016.02.012
EID:

2-s2.0-84960353709

Part of ISSN: 10958584 00222828
Contributors: Drum, B.M.L.; Yuan, C.; Li, L.; Liu, Q.; Wordeman, L.; Santana, L.F.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints

Cell Death and Disease
2016 | Journal article
DOI: 10.1038/cddis.2016.294
EID:

2-s2.0-85018964325

Part of ISSN: 20414889
Contributors: Guo, X.; Yin, H.; Chen, Y.; Li, L.; Li, J.; Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

TAK1 Regulates Myocardial Response to Pathological Stress via NFAT, NFκB, and Bnip3 Pathways

Scientific Reports
2015 | Journal article
DOI: 10.1038/srep16626
EID:

2-s2.0-84947474680

Part of ISSN: 20452322
Contributors: Li, L.; Chen, Y.; Li, J.; Yin, H.; Guo, X.; Doan, J.; Molkentin, J.D.; Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Transforming growth factor βactivated kinase 1 signaling pathway critically regulates myocardial survival and remodeling

Circulation
2014 | Journal article
DOI: 10.1161/CIRCULATIONAHA.114.011195
EID:

2-s2.0-84918511539

Part of ISSN: 15244539 00097322
Contributors: Li, L.; Chen, Y.; Doan, J.; Murray, J.; Molkentin, J.D.; Liu, Q.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling

Circulation Research
2012 | Journal article
DOI: 10.1161/CIRCRESAHA.111.260729
EID:

2-s2.0-84862809492

Part of ISSN: 00097330 15244571
Contributors: Liu, Q.; Chen, Y.; Auger-Messier, M.; Molkentin, J.D.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Protein kinase Cα as a heart failure therapeutic target

Journal of Molecular and Cellular Cardiology
2011 | Journal article
DOI: 10.1016/j.yjmcc.2010.10.004
EID:

2-s2.0-80052801123

Part of ISSN: 00222828 10958584
Contributors: Liu, Q.; Molkentin, J.D.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Functional divergence of platelet protein kinase C (PKC) isoforms in thrombus formation on collagen

Journal of Biological Chemistry
2010 | Journal article
DOI: 10.1074/jbc.M110.136176
EID:

2-s2.0-77954945985

Part of ISSN: 00219258 1083351X
Contributors: Gilio, K.; Harper, M.T.; Cosemans, J.M.E.M.; Konopatskaya, O.; Munnix, I.C.A.; Prinzen, L.; Leitges, M.; Liu, Q.; Molkentin, J.D.; Heemskerk, J.W.M. et al.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

ASK1 regulates cardiomyocyte death but not hypertrophy in transgenic mice

Circulation Research
2009 | Journal article
DOI: 10.1161/CIRCRESAHA.109.200741
EID:

2-s2.0-73349108105

Part of ISSN: 00097330 15244571
Contributors: Liu, Q.; Sargent, M.A.; York, A.J.; Molkentin, J.D.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes

Circulation Research
2009 | Journal article
DOI: 10.1161/CIRCRESAHA.109.194035
EID:

2-s2.0-70349236112

Part of ISSN: 00097330 15244571
Contributors: MacDonnell, S.M.; Weisser-Thomas, J.; Kubo, H.; Hanscome, M.; Liu, Q.; Jaleel, N.; Berretta, R.; Chen, X.; Brown, J.H.; Sabri, A.-K. et al.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point

Nature Cell Biology
2009 | Journal article
DOI: 10.1038/ncb1823
EID:

2-s2.0-59649116320

Part of ISSN: 14657392
Contributors: Liu, Q.; Busby, J.C.; Molkentin, J.D.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Protein kinase Cα, but Not PKCβ or PKCγ, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

Circulation Research
2009 | Journal article
DOI: 10.1161/CIRCRESAHA.109.195313
EID:

2-s2.0-68049086486

Part of ISSN: 00097330 15244571
Contributors: Liu, Q.; Chen, X.; Macdonnell, S.M.; Kranias, E.G.; Lorenz, J.N.; Leitges, M.; Houser, S.R.; Molkentin, J.D.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth

Molecular and Cellular Biology
2006 | Journal article
DOI: 10.1128/MCB.26.10.3785-3797.2006
EID:

2-s2.0-33646566490

Part of ISSN: 02707306
Contributors: Liu, Q.; Wilkins, B.J.; Lee, Y.J.; Ichijo, H.; Molkentin, J.D.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Protein phosphatase 2A-mediated cross-talk between p38 MAPK and ERK in apoptosis of cardiac myocytes

American Journal of Physiology - Heart and Circulatory Physiology
2004 | Journal article
DOI: 10.1152/ajpheart.01050.2003
EID:

2-s2.0-2542433090

Part of ISSN: 03636135
Contributors: Liu, Q.; Hofmann, P.A.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Acute p38 MAPK activation decreases force development in ventricular myocytes

American Journal of Physiology - Heart and Circulatory Physiology
2003 | Journal article
DOI: 10.1152/ajpheart.00365.2003
EID:

2-s2.0-0344440796

Part of ISSN: 03636135
Contributors: Chen, Y.; Rajashree, R.; Liu, Q.; Hofmann, P.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Modulation of protein phosphatase 2a by adenosine A<sub>1</sub> receptors in cardiomyocytes: Role for p38 MAPK

American Journal of Physiology - Heart and Circulatory Physiology
2003 | Journal article
DOI: 10.1152/ajpheart.00956.2002
EID:

2-s2.0-0038001420

Part of ISSN: 03636135
Contributors: Liu, Q.; Hofmann, P.A.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Antiadrenergic effects of adenosine A<sub>1</sub>, receptor-mediated protein phosphatase 2a activation in the heart

American Journal of Physiology - Heart and Circulatory Physiology
2002 | Journal article
DOI: 10.1152/ajpheart.00343.2002
EID:

2-s2.0-0036783558

Part of ISSN: 03636135
Contributors: Liu, Q.; Hofmann, P.A.
Source: Self-asserted source
Qinghang Liu via Scopus - Elsevier

Peer review (8 reviews for 5 publications/grants)

Review activity for American Heart Association (3)
Review activity for American Heart Association (1)
Review activity for Cell death and differentiation. (1)
Review activity for Journal of Molecular and Cellular Cardiology. (2)
Review activity for Nature communications (1)
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