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Works (7)

Allele‐Specific Editing of a Dominant SCN8A Epilepsy Variant Protects against Seizures and Lethality in a Murine Model

Annals of Neurology
2024-11 | Journal article
DOI: 10.1002/ana.27053
Contributors: Wenxi Yu; Sophie F. Hill; Yumei Huang; Limei Zhu; Yiannos Demetriou; Julie Ziobro; Faith Reger; Xiaoyan Jia; Joanna Mattis; Miriam H. Meisler
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Long‐Term Downregulation of the Sodium Channel Gene Scn8a Is Therapeutic in Mouse Models of SCN8A Epilepsy

Annals of Neurology
2024-04 | Journal article
DOI: 10.1002/ana.26861
Contributors: Sophie F. Hill*; Wenxi Yu*; Julie Ziobro; Sanjna Chalasani; Faith Reger; Miriam H. Meisler
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Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy

Epilepsia Open
2022-06 | Journal article
DOI: 10.1002/epi4.12564
Contributors: Jeremy A. Thompson; Raquel M. Miralles; Eric R. Wengert; Pravin K. Wagley; Wenxi Yu; Ian C. Wenker; Manoj K. Patel
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Correction of the hypomorphic Gabra2 splice site variant in mouse strain C57BL/6J modifies the severity of Scn8a encephalopathy

Human Genetics and Genomics Advances
2022-01 | Journal article
DOI: 10.1016/j.xhgg.2021.100064
Contributors: Wenxi Yu; Megan K. Mulligan; Robert W. Williams; Miriam H. Meisler
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Author Correction: Sodium channelopathies in neurodevelopmental disorders

Nature Reviews Neuroscience
2021-04-08 | Journal article
DOI: 10.1038/s41583-021-00449-5
Contributors: Miriam H. Meisler; Sophie F. Hill; Wenxi Yu
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Sodium channelopathies in neurodevelopmental disorders

Nature Reviews Neuroscience
2021-03 | Journal article
DOI: 10.1038/s41583-020-00418-4
Contributors: Miriam H. Meisler; Sophie F. Hill; Wenxi Yu
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Gabra2 is a genetic modifier of Scn8a encephalopathy in the mouse*

Epilepsia
2020-12 | Journal article
DOI: 10.1111/epi.16741
Contributors: Wenxi Yu; Sophie F. Hill; James G. Xenakis; Fernando Pardo‐Manuel de Villena; Jacy L. Wagnon; Miriam H. Meisler
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