Personal information

Emails & domains

Verified email addresses

Verified email domains

Websites & social links

BU Profiles
Microbiology Faculty

Biography

Expertise in non-segmented negative strand RNA virus transcription and replication mechanisms.

Activities

Collapse all

Works (50 of 55)

Items per page:
Page 1 of 2

Structural and functional analysis of the Nipah virus polymerase complex

Cell
2025-02 | Journal article
DOI: 10.1016/j.cell.2024.12.021
Contributors: Side Hu; Heesu Kim; Pan Yang; Zishuo Yu; Barbara Ludeke; Shawna Mobilia; Junhua Pan; Margaret Stratton; Yuemin Bian; Rachel Fearns et al.
Source: check_circle
Crossref

How does the polymerase of non-segmented negative strand RNA viruses commit to transcription or genome replication?

Journal of Virology
2024-08-20 | Journal article
DOI: 10.1128/jvi.00332-24
Contributors: Victoria A. Kleiner; Rachel Fearns; Suchetana Mukhopadhyay
Source: check_circle
Crossref

Structural and functional analysis of the Nipah virus polymerase complex

2024-05-29 | Preprint
DOI: 10.1101/2024.05.29.596445
Contributors: Side Hu; Heesu Kim; Pan Yang; Zishuo Yu; Barbara Ludeke; Shawna Mobilia; Junhua Pan; Margaret Stratton; Yuemin Bian; Rachel Fearns et al.
Source: check_circle
Crossref

Diversity of B Cell Populations and Ig Repertoire in Human Lungs

The Journal of Immunology
2023-08-01 | Journal article
DOI: 10.4049/jimmunol.2200340
Contributors: Fumiaki Aihara; Yumei Wang; Anna C Belkina; Rachel Fearns; Joseph P Mizgerd; Feng Feng; Thomas B Kepler
Source: check_circle
Crossref

Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses

PLOS Pathogens
2022-06-22 | Journal article
DOI: 10.1371/journal.ppat.1010451
Contributors: Tessa N. Cressey; Félix A. Rey; Afzaal M. Shareef; Victoria A. Kleiner; Sarah L. Noton; Patrick O. Byrne; Jason S. McLellan; Elke Mühlberger; Rachel Fearns
Source: check_circle
Crossref

DISTINCTIVE FEATURES OF THE RESPIRATORY SYNCYTIAL VIRUS PRIMING LOOP COMPARED TO OTHER NON-SEGMENTED NEGATIVE STRAND RNA VIRUSES

2022-03-18 | Preprint
DOI: 10.1101/2022.03.18.484858
Contributors: Tessa N. Cressey; Afzaal M. Shareef; Victoria A. Kleiner; Sarah L. Noton; Patrick O. Byrne; Jason S. McLellan; Elke Muhlberger; Rachel Fearns
Source: check_circle
Crossref

Helical ordering of envelope-associated proteins and glycoproteins in respiratory syncytial virus.

The EMBO journal
2021-12-22 | Journal article
DOI: 10.15252/embj.2021109728
PMID: 34935163
PMC: PMC8804925
Source: Self-asserted source
Rachel Fearns

Comparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases

PLOS Pathogens
2021-12-16 | Journal article
DOI: 10.1371/journal.ppat.1010151
Contributors: Afzaal M. Shareef; Sean P.J. Whelan; Barbara Ludeke; Paul Jordan; Jerome Deval; Rachel Fearns
Source: check_circle
Crossref

Structural architecture of a dimeric paramyxovirus polymerase complex

[]
2021-09-13 | Preprint
DOI: 10.1101/2021.09.13.460081
Source: Self-asserted source
Rachel Fearns

Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts

PLOS Pathogens
2021-05-18 | Journal article
DOI: 10.1371/journal.ppat.1009589
Contributors: Molly R. Braun; Carolina B. Lopez; Sarah L. Noton; Emmeline L. Blanchard; Afzaal Shareef; Philip J. Santangelo; W. Evan Johnson; Rachel Fearns
Source: check_circle
Crossref

EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model

PLOS Pathogens
2021-03-15 | Journal article
DOI: 10.1371/journal.ppat.1009428
Contributors: Michael H. J. Rhodin; Mark Krystal; Nicole V. McAllister; Jonathan Castillo; Sarah L. Noton; Rachel Fearns; In Jong Kim; Jianming Yu; Thomas P. Blaisdell; Joseph Panarese et al.
Source: check_circle
Crossref

Polymerase-tagged respiratory syncytial virus reveals a dynamic rearrangement of the ribonucleocapsid complex during infection

PLOS Pathogens
2020-10-08 | Journal article
DOI: 10.1371/journal.ppat.1008987
Contributors: Emmeline L. Blanchard; Sean P.J. Whelan; Molly R. Braun; Aaron W. Lifland; Barbara Ludeke; Sarah L. Noton; Daryll Vanover; Chiara Zurla; Rachel Fearns; Philip J. Santangelo
Source: check_circle
Crossref

RSV M2-1 Protein in Complex with RNA: Old Questions Are Answered and a New One Emerges.

Structure (London, England : 1993)
2020-09-01 | Journal article
DOI: 10.1016/j.str.2020.08.007
PMID: 32877647
Source: Self-asserted source
Rachel Fearns

Structure of the human metapneumovirus polymerase phosphoprotein complex.

Nature
2019-11-07 | Journal article
DOI: 10.1038/s41586-019-1759-1
PMID: 31698413
PMC: PMC6949429
Source: Self-asserted source
Rachel Fearns

The respiratory syncytial virus polymerase can perform RNA synthesis with modified primers and nucleotide analogs.

Virology
2019-11-06 | Journal article
DOI: 10.1016/j.virol.2019.11.002
PMID: 31739186
PMC: PMC7737601
Source: Self-asserted source
Rachel Fearns

The Respiratory Syncytial Virus Polymerase: A Multitasking Machine.

Trends in microbiology
2019-10-28 | Journal article
DOI: 10.1016/j.tim.2019.10.001
PMID: 31672264
Source: Self-asserted source
Rachel Fearns

Ebolavirus polymerase uses an unconventional genome replication mechanism.

Proceedings of the National Academy of Sciences of the United States of America
2019-04-08 | Journal article
DOI: 10.1073/pnas.1815745116
PMID: 30962389
PMC: PMC6486738
Source: Self-asserted source
Rachel Fearns

Killing two birds with one stone: How the respiratory syncytial virus polymerase initiates transcription and replication

PLOS Pathogens
2019-02-28 | Journal article
DOI: 10.1371/journal.ppat.1007548
Contributors: Sarah L. Noton; Rebecca Ellis Dutch; Chadene Z. Tremaglio; Rachel Fearns
Source: check_circle
Crossref

Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018.

Antiviral research
2018-12-28 | Journal article
DOI: 10.1016/j.antiviral.2018.12.015
PMID: 30597184
PMC: PMC7132404
Source: Self-asserted source
Rachel Fearns

Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex.

The Journal of biological chemistry
2018-09-11 | Journal article
DOI: 10.1074/jbc.ra118.004862
PMID: 30206124
PMC: PMC6204889
Source: Self-asserted source
Rachel Fearns

Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses.

Antimicrobial agents and chemotherapy
2018-07-27 | Journal article
DOI: 10.1128/aac.00766-18
PMID: 29891600
PMC: PMC6105843
Source: Self-asserted source
Rachel Fearns

Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter.

Nucleic acids research
2018-07-01 | Journal article
DOI: 10.1093/nar/gky480
PMID: 29873775
PMC: PMC6061868
Source: Self-asserted source
Rachel Fearns

Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene-Azide Cascade Chemistry.

The Journal of organic chemistry
2018-05-03 | Journal article
DOI: 10.1021/acs.joc.8b00222
PMID: 29663810
Source: Self-asserted source
Rachel Fearns

RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V

PLOS Pathogens
2017-12-27 | Journal article
DOI: 10.1371/journal.ppat.1006803
Contributors: Molly R. Braun; Sean P.J. Whelan; Laure R. Deflubé; Sarah L. Noton; Michael E. Mawhorter; Chadene Z. Tremaglio; Rachel Fearns
Source: check_circle
Crossref

Polymerases of paramyxoviruses and pneumoviruses.

Virus research
2017-01-16 | Journal article
DOI: 10.1016/j.virusres.2017.01.008
PMID: 28104450
PMC: PMC5476513
Source: Self-asserted source
Rachel Fearns

New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase.

Antiviral research
2016-08-27 | Journal article
DOI: 10.1016/j.antiviral.2016.08.006
PMID: 27575793
Source: Self-asserted source
Rachel Fearns

Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach.

Journal of virology
2016-04-29 | Journal article
DOI: 10.1128/jvi.02349-15
PMID: 26656699
PMC: PMC4859727
Source: Self-asserted source
Rachel Fearns

Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.

Antiviral research
2016-04-06 | Journal article
DOI: 10.1016/j.antiviral.2016.03.015
PMID: 27059228
PMC: PMC4937797
Source: Self-asserted source
Rachel Fearns

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys.

Nature
2016-03-02 | Journal article
DOI: 10.1038/nature17180
PMID: 26934220
PMC: PMC5551389
Source: Self-asserted source
Rachel Fearns

The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment.

Journal of virology
2015-11-25 | Journal article
DOI: 10.1128/jvi.02417-15
PMID: 26608311
PMC: PMC4733981
Source: Self-asserted source
Rachel Fearns

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.

PLoS pathogens
2015-06-22 | Journal article
DOI: 10.1371/journal.ppat.1004995
PMID: 26098424
PMC: PMC4476725
Source: Self-asserted source
Rachel Fearns

Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter.

Journal of virology
2015-05-20 | Journal article
DOI: 10.1128/jvi.00530-15
PMID: 25995255
PMC: PMC4505683
Source: Self-asserted source
Rachel Fearns

Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection.

Virology
2015-03-19 | Journal article
DOI: 10.1016/j.virol.2015.02.043
PMID: 25796077
PMC: PMC4437874
Source: Self-asserted source
Rachel Fearns

Initiation and regulation of paramyxovirus transcription and replication.

Virology
2015-02-13 | Journal article
DOI: 10.1016/j.virol.2015.01.014
PMID: 25683441
PMC: PMC4424093
Source: Self-asserted source
Rachel Fearns

Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis.

Journal of virology
2014-10-29 | Journal article
DOI: 10.1128/jvi.01783-14
PMID: 25355874
PMC: PMC4300676
Source: Self-asserted source
Rachel Fearns

Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation.

PloS one
2014-07-17 | Journal article
DOI: 10.1371/journal.pone.0102368
PMID: 25033192
PMC: PMC4102526
Source: Self-asserted source
Rachel Fearns

Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase.

Virology
2014-07-08 | Journal article
DOI: 10.1016/j.virol.2014.05.032
PMID: 25010481
PMC: PMC4125506
Source: Self-asserted source
Rachel Fearns

Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter.

2013-01-02 | Standards or policy
DOI:

10.1128/JVI.02862-12

PMID:

23283954
Source: Self-asserted source
Rachel Fearns

Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease.

Current topics in microbiology and immunology
2013-01-01 | Journal article
DOI: 10.1007/978-3-642-38919-1_1
PMID: 24362682
PMC: PMC4794264
Source: Self-asserted source
Rachel Fearns
grade
Preferred source (of 2)‎

The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter.

2012-10-18 | Standards or policy
DOI:

10.1371/journal.ppat.1002980

PMID:

23093940
Source: Self-asserted source
Rachel Fearns

The first two nucleotides of the respiratory syncytial virus antigenome RNA replication product can be selected independently of the promoter terminus.

2011-08-30 | Standards or policy
DOI:

10.1261/rna.2813411

PMID:

21878549
Source: Self-asserted source
Rachel Fearns

Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation.

2010-08-10 | Standards or policy
DOI:

10.1016/j.virol.2010.07.006

PMID:

20701943
Source: Self-asserted source
Rachel Fearns

Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion.

2010-05-17 | Standards or policy
DOI:

10.1073/pnas.0913065107

PMID:

20479224
Source: Self-asserted source
Rachel Fearns

How RNA viruses maintain their genome integrity.

2010-03-24 | Standards or policy
DOI:

10.1099/vir.0.020818-0

PMID:

20335491
Source: Self-asserted source
Rachel Fearns

Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism.

2009-09-09 | Standards or policy
DOI:

10.1128/JVI.01092-09

PMID:

19740993
Source: Self-asserted source
Rachel Fearns

Cation currents in human airway epithelial cells induced by infection with influenza A virus.

2009-04-29 | Standards or policy
DOI:

10.1113/jphysiol.2009.171223

PMID:

19403603
Source: Self-asserted source
Rachel Fearns

Unravelling the complexities of respiratory syncytial virus RNA synthesis.

2006-07-01 | Standards or policy
DOI:

10.1099/vir.0.81786-0

PMID:

16760383
Source: Self-asserted source
Rachel Fearns

Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodies.

2005-11-01 | Standards or policy
DOI:

10.1128/JVI.79.22.14112-14121.2005

PMID:

16254346
Source: Self-asserted source
Rachel Fearns

Evidence that the respiratory syncytial virus polymerase is recruited to nucleotides 1 to 11 at the 3' end of the nucleocapsid and can scan to access internal signals.

2005-09-01 | Standards or policy
DOI:

10.1128/JVI.79.17.11311-11322.2005

PMID:

16103183
Source: Self-asserted source
Rachel Fearns

Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity.

2005-02-01 | Standards or policy
DOI:

10.1128/JVI.79.4.2449-2460.2005

PMID:

15681446
Source: Self-asserted source
Rachel Fearns
Items per page:
Page 1 of 2

Peer review (12 reviews for 4 publications/grants)

Review activity for Nature communications (5)
Review activity for Nature reviews. (1)
Review activity for PLOS pathogens : (4)
Review activity for Virology. (2)
How many people are using ORCID?