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Employment (3)

Universität Bern: Bern, BE, CH

2010-02 to present | professor (Chemistry & Biochemistry)
Employment
Source: Self-asserted source
Oliver Mühlemann

Universität Bern: Bern, BE, CH

1999-10 to 2010-01 | junior group leader (Zellbiologie)
Employment
Source: Self-asserted source
Oliver Mühlemann

Brandeis University: Waltham, MA, US

1998-06 to 1999-09 | Postdoc (Biochemistry)
Employment
Source: Self-asserted source
Oliver Mühlemann

Education and qualifications (1)

Uppsala Universitet: Uppsala, SE

1998-03 | PhD
Education
Source: Self-asserted source
Oliver Mühlemann

Works (50 of 61)

Items per page:
Page 1 of 2

Universal features of Nsp1-mediated translational shutdown by coronaviruses

Molecular Cell
2023-10 | Journal article
DOI: 10.1016/j.molcel.2023.09.002
Part of ISSN: 1097-2765
Contributors: Katharina Schubert; Evangelos D. Karousis; Ivo Ban; Christopher P. Lapointe; Marc Leibundgut; Emilie Bäumlin; Eric Kummerant; Alain Scaiola; Tanja Schönhut; Jana Ziegelmüller et al.
Source: Self-asserted source
Oliver Mühlemann

Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control

Cell Reports
2023-09 | Journal article
DOI: 10.1016/j.celrep.2023.113056
Part of ISSN: 2211-1247
Contributors: Lukas-Adrian Gurzeler; Marion Link; Yvonne Ibig; Isabel Schmidt; Olaf Galuba; Julian Schoenbett; Christelle Gasser-Didierlaurant; Christian N. Parker; Xiaohong Mao; Francis Bitsch et al.
Source: Self-asserted source
Oliver Mühlemann

Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells

NAR Cancer
2023-06-09 | Journal article
DOI: 10.1093/narcan/zcad048
Contributors: Sofia Nasif; Martino Colombo; Anne-Christine Uldry; Markus S Schröder; Simone de Brot; Oliver Mühlemann
Source: check_circle
Crossref

A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance

RNA Biology
2022-12-31 | Journal article
DOI: 10.1080/15476286.2022.2065116
Contributors: Soumasree De; Oliver Mühlemann
Source: check_circle
Crossref

Production of human translation-competent lysates using dual centrifugation

RNA Biology
2022-12-31 | Journal article
DOI: 10.1080/15476286.2021.2014695
Contributors: Lukas-Adrian Gurzeler; Jana Ziegelmüller; Oliver Mühlemann; Evangelos D. Karousis
Source: check_circle
Crossref

The broader sense of nonsense

Trends in Biochemical Sciences
2022-11 | Journal article
DOI: 10.1016/j.tibs.2022.06.003
Contributors: Evangelos D. Karousis; Oliver Mühlemann
Source: check_circle
Crossref

Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction

Nucleic Acids Research
2021-08-20 | Journal article
DOI: 10.1093/nar/gkab579
Contributors: Yeonkyoung Park; Joori Park; Hyun Jung Hwang; Leehyeon Kim; Kwon Jeong; Hyun Kyu Song; Simone C Rufener; Oliver Mühlemann; Yoon Ki Kim
Source: check_circle
Crossref

Dissecting the import and export pathways of the human RNA helicase UPF1

2021-08-02 | Other
DOI: 10.1101/2021.08.02.454737
Contributors: Andrea B. Eberle; Karin Schranz; Sofia Nasif; Lena Grollmus; Oliver Mühlemann
Source: check_circle
Crossref

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation

Nucleic Acids Research
2021-07-21 | Journal article
DOI: 10.1093/nar/gkab582
Contributors: Stefan Reber; Daniel Jutzi; Helen Lindsay; Anny Devoy; Jonas Mechtersheimer; Brunno Rocha Levone; Michal Domanski; Eva Bentmann; Dorothee Dormann; Oliver Mühlemann et al.
Source: check_circle
Crossref

Characterisation of the Semliki Forest Virus-host cell interactome reveals the viral capsid protein as an inhibitor of nonsense-mediated mRNA decay

PLOS Pathogens
2021-05-21 | Journal article
DOI: 10.1371/journal.ppat.1009603
DOI: 10.1101/2020.10.12.335497
Contributors: Lara Contu; John T. Patton; Giuseppe Balistreri; Michal Domanski; Anne-Christine Uldry; Oliver Mühlemann
Source: Self-asserted source
Oliver Mühlemann
grade
Preferred source (of 3)‎

Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells

2021-04-30 | Preprint
DOI: 10.1101/2021.04.30.442116
Contributors: Evangelos D. Karousis; Foivos Gypas; Mihaela Zavolan; Oliver Mühlemann
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Readthrough of stop codons under limiting ABCE1 concentration involves frameshifting and inhibits nonsense-mediated mRNA decay

Nucleic Acids Research
2020-10-09 | Journal article
DOI: 10.1093/nar/gkaa758
Contributors: Giuditta Annibaldis; Michal Domanski; René Dreos; Lara Contu; Sarah Carl; Nina Kläy; Oliver Mühlemann
Source: check_circle
Crossref

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

Nature Structural & Molecular Biology
2020-10-09 | Journal article
DOI: 10.1038/s41594-020-0511-8
Contributors: Katharina Schubert; Evangelos D. Karousis; Ahmad Jomaa; Alain Scaiola; Blanca Echeverria; Lukas-Adrian Gurzeler; Marc Leibundgut; Volker Thiel; Oliver Mühlemann; Nenad Ban
Source: check_circle
Crossref

Human NMD ensues independently of stable ribosome stalling

Nature Communications
2020-08-17 | Journal article
DOI: 10.1038/s41467-020-17974-z
Contributors: Evangelos D. Karousis; Lukas-Adrian Gurzeler; Giuditta Annibaldis; René Dreos; Oliver Mühlemann
Source: check_circle
Crossref

Ribosome recycling factor ABCE1 depletion inhibits nonsense-mediated mRNA decay by promoting stop codon readthrough

2019-12-10 | Other
DOI: 10.1101/870097
Contributors: Giuditta Annibaldis; René Dreos; Michal Domanski; Sarah Carl; Oliver Mühlemann
Source: check_circle
Crossref

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation

2019-10-15 | Other
DOI: 10.1101/806158
Contributors: Stefan Reber; Helen Lindsay; Anny Devoy; Daniel Jutzi; Jonas Mechtersheimer; Michal Domanski; Oliver Mühlemann; Silvia M.L. Barabino; Marc-David Ruepp
Source: check_circle
Crossref

FUS-dependent liquid-liquid phase separation is an early event in double-strand break repair

2019-10-11 | Other
DOI: 10.1101/798884
Contributors: Brunno R. Levone; Silvia C. Lenzken; Marco Antonaci; Andreas Maiser; Alexander Rapp; Francesca Conte; Stefan Reber; Antonella E. Ronchi; Oliver Mühlemann; Heinrich Leonhardt et al.
Source: check_circle
Crossref

Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression

Seminars in cell & developmental biology
2018 | Journal article
DOI: 10.1016/j.semcdb.2017.08.053
Source: Self-asserted source
Oliver Mühlemann

Dissecting the functions of SMG5, SMG7, and PNRC2 in nonsense-mediated mRNA decay of human cells

RNA (New York, N.Y.)
2018 | Journal article
DOI: 10.1261/rna.063719.117
Source: Self-asserted source
Oliver Mühlemann
grade
Preferred source (of 2)‎

Nonsense-Mediated mRNA Decay Begins Where Translation Ends

Cold Spring Harbor perspectives in biology
2018 | Journal article
DOI: 10.1101/cshperspect.a032862
Source: Self-asserted source
Oliver Mühlemann

New functions in translation termination uncovered for NMD factor UPF3B

The EMBO journal
2017 | Journal article
DOI: 10.15252/embj.201798063
Source: Self-asserted source
Oliver Mühlemann
grade
Preferred source (of 2)‎

Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways

RNA (New York, N.Y.)
2017 | Journal article
DOI: 10.1261/rna.059055.116
Source: Self-asserted source
Oliver Mühlemann

Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay

Viruses
2017 | Journal article
DOI: 10.3390/v9010024
Source: Self-asserted source
Oliver Mühlemann

Identification of Interactions in the NMD Complex Using Proximity-Dependent Biotinylation (BioID)

PloS one
2016 | Journal article
DOI: 10.1371/journal.pone.0150239
Source: Self-asserted source
Oliver Mühlemann

Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants

The EMBO journal
2016 | Journal article
DOI: 10.15252/embj.201593791
Source: Self-asserted source
Oliver Mühlemann

Nonsense-mediated mRNA decay: novel mechanistic insights and biological impact

Wiley interdisciplinary reviews. RNA
2016 | Journal article
DOI: 10.1002/wrna.1357
Source: Self-asserted source
Oliver Mühlemann

Spermatogenesis Studies Reveal a Distinct Nonsense-Mediated mRNA Decay (NMD) Mechanism for mRNAs with Long 3'UTRs

PLoS genetics
2016 | Journal article
DOI: 10.1371/journal.pgen.1005979
Source: Self-asserted source
Oliver Mühlemann

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD

Nucleic acids research
2014 | Journal article
DOI: 10.1093/nar/gku645
Source: Self-asserted source
Oliver Mühlemann

Characterization of phosphorylation- and RNA-dependent UPF1 interactors by quantitative proteomics

Journal of proteome research
2014 | Journal article
DOI: 10.1021/pr5002143
Source: Self-asserted source
Oliver Mühlemann

Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms

PloS one
2014 | Journal article
DOI: 10.1371/journal.pone.0104391
Source: Self-asserted source
Oliver Mühlemann

Synthesis and characterization of photoaffinity probes that target the 5-HT3 receptor

Chimia
2014 | Journal article
DOI: 10.2533/chimia.2014.239
Source: Self-asserted source
Oliver Mühlemann

The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication

Cell host & microbe
2014 | Journal article
DOI: 10.1016/j.chom.2014.08.007
Source: Self-asserted source
Oliver Mühlemann

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

RNA (New York, N.Y.)
2013 | Journal article
DOI: 10.1261/rna.038893.113
Source: Self-asserted source
Oliver Mühlemann

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

Nature structural & molecular biology
2013 | Journal article
DOI: 10.1038/nsmb.2576
Source: Self-asserted source
Oliver Mühlemann

Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells

Biochimica et biophysica acta
2013 | Journal article
DOI: 10.1016/j.bbagrm.2013.02.005
Source: Self-asserted source
Oliver Mühlemann

Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2

PloS one
2013 | Journal article
DOI: 10.1371/journal.pone.0061980
Source: Self-asserted source
Oliver Mühlemann

Recent transcriptome-wide mapping of UPF1 binding sites reveals evidence for its recruitment to mRNA before translation

Translation (Austin, Tex.)
2013 | Journal article
DOI: 10.4161/trla.26977
Source: Self-asserted source
Oliver Mühlemann

RNA decay mechanisms: specificity through diversity

Biochimica et biophysica acta
2013 | Journal article
DOI: 10.1016/j.bbagrm.2013.04.002
Source: Self-asserted source
Oliver Mühlemann

Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs

Nature structural & molecular biology
2013 | Journal article
DOI: 10.1038/nsmb.2635
Source: Self-asserted source
Oliver Mühlemann

Analysis of nonsense-mediated mRNA decay in mammalian cells

Current protocols in cell biology
2012 | Journal article
DOI: 10.1002/0471143030.cb2704s55
Source: Self-asserted source
Oliver Mühlemann

Intimate liaison with SR proteins brings exon junction complexes to unexpected places

Nature structural & molecular biology
2012 | Journal article
DOI: 10.1038/nsmb.2454
Source: Self-asserted source
Oliver Mühlemann

mRNP quality control goes regulatory

Trends in genetics : TIG
2012 | Journal article
DOI: 10.1016/j.tig.2011.11.001
Source: Self-asserted source
Oliver Mühlemann

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

RNA (New York, N.Y.)
2011 | Journal article
DOI: 10.1261/rna.030247.111
Source: Self-asserted source
Oliver Mühlemann

Cotranscriptional effect of a premature termination codon revealed by live-cell imaging

RNA (New York, N.Y.)
2011 | Journal article
DOI: 10.1261/rna.02918111
Source: Self-asserted source
Oliver Mühlemann

Cutting the nonsense: the degradation of PTC-containing mRNAs

Biochemical Society transactions
2010 | Journal article
DOI: 10.1042/bst0381615
Source: Self-asserted source
Oliver Mühlemann

How and where are nonsense mRNAs degraded in mammalian cells?

RNA biology
2010 | Journal article
DOI: 10.4161/rna.7.1.10578
Source: Self-asserted source
Oliver Mühlemann

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

Cellular and molecular life sciences : CMLS
2010 | Journal article
DOI: 10.1007/s00018-009-0177-1
Source: Self-asserted source
Oliver Mühlemann

tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans

Nucleic acids research
2010 | Journal article
DOI: 10.1093/nar/gkq345
Source: Self-asserted source
Oliver Mühlemann

Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line

RNA (New York, N.Y.)
2009 | Journal article
DOI: 10.1261/rna.1516409
Source: Self-asserted source
Oliver Mühlemann

Processing bodies are not required for mammalian nonsense-mediated mRNA decay

RNA (New York, N.Y.)
2009 | Journal article
DOI: 10.1261/rna.1672509
Source: Self-asserted source
Oliver Mühlemann
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