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Scopus Author ID: 7005893299

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Works (34)

Use of the dTAG system <i>in vivo</i> to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities

Toxicological Sciences
2023-06-28 | Journal article | Author
DOI: 10.1093/toxsci/kfad049
Part of ISSN: 1096-6080
Part of ISSN: 1096-0929
Contributors: Paul Yenerall; Tae Sung; Kiran Palyada; Jessie Qian; Seda Arat; Steven W Kumpf; Shih-Wen Wang; Kathleen Biddle; Carlos Esparza; Stephanie Chang et al.
Source: Self-asserted source
Norimitsu Shirai

Gastric Neuroendocrine Tumors With Parietal Cell Atrophy in a Long-term Carcinogenicity Study in Rats

Toxicologic Pathology
2022-06 | Journal article
DOI: 10.1177/01926233221095445
Part of ISSN: 0192-6233
Part of ISSN: 1533-1601
Source: Self-asserted source
Norimitsu Shirai
grade
Preferred source (of 2)‎

Comprehensive Nonclinical Safety Assessment of Nirmatrelvir Supporting Timely Development of the SARS-COV-2 Antiviral Therapeutic, Paxlovid™

International Journal of Toxicology
2022-05-21 | Journal article
DOI: 10.1177/10915818221095489
Part of ISSN: 1091-5818
Part of ISSN: 1092-874X
Source: Self-asserted source
Norimitsu Shirai

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Nature Communications
2021 | Journal article
DOI: 10.1038/s41467-021-26239-2
EID:

2-s2.0-85117608948

Part of ISSN: 20411723
Contributors: Boras, B.; Jones, R.M.; Anson, B.J.; Arenson, D.; Aschenbrenner, L.; Bakowski, M.A.; Beutler, N.; Binder, J.; Chen, E.; Eng, H. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

De novo lipogenesis is essential for platelet production in humans

Nature Metabolism
2020 | Journal article
DOI: 10.1038/s42255-020-00272-9
EID:

2-s2.0-85090930662

Part of ISSN: 25225812
Contributors: Kelly, K.L.; Reagan, W.J.; Sonnenberg, G.E.; Clasquin, M.; Hales, K.; Asano, S.; Amor, P.A.; Carvajal-Gonzalez, S.; Shirai, N.; Matthews, M.D. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting

Journal of Medicinal Chemistry
2020 | Journal article
DOI: 10.1021/acs.jmedchem.0c00640
EID:

2-s2.0-85093887019

Part of ISSN: 15204804 00222623
Contributors: Huard, K.; Smith, A.C.; Cappon, G.; Dow, R.L.; Edmonds, D.J.; El-Kattan, A.; Esler, W.P.; Fernando, D.P.; Griffith, D.A.; Kalgutkar, A.S. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

EBioMedicine
2018 | Journal article
DOI: 10.1016/j.ebiom.2018.04.009
EID:

2-s2.0-85045447580

Part of ISSN: 23523964
Contributors: Esquejo, R.M.; Salatto, C.T.; Delmore, J.; Albuquerque, B.; Reyes, A.; Shi, Y.; Moccia, R.; Cokorinos, E.; Peloquin, M.; Monetti, M. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Testicular microlithiasis in a clinically healthy cynomolgus monkey (Macaca fascicularis)

Journal of Toxicologic Pathology
2018 | Journal article
DOI: 10.1293/tox.2017-0065
EID:

2-s2.0-85045947704

Part of ISSN: 09149198
Contributors: Shirai, N.; Evans, M.G.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Characterization of ectopic myelinated nerve fibers in the retina of a cynomolgus monkey (Macaca fascicularis)

Journal of Medical Primatology
2018-06 | Journal article
DOI: 10.1111/jmp.12335
Contributors: Norimitsu Shirai; Mark G. Evans
Source: check_circle
Crossref
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Preferred source (of 2)‎

Small structural changes of the imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitors produce an improved safety profile

MedChemComm
2017 | Journal article
DOI: 10.1039/c6md00564k
EID:

2-s2.0-85018489198

Part of ISSN: 20402511 20402503
Contributors: Futatsugi, K.; Huard, K.; Kung, D.W.; Pettersen, J.C.; Flynn, D.A.; Gosset, J.R.; Aspnes, G.E.; Barnes, R.J.; Cabral, S.; Dowling, M.S. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

The Application of Paraphenylenediamine Staining for Assessment of Phospholipidosis

Toxicologic Pathology
2016 | Journal article
DOI: 10.1177/0192623316673921
EID:

2-s2.0-85006489532

Part of ISSN: 15331601 01926233
Contributors: Shirai, N.; Geoly, F.J.; Bobrowski, W.F.; Okerberg, C.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Polycystic kidney disease in Sprague-Dawley rats

Experimental and Toxicologic Pathology
2015 | Journal article
DOI: 10.1016/j.etp.2015.02.002
EID:

2-s2.0-84930177403

Part of ISSN: 16181433 09402993
Contributors: Shoieb, A.; Shirai, N.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Using histopathologic evidence to differentiate reproductive senescence from xenobiotic effects in middle-aged female sprague-dawley rats

Toxicologic Pathology
2015 | Journal article
DOI: 10.1177/0192623315595137
EID:

2-s2.0-84948679670

Part of ISSN: 15331601 01926233
Contributors: Shirai, N.; Houle, C.; Mirsky, M.L.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Comparative nonclinical assessments of the proposed biosimilar PF-05280586 and rituximab (MabThera®)

Toxicologic Pathology
2014 | Journal article
DOI: 10.1177/0192623313520351
EID:

2-s2.0-84907525369

Part of ISSN: 15331601 01926233
Contributors: Ryan, A.M.; Sokolowski, S.A.; Ng, C.-K.; Shirai, N.; Collinge, M.; Shen, A.C.; Arrington, J.; Radi, Z.; Cummings, T.R.; Ploch, S.A. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Spontaneous unilateral renal dysplasia in a clinically healthy cynomolgus monkey (Macaca fascicularis)

Experimental and Toxicologic Pathology
2014 | Journal article
DOI: 10.1016/j.etp.2014.06.005
EID:

2-s2.0-84919334385

Part of ISSN: 16181433 09402993
Contributors: Shirai, N.; Muravnick, K.B.; Lettiere, D.J.; Evans, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

The Relationship of Glucokinase Activator–induced Hypoglycemia with Arteriopathy, Neuronal Necrosis, and Peripheral Neuropathy in Nonclinical Studies

Toxicologic Pathology
2014 | Journal article
DOI: 10.1177/0192623314526006
EID:

2-s2.0-84902077813

Part of ISSN: 15331601 01926233
Contributors: Pettersen, J.C.; Litchfield, J.; Neef, N.; Schmidt, S.P.; Shirai, N.; Walters, K.M.; Enerson, B.E.; Chatman, L.A.; Pfefferkorn, J.A.; Morton, D. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

An Atypical Case of Islet Cell Hyperplasia in a Wistar Rat

Toxicologic Pathology
2012 | Journal article
DOI: 10.1177/0192623312441410
EID:

2-s2.0-84862737952

Part of ISSN: 15331601 01926233
Contributors: Shirai, N.; Papanikolaou, A.; Perry, R.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Eosinophilic airway inflammation in a cynomolgus monkey

Veterinary Pathology
2010 | Journal article
DOI: 10.1177/0300985809359318
EID:

2-s2.0-77954000744

Part of ISSN: 03009858 15442217
Contributors: Shirai, N.; Geoly, F.J.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Renal dysplasia in Beagle dogs: four cases.

Toxicologic pathology
2010 | Journal article
DOI: 10.1177/0192623310382558
EID:

2-s2.0-79955031249

Part of ISSN: 15331601
Contributors: Bruder, M.C.; Shoieb, A.M.; Shirai, N.; Boucher, G.G.; Brodie, T.A.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Neuronal necrosis in a dog following exposure to an NMDA receptor antagonist

Journal of Toxicologic Pathology
2008 | Journal article
DOI: 10.1293/tox.21.185
EID:

2-s2.0-57049144873

Part of ISSN: 09149198
Contributors: Shirai, N.; Nii, A.; Horii, I.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Correlation among clinicopathological parameters of myocardial damage in rats treated with isoproterenol

Experimental Animals
2007 | Journal article
DOI: 10.1538/expanim.56.57
EID:

2-s2.0-33847663355

Part of ISSN: 13411357
Contributors: Kurata, M.; Iidaka, T.; Sasayama, Y.; Fukushima, T.; Sakimura, M.; Shirai, N.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice

Cancer Letters
2005 | Journal article
DOI: 10.1016/j.canlet.2004.07.015
EID:

2-s2.0-19944393208

Part of ISSN: 03043835
Contributors: Iidaka, T.; Tsukamoto, T.; Totsuka, Y.; Hirata, A.; Sakai, H.; Shirai, N.; Yamamoto, M.; Wakabayashi, K.; Yanai, T.; Masegi, T. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Detection of initiating and promoting activity of aminophenylnorharman with a five-week in vivo initiation assay

Journal of Toxicologic Pathology
2004 | Journal article
DOI: 10.1293/tox.17.1
EID:

2-s2.0-11144275775

Part of ISSN: 09149198
Contributors: Iidaka, T.; Sakai, H.; Tsukamoto, T.; Yamamoto, M.; Shirai, N.; Totsuka, Y.; Wakabayashi, K.; Yanai, T.; Masegi, T.; Tatematsu, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine

Journal of Cancer Research and Clinical Oncology
2003 | Journal article
DOI: 10.1007/s00432-003-0443-9
EID:

2-s2.0-0041658933

Part of ISSN: 01715216
Contributors: Sakai, H.; Tsukamoto, T.; Yamamoto, M.; Shirai, N.; Iidaka, T.; Hirata, A.; Yanai, T.; Masegi, T.; Donehower, L.A.; Tatematsu, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis

Carcinogenesis
2002 | Journal article
DOI: 10.1093/carcin/23.9.1541
EID:

2-s2.0-0036714714

Part of ISSN: 01433334
Contributors: Shirai, N.; Tsukamoto, T.; Yamamoto, M.; Iidaka, T.; Sakai, H.; Yanai, T.; Masegi, T.; Donehower, L.A.; Tatematsu, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Proliferative activity of canine mast cell tumours evaluated by bromodeoxyuridine incorporation and Ki-67 expression

Journal of Comparative Pathology
2002 | Journal article
DOI: 10.1053/jcpa.2002.0586
EID:

2-s2.0-0036853342

Part of ISSN: 00219975
Contributors: Sakai, H.; Noda, A.; Shirai, N.; Iidaka, T.; Yanai, T.; Masegi, T.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Summation of initiation activities in the liver after partial hepatectomy

Cancer Letters
2002 | Journal article
DOI: 10.1016/S0304-3835(01)00727-3
EID:

2-s2.0-18244392939

Part of ISSN: 03043835
Contributors: Sakai, H.; Tsukamoto, T.; Yamamoto, M.; Hirata, A.; Inagami, A.; Shirai, N.; Iidaka, T.; Yanai, T.; Masegi, T.; Tatematsu, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

The effects of allyl alcohol-induced cell proliferation for detection of initiation activities of chemicals in rat liver

Journal of Toxicologic Pathology
2002 | Journal article
DOI: 10.1293/tox.15.95
EID:

2-s2.0-10744232121

Part of ISSN: 09149198 09149198
Contributors: Okamura, M.; Sakai, H.; Takahashi, N.; Inagami, A.; Tsukamoto, T.; Yamamoto, M.; Shirai, N.; Iidaka, T.; Yanai, T.; Masegi, T. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

The effects of D-galactosamine- or carbon tetraehloride-induced regeneration on induction of rat liver cell foci in a model for detection of initiation activities of chemicals

Journal of Toxicologic Pathology
2002 | Journal article
DOI: 10.1293/tox.15.13
EID:

2-s2.0-29944443964

Part of ISSN: 09149198 09149198
Contributors: Sakai, H.; Inagami, A.; Hirata, A.; Tsukamoto, T.; Kobayashi, K.; Degawa, M.; Shirai, N.; Iidaka, T.; Yanai, T.; Masegi, T. et al.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Tongue carcinogenic susceptibility of p53 deficient mice to methyl-n-amylnitrosamine

Journal of Toxicologic Pathology
2002 | Journal article
DOI: 10.1293/tox.15.209
EID:

2-s2.0-27744521934

Part of ISSN: 09149198 09149198
Contributors: Shirai, N.; Tsukamoto, T.; Yamamoto, M.; Iidaka, T.; Sakai, H.; Yanai, T.; Masegi, T.; Donehower, L.A.; Tatematsu, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Differential effects of partial hepatectomy and carbon tetrachloride administration on induction of liver cell foci in a model for detection of initiation activity

Japanese Journal of Cancer Research
2001 | Journal article
DOI: 10.1111/j.1349-7006.2001.tb01055.x
EID:

2-s2.0-0034753487

Part of ISSN: 09105050
Contributors: Sakai, H.; Tsukamoto, T.; Yamamoto, M.; Shirai, N.; lidaka, T.; Yanai, T.; Masegi, T.; Tatematsu, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Expression of cyclin kinase inhibitor p27<sup>Kip1</sup> in skin tumours of dogs

Journal of Comparative Pathology
2001 | Journal article
DOI: 10.1053/jcpa.2001.0492
EID:

2-s2.0-0034751619

Part of ISSN: 00219975
Contributors: Sakai, H.; Yamane, T.; Yanai, T.; Shirai, N.; Masegi, T.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

Nontraumatic osteonecrosis: MR perfusion imaging evaluation in an experimental model

Academic Radiology
2000 | Journal article
DOI: 10.1016/S1076-6332(00)80455-9
EID:

2-s2.0-0034435669

Part of ISSN: 10766332
Contributors: Kawamoto, S.; Shirai, N.; Strandberg, J.D.; Boxerman, J.L.; Bluemke, D.A.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier

P53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis

Carcinogenesis
2000 | Journal article
DOI: 10.1093/carcin/21.10.1891
EID:

2-s2.0-0033790792

Part of ISSN: 01433334
Contributors: Yamamoto, M.; Tsukamoto, T.; Sakai, H.; Shirai, N.; Ohgaki, H.; Furihata, C.; Donehower, L.A.; Yoshida, K.; Tatematsu, M.
Source: Self-asserted source
Norimitsu Shirai via Scopus - Elsevier
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