Personal information

mild analgesics, pain, migraine, paracetamol/acetaminophen, ibuprofen, development, endocrine disruption
Denmark

Biography

As Professor and Group leader at Roskilde University and Rigshospitalet (Copenhagen University Hospital), I have the last years focused my research on investigating pain pathways and understanding off-target effects of everyday drugs in pain treatment using cellular assays, animal models, cohort studies as well as clinical randomized intervention studies.

Activities

Employment (2)

Roskilde University: Roskilde, DK

Professor of Molecular Physiology (Department of Science and Environment )
Employment
Source: Self-asserted source
David Møbjerg Kristensen

Rigshospitalet: Kobenhavn, DK

2017-10 to present (Department of Neurology)
Employment
Source: Self-asserted source
David Møbjerg Kristensen

Education and qualifications (1)

University of Copenhagen: Copenhagen, DK

PhD (Departmen of Biology)
Education
Source: Self-asserted source
David Møbjerg Kristensen

Professional activities (1)

IRSET: Rennes, Bretagne, FR

2017 to present
Invited position
Source: Self-asserted source
David Møbjerg Kristensen

Works (50 of 53)

Items per page:
Page 1 of 2

Paracetamol (N-acetyl-para-aminophenol) disrupts early human embryogenesis

2024-02-28 | Preprint
Contributors: David Kristensen; Brian Nielsen; Morten Petersen; Javier Martin-Gonzalez; Christian Holmberg; Heidi Mjøseng; Hanne Frederiksen; Cristal Rosenthal; Emma Jørgensen; Palle Serup et al.
Source: check_circle
Crossref

Hypothesis: Metformin is a potential reproductive toxicant.

Frontiers in endocrinology
2022-10 | Journal article
Contributors: Tavlo M; Skakkebæk NE; Mathiesen ER; Kristensen DM; Kjær KH; Andersson AM; Lindahl-Jacobsen R
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

The use of paracetamol during pregnancy: A qualitative study and possible strategies for a clinical trial.

PloS one
2022-09 | Journal article
Contributors: Vedel C; Jørgensen DS; Kristensen DM; Petersen OB; Greisen G
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort.

EBioMedicine
2022-08 | Journal article
Contributors: Sevelsted A; Gürdeniz G; Rago D; Pedersen CT; Lasky-Su JA; Checa A; Zhang P; Wheelock CE; Normann SS; Kristensen DM et al.
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

The PACAP pathway is independent of CGRP in mouse models of migraine: possible new drug target?

Brain : a journal of neurology
2022-07 | Journal article
Contributors: Ernstsen C; Christensen SL; Rasmussen RH; Nielsen BS; Jansen-Olesen I; Olesen J; Kristensen DM
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Reply to 'Paracetamol use in pregnancy - neglecting context promotes misinterpretation'.

Nature reviews. Endocrinology
2022-06 | Journal article
Contributors: Bauer AZ; Swan SH; Kriebel D; Liew Z; Taylor HS; Bornehag CG; Andrade AM; Olsen J; Jensen RH; Mitchell RT et al.
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Characterization of erenumab and rimegepant on calcitonin gene-related peptide induced responses in Xenopus Laevis oocytes expressing the calcitonin gene-related peptide receptor and the amylin-1 receptor.

The journal of headache and pain
2022-05 | Journal article
Contributors: Hage La Cour S; Juhler K; Kogelman LJA; Olesen J; Klærke DA; Kristensen DM; Jansen-Olesen I
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Ex vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents.

Journal of visualized experiments : JoVE
2022-05 | Journal article
Contributors: Rasmussen RH; Jansen-Olesen I; Kristensen DM; Christensen SL
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Human sperm cells can form paracetamol metabolite AM404 that directly interferes with sperm calcium signalling and function through a CatSper-dependent mechanism

Human Reproduction
2022-05-03 | Journal article
Contributors: A Rehfeld; H Frederiksen; R H Rasmussen; A David; J Chaker; B S Nielsen; J E Nielsen; A Juul; N E Skakkebæk; D M Kristensen
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Reply to 'Paracetamol use in pregnancy - caution over causal inference from available data'; 'Handle with care - interpretation, synthesis and dissemination of data on paracetamol in pregnancy'.

Nature reviews. Endocrinology
2022-03 | Journal article
Contributors: Bauer AZ; Swan SH; Kriebel D; Liew Z; Taylor HS; Bornehag CG; M Andrade A; Olsen J; Jensen RH; Mitchell RT et al.
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Comprehensive Evaluation of Blood Plasma and Serum Sample Preparations for HRMS-Based Chemical Exposomics: Overlaps and Specificities.

Analytical chemistry
2022-01 | Journal article
Contributors: Chaker J; Kristensen DM; Halldorsson TI; Olsen SF; Monfort C; Chevrier C; Jégou B; David A
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models.

Cephalalgia : an international journal of headache
2021-11 | Journal article
Contributors: Christensen SL; Rasmussen RH; Cour S; Ernstsen C; Hansen TF; Kogelman LJ; Lauritzen SP; Guzaite G; Styrishave B; Janfelt C et al.
Source: Self-asserted source
David Møbjerg Kristensen via Europe PubMed Central

Extreme secondary sexual dimorphism in the genus Florarctus (Heterotardigrada: Halechiniscidae)

Marine Biodiversity
2021-06 | Journal article
Contributors: Piotr Gąsiorek; David Møbjerg Kristensen; Reinhardt Møbjerg Kristensen
Source: check_circle
Crossref

No additive effect of combining sumatriptan and olcegepant in the GTN mouse model of migraine.

Cephalalgia : an international journal of headache
2020-10-15 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Functional gene networks reveal distinct mechanisms segregating in migraine families.

Brain : a journal of neurology
2020-10-01 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

ATP sensitive potassium (KATP) channel inhibition: A promising new drug target for migraine.

Cephalalgia : an international journal of headache
2020-05-16 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

No central action of CGRP antagonising drugs in the GTN mouse model of migraine.

Cephalalgia : an international journal of headache
2020-03-29 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Von Frey testing revisited: Provision of an online algorithm for improved accuracy of 50% thresholds.

European journal of pain (London, England)
2020-01-23 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Characterisation and localisation of the endocannabinoid system components in the adult human testis.

Scientific reports
2019-09-19 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Intrauterine exposure to drugs and reproduction—still reasons for concern!

Current Opinion in Endocrine and Metabolic Research
2019-09-07 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Targeting CGRP via receptor antagonism and antibody neutralisation in two distinct rodent models of migraine-like pain.

Cephalalgia : an international journal of headache
2019-07-09 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system.

Environmental health : a global access science source
2019-03-12 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Clarifying the link between ibuprofen and hypogonadism.

Nature reviews. Urology
2019-03-01 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism.

Toxicological sciences : an official journal of the Society of Toxicology
2018-06-01 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Correction for Kristensen et al., Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.

Proceedings of the National Academy of Sciences of the United States of America
2018-04-16 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Ibuprofen is deleterious for the development of first trimester human fetal ovary ex vivo.

Human reproduction (Oxford, England)
2018-03-01 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Effects of antihistamines on the H295R steroidogenesis - Autocrine up-regulation following 3β-HSD inhibition.

Toxicology in vitro : an international journal published in association with BIBRA
2018-02-01 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism.

Proceedings of the National Academy of Sciences of the United States of America
2018-01-08 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen
grade
Preferred source (of 2)‎

EDC IMPACT: Is exposure during pregnancy to acetaminophen/paracetamol disrupting female reproductive development?

Endocrine connections
2018-01-05 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen
grade
Preferred source (of 2)‎

Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study.

Environmental health : a global access science source
2017-06-21 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behaviour.

Reproduction (Cambridge, England)
2017-05-30 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen
grade
Preferred source (of 2)‎

Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice.

Journal of cellular physiology
2017-03-24 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Ibuprofen results in alterations of human fetal testis development.

Scientific reports
2017-03-10 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen
grade
Preferred source (of 2)‎

Maternal use of mild analgesics during pregnancy associated with reduced anogenital distance in sons: a cohort study of 1027 mother-child pairs.

Human reproduction (Oxford, England)
2016-11-16 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort.

Reproductive toxicology (Elmsford, N.Y.)
2016-08-31 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.

Nature reviews. Endocrinology
2016-05-06 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility.

Toxicological sciences : an official journal of the Society of Toxicology
2016-01-05 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen
grade
Preferred source (of 2)‎

Aniline Is Rapidly Converted Into Paracetamol Impairing Male Reproductive Development.

Toxicological sciences : an official journal of the Society of Toxicology
2015-08-10 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Physiological role of taurine--from organism to organelle.

Acta physiologica (Oxford, England)
2014-09-12 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice.

The Journal of biological chemistry
2014-04-17 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Paracetamol, aspirin, and indomethacin induce endocrine disturbances in the human fetal testis capable of interfering with testicular descent.

The Journal of clinical endocrinology and metabolism
2013-09-12 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Paracetamol (acetaminophen), aspirin (acetylsalicylic acid) and indomethacin are anti-androgenic in the rat foetal testis.

International journal of andrology
2012-06-01 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

A novel double staining strategy for improved detection of testicular carcinoma in situ cells in human semen samples.

Andrologia
2011-02-16 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Many putative endocrine disruptors inhibit prostaglandin synthesis.

Environmental health perspectives
2010-11-16 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.

Human reproduction (Oxford, England)
2010-11-08 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract.

Human reproduction (Oxford, England)
2010-02-18 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres.

Molecular human reproduction
2010-01-31 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Analysis of SOX2 expression in developing human testis and germ cell neoplasia.

The International journal of developmental biology
2010-01-01 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Origin of pluripotent germ cell tumours: the role of microenvironment during embryonic development.

Molecular and cellular endocrinology
2008-03-04 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen

Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms.

Human reproduction (Oxford, England)
2008-02-15 | Journal article
Source: Self-asserted source
David Møbjerg Kristensen
Items per page:
Page 1 of 2

Peer review (6 reviews for 2 publications/grants)

Review activity for Environment international. (2)
Review activity for Reproductive toxicology. (4)