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Biography

I received Ph.D. with Dr. Takuji Takeuchi from Tohoku University Japan. I did postdoctoral training at the Indiana University School of Medicine. I as a Research Associate worked with Dr. Heinz Arnheiter and as a Research Fellow with Dr. William Pavan, and then as a Scientist at the NIH, USA. I am a Professor at State Key Laboratory of Ophthalmology and Vision Science, Wenzhou Medical University, China, and continually investigate Ocular Pigment Cell Biology and Retinal Degeneration and Repair.

Activities

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Employment (3)

National Institutes of Health: Bethesda, MD, US

2004-11 to 2008-02 | Scientist (National Human Genome Research Institute)
Employment
Source: Self-asserted source
Ling Hou

National Institutes of Health: Bethesda, MD, US

2000-09 to 2004-11 | Research Fellow (National Human Genome Research Institute)
Employment
Source: Self-asserted source
Ling Hou

National Institutes of Health: Bethesda, MD, US

1997-07 to 2000-08 | Visiting Associate (National Institute of Neurological Disorders)
Employment
Source: Self-asserted source
Ling Hou

Education and qualifications (2)

Indiana University School of Medicine: Indianapolis, IN 46202,, US

1992-10 to 1997-05 | Postdoctoral Fellow (Walther Oncology Center and Department of Physiology)
Education
Source: Self-asserted source
Ling Hou

Tohoku University: Sendai, JP

1988-09 to 1992-09 | Ph.D. (Biological Institute)
Education
Source: Self-asserted source
Ling Hou

Works (50 of 52)

Items per page:
Page 1 of 2

Disrupting Hedgehog signaling in melanocytes by SUFU knockout leads to ocular melanocytosis and anterior segment malformation

Disease Models & Mechanisms
2023-08-01 | Journal article
DOI: 10.1242/dmm.050210
Contributors: Weizhuo Wang; Feiyang Li; Jing Wang; Zuimeng Liu; Meiyu Tian; Zhenhang Wang; Huirong Li; Jia Qu; Yu Chen; Ling Hou
Source: check_circle
Crossref

DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like features.

Redox biology
2023-03-15 | Journal article
DOI: 10.1016/j.redox.2023.102675
PMID: 36933392
PMC: PMC10031543
Contributors: Xiaoyin Ma; Chen H; Jian S; He J; Liu Y; Han S; Chang L; Li P; Chen YA; Liu X et al.
Source: Self-asserted source
Ling Hou

DAPL1 prevents epithelial-mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy.

Cell death & disease
2023-02-25 | Journal article | Author
DOI: 10.1038/s41419-023-05693-4
PMID: 36841807
PMC: PMC9968328
Contributors: Xiaoyin Ma; Han S; Liu Y; Chen Y; Li P; Liu X; Chang L; Chen YA; Chen F; Hou Q et al.
Source: Self-asserted source
Ling Hou

Sensitivity of the Dorsal-Central Retinal Pigment Epithelium to Sodium Iodate-Induced Damage Is Associated With Overlying M-Cone Photoreceptors in Mice.

Investigative ophthalmology & visual science
2022-08-01 | Journal article
DOI: 10.1167/iovs.63.9.29
PMID: 36018572
PMC: PMC9428360
Contributors: Lian L; Zhai Y; Wan X; Chen L; Liu Z; Liu R; Li S; Zhou J; Chen Y; Hou L et al.
Source: Self-asserted source
Ling Hou

High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3

Molecular Neurodegeneration
2021-12 | Journal article
DOI: 10.1186/s13024-021-00437-4
Contributors: Huirong Li; Bo Liu; Lili Lian; Jiajia Zhou; Shengjin Xiang; Yifan Zhai; Yu Chen; Xiaoyin Ma; Wencan Wu; Ling Hou
Source: check_circle
Crossref

LncRNA NEAT1 Recruits SFPQ to Regulate MITF Splicing and Control RPE Cell Proliferation.

Investigative ophthalmology & visual science
2021-11-01 | Journal article
DOI: 10.1167/iovs.62.14.18
PMID: 34787639
PMC: PMC8606808
Contributors: Hu X; Li F; He J; Yang J; Jiang Y; Jiang M; Wei D; Chang L; Hejtmancik JF; Hou L et al.
Source: Self-asserted source
Ling Hou

KIT ligand produced by limbal niche cells under control of SOX10 maintains limbal epithelial stem cell survival by activating the KIT/AKT signalling pathway

Journal of Cellular and Molecular Medicine
2020-10 | Journal article
DOI: 10.1111/jcmm.15830
Contributors: Zhongyuan Su; Jing Wang; Qinghua Lai; Huanyu Zhao; Ling Hou
Source: check_circle
Crossref

Personalized stem cell-based therapy for degenerative retinal diseases.

Stem cell reviews and reports
2020-10-01 | Journal article
DOI: 10.1007/s12015-020-10003-y
PMID: 32643085
Source: Self-asserted source
Ling Hou

MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium.

Redox biology
2020-04-16 | Journal article
DOI: 10.1016/j.redox.2020.101537
PMID: 32361183
PMC: PMC7191850
Source: Self-asserted source
Ling Hou

KIT ligand protects against both light-induced and genetic photoreceptor degeneration.

eLife
2020-04-03 | Journal article
DOI: 10.7554/elife.51698
PMID: 32242818
PMC: PMC7170656
Source: Self-asserted source
Ling Hou

The transcription factor MITF in RPE function and dysfunction.

Progress in retinal and eye research
2019-06-23 | Journal article
DOI: 10.1016/j.preteyeres.2019.06.002
PMID: 31242455
Source: Self-asserted source
Ling Hou

Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina.

Cell death and differentiation
2019-06-17 | Journal article
DOI: 10.1038/s41418-019-0371-0
PMID: 31209365
Source: Self-asserted source
Ling Hou

Photoreceptor degeneration in microphthalmia (Mitf) mice: partial rescue by pigment epithelium-derived factor

Disease Models & Mechanisms
2019-01-01 | Journal article
DOI: 10.1242/dmm.035642
Contributors: Yu Chen; Juan Yang; Huiqin Geng; Liping Li; Jinyang Li; Bing Cheng; Xiaoyin Ma; Huirong Li; Ling Hou
Source: check_circle
Crossref

Regulation of melanocyte stem cell behavior by the niche microenvironment

Pigment Cell & Melanoma Research
2018-09 | Journal article
DOI: 10.1111/pcmr.12701
Contributors: Huirong Li; Ling Hou
Source: check_circle
Crossref

Regulation of cell proliferation in the retinal pigment epithelium: Differential regulation of the death‐associated protein like‐1 DAPL1 by alternative MITF splice forms

Pigment Cell & Melanoma Research
2018-05 | Journal article
DOI: 10.1111/pcmr.12676
Contributors: Xiaoyin Ma; Jiajia Hua; Guoxiao Zheng; Fang Li; Chunbao Rao; Huirong Li; Jing Wang; Li Pan; Ling Hou
Source: check_circle
Crossref

MITF acts as an anti-oxidant transcription factor to regulate mitochondrial biogenesis and redox signaling in retinal pigment epithelial cells.

Experimental eye research
2018-02-24 | Journal article
DOI: 10.1016/j.exer.2018.02.023
PMID: 29486165
Source: Self-asserted source
Ling Hou

The T-Box Transcription Factor TBX2 Regulates Cell Proliferation in the Retinal Pigment Epithelium.

Current eye research
2017-09-14 | Journal article
DOI: 10.1080/02713683.2017.1338351
PMID: 28910203
Source: Self-asserted source
Ling Hou

Epilation induces hair and skin pigmentation through an EDN3/EDNRB-dependent regenerative response of melanocyte stem cells.

Scientific reports
2017-08-04 | Journal article
DOI: 10.1038/s41598-017-07683-x
PMID: 28779103
PMC: PMC5544680
Source: Self-asserted source
Ling Hou

DAPL1, a susceptibility locus for age-related macular degeneration, acts as a novel suppressor of cell proliferation in the retinal pigment epithelium.

Human molecular genetics
2017-05-01 | Journal article
DOI: 10.1093/hmg/ddx063
PMID: 28334846
Source: Self-asserted source
Ling Hou

The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.

FEBS letters
2017-03-06 | Journal article
DOI: 10.1002/1873-3468.12580
PMID: 28140449
Source: Self-asserted source
Ling Hou

Microphthalmia-associated transcription factor regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule

Experimental Dermatology
2016 | Journal article
DOI: 10.1111/exd.12835
EID:

2-s2.0-84954026443
Contributors: Rao, C.; Su, Z.; Li, H.; Ma, X.; Zheng, X.; Liu, Y.; Lu, F.; Qu, J.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Microphthalmia-associated transcription factor regulates the visual cycle genes Rlbp1 and Rdh5 in the retinal pigment epithelium

Scientific Reports
2016 | Journal article
DOI: 10.1038/srep21208
EID:

2-s2.0-84959478112
Contributors: Wen, B.; Li, S.; Li, H.; Chen, Y.; Ma, X.; Wang, J.; Lu, F.; Qu, J.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

MITF and cell migration: Opposing signals, similar outcome

Pigment Cell and Melanoma Research
2016 | Journal article
DOI: 10.1111/pcmr.12439
EID:

2-s2.0-84958643192
Contributors: Pan, L.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Sox10 regulates skin melanocyte proliferation by activating the DNA replication licensing factor MCM5

Journal of Dermatological Science
2016 | Journal article
DOI: 10.1016/j.jdermsci.2016.12.002
EID:

2-s2.0-85007560071
Contributors: Su, Z.; Zheng, X.; Zhang, X.; Wang, Y.; Zhu, S.; Lu, F.; Qu, J.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2

Molecular and Cellular Biochemistry
2016 | Journal article
DOI: 10.1007/s11010-016-2680-7
EID:

2-s2.0-84960359781
Contributors: Chen, Y.; Pan, L.; Su, Z.; Wang, J.; Li, H.; Ma, X.; Liu, Y.; Lu, F.; Qu, J.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Microphthalmia-associated transcription factor/T-box factor-2 axis acts through Cyclin D1 to regulate melanocyte proliferation

Cell Proliferation
2015 | Journal article
DOI: 10.1111/cpr.12227
EID:

2-s2.0-84983203534
Contributors: Pan, L.; Ma, X.; Wen, B.; Su, Z.; Zheng, X.; Liu, Y.; Li, H.; Chen, Y.; Wang, J.; Lu, F. et al.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Regulation of pigmentation by microRNAs: MITF-dependent microRNA-211 targets TGF-β receptor 2

Pigment Cell and Melanoma Research
2015 | Journal article
DOI: 10.1111/pcmr.12334
EID:

2-s2.0-84923080714
Contributors: Dai, X.; Rao, C.; Li, H.; Chen, Y.; Fan, L.; Geng, H.; Li, S.; Qu, J.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells

Experimental Cell Research
2014 | Journal article
DOI: 10.1016/j.yexcr.2013.09.017
EID:

2-s2.0-84888197622
Contributors: Yang, J.; Wang, J.; Pan, L.; Li, H.; Rao, C.; Zhang, X.; Niu, G.; Qu, J.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Dlic1 deficiency impairs ciliogenesis of photoreceptors by destabilizing dynein

Cell Research
2013 | Journal article
DOI: 10.1038/cr.2013.59
EID:

2-s2.0-84878732958
Contributors: Kong, S.; Du, X.; Peng, C.; Wu, Y.; Li, H.; Jin, X.; Hou, L.; Deng, K.; Xu, T.; Tao, W.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Inhibitory effect of microRNA-34a on retinal pigment epithelial cell proliferation and migration

Investigative Ophthalmology and Visual Science
2013 | Journal article
DOI: 10.1167/iovs.13-11873
EID:

2-s2.0-84885027483
Contributors: Hou, Q.; Tang, J.; Wang, Z.; Wang, C.; Chen, X.; Hou, L.; Dong, X.D.; Tu, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Microphthalmia-associated transcription factor acts through PEDF to regulate RPE cell migration

Experimental Cell Research
2012 | Journal article
DOI: 10.1016/j.yexcr.2011.11.002
EID:

2-s2.0-84855835939
Contributors: Ma, X.; Pan, L.; Jin, X.; Dai, X.; Li, H.; Wen, B.; Chen, Y.; Ma, A.; Qu, J.; Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Allele-specific genetic interactions between Mitf and Kit affect melanocyte development

Pigment Cell and Melanoma Research
2010 | Journal article
DOI: 10.1111/j.1755-148X.2010.00699.x
EID:

2-s2.0-77952578126
Contributors: Wen, B.; Chen, Y.; Li, H.; Wang, J.; Shen, J.; Ma, A.; Qu, J.; Bismuth, K.; Debbache, J.; Arnheiter, H. et al.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy

Human Molecular Genetics
2008 | Journal article
DOI: 10.1093/hmg/ddn110
EID:

2-s2.0-46249117044
Contributors: Matera, I.; Watkins-Chow, D.E.; Loftus, S.K.; Hou, L.; Incao, A.; Silver, D.L.; Rivas, C.; Elliott, E.C.; Baxter, L.L.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

The secreted metalloprotease ADAMTS20 is required for melanoblast survival

PLoS Genetics
2008 | Journal article
DOI: 10.1371/journal.pgen.1000003
EID:

2-s2.0-40149083619
Contributors: Silver, D.L.; Hou, L.; Somerville, R.; Young, M.E.; Apte, S.S.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: Do all roads lead to Mitf?

Cell Research
2008 | Journal article
DOI: 10.1038/cr.2008.303
EID:

2-s2.0-57049091596
Contributors: Hou, L.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage

Mechanisms of Development
2006 | Journal article
DOI: 10.1016/j.mod.2005.11.004
EID:

2-s2.0-32444447812
Contributors: Hakami, R.M.; Hou, L.; Baxter, L.L.; Loftus, S.K.; Southard-Smith, E.M.; Incao, A.; Cheng, J.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Interspecies difference in the regulation of melanocyte development by SOX10 and MITF

Proceedings of the National Academy of Sciences of the United States of America
2006 | Journal article
DOI: 10.1073/pnas.0603114103
EID:

2-s2.0-33745177750
Contributors: Hou, L.; Arnheiter, H.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Cell-autonomous and cell non-autonomous signaling through endothelin receptor B during melanocyte development

Development
2004 | Journal article
DOI: 10.1242/dev.01193
EID:

2-s2.0-4243198354
Contributors: Hou, L.; Pavan, W.J.; Shin, M.K.; Arnheiter, H.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Complementation of Melanocyte Development in SOX10 Mutant Neural Crest Using Lineage-Directed Gene Transfer

Developmental Dynamics
2004 | Journal article
DOI: 10.1002/dvdy.10468
EID:

2-s2.0-0347417022
Contributors: Hou, L.; Loftus, S.K.; Incao, A.; Chen, A.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Spotlight on spotted mice: A review of white spotting mouse mutants and associated human pigmentation disorders

Pigment Cell Research
2004 | Journal article
DOI: 10.1111/j.1600-0749.2004.00147.x
EID:

2-s2.0-2642532618
Contributors: Baxter, L.L.; Hou, L.; Loftus, S.K.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

220- and 130-kDa MLCKs have distinct tissue distributions and intracellular localization patterns

American Journal of Physiology - Cell Physiology
2002 | Journal article
EID:

2-s2.0-0036080607
Contributors: Blue, E.K.; Goeckeler, Z.M.; Jin, Y.; Hou, L.; Dixon, S.A.; Paul Herring, B.; Wysolmerski, R.B.; Gallagher, P.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

Proceedings of the National Academy of Sciences of the United States of America
2002 | Journal article
DOI: 10.1073/pnas.072071099
EID:

2-s2.0-0037007031
Contributors: Steingrímsson, E.; Tessarollo, L.; Pathak, B.; Hou, L.; Arnheiter, H.; Copeland, N.G.; Jenkins, N.A.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase

Developmental Biology
2001 | Journal article
DOI: 10.1006/dbio.2001.0372
EID:

2-s2.0-0035884056
Contributors: Potterf, S.B.; Mollaaghababa, R.; Hou, L.; Southard-Smith, E.M.; Hornyak, T.J.; Arnheiter, H.; Pavan, W.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Identification of a New Form of Death-associated Protein Kinase that Promotes Cell Survival

Journal of Biological Chemistry
2001 | Journal article
DOI: 10.1074/jbc.M101886200
EID:

2-s2.0-0035955620
Contributors: Jin, Y.; Blue, E.K.; Dixon, S.; Hou, L.; Wysolmerski, R.B.; Gallagher, P.J.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: Interactions between KIT and MITF

Development
2000 | Journal article
EID:

2-s2.0-0034521252
Contributors: Hou, L.; Panthier, J.-J.; Arnheiter, H.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Effects of local tissue environment on the differentiation of neural crest cells in turtle, with special reference to understanding the spatial distribution of pigment cells

Pigment Cell Research
1999 | Journal article
EID:

2-s2.0-0033109209
Contributors: Hou, L.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Characterization and subcellular localization of human Pmel 17/silver, a 100-kDa (pre)melanosomal membrane protein associated with 5,6,-dihydroxyindole-2-carboxylic acid (DHICA) converting activity

Journal of Investigative Dermatology
1996 | Journal article
EID:

2-s2.0-0029876125
Contributors: Lee, Z.H.; Hou, L.; Moellmann, G.; Kuklinska, E.; Antol, K.; Fraser, M.; Halaban, R.; Kwon, B.S.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Turtle lung cells produce a melanization-stimulating activity that promotes melanocytic differentiation of avian neural crest cells.

Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society
1995 | Journal article
EID:

2-s2.0-0029284156
Contributors: Hou, L.; Kwon, B.S.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier

Neural Crest Development in Reptilian Embryos, Studied with Monoclonal Antibody, HNK- 1

ZOOLOGICAL SCIENCE
1994 | Journal article
Source: Self-asserted source
Ling Hou

Structural organization of the human tyrosinase gene and sequence analysis and characterization of its promoter region

Journal of Investigative Dermatology
1994 | Journal article
EID:

2-s2.0-0028346248
Contributors: Ponnazhagan, S.; Hou, L.; Kwon, B.S.
Source: Self-asserted source
Ling Hou via Scopus - Elsevier
Items per page:
Page 1 of 2
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