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Epidemiology, Integrative Tumor Epidemiology, Breast Cancer, Bladder Cancer, Genetic Susceptibility, Risk Prediction
United States

Biography

Professor Montserrat García-Closas received her M.D. from the University of Barcelona, Spain, a Master of Public Health in quantitative methods, and a Doctorate of Public Health in epidemiology from the Harvard School of Public Health. She joined the Division of Cancer Epidemiology and Genetics (DCEG) of the National Cancer Institute in the USA in 1996 as a postdoctoral fellow, became a tenure-track investigator in 1999 and a tenured senior investigator in 2007. From 2008-2010, she was a visiting scientist at the Department of Oncology and Strangeways Laboratory, Cambridge University, U.K. In 2010, she became a Professor of Epidemiology at the Division of Genetic and Epidemiology of the Institute of Cancer Research (ICR), University of London, U.K. In 2015, she returned to DCEG as Deputy Director and senior investigator. She served as Interim Branch Chief for the Integrative Tumor Epidemiology Branch (ITEB) from 2016-2020, and as Director of the Trans-Divisional Research Program (TDRP) from 2020-2023. In 2023 she returned to the ICR in London as Professor of Epidemiology.

Professor García-Closas investigates the causes of cancer with the aim of understanding carcinogenic processes and improving risk assessment for precision prevention. She carries out a multidisciplinary research program on the genetic susceptibility, etiologic heterogeneity, and risk prediction for breast cancer. She is the principal investigator (PI) of the Breast Cancer Now Generations Study, a prospective cohort study of 110,000 women in the UK to study cancer aetiology and its outcomes, and the Male Breast Cancer Study, a case-control study of 2,000 men with breast cancer and 1,500 controls to study the genetic and environmental causes of male breast cancer. Professor Garcia-Closas also contributes to molecular epidemiology studies of bladder and other cancers.

Professor García-Closas is a founder member of several large consortia. She served as the Chair of the Coordinating Committee for the International Consortium of Case-Control Studies of Bladder Cancer from 2005-2011, and since 2006 she co-Chairs the Pathology and Survival Working Group of the Breast Cancer Association Consortium (BCAC). Professor Garcia-Closas co-led the European Commission Horizon 2020-funded Breast CAncer STratification (BCAST) Project within BCAC. She initiated and is the Chair of the Scientific Steering Committee for the Confluence Project which brings together multiple consortia for trans-ancestry genetic susceptibility studies of female and male breast cancer. She is an active member of the NCI Cohort Consortium, where she co-leads the Breast Cancer Prediction Project, an NCI Cohort Consortium collaboration to develop a comprehensive tool to predict breast cancer risk, overall and by sub-types, across major racial/ethnic groups. She served as the founding PI of Connect for Cancer Prevention (2016-2023), a new prospective study of 200,000 adults in the USA, and she currently serves in the International Advisory Committee.

Activities

Employment (13)

Institute of Cancer Research: London, GB

2023-05-09 to present | Professor of Epidemiology (Division of Cancer Genetics and Epidemiology)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2020 to 2023-05 | Trans-Divisional Research Program Director (Division of Cancer Epidemiology and Genetics)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, MD, US

2015-09-01 to 2022-09 | Deputy Director (Division of Cancer Epidemiology and Genetics)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2016 to 2020 | Interim Branch Chief for the Integrative Tumor Epidemiology Branch (Division of Cancer Epidemiology and Genetics)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

Institute of Cancer Research: London, UK, GB

2010-09 to 2015-08 | Professor of Epidemiology (Division of Genetics and Epidemiology and Breakthrough Toby Robins Breast Cancer Research Centre )
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

University of Cambridge: Cambridge, Cambridgeshire, GB

2008-09 to 2010-08 | Visiting Scientist (Strangeways Laboratory, Department of Public Health and Primary Care)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2007 to 2010-08 | Senior Tenured Investigator (Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

1999 to 2007 | Tenure Track Investigator (Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

1997 to 1999 | Research Fellow (Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

1996 to 1997 | Visiting Fellow (Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

Harvard School of Public Health: Boston, MA, US

1994 to 1995 | Research Fellow (Department of Epidemiology)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

Harvard School of Public Health: Boston, MA, US

1991 to 1992 | Research Fellow (Occupational Health Program, Department of Environmental Sciences)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

Massachusetts General Hospital: Boston, Massachusetts, US

1990 to 1991 | Research Fellow (Division of Nuclear Medicine, Department of Radiology)
Employment
Source: Self-asserted source
Montserrat Garcia-Closas

Education and qualifications (3)

Harvard School of Public Health: Boston, MA, US

1993 to 1996 | Doctor of Public Health (Department of Epidemiology)
Education
Source: Self-asserted source
Montserrat Garcia-Closas

Harvard School of Public Health: Boston, MA, US

1992 to 1993 | Master of Public Health (Department of Epidemiology)
Qualification
Source: Self-asserted source
Montserrat Garcia-Closas

University of Barcelona: Barcelona, Catalonia, ES

1984 to 1990 | Medical Doctor (Medical School)
Qualification
Source: Self-asserted source
Montserrat Garcia-Closas

Professional activities (62)

Instituto de Salud Global Barcelona: Barcelona, Catalunya, ES

2017 to present | Member (External Advisory Committee)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

American Epidemiological Society: Minneapolis, US

2017 to present | Member
Invited position
Source: Self-asserted source
Montserrat Garcia-Closas

NCI Cohort Consortium: Bethesda, MD, US

2010 to present | Member
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

Breast Cancer Association Consortium: Cambridge, GB

2005 to present | Founding Member
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2002 to present | Member
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

International Molecular Pathological Epidemiology: Boston, MA, US

2013 to 2024 | Committee Co-Chair
Service
Source: Self-asserted source
Montserrat Garcia-Closas

Cancer Research UK: London, GB

2023-03 to 2023-03 | Recruitment Panel Member (Cancer Data Driven Detection (CD3) Scientific Director)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, USA, US

2023 | NCI Director's Award for Oversight of Programmatic Vision-Scientific (NCI Office of the Director)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, US

2023 | Group NCI Director's Award, Sherlock-Lung Team, for Population Science-Scientific (NCI Office of the Director)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

American Statistical Association: Alexandria, VA, US

2022 | ASA Jeanne E. Griffith Mentoring Award
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Institutes of Health: Bethesda, Maryland, US

2022 to 2022 | Search Committee Member (Center for Biomedical Informatics and Information Technology (CBIIT), Data Ecosystems Branch Chief)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, MD, US

2022 to 2022 | Search Committee Member, DCCPS Deputy Director (Division of Cancer Control and Population Sciences (DCCPS))
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2020 to 2022 | Member (NCI Equity Council)
Invited position
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, MD, US

2021 | NCI Director's Award of Merit for the DCEG Strategic Planning Group: For leadership in Developing the 2020-2025 DCEG Strategic Plan (NCI Office of the Director)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Center: Bethesda, MD, US

2021 | NCI Director's Award of Merit ( NCI Equity and Inclusion Group: For Outstanding Dedication and Collaboration in Launching the Equity and Inclusion Program to Promote Diversity, Equity and Inclusion Across NCI and the Cancer Research Community)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, MD, US

2021 to 2021 | Search Committee Member (Division of Cancer Control and Population Sciences (DCCPS), Director )
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, MD, US

2021 to 2021 | Chair (Breast Cancer and the Environment: Controversial and Emerging Exposures Workshop )
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, MD, US

2020 | NCI Director's Award of Merit (MyDCEG Team: For the Development and Deployment of myDCEG, a Suite of Tools Built to Improve Decision-Making, Administrative, and Business Processes in DCEG)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Institutes of Health: Bethesda, Maryland, US

2020 to 2020 | Search Committee Member (All of Us Chief Medical Officer and Chief Scientific Officer)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2020 to 2020 | Search Committee Member (Center for Global Health (CGH), Deputy Director)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2019 to 2020 | Committee Chair, DCEG Strategic Plan 2020-2025 (Division of Cancer Epidemiology and Genetics (DCEG))
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Institutes of Health Office of Intramural Research: Bethesda, MD, US

2017 to 2020 | Member of the Trans-NIH Liaisons Coordinating Team (NIH All of Us Research Program, )
Service
Source: Self-asserted source
Montserrat Garcia-Closas

Agence nationale de la recherche: Paris, ÃŽle-de-France, FR

2017 to 2019 | Member of external evaluation group (COHORTES: Investment for the Future Program)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, MD, US

2016 | Breast cancer risk stratification in precision prevention (NCI Intramural Scientific Highlights)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

NHS Breast Screening Programme: London, England, GB

2014 to 2015 | Member (Advisory Committee)
Invited position
Source: Self-asserted source
Montserrat Garcia-Closas

UK Molecular Epidemiology Group (MEG-UK): London, GB

2012 to 2015 | Committee Member
Service
Source: Self-asserted source
Montserrat Garcia-Closas

Royal Marsden Hospital: London, England, GB

2010 to 2015 | Honorary Appointment
Invited position
Source: Self-asserted source
Montserrat Garcia-Closas

Cancer Epidemiology Biomarkers and Prevention: Philadelphia, US

2008 to 2015 | Senior Editor for Molecular and Genetic Epidemiology
Service
Source: Self-asserted source
Montserrat Garcia-Closas

Breast and Prostate Cancer Cohort Consortium (BPC3): Bethesda, US

2006 to 2015 | Member
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

Breast Cancer Campaign: London, GB

2013 to 2013 | Working Group Member (Breast Cancer Campaign Gap Analysis Risk and Prevention Working Group)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2013 to 2013 | Member of Strategy Planning Session (Molecular Epidemiology Group)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2013 to 2013 | Member of Scientific Committee (AACR Annual Meeting 2014)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

European Commission: Brussels, BE

2009 to 2013 | Member of the Scientific Steering Committee (Collaborative Oncological Gene-environment Study (COGS))
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

Center for Research in Environmental Epidemiology: Barcelona, ES

2009 to 2012 | External Scientific Committee (The Multicenter Case-Control Study )
Service
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2009 to 2011 | Member (AACR Cancer Epidemiology and Prevention Awards Committee)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2010 to 2010 | Member (2011 AACR Annual Meeting Education Committee)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2010 to 2010 | Member of Scientific Review Committee (Landon Foundation-AACR INNOVATOR Award for Cancer Prevention Research)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2009 to 2010 | Program Committee Member (Molecular Epidemiology Group (MEG): "The future of molecular epidemiology: novel biomarkers of risk and reponse")
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Institute of Environmental Health Sciences: Research Triangle Park, NC, US

2007 to 2010 | Scientific Advisory Board (The Sister Study)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

E2C2 Consortium of Endometrial Cancer: Bethesda, MD, US

2006 to 2010 | Member
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

Ovarian Cancer Association Consortium: Cambridge, GB

2005 to 2010 | Member
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

International Consortium of Bladder Cancer: Bethesda, MD, US

2005 to 2010 | Chair, Coordinating Committee
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

American Association for Cancer Research: Philadelphia, PA, US

2009 to 2009 | Member of Program Committee (2010 AACR Annual Meeting (Washington DC))
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockvillle, MD, US

2007 to 2009 | Steering Committee of Molecular Epidemiology Working Group (MEG)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Institutes of Health: Bethesda, MD, US

2008 | NIH Merit Award (A group award for successfully conducting a multidisciplinary study of breast, endometrial and ovarian cancers in Poland that enabled new insights into the etiologic heterogeneity of these tumors. )
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, MD, US

2007 to 2008 | Estrogen Receptor Negative Breast Cancer Work Group
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, MD, US

2006 to 2008 | Etiology and Early Marker Studies (EEMS) Review Panel for PLCO Studies (Division for Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, MD, US

2006 to 2008 | Women Scientist Advisor, Elected (Division of Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

Cancer Epidemiology Biomarkers and Prevention: Philadelphia, US

2005 to 2008 | Editorial Board Member
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2007 | NCI Mentor of Merit Award (For excellence in mentoring and guiding the careers of trainees in cancer research)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, MD, US

2007 to 2007 | Search Committee for Tenure-track Investigator (Biostatistics Branch, Division of Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, MD, US

2007 to 2007 | Search Committee for Branch Chief (Biostatistics Branch, Division of Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, MD, US

2007 to 2007 | Search Committee for Tenure-track/Tenure Investigator (Laboratory of Translational Genetics, Division of Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute : Rockville, Maryland, US

2005 to 2005 | Tenure-track Search Committee (Biostatistics Branch, Division of Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, Maryland, US

2005 to 2005 | Tenure-track Search Committee (Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Bethesda, Maryland, US

2004 | Intramural Research Award
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute: Rockville, Maryland, US

2003 to 2003 | Technical Evaluation of Protocols Committee Member (Division of Cancer Epidemiology and Genetics )
Service
Source: Self-asserted source
Montserrat Garcia-Closas

National Institues of Health: Bethesda, MD, US

2001 | NIH Merit Award (In recognition of research contributions that have defined methods for assessing gene-enviornment interactions within the context of epidemiologic studies)
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

American Cancer Society Fellowship: Santa Cruz, CA, US

1999 | The Schilling Research Conference
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

National Cancer Institute : Rockville, MD, US

1998 to 1998 | Technical Evaluation of Questionnaires Committee Member (Division of Cancer Epidemiology and Genetics)
Service
Source: Self-asserted source
Montserrat Garcia-Closas

Society for Epidemiologic Research: Clearfield, UT, US

1995 to 1997
Membership
Source: Self-asserted source
Montserrat Garcia-Closas

Fogarty International Center: Bethesda, Md., US

1996 | Visiting Fellow Award
Distinction
Source: Self-asserted source
Montserrat Garcia-Closas

Funding (12)

"The Generations Study Resource: Maximising Access and Enriching Data to Advance Breast Cancer Research" ; "Understanding the breast cancer risk continuum: leveraging the Generations Study from aetiology to clinical outcomes"

2024-09 to 2029-08 | Grant
Breast Cancer Now (London, GB)
GRANT_NUMBER:

BGS-Q4-Y1 to Y5

Source: Self-asserted source
Montserrat Garcia-Closas

Role of Serum Hormones in Breast Cancer Risk Assessment and Response to Endocrine Preventive Treatment

2023-09 to 2025-08 | Grant
Breast Cancer Research Foundation (NY, NY, US)
GRANT_NUMBER:

WT 11465176, EMSR1G7

Source: Self-asserted source
Montserrat Garcia-Closas

Generations Study 2023/24

2023-09 to 2024-08 | Grant
Breast Cancer Now (London, GB)
GRANT_NUMBER:

BGS-Q3-Y10

Source: Self-asserted source
Montserrat Garcia-Closas

Multifactoral Breast Cancer Risk Prediction Accounting for Ethnic and Tumor Diversity

2021 to 2025 | Grant
National Cancer Center (Bethesda, MD, US)
GRANT_NUMBER:

5U01CA249866-02

Source: Self-asserted source
Montserrat Garcia-Closas

Statistical Methods for Development, Validation, and Implementation of Absolute Risk Models

2016-01 to 2020-02 | Grant
Patient-Centered Outcomes Research Institute (D.C., D.C., US)
Source: Self-asserted source
Montserrat Garcia-Closas

The Confluence Project

2016 to present | Award
National Cancer Institute (Bethesda, MD, US)
Source: Self-asserted source
Montserrat Garcia-Closas

Connect for Cancer Prevention Study

2016 to 2023 | Award
National Cancer Institute (Bethesda, MD, US)
Source: Self-asserted source
Montserrat Garcia-Closas

Breast cancer studies of genetic susceptibility, etiology heterogeneity and risk prediction

2015-09 to 2023 | Award
National Cancer Institute (Bethesda, MD, US)
Source: Self-asserted source
Montserrat Garcia-Closas

Breast Cancer Stratitication:B-CAST

2015-09 to 2021-09 | Grant
Horizon 2020 European Commission (Brussels, BE)
GRANT_NUMBER:

EU 633784-B-CAST

Source: Self-asserted source
Montserrat Garcia-Closas

Generations Cohort Study

Source: Self-asserted source
Montserrat Garcia-Closas

Breast Cancer Studies in the Generations Cohort Study

2010-09 to 2014-08 | Grant
Breakthrough Breast Cancer (London, GB)
Source: Self-asserted source
Montserrat Garcia-Closas

Molecular Epidemiology of Breast and Bladder Cancer

1996 to 2010 | Award
National Cancer Institute (Bethesda, MD, US)
Source: Self-asserted source
Montserrat Garcia-Closas

Peer review (9 reviews for 7 publications/grants)

Review activity for Breast cancer research and treatment. (1)
Review activity for Journal of the National Cancer Institute : (2)
Review activity for Nature communications (2)
Review activity for Nature reviews. (1)
Review activity for NPJ breast cancer. (1)
Review activity for npj precision oncology. (1)
Review activity for PLoS medicine. (1)