Personal information

Complement system, Neuroinflammation, antisense oligonucleotides, Traumatic Brain Injury
Netherlands

Activities

Employment (2)

Leiden university medical center (LUMC): Leiden, NL

2017-01-01 to present | Assistant professor (Clinical Genetics/LDGA)
Employment
Source: Self-asserted source
Kees Fluiter

AMC: Amsterdam, North Holland, NL

1998-05-01 to 2016-12-31 | Research scientist (Neurogenetics/clinical genetics)
Employment
Source: Self-asserted source
Kees Fluiter

Education and qualifications (2)

Universiteit Leiden: Leiden, Zuid-Holland, NL

1993-09-01 to 1998-06-23 | PhD (Biopharmaceutics)
Education
Source: Self-asserted source
Kees Fluiter

Universiteit van Amsterdam: Amsterdam, NL

1989-09-01 to 1993-08-23 | Msc (Biology)
Education
Source: Self-asserted source
Kees Fluiter

Works (50 of 55)

Items per page:
Page 1 of 2

PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells.

Brain : a journal of neurology
2024-05-14 | Journal article
Contributors: Robert Prior; Silva A; Vangansewinkel T; Idkowiak J; Tharkeshwar AK; Hellings TP; Michailidou I; Vreijling J; Loos M; Koopmans B et al.
Source: Self-asserted source
Kees Fluiter

Editorial: Complement in nervous system disease.

Frontiers in cellular neuroscience
2023-08-07 | Journal article
Contributors: Michailidou I; Fluiter K; Boziki M; Grigoriadis N; Baas F
Source: Self-asserted source
Kees Fluiter

Ldlr-/-.Leiden mice develop neurodegeneration, age-dependent astrogliosis and obesity-induced changes in microglia immunophenotype which are partly reversed by complement component 5 neutralizing antibody

Frontiers in Cellular Neuroscience
2023-06-29 | Journal article
Part of ISSN: 1662-5102
Contributors: Florine Seidel; Kees Fluiter; Robert Kleemann; Nicole Worms; Anita van Nieuwkoop; Martien P. M. Caspers; Nikolaos Grigoriadis; Amanda J. Kiliaan; Frank Baas; Iliana Michailidou et al.
Source: Self-asserted source
Kees Fluiter

The systemic inhibition of the terminal complement system reduces neuroinflammation but does not improve motor function in mouse models of CMT1A with overexpressed PMP22

Current Research in Neurobiology
2023-02 | Journal article | Author
Part of ISSN: 2665-945X
Contributors: Iliana Michailidou; Jeroen Vreijling; Matthijs Rumpf; Maarten Loos; Bastijn Koopmans; Nina Vlek; Nina Straat; Cedrick Agaser; Thomas B. Kuipers; Hailiang Mei et al.
Source: Self-asserted source
Kees Fluiter

Tackling Neuroinflammation After Traumatic Brain Injury: Complement Inhibition as a Therapy for Secondary Injury

Neurotherapeutics
2022 | Journal article
EID:

2-s2.0-85139676092

Part of ISSN: 18787479 19337213
Contributors: van Erp, I.A.M.; Michailidou, I.; van Essen, T.A.; van der Jagt, M.; Moojen, W.; Peul, W.C.; Baas, F.; Fluiter, K.
Source: Self-asserted source
Kees Fluiter via Scopus - Elsevier

Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice.

International journal of molecular sciences
2022-09-14 | Journal article | Conceptualization, Investigation
Contributors: Kees Fluiter
Source: Self-asserted source
Kees Fluiter
grade
Preferred source (of 2)‎

Development, Characterization, and in vivo Validation of a Humanized C6 Monoclonal Antibody that Inhibits the Membrane Attack Complex

Journal of Innate Immunity
2022-05-12 | Journal article
Part of ISSN: 1662-811X
Part of ISSN: 1662-8128
Source: Self-asserted source
Kees Fluiter
grade
Preferred source (of 2)‎

Safety and efficacy of C1-inhibitor in traumatic brain injury (CIAO@TBI): study protocol for a randomized, placebo-controlled, multi-center trial.

Trials
2021-12-04 | Journal article
Source: Self-asserted source
Kees Fluiter
grade
Preferred source (of 2)‎

Systemic inhibition of the membrane attack complex impedes neuroinflammation in chronic relapsing experimental autoimmune encephalomyelitis

Acta Neuropathologica Communications
2018 | Journal article
WOSUID:

WOS:000431520400001

Contributors: Michailidou, Iliana; Jongejan, Aldo; Vreijling, Jeroen P.; Georgakopoulou, Theodosia; de Wissel, Marit B.; Wolterman, Ruud A.; Ruizendaal, Patrick; Klar-Mohamad, Ngaisah; Grootemaat, Anita E.; Picavet, Daisy I. et al.
Source: Self-asserted source
Kees Fluiter via ResearcherID
grade
Preferred source (of 2)‎

Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis.

PloS one
2017-10-23 | Journal article
Source: Self-asserted source
Kees Fluiter
grade
Preferred source (of 2)‎

TUB gene expression in hypothalamus and adipose tissue and its association with obesity in humans.

International journal of obesity (2005)
2017-08 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Deregulated expression of EZH2 in congenital brainstem disconnection.

Neuropathology and applied neurobiology
2017-06 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

M. leprae components induce nerve damage by complement activation: identification of lipoarabinomannan as the dominant complement activator.

Acta neuropathologica
2015-05 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Aberrant expression of miR-218 and miR-204 in human mesial temporal lobe epilepsy and hippocampal sclerosis-convergence on axonal guidance.

Epilepsia
2014-12 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

The microRNA-15 family inhibits the TGFβ-pathway in the heart.

Cardiovascular research
2014-10 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Toll-like receptor 4 activation in Barrett's esophagus results in a strong increase in COX-2 expression.

Journal of gastroenterology
2014-07 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Inhibition of the membrane attack complex of the complement system reduces secondary neuroaxonal loss and promotes neurologic recovery after traumatic brain injury in mice.

Journal of immunology (Baltimore, Md. : 1950)
2014-03 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Traumatic brain injury in rats induces lung injury and systemic immune suppression.

Journal of neurotrauma
2013-12 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Glucocorticoid-induced changes in gene expression of airway smooth muscle in patients with asthma.

American journal of respiratory and critical care medicine
2013-05 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response.

PloS one
2012 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy.

Human molecular genetics
2012-01 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Ultrastructural localization and expression of TRPM1 in the human retina.

Investigative ophthalmology & visual science
2011 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development.

Brain
2011-04 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia.

Human molecular genetics
2011-04 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Embryonic stem cell-like cells derived from adult human testis

Journal of Urology
2010 | Journal article
EID:

2-s2.0-77956543330

Part of ISSN: 00225347
Contributors: Mizrak, S.C.; Chikhovskaya, J.V.; Sadri-Ardekani, H.; Van Daalen, S.; Korver, C.M.; Hovingh, S.E.; Roepers-Gajadien, H.L.; Raya, A.; Fluiter, K.; De Reijke, T.M. et al.
Source: Self-asserted source
Kees Fluiter via Scopus - Elsevier

Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.

The American journal of pathology
2010-12 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Induction of sodium channel Na(x) (SCN7A) expression in rat and human hippocampus in temporal lobe epilepsy.

Epilepsia
2010-09 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

In vivo efficacy and off-target effects of locked nucleic acid (LNA) and unlocked nucleic acid (UNA) modified siRNA and small internally segmented interfering RNA (sisiRNA) in mice bearing human tumor xenografts.

Artificial DNA, PNA & XNA
2010-07 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo.

Molecular bioSystems
2010-05 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy.

The European journal of neuroscience
2010-03 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Embryonic stem cell-like cells derived from adult human testis.

Human reproduction (Oxford, England)
2010-01 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

The therapeutic potential of LNA-modified siRNAs: reduction of off-target effects by chemical modification of the siRNA sequence.

Methods in molecular biology (Clifton, N.J.)
2009 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Filling the gap in LNA antisense oligo gapmers: the effects of unlocked nucleic acid (UNA) and 4'-C-hydroxymethyl-DNA modifications on RNase H recruitment and efficacy of an LNA gapmer.

Molecular bioSystems
2009-08 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Allele-specific cancer cell killing in vitro and in vivo targeting a single-nucleotide polymorphism in POLR2A.

Cancer gene therapy
2009-06 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia.

Nature genetics
2008-09 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Evaluation of locked nucleic acid-modified small interfering RNA in vitro and in vivo.

Molecular cancer therapeutics
2007-03 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Evaluation of LNA-modified DNAzymes targeting a single nucleotide polymorphism in the large subunit of RNA polymerase II.

Oligonucleotides
2005-12 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

On the in vitro and in vivo properties of four locked nucleic acid nucleotides incorporated into an anti-H-Ras antisense oligonucleotide.

Chembiochem : a European journal of chemical biology
2005-06 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Killing cancer by targeting genes that cancer cells have lost: allele-specific inhibition, a novel approach to the treatment of genetic disorders.

Cellular and molecular life sciences : CMLS
2003-05 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides.

Nucleic acids research
2003-02 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Tumor genotype-specific growth inhibition in vivo by antisense oligonucleotides against a polymorphic site of the large subunit of human RNA polymerase II

Cancer Research
2002 | Journal article
EID:

2-s2.0-0036532142

Part of ISSN: 00085472
Contributors: Fluiter, K.; Ten Asbroek, A.L.M.A.; Van Groenigen, M.; Nooij, M.; Aalders, M.C.G.; Baas, F.
Source: Self-asserted source
Kees Fluiter via Scopus - Elsevier

Tumor genotype-specific growth inhibition in vivo by antisense oligonucleotides against a polymorphic site of the large subunit of human RNA polymerase II.

Cancer research
2002-04 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central

Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL

Annals of the New York Academy of Sciences
2000 | Book
EID:

2-s2.0-0034086136

Part of ISSN: 00778923
Contributors: Van Berkel, T.J.C.; Van Eck, M.; Herijgers, N.; Fluiter, K.; Nion, S.
Source: Self-asserted source
Kees Fluiter via Scopus - Elsevier

Targeted delivery of antisense oligonucleotides to parenchymal liver cells in vivo.

Methods in enzymology
2000 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Scavenger receptor classes A and B. Their roles in atherogenesis and the metabolism of modified LDL and HDL.

Annals of the New York Academy of Sciences
2000-05 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central

Polymorphisms in the large subunit of human RNA polymerase II as target for allele-specific inhibition.

Nucleic acids research
2000-03 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo.

Biochemical Journal
1999-06 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Scavenger receptor BI mediates the selective uptake of oxidized cholesterol esters by rat liver.

The Journal of biological chemistry
1999-03 | Journal article
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

In vivo regulation of scavenger receptor BI and the selective uptake of high density lipoprotein cholesteryl esters in rat liver parenchymal and Kupffer cells.

The Journal of biological chemistry
1998-04 | Journal article
PMID: 9525955
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎

Scavenger receptor B1 (SR-B1) substrates inhibit the selective uptake of high-density-lipoprotein cholesteryl esters by rat parenchymal liver cells.

Biochemical Journal
1997-09 | Journal article
PMID: 9291126
Source: Self-asserted source
Kees Fluiter via Europe PubMed Central
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2

Peer review (1 review for 1 publication/grant)

Review activity for Neurotherapeutics. (1)