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Scopus Author ID: 6602377333
ResearcherID: K-6256-2015

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Employment (1)

University of Queensland: Brisbane, QLD, AU

2006-12-01 to present | Research Fellow/PI (School of Biomedical Sciences)
Employment
Source: Self-asserted source
Bradley Launikonis

Education and qualifications (1)

La Trobe University: Bundoora, VIC, AU

1996-03-01 to 2000-10-01 | PhD (Zoology)
Education
Source: Self-asserted source
Bradley Launikonis

Professional activities (3)

Biophysical Society: Rockville, MD, US

1999 to present
Service
Source: Self-asserted source
Bradley Launikonis

Australian Physiological Society: Burwood, VIC, AU

1996 to present | member
Service
Source: Self-asserted source
Bradley Launikonis

Australian Physiological Society: Burwood, VIC, AU

2012 to 2015 | Treasurer
Service
Source: Self-asserted source
Bradley Launikonis

Funding (9)

Calcium cycling and heat generation in skeletal muscle fibres.

2018-01 to 2021-01 | Grant
Australian Research Council (ACT, ACT, AU)
GRANT_NUMBER:

DP180100937
Source: Self-asserted source
Bradley Launikonis

Physiological activation and targets of calcium signalling in muscle

2014-01-01 to 2018-12-31 | Grant
Australian Research Council (Canberra, AU)
URL: https://grants.uberresearch.com/501100000923/FT140101309/Physiological-activation-and-targets-of-calcium-signalling-in-muscle
GRANT_NUMBER: FT140101309
Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Calcium regulation in healthy and dystrophic skeletal muscle

Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Muscle fibre excitability and calcium regulation in skeletal muscle of amphibians and mammals

Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Gamma-Secretase inhibitors to target stroke-induced brain injury

Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Regulation of calcium entry in healthy and dystrophic muscle

Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Calcium regulation in the skeletal muscle triad and along the fibre

2008-01-01 to 2009-12-31 | Grant
Australian Research Council (Canberra, AU)
URL: https://grants.uberresearch.com/501100000923/DP0879780/Calcium-regulation-in-the-skeletal-muscle-triad-and-along-the-fibre
GRANT_NUMBER: DP0879780
Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Membrane excitability and cellular calcium regulation in the peripheral nervous system under different (patho)-physiological conditions and in inflammatory disease

Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Control of Ca2+ release in excitation-contraction coupling and its modulation by membrane cholesterol.

Source: Self-asserted source
Bradley Launikonis via DimensionsWizard

Works (50 of 68)

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Page 1 of 2

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression

Nature Communications
2025-03-28 | Journal article
DOI: 10.1038/s41467-025-58393-2
Contributors: Aldo Meizoso-Huesca; Cedric R. Lamboley; James R. Krycer; Mark P. Hodson; James E. Hudson; Bradley S. Launikonis
Source: check_circle
Crossref

Muscle fibre mitochondrial [Ca2+] dynamics during Ca2+ waves in RYR1 gain‐of‐function mouse

Acta Physiologica
2024-03 | Journal article
DOI: 10.1111/apha.14098
Contributors: Rhayanna B. Gaglianone; Bradley S. Launikonis
Source: check_circle
Crossref

A bivalent remipede toxin promotes calcium release via ryanodine receptor activation.

Nature communications
2023-02-23 | Journal article | Author
DOI: 10.1038/s41467-023-36579-w
PMID: 36823422
PMC: PMC9950431
Contributors: Maxwell MJ; Thekkedam C; Lamboley C; Chin YK; Theo Crawford; Smith JJ; Junyu Liu; Xinying Jia; Vetter I; Laver DR et al.
Source: Self-asserted source
Bradley Launikonis

Evolutionary isolation of ryanodine receptor isoform 1 for muscle-based thermogenesis in mammals

Proceedings of the National Academy of Sciences USA
2023-01-24 | Journal article | Author
DOI: 10.1073/pnas.2117503120
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Daniel Singh; Luke Pearce; Rocky H. Choi; Aldo Meizoso-Huesca; Stefan Wette; John W. Scott; Cedric R. Lamboley; Robyn M. Murphy; Bradley Launikonis
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

Tiny changes in cytoplasmic [Ca<sup>2+</sup>] cause large changes in mitochondrial Ca<sup>2+</sup>: what are the triggers and functional implications?

American journal of physiology. Cell physiology
2022-09-12 | Journal article | Author
DOI: 10.1152/ajpcell.00092.2022
PMID: 36094438
Contributors: Seng C; Pearce L; Meizoso-Huesca A; Singh DP; Robyn Murphy; Lamboley CR; Bradley Launikonis
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

A mathematical model to quantify RYR Ca2+ leak and associated heat production in resting human skeletal muscle fibers

Journal of General Physiology
2022-09-05 | Journal article
DOI: 10.1085/jgp.202112994
Part of ISSN: 0022-1295
Part of ISSN: 1540-7748
Source: Self-asserted source
Bradley Launikonis

Ryanodine receptor activity and store-operated Ca<sup>2+</sup> entry: Critical regulators of Ca<sup>2+</sup> content and function in skeletal muscle.

The Journal of physiology
2022-02-25 | Journal article
DOI: 10.1113/jp279512
PMID: 35218018
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

Ca<sup>2+</sup> leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle.

Proceedings of the National Academy of Sciences of the United States of America
2022-01-01 | Journal article
DOI: 10.1073/pnas.2119203119
PMID: 35046046
PMC: PMC8794839
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

Cardiac ryanodine receptor N-terminal region biosensors identify novel inhibitors via FRET-based high-throughput screening

Journal of Biological Chemistry
2021-11 | Journal article
DOI: 10.1016/j.jbc.2021.101412
Part of ISSN: 0021-9258
Source: Self-asserted source
Bradley Launikonis

Ryanodine receptor leak triggers fiber Ca 2+ redistribution to preserve force and elevate basal metabolism in skeletal muscle

Science Advances
2021-10-29 | Journal article
DOI: 10.1126/sciadv.abi7166
Part of ISSN: 2375-2548
Source: Self-asserted source
Bradley Launikonis

Components of activation heat in skeletal muscle

Journal of Muscle Research and Cell Motility
2021-03 | Journal article
DOI: 10.1007/s10974-019-09547-5
Contributors: C. J. Barclay; B. S. Launikonis
Source: check_circle
Crossref

A chloride channel blocker prevents the suppression by inorganic phosphate of the cytosolic calcium signals that control muscle contraction

The Journal of Physiology
2021-01 | Journal article
DOI: 10.1113/jp279917
Part of ISSN: 0022-3751
Part of ISSN: 1469-7793
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle

Journal of General Physiology
2021-01-04 | Journal article
DOI: 10.1085/jgp.202012747
Part of ISSN: 0022-1295
Part of ISSN: 1540-7748
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Scientific Reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-58461-1
Part of ISSN: 2045-2322
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

Phasic Store-Operated Ca2+ Entry During Excitation-Contraction Coupling in Skeletal Muscle Fibers From Exercised Mice

Frontiers in Physiology
2020-11-12 | Journal article
DOI: 10.3389/fphys.2020.597647
Part of ISSN: 1664-042X
Source: Self-asserted source
Bradley Launikonis

Multi-species transcriptomics reveals evolutionary diversity in the mechanisms regulating shrimp tail muscle excitation-contraction coupling

Gene
2020-08 | Journal article
DOI: 10.1016/j.gene.2020.144765
Part of ISSN: 0378-1119
Source: Self-asserted source
Bradley Launikonis

BTP2 negatively regulates Orai1 and ryanodine receptor function in skeletal muscle

2020-04-16 | Preprint
DOI: 10.21203/rs.3.rs-22948/v1
Contributors: Aldo Meizoso-Huesca; Bradley Launikonis
Source: check_circle
Crossref

A New Selective Pharmacological Enhancer of the Orai1 Ca2+ Channel Reveals Roles for Orai1 in Smooth and Skeletal Muscle Functions

ACS Pharmacology & Translational Science
2020-02-14 | Journal article
DOI: 10.1021/acsptsci.9b00081
Part of ISSN: 2575-9108
Part of ISSN: 2575-9108
Source: Self-asserted source
Bradley Launikonis

BTP2 negatively regulates Orai1 and ryanodine receptor function in skeletal muscle

2020-01-24 | Preprint
DOI: 10.21203/rs.2.21863/v1
Contributors: Aldo Meizoso-Huesca; Bradley Launikonis
Source: check_circle
Crossref

Mechanistic insights into store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2019-07 | Journal article
DOI: 10.1016/j.bbamcr.2019.02.014
Part of ISSN: 0167-4889
Source: Self-asserted source
Bradley Launikonis

Junctional membrane Ca<sup>2+</sup>dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation

Proceedings of the National Academy of Sciences of the United States of America
2018 | Journal article
DOI: 10.1073/pnas.1800490115
EID:

2-s2.0-85053497184
Contributors: Cully, T.R.; Choi, R.H.; Bjorksten, A.R.; George Stephenson, D.; Murphy, R.M.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier
grade
Preferred source (of 2)‎

NHE- and diffusion-dependent proton fluxes across the tubular system membranes of fast-twitch muscle fibers of the rat

Journal of General Physiology
2018 | Journal article
DOI: 10.1085/jgp.201711891
EID:

2-s2.0-85039962923
Contributors: Launikonis, B.S.; Cully, T.R.; Csernoch, L.; George Stephenson, D.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier
grade
Preferred source (of 2)‎

Store-operated Ca2+ entry is activated by every action potential in skeletal muscle

Communications Biology
2018-12 | Journal article
DOI: 10.1038/s42003-018-0033-7
Part of ISSN: 2399-3642
Source: Self-asserted source
Bradley Launikonis
grade
Preferred source (of 2)‎

Dantrolene requires Mg<sup>2+</sup>to arrest malignant hyperthermia

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
DOI: 10.1073/pnas.1619835114
EID:

2-s2.0-85018239404
Contributors: Choi, R.H.; Koenig, X.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier
grade
Preferred source (of 2)‎

Doublet stimulation increases Ca<sup>2+</sup>binding to troponin C to ensure rapid force development in skeletal muscle

Journal of General Physiology
2017 | Journal article
DOI: 10.1085/jgp.201611727
EID:

2-s2.0-85017242307
Contributors: Bakker, A.J.; Cully, T.R.; Wingate, C.D.; Barclay, C.J.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier
grade
Preferred source (of 2)‎

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

Proceedings of the National Academy of Sciences of the United States of America
2017 | Journal article
DOI: 10.1073/pnas.1707316114
EID:

2-s2.0-85030257223
Contributors: Mills, R.J.; Titmarsh, D.M.; Koenig, X.; Parker, B.L.; Ryall, J.G.; Quaife-Ryan, G.A.; Voges, H.K.; Hodson, M.P.; Ferguson, C.; Drowley, L. et al.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Human skeletal muscle plasmalemma alters its structure to change its Ca<sup>2+</sup>-handling following heavy-load resistance exercise

Nature Communications
2017 | Journal article
DOI: 10.1038/ncomms14266
EID:

2-s2.0-85012305737
Contributors: Cully, T.R.; Murphy, R.M.; Roberts, L.; Raastad, T.; Fassett, R.G.; Coombes, J.S.; Jayasinghe, I.D.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier
grade
Preferred source (of 2)‎

A quantitative description of tubular system Ca<sup>2+</sup> handling in fast- and slow-twitch muscle fibres

Journal of Physiology
2016 | Journal article
DOI: 10.1113/JP271658
EID:

2-s2.0-84959299697
Contributors: Cully, T.R.; Edwards, J.N.; Murphy, R.M.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Additional in-series compliance reduces muscle force summation and alters the time course of force relaxation during fixed-end contractions

Journal of Experimental Biology
2016 | Journal article
DOI: 10.1242/jeb.143123
EID:

2-s2.0-84995947178
Contributors: Mayfield, D.L.; Launikonis, B.S.; Cresswell, A.G.; Lichtwark, G.A.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Leaky ryanodine receptors delay the activation of store overload-induced ca<sup>2+</sup>release, a mechanism underlying malignant hyperthermia-like events in dystrophic muscle

American Journal of Physiology - Cell Physiology
2016 | Journal article
DOI: 10.1152/ajpcell.00366.2015
EID:

2-s2.0-84983399287
Contributors: Cully, T.R.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Activation and propagation of Ca<sup>2+</sup> release from inside the sarcoplasmic reticulum network of mammalian skeletal muscle

Journal of Physiology
2014 | Journal article
DOI: 10.1113/jphysiol.2014.274274
EID:

2-s2.0-84906939707
Contributors: Cully, T.R.; Edwards, J.N.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

Neurobiology of Disease
2014 | Journal article
DOI: 10.1016/j.nbd.2013.10.009
EID:

2-s2.0-84887143993
Contributors: Cheng, Y.-L.; Park, J.-S.; Manzanero, S.; Choi, Y.; Baik, S.-H.; Okun, E.; Gelderblom, M.; Fann, D.Y.W.; Magnus, T.; Launikonis, B.S. et al.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Observation of the molecular organization of calcium release sites in fast- and slowtwitch skeletal muscle with nanoscale imaging

Journal of the Royal Society Interface
2014 | Journal article
DOI: 10.1098/rsif.2014.0570
EID:

2-s2.0-84992010326
Contributors: Jayasinghe, I.D.; Munro, M.; Baddeley, D.; Launikonis, B.S.; Soeller, C.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Evidence That the EphA2 Receptor Exacerbates Ischemic Brain Injury

PLoS ONE
2013 | Journal article
DOI: 10.1371/journal.pone.0053528
EID:

2-s2.0-84872141120
Contributors: Thundyil, J.; Manzanero, S.; Pavlovski, D.; Cully, T.R.; Lok, K.-Z.; Widiapradja, A.; Chunduri, P.; Jo, D.-G.; Naruse, C.; Asano, M. et al.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Examination of the subsarcolemmal tubular system of mammalian skeletal muscle fibers

Biophysical Journal
2013 | Journal article
DOI: 10.1016/j.bpj.2013.04.029
EID:

2-s2.0-84878845693
Contributors: Jayasinghe, I.D.; Lo, H.P.; Morgan, G.P.; Baddeley, D.; Parton, R.G.; Soeller, C.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Store-operated Ca2+ entry is not required for store refilling in skeletal muscle

Clinical and Experimental Pharmacology and Physiology
2013 | Journal article
DOI: 10.1111/1440-1681.12078
EID:

2-s2.0-84876846781
Contributors: Cully, T.R.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Three-dimensional reconstruction and analysis of the tubular system of vertebrate skeletal muscle

Journal of Cell Science
2013 | Journal article
DOI: 10.1242/jcs.131565
EID:

2-s2.0-84883279062
Contributors: Jayasinghe, I.D.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca<sup>2+</sup>signaling in dystrophic mdx mouse muscle

American Journal of Physiology - Cell Physiology
2012 | Journal article
DOI: 10.1152/ajpcell.00144.2012
EID:

2-s2.0-84865796279
Contributors: Cully, T.R.; Edwards, J.N.; Friedrich, O.; George Stephenson, D.; Murphy, R.M.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Growth hormone secretagogues preserve the electrophysiological properties of mouse cardiomyocytes isolated from in Vitro ischemia/reperfusion heart

Endocrinology
2012 | Journal article
DOI: 10.1210/en.2012-1404
EID:

2-s2.0-84867771904
Contributors: Ma, Y.; Zhang, L.; Launikonis, B.S.; Chen, C.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium

PLoS ONE
2012 | Journal article
DOI: 10.1371/journal.pone.0035265
EID:

2-s2.0-84859485950
Contributors: Ma, Y.; Zhang, L.; Edwards, J.N.; Launikonis, B.S.; Chen, C.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Longitudinal and transversal propagation of excitation along the tubular system of rat fast-twitch muscle fibres studied by high speed confocal microscopy

Journal of Physiology
2012 | Journal article
DOI: 10.1113/jphysiol.2011.221796
EID:

2-s2.0-84856348122
Contributors: Edwards, J.N.; Cully, T.R.; Shannon, T.R.; Stephenson, D.G.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Store-operated calcium entry remains fully functional in aged mouse skeletal muscle despite a decline in STIM1 protein expression

Aging Cell
2011 | Journal article
DOI: 10.1111/j.1474-9726.2011.00706.x
EID:

2-s2.0-79960295027
Contributors: Edwards, J.N.; Blackmore, D.G.; Gilbert, D.F.; Murphy, R.M.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Toward the roles of store-operated Ca2+ entry in skeletal muscle

Pflugers Archiv European Journal of Physiology
2010 | Journal article
DOI: 10.1007/s00424-010-0856-7
EID:

2-s2.0-77957891935
Contributors: Launikonis, B.S.; Murphy, R.M.; Edwards, J.N.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Ultra-rapid activation and deactivation of store-operated Ca<sup>2+</sup>entry in skeletal muscle

Cell Calcium
2010 | Journal article
DOI: 10.1016/j.ceca.2010.04.001
EID:

2-s2.0-77952950990
Contributors: Edwards, J.N.; Murphy, R.M.; Cully, T.R.; von Wegner, F.; Friedrich, O.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle

American Journal of Physiology - Cell Physiology
2010 | Journal article
DOI: 10.1152/ajpcell.00524.2009
EID:

2-s2.0-77953787701
Contributors: Edwards, J.N.; Friedrich, O.; Cully, T.R.; Von Wegner, F.; Murphy, R.M.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Rapid Ca<sup>2+</sup> flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle

Journal of Physiology
2009 | Journal article
DOI: 10.1113/jphysiol.2009.168682
EID:

2-s2.0-65749100189
Contributors: Launikonis, B.S.; Stephenson, D.G.; Friedrich, O.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Calcium-dependent inactivation terminates calcium release in skeletal muscle of amphibians

Journal of General Physiology
2008 | Journal article
DOI: 10.1085/jgp.200709870
EID:

2-s2.0-41649104750
Contributors: Ríos, E.; Zhou, J.; Brum, G.; Launikonis, B.S.; Stern, M.D.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Inhibitory control over Ca<sup>2+</sup> sparks via mechanosensitive channels is disrupted in dystrophin deficient muscle but restored by mini-dystrophin expression

PLoS ONE
2008 | Journal article
DOI: 10.1371/journal.pone.0003644
EID:

2-s2.0-56149120851
Contributors: Teichmann, M.D.H.; Wegner, F.V.; Fink, R.H.A.; Chamberlain, J.S.; Launikonis, B.S.; Martinac, B.; Friedrich, O.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

The accessibility and interconnectivity of the tubular system network in toad skeletal muscle

Journal of Physiology
2008 | Journal article
DOI: 10.1113/jphysiol.2008.155127
EID:

2-s2.0-55349118195
Contributors: Edwards, J.N.; Launikonis, B.S.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier

Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells

Molecular Biology of the Cell
2007 | Journal article
DOI: 10.1091/mbc.E07-01-0024
EID:

2-s2.0-34548508978
Contributors: Larina, O.; Bhat, P.; Pickett, J.A.; Launikonis, B.S.; Shah, A.; Kruger, W.A.; Edwardson, J.M.; Thorn, P.
Source: Self-asserted source
Bradley Launikonis via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (10 reviews for 3 publications/grants)

Review activity for Cell reports medicine. (2)
Review activity for Faculty Opinions (7)
Review activity for PloS one. (1)
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